Page last updated: 2024-08-24

zileuton and hydroxyurea

zileuton has been researched along with hydroxyurea in 375 studies

Research

Studies (375)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's160 (42.67)18.2507
2000's109 (29.07)29.6817
2010's88 (23.47)24.3611
2020's18 (4.80)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Clement, B; Indorf, P; Kubitza, C; Kunze, T; Scheidig, AJ1
Chamulitrat, W; Mason, RP; Riendeau, D1
Grisham, MB; Keenan, CM; Vaananen, PM; Wallace, JL1
Abraham, WM; Ahmed, A; Bell, RL; Bouska, J; Cortes, A; Hinz, W; Lanni, C; Sielczak, MW1
Coblyn, JS; Helfgott, S; Henson, B; Kremer, JM; Maier, AL; Petrillo, G; Rubin, P; Sperling, R; Weinblatt, ME1
Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER1
Desai, SN; Jamieson-Leclercq, T; Noonan, TC1
Henson, PM; Hill, E; Maclouf, J; Murphy, RC1
Alvarez, FJ; Slade, RT1
Bobadilla, J; Borovoy, J; Cabrera, G; Collawn, C; Kershenobich, D; Perez, N; Reyes, E; Rubin, P1
Albert, D; Bell, RL; Brooks, DW; Carter, GW; Lanni, C; Rubin, P; Summers, JB; Young, PR1
Nellans, HN; Sweeny, DJ2
Chan, CC; Foster, A; Guay, J; Riendeau, D; Wolfe, S1
Borgeat, P; Dubé, L; Kesterson, J; Lauzière, M; Rubin, P; Sirois, P1
O'Donnell, M; Payne, AN1
Knapp, HR1
Bendele, AM; Fleisch, JH; Wong, WS1
Albert, D; Braeckman, R; Carter, G; Dubé, L; Hansen, R; Rubin, P; Swanson, L1
Bell, RL; Brooks, DW; Carter, GW; Lanni, C; Summers, JB; Young, PR1
Albert, DH; Bell, RL; Bouska, J; Brooks, DW; Carter, GW; Dyer, R; Summers, JB; Young, PR1
Barnes, NC; Barnes, PJ; Hui, KP; Kesterson, J; Rubin, P; Taylor, GW; Taylor, IK1
Bukantz, SC1
Bukhave, K; Lauritsen, K; Laursen, LS; Naesdal, J; Rask-Madsen, J1
Anderson, CB; Mangino, MJ1
Raub, W1
Dermarkarian, R; Drazen, JM; Israel, E; Rosenberg, M; Rubin, P; Sperling, R; Taylor, G1
Bruin, KF; Hommes, DW; Jansen, J; Tytgat, GN; van Deventer, SJ; Wouter ten Cate, J1
Buckner, CK; Cook, E; Doran, O; Graziano, FM; Stahl, J1
Awni, WM; Cohn, J; Drazen, JM; Fischer, AR; Frantz, R; Israel, E; McFadden, CA1
Awni, WM; Brandwein, SR; Dube, LM; Granneman, GR; Locke, CS1
Ado, VA; Mokronosova, MA; Perlamutrov, IuN1
Bailie, MB; Carter, GW; Dahm, LJ; Harris, RR; Peters-Golden, M; Roth, RA1
Bochnowicz, S; Underwood, DC1
Chan, TC; Knapp, DW; Kuczek, T; Park, B; Reagan, WJ1
Cohn, J; Kaminsky, DA; Martin, RJ; Trudeau, JB; Wenzel, SE; Westcott, JY1
Buckner, CK; Conklin, R; Doran, O; Fishleder, RI; Graziano, FM; Will, JA1
Cozzi, P; Leff, AR; Mitchell, RW; Ndukwu, IM; Padrid, PA; Shiou P [corrected to Shiue, P]; Shiue, P; Spaethe, S1
