Page last updated: 2024-09-03

zk 91296 and diazepam

zk 91296 has been researched along with diazepam in 11 studies

Compound Research Comparison

Studies
(zk 91296)
Trials
(zk 91296)
Recent Studies (post-2010)
(zk 91296)
Studies
(diazepam)
Trials
(diazepam)
Recent Studies (post-2010) (diazepam)
371018,3772,3291,790

Protein Interaction Comparison

ProteinTaxonomyzk 91296 (IC50)diazepam (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0108
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0227
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0106
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)0.0101
GABA theta subunitRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)0.0101

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19907 (63.64)18.7374
1990's4 (36.36)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Depaulis, A; Piret, B; Vergnes, M1
Franklin, SR; Tang, AH1
Donoso, AO; Gargiulo, PA1
Coenen, AM; van Luijtelaar, EL1
Randall, JI; Rodgers, RJ1
Klockgether, T; Schwarz, M; Sontag, KH; Turski, L1
Atsoggiu, T; Biggio, G; Concas, A; Serra, M1
De Deyn, PP; Macdonald, RL2
Jensen, LH; Marescaux, C; Micheletti, G; Petersen, EN; Vergnes, M1
Blaney, FE; Edge, C; Phippen, RW1

Other Studies

11 other study(ies) available for zk 91296 and diazepam

ArticleYear
Opposite effects of agonist and inverse agonist ligands of benzodiazepine receptor on self-defensive and submissive postures in the rat.
    Psychopharmacology, 1991, Volume: 103, Issue:1

    Topics: Aggression; Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Grooming; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Social Behavior; Social Dominance

1991
The discriminative stimulus effects of diazepam in rats at two training doses.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:3

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Buspirone; Carbolines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Flumazenil; Male; Morphine; Pentobarbital; Pyrazoles; Pyridazines; Rats; Rats, Inbred Strains; Triazolam

1991
Is inhibition by diazepam and beta-carbolines of estrogen-induced luteinizing hormone secretion related to sedative effects?
    Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Diazepam; Estrogen Antagonists; Female; Hypnotics and Sedatives; Luteinizing Hormone; Ovariectomy; Rats; Rats, Inbred Strains

1991
Effects of diazepam and two beta-carbolines on epileptic activity and on EEG and behavior in rats with absence seizures.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1

    Topics: Animals; Anticonvulsants; Appetite Depressants; Behavior, Animal; Carbolines; Diazepam; Electroencephalography; Epilepsy; Female; Male; Muscle Tonus; Rats; Rats, Inbred Strains; Sleep

1989
Are the analgesic effects of social defeat mediated by benzodiazepine receptors?
    Physiology & behavior, 1987, Volume: 41, Issue:3

    Topics: Analgesia; Animals; Behavior, Animal; Carbolines; Diazepam; Flumazenil; Male; Mice; Mice, Inbred DBA; Pyrazoles; Receptors, GABA-A; Social Behavior

1987
ZK 91296, an anticonvulsant beta-carboline which lacks muscle relaxant properties.
    European journal of pharmacology, 1985, Apr-16, Volume: 110, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Electromyography; Electroshock; Flumazenil; Indoles; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Relaxants, Central; Muscle Tonus; Phenobarbital; Rats; Rats, Inbred Strains

1985
Foot-shock stress and anxiogenic beta-carbolines increase t-[35S]butylbicyclophosphorothionate binding in the rat cerebral cortex, an effect opposite to anxiolytics and gamma-aminobutyric acid mimetics.
    Journal of neurochemistry, 1988, Volume: 51, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cell Membrane; Cerebral Cortex; Convulsants; Diazepam; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological

1988
Effects of non-sedative anxiolytic drugs on responses to GABA and on diazepam-induced enhancement of these responses on mouse neurones in cell culture.
    British journal of pharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Buspirone; Carbolines; Cells, Cultured; Convulsants; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Mice; Neurons; Pyrazoles; Quinolines; Spinal Cord

1988
CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1

    Topics: Animals; Brain; Carbolines; Cells, Cultured; Diazepam; Electrophysiology; Flumazenil; gamma-Aminobutyric Acid; Mice; Neurons; Pyrazoles; Receptors, GABA-A; Spinal Cord

1987
Antiepileptic action of the beta-carboline ZK 91296 in a genetic petit mal model in rats.
    European journal of pharmacology, 1984, Jul-20, Volume: 102, Issue:3-4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Carbolines; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Indoles; Male; Rats; Rats, Inbred Strains

1984
Molecular surface comparison. 2. Similarity of electrostatic vector fields in drug design.
    Journal of molecular graphics, 1995, Volume: 13, Issue:3

    Topics: Anti-Anxiety Agents; Benzamides; Benzazepines; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Diazepam; Drug Design; Electricity; GABA-A Receptor Agonists; Granisetron; Indoles; Isomerism; Molecular Conformation; Ondansetron; Pharmaceutical Preparations; Protein Binding; Pyrazoles; Pyridazines; Receptors, Drug; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Structure-Activity Relationship; Surface Properties; Triazolam; Tropisetron

1995