Page last updated: 2024-09-05

zm 241385 and adenosine-5'-(n-ethylcarboxamide)

zm 241385 has been researched along with adenosine-5'-(n-ethylcarboxamide) in 39 studies

Compound Research Comparison

Studies (zm 241385)	Trials (zm 241385)	Recent Studies (post-2010) (zm 241385)	Studies (adenosine-5'-(n-ethylcarboxamide))	Trials (adenosine-5'-(n-ethylcarboxamide))	Recent Studies (post-2010) (adenosine-5'-(n-ethylcarboxamide))
401	3	124	1,333	4	133

Protein Interaction Comparison

Protein	Taxonomy	adenosine-5'-(n-ethylcarboxamide) (IC50)
Adenosine receptor A3	Homo sapiens (human)	0.0097
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	0.037
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	0.037
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	0.037
Adenosine receptor A1	Rattus norvegicus (Norway rat)	0.4498
Adenosine receptor A2a	Homo sapiens (human)	0.0336
Adenosine receptor A2b	Rattus norvegicus (Norway rat)	0.0175
Adenosine receptor A1	Homo sapiens (human)	0.0007
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	0.0513
Adenosine receptor A1	Gallus gallus (chicken)	0.017

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (23.08)	18.2507
2000's	20 (51.28)	29.6817
2010's	9 (23.08)	24.3611
2020's	1 (2.56)	2.80

Authors

Authors	Studies
Figler, H; Jin, X; Linden, J; Robeva, AS; Thai, T	1
Beukers, MW; Brouwer, J; den Dulk, H; Ijzerman, AP; van Tilburg, EW	1
Ahern, DG; Jacobson, KA; Ji, X; Kim, YC; Linden, J	1
Castelhano, AL; Ma, C; MacLennan, SJ; McKibben, B; Song, JP; Steinig, AG; Stewart, M	1
Beukers, MW; Brussee, J; de Graaf, O; de Vries, H; Göblyös, A; Ijzerman, AP; Link, R; Mantri, M; Mulder-Krieger, T; van Veldhoven, J; von Frijtag Drabbe Künzel, JK	1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L	1
de Lera Ruiz, M; Lim, YH; Zheng, J	1
Handa, C; Momose, T; Muranaka, H; Ozawa, T	1
Berizzi, A; Bird, L; Culurgioni, S; Navratilova, IH; Olsen, RHJ; Rawlins, PB; Robinson, S; Shepherd, C; Thompson, LEJ; Varzandeh, S	1
Hourani, SM; Prentice, DJ	1
Constantino, MD; Cunha, RA; Ribeiro, JA	1
Hourani, SM; Payne, SL; Prentice, DJ	1
McGrath, JC; Moore, FP; Thomson, NC	1
Baraldi, PG; Borea, PA; Cacciari, B; Dionisotti, S; Ongini, E; Varani, K	1
Cutler, BS; Dobson, JG; Fenton, RA; Li, Jm; Peyton, BD; Powell, CC; Wheeler, HB	1
Enyeart, JJ; Xu, L	1
Fei, Q; Loutzenhiser, R; Parker, M; Tang, L	1
Abebe, W; Arif Hasan, AZ; Mustafa, SJ	1
Feoktistov, I; Mustafa, SJ; Olanrewaju, HA; Qin, W; Scemama, JL	1
Breschi, MC; Calderone, V; Martinotti, E; Nieri, P	1
Belem, PC; Chen, JF; Cronstein, B; Elson, G; Fink, JS; Jacobson, M; Leibovich, SJ; Montesinos, C; Pinhal-Enfield, G; Ramanathan, M; Rosania, A; Schwarzschild, MA	1
Borea, PA; Cattabriga, E; Iannotta, V; Manfredini, R; Pancaldi, C; Portaluppi, F; Uluoglu, C; Varani, K	1
Diniz, C; Gonçalves, J; Leal, S	1
Fredholm, BB; Hellsten, Y; Lynge, J; Nordsborg, N; Schulte, G	1
Abebe, W; Mozaffari, MS	1
Ho, CM; Ho, ST; Peng, SC; Su, CK; Tsai, SK	1
Briones, R; Donoso, MV; Huidobro-Toro, JP; López, R; Miranda, R	1
Hikichi, T; Kawahara, A; Kitaya, N; Mori, F; Takahashi, J; Yoshida, A	1
Grden, M; Kocbuch, K; Pawelczyk, T; Podgorska, M; Szutowicz, A	1
Hao, I; Leibovich, SJ; Pinhal-Enfield, G; Ramanathan, M	1
Hurley, DJ; Moore, JN; Murray, TF; Sun, WC; Vandenplas, ML	1
Cao, Z; Hurley, DJ; Linden, J; Moore, JN; Murray, TF; Sun, WC; Vandenplas, ML	1
Csóka, B; Haskó, G; Leibovich, SJ; Lukashev, D; Luo, W; Ramanathan, M; Sitkovsky, MV	1
Beukers, MW; Guo, D; Ijzerman, AP; Müller, CE; Peeters, MC; van Westen, GJ; Wisse, LE	1
Bennett, K; Edwards, PC; Langmead, CJ; Lebon, G; Leslie, AG; Tate, CG; Warne, T	1
Falck, JR; Morisseau, C; Mustafa, SJ; Nayeem, MA; Pradhan, I; Zeldin, DC	1
Frøbert, O; Hedegaard, ER; Mogensen, S; Nielsen, BD; Rembold, CM; Simonsen, U	1
Åqvist, J; Gutiérrez-de-Terán, H; Keränen, H	1
Ernst, OP; García, AE; Larda, ST; Lyda, B; Neale, C; Pichugin, D; Pomès, R; Prosser, RS; Sljoka, A; Sunahara, RK; Tsuchimura, N; Ye, L	1