Awni, WM; Braeckman, RA; Cavanaugh, JH; Granneman, GR; Locke, CS; St Peter, JV1
Henson, PM; Hill, E; MacMillan, D; Murphy, RC; Sala, A1
Ford-Hutchinson, AW1
Chabot-Fletcher, M; Chilton, FH; Fonteh, AN; Huang, L; Marshall, LA; Sung, CM; Winkler, JD1
Kazmi, SM; Lau, CY; Plante, RK; Taylor, GR; Visconti, V; Zhou, L1
Brandwein, SR; Hackshaw, KV; Jones, K; Shi, Y; Westcott, JY1
Callery, JC; Cohn, J; Drazen, JM; Fischer, AR; Igarashi, Y; Kaliner, MA; Lilly, CM; Rosenberg, MA; Rubin, P; White, MV1
Bell, RL; Bouska, JB; Brooks, DW; Carter, GW; Harris, RR; Lanni, C; Malo, PE; Otis, ER; Stewart, AO1
Camerini, R; Caputi, AP; Graziani, P; Squadrito, F; Zingarelli, B1
Carpenter, TG; Cuthbert, NJ; Fitzgerald, MF; Francis, HP; Gardiner, PJ; Mohrs, K; Müller-Peddinghaus, R; Newton, BB; Patel, UP; Thompson, AM1
Henson, PM; Hill, E; MacMillan, DK; Murphy, RC; Sala, A; Shuman, T; Sigal, E1
Guidot, DM; Repine, JE; Repine, MJ; Westcott, JY1
Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB1
Bell, RL; Brooks, DW; Carter, GW; Hansen, R; Lanni, C; Malo, PE; Rubin, P; Stewart, AO1
Ellis, JL; Undem, BJ1
Breton, J; Chabot-Fletcher, M; DeWolf, W; Griswold, D; Hillegass, L; Keller, P1
Black, C; Brideau, C; Chan, C; Ford-Hutchinson, A; Frenette, R; Tagari, P1
Anderson, CB; Mangino, MJ; Murphy, MK1
Bell, RL; Bouska, J; Brooks, DW; Carter, GW; Lanni, C; Machinist, J; Malo, PE; Summers, JB; Young, PR1
Busse, W; Cohn, J; Drazen, JM; Fish, J; Grossman, J; Israel, E; Kaiser, HB; Karahalios, P; Kemp, JP; Lanni, C; Ledford, D; Murray, JJ; Pearlman, H; Pierson, W; Rosenthal, R; Rubin, P; Segal, AT; Siegel, SC; Tinkelman, D; Wenzel, S1
Callery, JC; Cohn, J; Drazen, JM; Fischer, AR; Israel, E; Lilly, CM; Rosenberg, MA; Rubin, P; Shapiro, J1
Frossard, N; LeGall, G; Poaty, V; Riquet, M1
Chertock, H; DiPasquale, G; Koeler, J; Peppard, J; Raychaudhuri, A; White, WD1
Belfast, MT; Carlson, RP; Glaser, KB; Hartman, DA; Ochalski, SJ; Walter, TL1
Fitzpatrick, FA; Lepley, RA1
Howell, RE; Jenkins, LP; Rubin, EB; Sickels, BD; Weichman, BM; Woeppel, SL1
Colombo, C; DiPasquale, G; Fryer, LR; Greenspan, PD; Haston, W; Healy, C; Kotyuk, B; Pastor, G; Pellas, TC; Raychaudhuri, A1
Berkenkopf, JW; Carlson, RP; Grimes, D; Kreft, AF; Marinari, LR; Musser, JH; Sturm, RJ; Weichman, BM1
Currie, JL; Isakson, PC; Rao, TS; Shaffer, AF1
Kasiske, BL; Keane, WF; Kim, Y; O'Donnell, MP1
Falgueyret, JP; Hutchinson, JH; Riendeau, D1
Berkenkopf, JW; Grimes, D; Heaslip, RJ; Ilsemann, BA; Sickels, BD; Weichman, BM1
