zimeldine has been researched along with 4-hydroxyphenylacetic-acid* in 1 studies
1 other study(ies) available for zimeldine and 4-hydroxyphenylacetic-acid
| Article | Year |
|---|---|
(Z)-3-(4-bromophenyl)-3-(3-pyridyl)allylamine as substrate for studies of myeloperoxidase activity.
(Z)-3-(4-Bromophenyl)-3-(3-pyridyl)allylamine (CPP 200) is transformed to the corresponding chloroimine by hypochlorite ion (ClO-) formed in the presence of myeloperoxidase. A scheme for this transformation is given. The influence of various compounds on this process has been studied. Cysteamine, cysteine and 6-chloro-3-hydrazino-pyridazine inhibited the transformation of CPP 200, while some p-hydroxyphenyl derivatives increased the rate of transformation of CPP 200. The increase seen on addition of the p-hydroxyphenyl derivatives is not a chloride-dependent reaction. Various mechanisms for the inhibiting effect as well as for the activating effect on the transformation of CPP 200 are discussed. Topics: Acetaminophen; Chlorides; Chromatography, Thin Layer; Cysteamine; Cysteine; Gas Chromatography-Mass Spectrometry; Hypochlorous Acid; Magnetic Resonance Spectroscopy; Parabens; Peroxidase; Phenylacetates; Phenylpropionates; Pyridazines; Spectrophotometry, Ultraviolet; Substrate Specificity; Zimeldine | 1995 |