Reviews

2 review(s) available for zm 241385 and adenosine-5'-(n-ethylcarboxamide)

Article	Year
Fluorescent ligands for adenosine receptors. Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1 Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1	2013
Adenosine A2A receptor as a drug discovery target. Journal of medicinal chemistry, 2014, May-08, Volume: 57, Issue:9 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Crystallography, X-Ray; Drug Discovery; Humans; Ligands; Protein Conformation; Receptor, Adenosine A2A; Signal Transduction	2014

Trials

1 trial(s) available for zm 241385 and adenosine-5'-(n-ethylcarboxamide)

Article	Year
Effects of doxazosin and propranolol on A2A adenosine receptors in essential hypertension. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:6 Topics: Adenosine-5'-(N-ethylcarboxamide); Adult; Antihypertensive Agents; Binding, Competitive; Blood Pressure; Body Mass Index; Cyclic AMP; Diastole; Doxazosin; Female; Humans; Hypertension; Lymphocytes; Male; Middle Aged; Neutrophils; Propranolol; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Reference Values; Systole; Treatment Outcome; Triazines; Triazoles	2002

Article

Year

Effects of doxazosin and propranolol on A2A adenosine receptors in essential hypertension.

Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:6

Topics: Adenosine-5'-(N-ethylcarboxamide); Adult; Antihypertensive Agents; Binding, Competitive; Blood Pressure; Body Mass Index; Cyclic AMP; Diastole; Doxazosin; Female; Humans; Hypertension; Lymphocytes; Male; Middle Aged; Neutrophils; Propranolol; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Reference Values; Systole; Treatment Outcome; Triazines; Triazoles

2002

Other Studies

36 other study(ies) available for zm 241385 and adenosine-5'-(n-ethylcarboxamide)