Currie, JL; Isakson, PC; Kim, S; Rao, T; Shaffer, AF; Smith, WG; Thompson, JM1
Blancuzzi, V; Chertock, H; Kimble, E; Koehler, J; Kowalski, T; Lee, W; Peters, P; Raychaudhuri, A; van Duzer, J1
Carlson, RP; Gray, WB; Grimes, D; Hartman, DA; Howell, RE; Jenkins, LP; Kreft, AF; Kubrak, D1
Chourmouzis, E; Fung-Leung, WP; Lau, CY; Pope, BL; Zhou, L1
Carlson, RP; Glaser, K; Grimes, D; Gunawan, I; Hartman, DA; Howell, R; Kanzelberger, M; Malamas, MS; Nelson, JA; Shah, U1
Clausen, M; Gautschi, K; Reinboth, JJ; Remé, CE1
Cohn, J; Dworski, R; Fish, JE; Kane, GC; Kim, CJ; Murray, JJ; Peters, SP; Pollice, M; Sheller, J; Tollino, M1
Cohn, J; Drazen, JM; Dubé, L; Israel, E1
Medvedeff, ED; Nickerson-Nutter, CL1
Bailie, MB; Fink, GD; Pearson, JM; Roth, RA2
Braeckman, RA; Erdman, KA; Granneman, GR1
Awni, WM; Cavanaugh, JH; Dubé, LM; Granneman, GR; Tzeng, TB; Witt, G1
Awni, WM; Braeckman, RA; Cavanaugh, JH; Dubé, LM; Granneman, GR; Linnen, PJ; Locke, CS1
Awni, WM; Braeckman, RA; Dubé, LM; Granneman, GR; Witt, G1
Bopp, BA; Kukulka, MJ; Machinist, JM1
Awni, WM; Braeckman, RA; Cavannaugh, JH; Granneman, GR; Locke, CS; Machinist, JM1
Awni, WM; Braeckman, RA; Cavanaugh, JH; Chu, SY; Granneman, GR; Machinist, JM; Patterson, KJ1
Awni, WM; Cavanaugh, JH; Dubé, LM; Granneman, GR; Witt, G1
Awni, WM; Cavanaugh, JH; Dubé, LM; Granneman, GR; Hussein, Z; Patterson, KJ1
Awni, WM; Braeckman, RA; Cavanaugh, JH; Dubé, LM; Granneman, GR; Locke, CS1
Cavanaugh, JH; Granneman, GR; Mukherjee, D; Samara, E1
Awni, WM; Cavanaugh, JH; Dubé, LM; el-Shourbagy, T; Locke, CS; Wong, SL1
Awni, WM; Cavanaugh, JH; Dubé, LM; Granneman, GR; Hussein, Z1
Awni, WM; Braeckman, RA; Dubé, LM; Granneman, GR; Locke, CS1
Cohn, J; Dworski, RT; Fish, JE; Kane, GC; Kim, CJ; Murray, JJ; Peters, SP; Pollice, M; Sheller, JR1
Bleecker, ER; Cohn, J; Hasday, JD; Meltzer, SS1
Ferrero, JL; Machinist, JM; Mayer, MD; Rodrigues, AD; Shet, MS1
Machinist, JM; Rodrigues, AD1
Rainsford, KD; Smith, F; Ying, C1
Elrod, L; Gay, CM; Morley, JA; Shada, DM; Wong, CF1
Busse, WW; McGill, KA1
Harada, K; Hibi, S; Kawahara, T; Kobayashi, N; Miyamoto, K; Numata, H; Okamoto, Y; Shinoda, M; Tagami, K; Yamatsu, I1
Hussey, HJ; Tisdale, MJ1
Broutman, L; Callaghan, C; Doria, MI; Eiznhamer, D; Keshavarzian, A; Zarif, A1
Andresen, CJ; Eggler, JF; Smith, WB; Turner, CR; Watson, JW1
Ganey, PE; Peters-Golden, M; Schiamberg, E; Tithof, PK1
Smith, LJ1
Dubé, LM; Lancaster, J; Liu, MC1
Tanaka, R1
Jackson, SK; Larsen, JS1
Bell, RL; Carter, GW; Goodfellow, C; Harris, RR; Namovic, MT; Walsh, RE1
