zn(ii)-phthalocyanine and ferric-ferrocyanide

Polycyclodextrin (denoted PCD) composed of cyclodextrin monomer units and 1,3-diethoxypropan-2-ol containing many hydroxyl groups with lone pairs of electrons, easily coordinated with transition metals with empty orbitals. The CD unit can also provide host-guest binding sites for functional molecules. This article utilizes this feature of PCD for the first time as a "linker" to combine transition metal nanomaterials with synergistic functional molecules. We synthesized PCD with 50% CD monomer by epichlorohydrin cross-linking method. Utilizing the coordination effect of the hydroxyl group in PCD and the iron ion in photothermal nanoparticles (PB-Yb), the PCD is coated on its surface; simultaneously, CD in PCD can form a host-guest complex with adamantane-modified zinc phthalocyanine (Pc) photosensitizer. Using PCD as a "linker", PB-Yb and Pc (denoted PYPP) were combined to improve the solubility of PB-Yb, reduce the aggregation degree of Pc to increase their activity, and achieve photothermal and photodynamic synergistic tumor therapy.

Topics: Adamantane; Animals; Antineoplastic Agents; Cyclodextrins; Female; Ferrocyanides; HeLa Cells; Humans; Isoindoles; Light; Mice, Inbred BALB C; Nanomedicine; Nanoparticles; Neoplasms; Organometallic Compounds; Photosensitizing Agents; Polymers; Reactive Oxygen Species; Ytterbium; Zinc Compounds