Page last updated: 2024-09-03

zk 93423 and diazepam

zk 93423 has been researched along with diazepam in 9 studies

Compound Research Comparison

Studies
(zk 93423)
Trials
(zk 93423)
Recent Studies (post-2010)
(zk 93423)
Studies
(diazepam)
Trials
(diazepam)
Recent Studies (post-2010) (diazepam)
300218,3772,3291,790

Protein Interaction Comparison

ProteinTaxonomyzk 93423 (IC50)diazepam (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0108
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0227
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0106
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)0.0101
GABA theta subunitRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)0.0101

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's4 (44.44)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cook, JM; Diaz-Arauzo, H; Evoniuk, GE; Skolnick, P1
Fryer, RI; Gu, ZQ; Kamath, PG; Langer, T; Skolnick, P; Wang, CG1
Cook, JM; Harris, B; Koehler, KF; Skolnick, P; Zhang, W1
Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S1
Devi, K; Hrishikeshavan, HJ; Munonyedi, S; Shanbhogue, R1
Randall, JI; Rodgers, RJ1
Atsoggiu, T; Biggio, G; Concas, A; Serra, M1
Biggio, G; Carcangiu, P; Corda, MG; Giorgi, O; Mereu, G1
Klockgether, T; Pardowitz, I; Schwarz, M; Sontag, KH; Turski, L1

Other Studies

9 other study(ies) available for zk 93423 and diazepam

ArticleYear
The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Mice; Receptors, GABA-A

1991
Computer-aided molecular modeling, synthesis, and biological evaluation of 8-(benzyloxy)-2-phenylpyrazolo[4,3-c]quinoline as a novel benzodiazepine receptor agonist ligand.
    Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6

    Topics: Animals; Computer Simulation; Evaluation Studies as Topic; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Ligands; Models, Chemical; Molecular Conformation; Monte Carlo Method; Pyrazoles; Quinolones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thermodynamics

1995
Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors.
    Journal of medicinal chemistry, 1994, Mar-18, Volume: 37, Issue:6

    Topics: Animals; Anticonvulsants; Benzodiazepines; Ligands; Male; Mice; Models, Molecular; Receptors, GABA-A; Structure-Activity Relationship

1994
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
    Journal of medicinal chemistry, 2000, Jan-13, Volume: 43, Issue:1

    Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship

2000
Behavioral neurobiology of inverse agonist FG 7142 induced anxiety syndrome in rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1990, Volume: 14, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Avoidance Learning; Carbolines; Diazepam; Exploratory Behavior; Flumazenil; Grooming; Male; Motor Activity; Rats; Rats, Inbred Strains; Stereotyped Behavior

1990
Are the analgesic effects of social defeat mediated by benzodiazepine receptors?
    Physiology & behavior, 1987, Volume: 41, Issue:3

    Topics: Analgesia; Animals; Behavior, Animal; Carbolines; Diazepam; Flumazenil; Male; Mice; Mice, Inbred DBA; Pyrazoles; Receptors, GABA-A; Social Behavior

1987
Foot-shock stress and anxiogenic beta-carbolines increase t-[35S]butylbicyclophosphorothionate binding in the rat cerebral cortex, an effect opposite to anxiolytics and gamma-aminobutyric acid mimetics.
    Journal of neurochemistry, 1988, Volume: 51, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cell Membrane; Cerebral Cortex; Convulsants; Diazepam; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological

1988
The beta-carboline ZK 93423 inhibits reticulata neurons: an effect reversed by benzodiazepine antagonists.
    Life sciences, 1987, Apr-06, Volume: 40, Issue:14

    Topics: Action Potentials; Animals; Carbolines; Diazepam; Flumazenil; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra

1987
Evaluation of the muscle relaxant properties of a novel beta-carboline, ZK 93423 in rats and cats.
    British journal of pharmacology, 1985, Volume: 86, Issue:2

    Topics: Animals; Benzodiazepinones; Carbolines; Cats; Decerebrate State; Diazepam; Electromyography; Evoked Potentials; Female; Flumazenil; Male; Muscle Relaxants, Central; Neurons, Afferent; Rats; Rats, Mutant Strains; Reflex; Species Specificity; Time Factors

1985