Bartolí, R; Bertrán, X; Castellá, E; Esteve, M; Fernández-Bañares, F; Gassull, MA; Mañé, J; Ojanguren, I1
Bolognese, B; Marshall, LA; Roshak, A; Winkler, JD1
Dube, LM; Hawkey, CJ; Lancaster, JF; Linnen, PJ; Rountree, LV1
Douglas, I; Herrnreiter, A; Leff, AR; Mayer, D; Muñoz, NM; Zhu, X1
Awni, WM; Cao, G; Cavanaugh, JH; Dube, LM; Kasier, J; Leese, P; Locke, CS1
Kotadia, B; Mangino, JE; Mangino, MJ; Sielczak, M1
Awni, WM; Cavanaugh, JH; Dube, LM; Locke, C1
Awni, WM; Chu, SY; Drajesk, J; Halstenson, CE; Hansen, R; Keane, WF; Machinist, JM; Patterson, K; Wong, S1
Lau, R1
Schiff, M1
Spector, SL; Tan, RA1
Magnussen, H; Rabe, KF; Watson, N2
Bell, RL; Bouska, JJ; Brooks, CD; Carter, GW; Goodfellow, CL; Stewart, AO1
Bell, RL; Harris, RR; Komater, VA; Marett, RA; Wilcox, DM1
Brock, TG; McNish, RW; Peters-Golden, M1
Dubé, LM; Lancaster, JF; Petty, T; Schwartz, HJ; Swanson, LJ1
Drazen, JM1
Bootsma, GP; Dekhuijzen, PN; Festen, J; van den Berg, LR; van Herwaarden, CL; Wielders, PL1
Tan, RA1
Kearney, AS; McLoughlin, M; Palepu, NR1
Wenzel, SE1
Cheskin, H; Hui, HW; Qiu, Y1
Bochenek, G; Boodhoo, TI; Dahlén, B; Dahlén, SE; Dubé, LM; Kumlin, M; Mastalerz, L; Nizankowska, E; Pinis, G; Swanson, LJ; Szczeklik, A; Wright, S; Zetterström, O1
Spector, S; Tan, RA1
Bolognese, B; Hubbard, WC; Jackson, JR; Mangar, CA; Marshall, LA; Winkler, JD1
Busse, WW; Horwitz, RJ; McGill, KA1
Barberà, JA; Chung, KF; Gómez, FP; Iglesia, R; Roca, J; Rodriguez-Roisin, R1
Aoki, Y; Kao, PN; Qiu, D; Zhao, GH1
Drazen, J1
Callens, E; Djebbar, R; Ruff, F; Santais, MC1
Bouboulis, D; Frieri, M; Lark, G; Sansone, G; Schaefer, PA; Therattil, JM; Wang, SF; Zitt, M1
Ellis, MH1
Abraham, WM; Ahmed, A; Botvinnikova, Y; Lauredo, IT; Sabater, JR1
Lane, SJ1
Andry, C; Dolan, R; Grillone, G; Hartshorn, K; McAvoy, D; Suntra, C; Tablante, J1
Abraham, WM; Allegra, L; Scuri, M1
Dubé, LM; DuBuske, LM; Grossman, J; Lancaster, JF; Swanson, LJ1
Carpentier, PJ; Dubé, LM; Kemp, JP; Lancaster, JF; Lazarus, SC; Lee, T; Ochs, RF; Wenzel, S1
Carlson, R; Glaser, K; Hartman, D; Kreft, A; Lock, Y; Tomchek, L; Weichman, B1
Dahlén, SE; Larsson, L; Sydbom, A1
Hardy, DB; Pereria, LE; Yang, K1
Wedekind, CA1
Colombel, JF; Desreumaux, P; Ectors, N; Geboes, K; Jouret, A; Rutgeerts, P1
Kuna, P; Kupczyk, M1
Simon, RA; Woodmansee, DP1
Hirasawa, N; Kushihara, M; Ohuchi, K; Takahagi, H; Takasaki, W; Takayanagi, M; Yamashita, M1
Bleecker, ER; Dubé, LM; Hasday, JD; Hebel, JR; Lanni, C; Meltzer, SS; Moore, WC; Wisniewski, P1