Article	Year
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular pharmacology, 1999, Volume: 56, Issue:4 Topics: Animals; Anti-Asthmatic Agents; Blotting, Western; Calcium; Cell Degranulation; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Kidney; Mast Cells; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Theophylline; Type C Phospholipases; Xanthines	1999
Why are A(2B) receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A(2B) receptor for 2-(1-Hexynyl)adenosine. Molecular pharmacology, 2000, Volume: 58, Issue:6 Topics: Adenosine; Alkynes; Amino Acid Sequence; Animals; Asparagine; COS Cells; Cyclic AMP; Molecular Sequence Data; Mutation; Point Mutation; Protein Conformation; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Sequence Homology, Amino Acid; Transfection; Tyrosine	2000
[3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochemical pharmacology, 2001, Mar-15, Volume: 61, Issue:6 Topics: Acetamides; Cells, Cultured; Humans; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Radiopharmaceuticals; Receptor, Adenosine A2B; Tritium	2001
[3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. Biochemical pharmacology, 2004, Jul-15, Volume: 68, Issue:2 Topics: Adenosine A2 Receptor Antagonists; Cells, Cultured; Humans; Pyrimidines; Pyrroles; Radioligand Assay; Time Factors; Tritium	2004
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Adenosine A2 Receptor Antagonists; Amines; Animals; Cell Line; Cricetinae; Cyclic AMP; Furans; Humans; Models, Molecular; Molecular Structure; Nicotinic Acids; Nitriles; Receptor, Adenosine A2A; Structure-Activity Relationship	2008
Photoaffinity Labeling of the Human A ACS medicinal chemistry letters, 2017, Jun-08, Volume: 8, Issue:6 Topics:	2017
Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments. ACS medicinal chemistry letters, 2022, Jul-14, Volume: 13, Issue:7 Topics:	2022
Adenosine analogues relax guinea-pig taenia caeci via an adenosine A2B receptor and a xanthine-resistant site. European journal of pharmacology, 1997, Mar-26, Volume: 323, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cecum; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines	1997
ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. British journal of pharmacology, 1997, Volume: 122, Issue:7 Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Binding Sites; Hippocampus; Ligands; Membranes; Phenethylamines; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rats; Synaptic Transmission; Synaptosomes; Triazines; Triazoles; Visual Cortex	1997
Activation of two sites by adenosine receptor agonists to cause relaxation in rat isolated mesenteric artery. British journal of pharmacology, 1997, Volume: 122, Issue:7 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Arrhythmia Agents; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Male; Mesenteric Arteries; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents	1997
Adenosine A1 receptor-mediated activation of AMP-activated protein kinase in bovine bronchial rings. Biochemical Society transactions, 1997, Volume: 25, Issue:4 Topics: Adenosine-5'-(N-ethylcarboxamide); Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bronchi; Cattle; Enzyme Activation; In Vitro Techniques; Multienzyme Complexes; Phenylisopropyladenosine; Protein Kinases; Protein Serine-Threonine Kinases; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Ribonucleotides; Triazines; Triazoles; Xanthines	1997
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors. Life sciences, 1998, Volume: 63, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Kidney; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Transfection; Triazines; Triazoles	1998
Adenosine A2a receptors increase arterial endothelial cell nitric oxide. The Journal of surgical research, 1998, Volume: 80, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carotid Arteries; Cells, Cultured; Endothelium, Vascular; Humans; Iliac Artery; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Xanthines	1998
Adenosine inhibits a non-inactivating K+ current in bovine adrenal cortical cells by activation of multiple P1 receptors. The Journal of physiology, 1999, Nov-15, Volume: 521 Pt 1 Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; GTP-Binding Proteins; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Purinergic P1; Signal Transduction; Triazines; Triazoles; Xanthines; Zona Fasciculata	1999
Afferent arteriolar adenosine A2a receptors are coupled to KATP in in vitro perfused hydronephrotic rat kidney. The American journal of physiology, 1999, Volume: 277, Issue:6 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Arterioles; Blood Pressure; Enzyme Inhibitors; Hydronephrosis; Kidney; Perfusion; Potassium Channels; Potassium Chloride; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Renal Artery; Renal Circulation; Triazines; Triazoles; Vasoconstriction; Vasodilation; Vasodilator Agents; Xanthines	1999
Antagonism of coronary artery relaxation by adenosine A2A-receptor antagonist ZM241385. Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Coronary Vessels; Dinoprost; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Vasodilator Agents	2000
Adenosine A(2A) and A(2B) receptors in cultured human and porcine coronary artery endothelial cells. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:2 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; Binding, Competitive; Cells, Cultured; Coronary Vessels; Cyclic AMP; Endothelium, Vascular; Gene Expression Regulation; Humans; Iodine Radioisotopes; Iodobenzenes; Kinetics; Phenethylamines; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Swine; Transcription, Genetic; Triazines; Triazoles	2000
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. British journal of pharmacology, 2001, Volume: 134, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines	2001
Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. The American journal of pathology, 2002, Volume: 160, Issue:6 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blotting, Western; Cells, Cultured; Drosophila Proteins; Endothelial Growth Factors; Female; Interferon-gamma; Lipopolysaccharides; Lymphokines; Macrophages, Peritoneal; Male; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenethylamines; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Cell Surface; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Theobromine; Toll-Like Receptor 4; Toll-Like Receptors; Triazines; Triazoles; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xanthines	2002
Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens. European journal of pharmacology, 2003, Jan-24, Volume: 460, Issue:2-3 Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Epididymis; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenethylamines; Prostate; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theobromine; Triazines; Triazoles; Vas Deferens; Xanthines	2003
Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells. Biochemical and biophysical research communications, 2003, Jul-18, Volume: 307, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phenethylamines; Phosphorylation; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; RNA; Triazines; Triazoles	2003
Effect of taurine deficiency on adenosine receptor-mediated relaxation of the rat aorta. Vascular pharmacology, 2003, Volume: 40, Issue:4 Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta, Thoracic; beta-Alanine; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Rats; Rats, Inbred WKY; Receptors, Purinergic P1; Taurine; Triazines; Triazoles; Vasoconstrictor Agents; Vasodilator Agents	2003
The role of intraspinal adenosine A1 receptors in sympathetic regulation. European journal of pharmacology, 2004, May-10, Volume: 492, Issue:1 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Dihydropyridines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Cord; Splanchnic Nerves; Sympathetic Nervous System; Synaptic Transmission; Theobromine; Theophylline; Triazines; Triazoles	2004
A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:5 Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Arachidonic Acid; Chorion; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Placenta; Pregnancy; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Triazines; Triazoles; Vasoconstriction; Vasodilator Agents; Xanthines	2005
Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits. Experimental eye research, 2005, Volume: 80, Issue:4 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport, Active; Dihydropyridines; Fluorescein; Fluoresceins; Fluorophotometry; Injections, Intravenous; Male; Pigment Epithelium of Eye; Purinergic P1 Receptor Antagonists; Rabbits; Retinal Detachment; Triazines; Triazoles; Xanthines	2005
Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level. Archives of biochemistry and biophysics, 2006, Nov-01, Volume: 455, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Glucose; Heart Ventricles; Insulin; Male; Phenethylamines; Protein Isoforms; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Triazines; Triazoles	2006
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Molecular biology of the cell, 2007, Volume: 18, Issue:1 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Hypoxia; DNA; Exons; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Response Elements; RNA, Messenger; Sequence Deletion; Toll-Like Receptor 4; Transcription, Genetic; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A	2007
Effects of stimulation of adenosine A2A receptors on lipopolysaccharide-induced production of reactive oxygen species by equine neutrophils. American journal of veterinary research, 2007, Volume: 68, Issue:6 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Dose-Response Relationship, Drug; Horses; Lipopolysaccharides; Neutrophils; Reactive Oxygen Species; Receptor, Adenosine A2A; Rolipram; Triazines; Triazoles	2007
Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes. Veterinary immunology and immunopathology, 2008, Jan-15, Volume: 121, Issue:1-2 Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cyclic AMP; Horses; Immunoenzyme Techniques; Lipopolysaccharides; Monocytes; Phenethylamines; Piperidines; Receptor, Adenosine A2A; Regression Analysis; Triazines; Triazoles; Tumor Necrosis Factor-alpha	2008
Differential regulation of HIF-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists. Journal of leukocyte biology, 2009, Volume: 86, Issue:3 Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Drug Combinations; Female; Gene Expression Regulation; Genes, Reporter; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Luciferases, Renilla; Macrophages, Peritoneal; Mice; Mice, Congenic; Mice, Inbred C57BL; NF-kappa B; Nitriles; Phenethylamines; Protein Isoforms; Purinergic P1 Receptor Agonists; RNA, Messenger; Sulfones; Toll-Like Receptor 4; Transfection; Triazines; Triazoles; Vascular Endothelial Growth Factor A	2009
GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011, Volume: 25, Issue:2 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Aminopyridines; Gene Expression Regulation; Humans; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Protein Conformation; Receptor, Adenosine A2B; Saccharomyces cerevisiae; Triazines; Triazoles	2011
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature, 2011, May-18, Volume: 474, Issue:7352 Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Drug Inverse Agonism; Humans; Ligands; Models, Molecular; Molecular Conformation; Receptor, Adenosine A2A; Triazines; Triazoles	2011
Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ. American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Jan-01, Volume: 304, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzamides; Benzoates; Butyrates; Enzyme Inhibitors; Epoxide Hydrolases; Female; Gene Silencing; Lauric Acids; Male; Mice; NG-Nitroarginine Methyl Ester; Oxygenases; Phenethylamines; Phenylurea Compounds; PPAR gamma; Pyridines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles; Urea; Vasodilation; Vasodilator Agents	2013
Mechanisms involved in increased sensitivity to adenosine A(2A) receptor activation and hypoxia-induced vasodilatation in porcine coronary arteries. European journal of pharmacology, 2014, Jan-15, Volume: 723 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Coronary Vessels; Cyclic AMP; Dinoprost; HSP20 Heat-Shock Proteins; Hypoxia; In Vitro Techniques; Oxygen; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Vasodilation	2014
Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding. PloS one, 2014, Volume: 9, Issue:10 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Binding Sites; Humans; Ligands; Mutant Proteins; Mutation; Receptor, Adenosine A2A; Thermodynamics; Triazines; Triazoles	2014
Mechanistic insights into allosteric regulation of the A Nature communications, 2018, 04-10, Volume: 9, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Calcium; Cations, Divalent; Crystallography, X-Ray; Gene Expression; Humans; Kinetics; Magnesium; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Receptor, Adenosine A2A; Recombinant Proteins; Sf9 Cells; Spodoptera; Thermodynamics; Triazines; Triazoles	2018