zithromax and aerobactin

zithromax has been researched along with aerobactin* in 1 studies

Other Studies

1 other study(ies) available for zithromax and aerobactin

ArticleYear
Genetic characterization of Shiga toxin producing Escherichia coli belonging to the emerging hybrid pathotype O80:H2 isolated from humans 2010-2017 in Switzerland.
    International journal of medical microbiology : IJMM, 2018, Volume: 308, Issue:5

    Shiga toxin-producing E. coli (STEC) O80:H2 is an uncommon hybrid pathotype that has recently emerged in France. We analysed 18 STEC O80:H2 isolated from humans in Switzerland during 2010-2017. All isolates carried stx2a or stx2d, the rare eae variant eae-ΞΎ and at least seven virulence genes associated with pS88, a plasmid that is found in extraintestinal pathogenic E. coli (ExPEC). Whole genome sequencing (WGS) identified additional chromosomal extraintestinal virulence genes encoding for type 1 fimbria (fimA, fimC and fimH), aerobactin (iuc/iutA) and afimbrial adhesins (afaA/C/D/E-VIII). Core genome multi-locus sequence typing (cgMLST) detected two closely related but distinct subclusters with different stx2 and iuc/iutA genotypes. All isolates were multidrug resistant (MDR), but susceptible to third generation cephalosporins and azithromycin. STEC/ExPEC hybrid pathotypes such as STEC O80:H2 represent a therapeutical challenge in the event of extraintestinal infection.

    Topics: Adhesins, Bacterial; Adhesins, Escherichia coli; Azithromycin; Cephalosporins; Drug Resistance, Multiple, Bacterial; Escherichia coli Proteins; Extraintestinal Pathogenic Escherichia coli; Fimbriae Proteins; Genome, Bacterial; Humans; Hydroxamic Acids; Microbial Sensitivity Tests; Multilocus Sequence Typing; Plasmids; Shiga Toxin; Shiga-Toxigenic Escherichia coli; Switzerland; Virulence Factors

2018