Heerschap, A; Mayatepek, E; Rotteveel, JJ; Steijlen, PM; Willemsen, MA1
Dellaripa, PF; Drazen, J; Roth, ME; Wechsler, ME1
Lang, DM1
Daffern, PJ; Pauls, JD; Simon, RA; Stevenson, DD1
Agustí, C; Cardell, LO; Nadel, JA1
Mancuso, P; Peters-Golden, M1
Bisgaard, H1
Audouin, C; Hénichart, JP; Houssin, R; Lassoie, MA; Mestdagh, N1
Drazen, JM; Dubé, L; Israel, E; Juniper, EF; Moy, ML; Weiss, ST1
Bizer, C; Schapowal, A; Simon, HU; Thomet, OA; Wiesmann, UN1
Krawiec, ME; Wenzel, SE1
García-Marcos, L; Schuster, A1
Spector, SL1
Harada, K; Inoue, T; Nagakura, N; Oketani, K1
Alcaraz, MJ; Guillén, MI; Vicente, AM1
Crow, DW; Marsella, R; Nicklin, CF1
Amacher, DE; Beierschmitt, WP; Griffiths, RJ; McNeish, JD; Nagahisa, A; Nakane, M1
Taşkapan, MO1
Coffey, MJ; Peters-Golden, M; Phare, SM2
Adachi, M; Minoguchi, K1
Chen, N; Reiss, CS; Restivo, A1
Hayden, ML1
Cruysberg, JR; Lutt, MA; Mayatepek, E; Nijhuis-van der Sanden, MW; Pasman, JW; Rotteveel, JJ; Steijlen, PM; van der Graaf, M; Willemsen, MA1
Askonas, LJ; Ghoreishi-Haack, N; Kachur, JF; Liang, CD; Russell, MA; Smith, WG; Villani-Price, D; Won-Kim, S1
Norwood, C; Skelton, H; Smith, KJ1
Abbasi, AA; Dempsey, JA; Haverkamp, HC; Meyer, KC; Rice, AJ; Sonetti, DA; Wetter, TJ; Xiang, Z1
Mastalerz, L; Nizankowska-Mogilnicka, E; Swierczyńska, M1
Achucarro, P; Guski, H; Heinicken, D; Jacobi, CA; Kilian, M; Müller, JM; Schimke, I; Wenger, FA1
Gunning, WT; Kramer, PM; Pereira, MA; Steele, VE1
Bisevac, M; Guski, H; Khodadayan, C; Kilian, M; Müller, JM; Schimke, I; von Seebach, M; Wenger, FA1
Capella, GL1
Valacer, DJ1
Badr, KF; Montero, A; Munger, KA; Valdivielso, JM1
Chacur, M; Cury, Y; Guerra, JL; Gutiérrez, JM; Lomonte, B; Longo, I; Picolo, G; Teixeira, CF1
Glori, M; Hintz, KH; Welliver, RC1
Adler, YD; Camera, E; Cunliffe, WJ; Nestoris, S; Orfanos, CE; Orth, M; Picardo, M; Zouboulis, CC1
Kast, RE1
Dev, A; Leong, AB; Wu, X1
Jung, A1
Lu, P; Raab, CE; Rodrigues, AD; Schrag, ML; Shou, M; Slaughter, DE1
Darling, T; Guardiano, RA; Lee, W; Norwood, C1
Kemp, JP1
Baliga, BS; Haynes, J; Obiako, B; Ofori-Acquah, S; Pace, B1
Chordia, MD; Heasley, BH; Joshi, EM; Macdonald, TL1
Blanc, PD; Eisner, MD; Katz, PP; Snyder, L; Yelin, EH1
Gershwin, ME; Morrissey, BM; Naguwa, S; Vang, K; Watnik, M; Wineinger, J; Ziboh, VA1
Kulkarni, SK; Patil, CS; Singh, VP2
Britti, D; Chatterjee, PK; Cuzzocrea, S; Di Paola, R; Patel, NS; Sautebin, L; Thiemermann, C1
Fiorucci, S; Hollenberg, MD; von der Weid, PY; Wallace, JL1
Collin, M; Collino, M; Cuzzocrea, S; Di Paola, R; Hadley, J; Patel, NS; Rossi, A; Sautebin, L; Thiemermann, C1
