Compounds > zm 241385
Page last updated: 2024-09-05

zm 241385 and glutamic acid

zm 241385 has been researched along with glutamic acid in 17 studies

Compound Research Comparison

Studies
(zm 241385)		Trials
(zm 241385)		Recent Studies (post-2010)
(zm 241385)		Studies
(glutamic acid)		Trials
(glutamic acid)		Recent Studies (post-2010) (glutamic acid)
401312441,75745212,876

Protein Interaction Comparison

ProteinTaxonomyzm 241385 (IC50)glutamic acid (IC50)
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2Rattus norvegicus (Norway rat)0.821
Chain A, Glutamate Receptor Subunit 2Rattus norvegicus (Norway rat)0.821
Chain B, Glutamate Receptor Subunit 2Rattus norvegicus (Norway rat)0.821
Metabotropic glutamate receptor 8Homo sapiens (human)0.0057
Glutamate receptor ionotropic, NMDA 2DHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 3BHomo sapiens (human)0.07
Glutamate receptor 1Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 2Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 3Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 4Rattus norvegicus (Norway rat)0.5885
Glutamate receptor ionotropic, kainate 1Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 2Rattus norvegicus (Norway rat)0.38
Glutamate receptor 1Homo sapiens (human)0.613
Glutamate receptor 2Homo sapiens (human)0.613
Glutamate receptor 3Homo sapiens (human)0.613
Glutamate receptor ionotropic, kainate 3Rattus norvegicus (Norway rat)0.38
Excitatory amino acid transporter 1Homo sapiens (human)207
Glutamate receptor 4Homo sapiens (human)0.613
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 4Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2CHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 5Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 3AHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.1533

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (82.35)29.6817
2010's3 (17.65)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO1
Agostinho, P; Cunha, RA; Melo, J; Oliveira, CR; Rego, AC1
Gao, ZG; Ijzerman, AP; Jacobson, KA; Jiang, Q1
Cunha, RA; Fredholm, BB; Kull, B; Lopes, LV; Ribeiro, JA1
D'Ambrosio, R; Iliff, JJ; Ngai, AC; Winn, HR1
Boehm, S; Freissmuth, M; Just, H; Klinger, M; Korkhov, VM; Kudlacek, O; Nanoff, C; Pankevych, H; Vartian, N; Yang, Q1
Galluzzo, M; Grieco, R; Pèzzola, A; Pintor, A; Popoli, P; Reggio, R1
Domenici, MR; Frank, C; Grieco, R; Martire, A; Pepponi, R; Pintor, A; Popoli, P; Potenza, RL; Tebano, MT1
Boeck, CR; Bronzatto, MJ; Kroth, EH; Vendite, D1
Almeida, T; Cunha, RA; Oliveira, CR; Richardson, PJ; Rodrigues, RJ1
Baunez, C; Bernardi, G; Calabresi, P; Centonze, D; De Chiara, V; Gubellini, P; Picconi, B; Prosperetti, C; Rossi, S; Tscherter, A1
Baranyi, M; Illes, P; Sperlágh, B; Vizi, ES; Zsilla, G1
Belcastro, V; Borsini, F; Calabresi, P; Centonze, D; Costa, C; Picconi, B; Tantucci, M; Tozzi, A; Tscherter, A1
Ferrante, A; Ferretti, R; Martire, A; Pepponi, R; Popoli, P1
Dziubina, A; Gołembiowska, K2
An, JH; Chen, JF; Dai, SS; Li, W; Ning, YL; Wang, H; Yang, N; Zhou, YG; Zhu, PF1

Trials

1 trial(s) available for zm 241385 and glutamic acid

ArticleYear
Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury.
    The Journal of experimental medicine, 2013, Apr-08, Volume: 210, Issue:4

    Topics: Acute Lung Injury; Adenosine; Adenosine A2 Receptor Agonists; Adult; Animals; Bone Marrow Cells; Brain Injuries; Disease Models, Animal; Female; Glutamic Acid; Humans; Male; Mice; Mice, Knockout; Middle Aged; Phenethylamines; Protein Kinase C; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Triazines; Triazoles; Type C Phospholipases

2013

Other Studies

16 other study(ies) available for zm 241385 and glutamic acid

ArticleYear
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
    Journal of medicinal chemistry, 2005, Nov-03, Volume: 48, Issue:22

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles

2005
Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells.
    Experimental eye research, 2000, Volume: 70, Issue:5

