zm 241385 has been researched along with istradefylline in 15 studies
| Studies (zm 241385) | Trials (zm 241385) | Recent Studies (post-2010) (zm 241385) | Studies (istradefylline) | Trials (istradefylline) | Recent Studies (post-2010) (istradefylline) |
|---|---|---|---|---|---|
| 401 | 3 | 124 | 212 | 18 | 121 |
| Protein | Taxonomy | zm 241385 (IC50) | istradefylline (IC50) |
|---|---|---|---|
| Adenosine receptor A2a | Homo sapiens (human) | 5.249 | |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | 0.228 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO | 1 |
| Andrews, SP; Congreve, M; Errey, JC; Marshall, FH; Mason, JS; Robertson, N; Tehan, B; Weir, M; Zhukov, A | 1 |
| Capuano, B; Jörg, M; Mak, FS; Miller, ND; Scammells, PJ; Shonberg, J; Yuriev, E | 1 |
| Chevalier, V; Hatfield, S; Jones, GB; Lee, J; Ondrechen, MJ; Sadler, S; Selesniemi, K; Sitkovsky, M; Thomas, R | 1 |
| de Lera Ruiz, M; Lim, YH; Zheng, J | 1 |
| Terre'Blanche, G; Van der Walt, MM | 1 |
| Agouridas, L; Duroux, R; El Bakali, J; Furman, C; Melnyk, P; Renault, N; Yous, S | 1 |
| Gaba, S; Gupta, GD; Monga, V; Patel, R; Saini, A; Singh, G | 1 |
| Barczyk, A; Bolteau, R; Cherezov, V; Coevoet, M; Duroux, R; Han, GW; Laversin, A; Liberelle, M; Melnyk, P; Ravez, S; Renault, N; Shiriaeva, A; Stauch, B; Vreulz, B; Yous, S | 1 |
| Harvey, V; Jones, J; Knight, AR; Misra, A; Quirk, K | 1 |
| Costentin, J; El Yacoubi, M; Vaugeois, JM | 1 |
| Benwell, K; Cliffe, IA; Dourish, CT; Gillespie, RJ; Knight, AR; Lerpiniere, J; Misra, A; Pratt, RM; Revell, D; Upton, R; Weiss, SM | 1 |
| Alexander, SP; Beckett, SR; Harper, LK; Marsden, CA; McCreary, AC | 1 |
| Han, K; Pang, X; Yang, M | 1 |
| Bonaventura, J; Brugarolas, M; Casadó, V; Cellai, L; Chang, CP; Chern, Y; Cortés, A; Dettori, I; Ferré, S; Guitart, X; Narayanan, M; Orrú, M; Pedata, F; Rea, W | 1 |
2 review(s) available for zm 241385 and istradefylline
| Article | Year |
|---|---|
Adenosine A2A receptor as a drug discovery target.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Crystallography, X-Ray; Drug Discovery; Humans; Ligands; Protein Conformation; Receptor, Adenosine A2A; Signal Transduction | 2014 |
Adenosine receptor antagonists: Recent advances and therapeutic perspective.
Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Structure-Activity Relationship | 2022 |
13 other study(ies) available for zm 241385 and istradefylline
| Article | Year |
|---|---|
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles | 2005 |
Biophysical mapping of the adenosine A2A receptor.
Topics: Adenosine A2 Receptor Antagonists; Binding Sites; Drug Design; Ligands; Models, Molecular; Mutation; Pyrimidines; Receptor, Adenosine A2A; Small Molecule Libraries; Triazines; Triazoles; Xanthines | 2011 |
Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.
Topics: Adenosine A2 Receptor Antagonists; Binding Sites; Humans; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Receptor, Adenosine A2A; Triazines; Triazoles | 2013 |
Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies.
Topics: Cell Line; Crystallography, X-Ray; Drug Design; Humans; Hypoxia; Immunotherapy; Models, Molecular; Polyethylene Glycols; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Xanthine | 2013 |
1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor.
Topics: Adenosine A1 Receptor Antagonists; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Binding; Receptor, Adenosine A1; Structure-Activity Relationship; Xanthines | 2015 |
Antagonists of the adenosine A
Topics: Adenosine A2 Receptor Antagonists; Benzoxazoles; Caco-2 Cells; Cell Line, Tumor; Drug Design; Humans; Microsomes, Liver; Receptor, Adenosine A2A; Solubility | 2018 |
High ligand efficiency quinazoline compounds as novel A
Topics: Adenosine A2 Receptor Antagonists; Ligands; Molecular Docking Simulation; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Structure-Activity Relationship | 2022 |
Solubilisation and immunoprecipitation of rat striatal adenosine A(2A) receptors.
Topics: Adenosine; Animals; Cholic Acids; Corpus Striatum; Detergents; Phenethylamines; Precipitin Tests; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Solubility; Triazines; Triazoles | 2001 |
Adenosine A2A receptors and depression.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Depression; Disease Models, Animal; Dopamine Antagonists; Drug Interactions; Haloperidol; Mice; Mice, Knockout; Motor Activity; Neurotransmitter Agents; Parkinsonian Disorders; Purines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles | 2003 |
Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mefloquine; Mice; Motor Activity; Neuroprotective Agents; Parkinsonian Disorders; Phenethylamines; Purines; Pyrimidines; Radioligand Assay; Rats; Triazines; Triazoles | 2003 |
Effects of the A 2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo.
Topics: Animals; Binding, Competitive; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Purines; Rats; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2006 |
Antagonist binding and induced conformational dynamics of GPCR A2A adenosine receptor.
Topics: Adenosine A2 Receptor Antagonists; Animals; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Conformation; Purines; Rats; Receptor, Adenosine A2A; Thermodynamics; Triazines; Triazoles | 2013 |
Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Locomotion; Nucleoside Transport Proteins; Prefrontal Cortex; Psychomotor Disorders; Purines; Rats; Rats, Transgenic; Receptor, Adenosine A2A; Triazines; Triazoles; Trinucleotide Repeat Expansion; Tritium | 2016 |