zinostatin has been researched along with stallimycin* in 2 studies
1 review(s) available for zinostatin and stallimycin
| Article | Year |
|---|---|
Sequence specificity of drug-DNA interactions.
Methods for determining sequence specificities of anticancer drugs, carcinogens, and mutagens which interact with natural DNA's are presented. For drugs which nick or covalently bind to DNA and thus leave a permanent record of their residence position on the helix, the sequences important in drug action can be readily determined. For agents which interact with DNA in an equilibrium fashion, "footprinting" analysis, a technique used to investigate protein-DNA binding, has proved to be useful in studying drug-DNA interactions. The sequence specificities of a number of small ligands which interact with natural DNA's are also presented. Topics: Anti-Bacterial Agents; Base Sequence; Bleomycin; Cisplatin; Dactinomycin; Distamycins; DNA; DNA Restriction Enzymes; Doxorubicin; Edetic Acid; Humans; Iron; Methods; Micrococcal Nuclease; Netropsin; Organometallic Compounds; Peptides; Pharmaceutical Preparations; Phenanthrolines; Phleomycins; Plicamycin; Substrate Specificity; Zinostatin | 1983 |
1 other study(ies) available for zinostatin and stallimycin
| Article | Year |
|---|---|
DNA cleavage characteristics of non-protein enediyne antibiotic N1999A2.
N1999A2 (NA2) is a new non-protein antitumor antibiotic that contains a stable 9-membered ring enediyne chromophore similar to a neocarzinostatin chromophore (NCS-chr). We have compared DNA cleavage reactions between NA2 and NCS-chr, and also clarified some characteristics of DNA strand scission by NA2. It was found that: (1) NA2 is considerably stable in nature, (2) the compound intercalates into base pairs of a DNA minor groove and decreases its base-attacking frequency in the order of T>A>> C>G, (3) the base-sequence specificity 5(')-GGT/3(')-CCA presented by NA2 is significantly related to recognition of the base pair with the naphthoate moiety, and (4) the different cleavage property between NCS-chr and NA2 is associated with the presence or absence of an aminoglycoside residue. Based on the results of the site-specific cleavage by NA2 for certain bulged DNAs and a fluorescence study of NA2-DNA oligomer complexes, the DNA interaction mode of NA2 has also been examined. These results provide important information to design a new enediyne molecule for a DNA target. Topics: Anti-Bacterial Agents; Base Sequence; Binding Sites; Distamycins; DNA, Bacterial; Drug Stability; Enediynes; Epoxy Compounds; Hydrogen-Ion Concentration; Molecular Sequence Data; Naphthalenes; Spectrometry, Fluorescence; Sulfhydryl Compounds; Temperature; Ultraviolet Rays; Zinostatin | 2003 |