zithromax and arginine-beta-naphthylamide

zithromax has been researched along with arginine-beta-naphthylamide* in 2 studies

Other Studies

2 other study(ies) available for zithromax and arginine-beta-naphthylamide

Article	Year
Boosting the Antibacterial Activity of Azithromycin on Multidrug-Resistant International journal of molecular sciences, 2023, May-12, Volume: 24, Issue:10 The global spread of multidrug-resistant (MDR) bacteria increases the demand for the discovery of new antibiotics and adjuvants. Phenylalanine-arginine β-naphthylamide (PAβN) is an inhibitor of efflux pumps in Gram-negative bacteria, such as the AcrAB-TolC complex in Topics: Anti-Bacterial Agents; Azithromycin; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Proteins; Macrolides; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Phenylalanine	2023
Decreased Susceptibility to Azithromycin Among Clinical Shigella Isolates from China. Microbial drug resistance (Larchmont, N.Y.), 2017, Volume: 23, Issue:5 The aim of this study was to detect the decreased susceptibility to azithromycin (DSA) and associated mechanisms in Shigella from China. Three hundred and ninety-two Shigella isolates, including 134 Shigella flexneri and 258 Shigella sonnei isolates, were examined for minimum inhibitory concentrations (MICs) and zone sizes to azithromycin by broth microdilution and disk diffusion methods, respectively. The MICs were compared with corresponding zone diameters to find whether there was uniformity between both tests. Twelve macrolide-resistant genes located on mobile elements were determined for the DSA isolates by PCR, and chromosomal efflux pump activity was analyzed using Phe-Arg-β-naphthylamide inhibition test and quantitative real-time PCR. Shigella isolates displayed MICs of 0.125-512 μg/ml and zone sizes of 6-26 mm against azithromycin. There were 80 (20.4%) isolates to be DSA. No significant difference was found between the DSA rates of S. flexneri and S. sonnei isolates (p = 0.052). There was an intimate relativity between MICs and zone diameters (p < 0.001). Only the plasmid-borne mphA conferring high-level DSA was detected in 55.0% (44/80) DSA-Shigella isolates. This study highlighted the prevalence of DSA-Shigella and mphA in the region studied. Clinical laboratories and clinicians should pay attention to the elevated azithromycin MICs in Shigella spp. Topics: Anti-Bacterial Agents; Arginine; Azithromycin; Bacterial Proteins; Biological Transport; China; Drug Resistance, Bacterial; Dysentery, Bacillary; Gene Expression; Humans; Microbial Sensitivity Tests; Phosphotransferases (Alcohol Group Acceptor); Plasmids; Shigella flexneri; Shigella sonnei	2017

Article

Year

Boosting the Antibacterial Activity of Azithromycin on Multidrug-Resistant

International journal of molecular sciences, 2023, May-12, Volume: 24, Issue:10

The global spread of multidrug-resistant (MDR) bacteria increases the demand for the discovery of new antibiotics and adjuvants. Phenylalanine-arginine β-naphthylamide (PAβN) is an inhibitor of efflux pumps in Gram-negative bacteria, such as the AcrAB-TolC complex in

Topics: Anti-Bacterial Agents; Azithromycin; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Proteins; Macrolides; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Phenylalanine

2023

Decreased Susceptibility to Azithromycin Among Clinical Shigella Isolates from China.

Microbial drug resistance (Larchmont, N.Y.), 2017, Volume: 23, Issue:5

The aim of this study was to detect the decreased susceptibility to azithromycin (DSA) and associated mechanisms in Shigella from China. Three hundred and ninety-two Shigella isolates, including 134 Shigella flexneri and 258 Shigella sonnei isolates, were examined for minimum inhibitory concentrations (MICs) and zone sizes to azithromycin by broth microdilution and disk diffusion methods, respectively. The MICs were compared with corresponding zone diameters to find whether there was uniformity between both tests. Twelve macrolide-resistant genes located on mobile elements were determined for the DSA isolates by PCR, and chromosomal efflux pump activity was analyzed using Phe-Arg-β-naphthylamide inhibition test and quantitative real-time PCR. Shigella isolates displayed MICs of 0.125-512 μg/ml and zone sizes of 6-26 mm against azithromycin. There were 80 (20.4%) isolates to be DSA. No significant difference was found between the DSA rates of S. flexneri and S. sonnei isolates (p = 0.052). There was an intimate relativity between MICs and zone diameters (p < 0.001). Only the plasmid-borne mphA conferring high-level DSA was detected in 55.0% (44/80) DSA-Shigella isolates. This study highlighted the prevalence of DSA-Shigella and mphA in the region studied. Clinical laboratories and clinicians should pay attention to the elevated azithromycin MICs in Shigella spp.

Topics: Anti-Bacterial Agents; Arginine; Azithromycin; Bacterial Proteins; Biological Transport; China; Drug Resistance, Bacterial; Dysentery, Bacillary; Gene Expression; Humans; Microbial Sensitivity Tests; Phosphotransferases (Alcohol Group Acceptor); Plasmids; Shigella flexneri; Shigella sonnei

2017