Erlendsdóttir, H; Gunnarsson, E; Haraldsson, A; Olafsson, O; Thors, VS1
Beer, DG; Chen, X; Giordano, TJ; Jin, Z; Lin, Y; Lubet, RA; Shih, WC; Sood, S; Wang, P; Wang, S; Wu, N; Yang, CS1
Leru, P1
Boschnakow, A; Saborowski, A; Zouboulis, ChC1
Elstad, MR; Grissom, CK; Richer, LD1
Chen, X; Fang, M; Li, N; Sood, S; Sun, Z; Wang, P; Wang, S; Yang, CS1
Baliga, BS; Gardner, R; Haynes, J; Kuvibidila, S; Ode, D; Velez, M; Warrier, R; Yu, L1
Dahlén, SE; Kumlin, M; Larsson, BM; Larsson, K; Palmberg, L; Sundblad, BM1
Gregor, JI; Heukamp, I; Jacobi, CA; Kiewert, C; Kilian, M; Kristiansen, G; Schimke, I; Walz, MK; Wenger, FA1
Hénichart, JP; Pommery, J; Pommery, N1
Kulkarni, SK; Kumar, M; Patil, CS; Singh, VP1
Dahlén, SE1
Aronoff, DM; Canetti, C; Chen, GH; Choe, M; Flamand, N; Peters-Golden, M; Toews, GB; Wettlaufer, S1
Haynes, J; Hester, RB; King, JA; Obiako, B; Ofori-Acquah, S1
Mazziotti, DA; Rohrman, BA1
Capra, V; Cole, DE; Folco, G; Rovati, GE; Sala, A; Thompson, MD1
Angersbach, BS; Karlage, K; Kuehl, PJ; Merrill, BA; Myrdal, PB; Wightman, PD1
Ludington, E; Mehra, P; Simon, RA; Stevenson, DD; White, A1
Chandrasekaran, A; Jordan, R; Li, H; Markiewicz, V; Scatina, J; Shen, L; Tong, Z; Xiang, Q1
Dickerson, KS; Luttermoser, GK; Scow, DT1
Dahlén, B; Dahlén, SE; Delin, I; Gaber, F; James, A; Kumlin, M; Sampson, AP; Wetterholm, A1
Balter, M; Boulet, LP; Cairns, CB; Löfdahl, CG; O'Connor, BJ; Szczeklik, A1
Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Jiang, X; Karlsson, L; Lundeen, KA; Rao, NL; Riley, JP; Williams, KN; Xue, X1
Berger, W; Cairns, CB; De Chandt, MT1
Busse, W; Calhoun, W; Dube, L; Harris, J; Panettieri, R; Peters-Golden, M; Russell, H; Walton-Bowen, K; Wenzel, S1
Funk, AJ; Kosanke, SD; Li, CS; Lokey, SJ; Mandrell, TD; Potters, CF1
Berger, W; Casale, T; Corren, J; Dube, L; Kemp, J; LaVallee, N; Nelson, H; Stepanians, M; Walton-Bowen, K1
Cameron, CM; Dube, LM; Kasten, LE; Walton-Bowen, K; Watkins, PB1
Andoh, T; Kamimura, K; Kawai, S; Kuraishi, Y; Nakano, T; Nojima, H; Ohtsuka, E1
Chordia, MD; Li, F; Macdonald, TL; Woodling, KA1
Bramanti, P; Caminiti, R; Cuzzocrea, S; Di Paola, R; Genovese, T; Mazzon, E; Muià, C; Rossi, A; Sautebin, L1
Denis, JN; Guinchard, X1
Amann, JM; Backlund, MG; Johnson, DH1
Bedor, M; Edelman, MJ; Gajra, A; Green, MJ; Hodgson, L; Jewell, S; Kratzke, RA; Masters, GA; Mauer, AM; Morrison, C; Vokes, EE; Wang, X; Watson, D1
Anderson, GD; Dufield, DR; Hardy, MM; Masferrer, JL; Pufahl, RA; Zweifel, BS1