    Topics: Adenosine; Analysis of Variance; Animals; Aspartic Acid; Bicuculline; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Extracellular Space; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycolysis; Humans; Ischemia; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Retina; Triazines; Triazoles; Xanthines

2000
Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation.
    Biochemical pharmacology, 2000, Sep-01, Volume: 60, Issue:5

    Topics: Animals; Binding, Competitive; Drug Interactions; Glutamic Acid; Guanosine Triphosphate; Histidine; Humans; In Vitro Techniques; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sodium; Triazines; Triazoles; Tritium

2000
Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.
    Neuroscience, 2002, Volume: 112, Issue:2

    Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Synaptic Transmission; Transfection; Triazines; Triazoles; Xanthines

2002
Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:5

    Topics: Animals; Arterioles; Blood Pressure; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Glutamic Acid; Male; N-Methylaspartate; Pia Mater; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation

2003
The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Adenylyl Cyclases; Animals; Benzamides; Binding, Competitive; Cell Cycle; Cell Membrane; Cofilin 1; Colforsin; Cyclic AMP; Cytoskeletal Proteins; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enzyme Activation; Gene Expression; Glutamic Acid; Humans; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pertussis Toxin; Phenethylamines; Phosphodiesterase Inhibitors; Phosphoproteins; Propionates; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrrolidines; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Purinergic P1; Thionucleotides; Transfection; Triazines; Triazoles; Xenopus Proteins

2003
Adenosine A 2A receptor antagonists prevent the increase in striatal glutamate levels induced by glutamate uptake inhibitors.
    Journal of neurochemistry, 2004, Volume: 89, Issue:1

    Topics: Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dicarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Male; Microdialysis; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Pyrimidines; Pyrrolidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles

2004
Adenosine A2A receptor blockade differentially influences excitotoxic mechanisms at pre- and postsynaptic sites in the rat striatum.
    Journal of neuroscience research, 2004, Jul-01, Volume: 77, Issue:1

    Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Calcium; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Models, Biological; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Phenethylamines; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptic Transmission; Triazines; Triazoles

2004
Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity.
    Neuropharmacology, 2005, Volume: 49, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebellum; Cyclic AMP; Drug Antagonism; Excitatory Amino Acid Agonists; Glutamic Acid; Hydrolysis; N-Methylaspartate; Neurons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles

2005
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jul-06, Volume: 25, Issue:27

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Astrocytoma; Calcium; Cell Line; Cell Line, Tumor; Glutamic Acid; Hippocampus; Kidney; Male; Potassium; Pyramidal Cells; Pyridoxal Phosphate; Rats; Rats, Wistar; Receptors, Presynaptic; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Recombinant Fusion Proteins; RNA, Messenger; Subcellular Fractions; Suramin; Synaptosomes; Transfection; Triazines; Triazoles; Xanthines

2005
Deficits of glutamate transmission in the striatum of experimental hemiballism.
    Neuroscience, 2006, Nov-17, Volume: 143, Issue:1

    Topics: Anesthetics, Local; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Dyskinesias; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sulpiride; Synaptic Transmission; Tetrodotoxin; Triazines; Triazoles

2006
Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus.
    Neuroscience, 2007, Oct-12, Volume: 149, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Analgesics; Animals; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Ischemia; Male; Phenethylamines; Purinergic Agonists; Purinergic Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptors, Purinergic; Sodium Channel Blockers; Tetrodotoxin; Triazines; Triazoles; Xanthines

2007
Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.
    Neuropharmacology, 2007, Volume: 53, Issue:6

    Topics: Adenine; Adenosine; Animals; Cerebral Cortex; Corpus Striatum; Dopamine Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Phenethylamines; Quinpirole; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D2; Synaptic Transmission; Triazines; Triazoles

2007
Region-specific neuroprotective effect of ZM 241385 towards glutamate uptake inhibition in cultured neurons.
    European journal of pharmacology, 2009, Sep-01, Volume: 617, Issue:1-3

    Topics: Adenosine A2 Receptor Antagonists; Animals; Binding, Competitive; Biological Transport; Biomimetics; Blotting, Western; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Female; Gene Expression Regulation; Glutamic Acid; Neostriatum; Neurons; Neuroprotective Agents; Organ Specificity; Pregnancy; Pyrrolidines; Rats; Receptor, Adenosine A2A; Substrate Specificity; Triazines; Triazoles

2009
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
    Neurotoxicity research, 2012, Volume: 21, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles

2012
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2.
    Neurotoxicity research, 2012, Volume: 22, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Triazines; Triazoles; Vesicular Monoamine Transport Proteins

2012