Compounds > zm 241385
Page last updated: 2024-09-05

zm 241385 and rolipram

zm 241385 has been researched along with rolipram in 4 studies

Compound Research Comparison

Studies
(zm 241385)		Trials
(zm 241385)		Recent Studies (post-2010)
(zm 241385)		Studies
(rolipram)		Trials
(rolipram)		Recent Studies (post-2010) (rolipram)
40131241,60417401
401312426015

Protein Interaction Comparison

ProteinTaxonomyzm 241385 (IC50)rolipram (IC50)
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.2233
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)1.2233
Retina-specific copper amine oxidaseHomo sapiens (human)0.0003
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.0975
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)3.63
ReninHomo sapiens (human)3.5
Tumor necrosis factorHomo sapiens (human)0.35
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)0.7287
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)0.7287
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)0.8447
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)1.1942
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.095
Delta-type opioid receptorMus musculus (house mouse)1.5
Delta-type opioid receptorRattus norvegicus (Norway rat)1.5
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)0.7287
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)0.835
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)1.1005
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)1.61
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)1.0794
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.835
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)0.835
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)0.835
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)0.835
Chain A, cAMP-specific phosphodiesterase PDE4D2Homo sapiens (human)0.33
Chain A, cAMP-specific phosphodiesterase PDE4D2Homo sapiens (human)0.33
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.288
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.288
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.288
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.288
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.288
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.288
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.288
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.5

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
French, SW; Khachatoorian, R; Micewicz, ED; Ruchala, P1
Buster, BL; Linden, J; Scheld, WM; Sullivan, GW1
Lappas, CM; Linden, J; Rieger, JM1
Hurley, DJ; Moore, JN; Murray, TF; Sun, WC; Vandenplas, ML1

Other Studies

4 other study(ies) available for zm 241385 and rolipram

ArticleYear
Identification of novel small-molecule inhibitors of Zika virus infection.
    Bioorganic & medicinal chemistry letters, 2018, 02-01, Volume: 28, Issue:3

    Topics: A549 Cells; Antiviral Agents; Cell Survival; Dose-Response Relationship, Drug; Humans; Molecular Structure; Small Molecule Libraries; Structure-Activity Relationship; Zika Virus; Zika Virus Infection

2018
Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram.
    The Journal of infectious diseases, 1999, Volume: 180, Issue:5

    Topics: Adenosine; Animals; Blood-Brain Barrier; Cell Adhesion; Cyclic AMP; Disease Models, Animal; Drug Synergism; Humans; Leukocytosis; Meningitis, Bacterial; Neutrophil Activation; Neutrophils; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiratory Burst; Rolipram; Superoxides; Triazines; Triazoles; Tumor Necrosis Factor-alpha

1999
A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Jan-15, Volume: 174, Issue:2

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; CD4-Positive T-Lymphocytes; Cell Line; Cyclic AMP; Cyclohexanecarboxylic Acids; Gene Dosage; Humans; Interferon-gamma; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Purines; Receptor, Adenosine A2A; Receptors, Antigen, T-Cell; RNA, Messenger; Rolipram; Triazines; Triazoles

2005
Effects of stimulation of adenosine A2A receptors on lipopolysaccharide-induced production of reactive oxygen species by equine neutrophils.
    American journal of veterinary research, 2007, Volume: 68, Issue:6

    Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Dose-Response Relationship, Drug; Horses; Lipopolysaccharides; Neutrophils; Reactive Oxygen Species; Receptor, Adenosine A2A; Rolipram; Triazines; Triazoles

2007