zinostatin and styrene-oxide

zinostatin has been researched along with styrene-oxide* in 1 studies

Other Studies

1 other study(ies) available for zinostatin and styrene-oxide

Article	Year
Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster. Organic letters, 2010, Sep-03, Volume: 12, Issue:17 Neocarzinostatin (1) biosynthesis is proposed to involve a vicinal diol intermediate. It is reported that NcsF2, one of two epoxide hydrolases encoded by the NCS gene cluster, catalyzes regiospecific addition of H(2)O to C-2 of both (R)- and (S)-styrene oxides to afford (R)- and (S)-1-phenyl-1,2-ethanediols, respectively, supporting its proposed role in 1 biosynthesis. (R)-1-Phenyl-1,2-ethanediol (87% yield and 99% ee) was obtained from (+/-)-styrene oxide hydrolysis by cocatalysis using NcsF2 and SgcF, the complementary epoxide hydrolase from the C-1027 biosynthetic pathway. Topics: Catalysis; Epoxide Hydrolases; Epoxy Compounds; Molecular Structure; Stereoisomerism; Streptomyces; Zinostatin	2010

Article

Year

Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster.

Organic letters, 2010, Sep-03, Volume: 12, Issue:17

Neocarzinostatin (1) biosynthesis is proposed to involve a vicinal diol intermediate. It is reported that NcsF2, one of two epoxide hydrolases encoded by the NCS gene cluster, catalyzes regiospecific addition of H(2)O to C-2 of both (R)- and (S)-styrene oxides to afford (R)- and (S)-1-phenyl-1,2-ethanediols, respectively, supporting its proposed role in 1 biosynthesis. (R)-1-Phenyl-1,2-ethanediol (87% yield and 99% ee) was obtained from (+/-)-styrene oxide hydrolysis by cocatalysis using NcsF2 and SgcF, the complementary epoxide hydrolase from the C-1027 biosynthetic pathway.

Topics: Catalysis; Epoxide Hydrolases; Epoxy Compounds; Molecular Structure; Stereoisomerism; Streptomyces; Zinostatin

2010