Butler, BD; Little, T1
Alves, AS; Britto, LR; Curi, R; Cury, Y; Della-Casa, MS; Gonçalves, LR; Greco, K; Otton, R; Sampaio, SC; Spadacci-Morena, DD; Sudo-Hayashi, LS; Zambelli, VO; Zychar, BC1
Donoghue, DJ; McAndrew, CW; Meyer, AN1
Borey, AJ; Clark, JD; Cui, J; Donahue, F; Han, L; Hassan-Zahraee, M; Leach, MW; Lee, KL; Marusic, S; McKew, JC; Pelker, JW; Shen, MW; Shimizu, T; Stedman, NL; Thakker, P; Wolf, SF; Xu, X1
Chen, Z; Fang, SH; Huang, XJ; Li, CT; Lu, YB; Qi, LL; Wei, EQ; Yuan, YM; Zhang, L; Zhang, LH; Zhang, WP1
Bhattacharjee, R; Dayyat, E; Goldman, JL; Gozal, D; Kheirandish-Gozal, L; Serpero, LD; Snow, A1
Klanderman, B; Lima, J; Sylvia, J; Tantisira, KG; Weiss, ST1
Fegn, L; Wang, Z1
Heasley, BH; Joshi, EM; Macdonald, TL1
Chen, CM; Shi, SS; Tu, XK; Wang, CH; Yang, WZ1
Arias, K; Baig, M; Chu, D; Colangelo, M; Coyle, A; Goncharova, S; Jordana, M; Vadas, P; Walker, T; Waserman, S1
Gelb, AF; Shinar, C; Simmons, M; Taylor, CF1
Ayers, DC; Fanning, PJ; Gaur, T; Lian, JB; Mason-Savas, A; O'Connell, SL; Silva, J; Stein, GS; Wixted, JJ1
Anderson, GD; Cortes-Burgos, LA; Graneto, MJ; Happa, FA; Hardy, MM; Hu, G; Masferrer, JL; Muthian, S; Pufahl, RA; Settle, SL; Stewart, Z; Weir, DE; Zweifel, BS1
Alestas, T; Seltmann, H; Zouboulis, CC1
Li, W; Lou, TF; Mackie, A; Pace, BS; Singh, M1
Hu, JH; Li, FQ; Liu, JY; Liu, YX; Pan, YH; Peng, C; Wang, XR; Wu, L; Xu, JG; You, BM; Zhu, QG; Zhu, Y1
Choi, HE; Kwak, HJ; Lim, HJ; Park, HY; Park, JH; Park, KM1
Chen, Y; Li, D; Li, S1
Bates, G; Di Capite, J; Nelson, C; Parekh, AB1
Horn, TL; Johnson, WD; Lubet, RA; McCormick, DL; Phillips, JM; Steele, VE1
Jensen, A; Karlage, KL; Mogalian, E; Myrdal, PB1
Chen, CM; Jin, CD; Shi, SS; Tu, XK; Wang, CH; Wen, S; Yang, WZ; Yang, YK; Zhang, YL1
DeMarcantonio, MA; Han, JK1
Boschi, D; Cena, C; Coruzzi, G; Di Stilo, A; Fruttero, R; Gasco, A; Giorgis, M; Guaita, E; Morini, G; Talniya, NC1
Bramanti, P; Cuzzocrea, S; Dehm, F; Hoffmann, M; Koeberle, A; Pergola, C; Rossi, A; Sautebin, L; Werz, O1
Dropinski, J; Rzeszutko, M; Sanak, M; Sokołowska, B; Szczeklik, A; Szczeklik, W1
Albert, RK; Bailey, WC; Casaburi, R; Connett, JE; Cooper, JA; Criner, GJ; Curtis, JL; Dransfield, MT; Han, MK; Harnden, SM; Kim, V; Lazarus, SC; Marchetti, N; Martinez, FJ; McEvoy, CE; Niewoehner, DE; Reilly, JJ; Rice, K; Scanlon, PD; Scharf, SM; Sciurba, FC; Washko, GR; Woodruff, PG1
Chu, J; Praticò, D2
Chen, WJ; Li, CT; Wei, EQ; Zhang, LH; Zhang, XY; Zhao, JB1
Gibbons, RD; Joo, MJ; Lee, TA; Schumock, GT; Stayner, LT; Valuck, RJ1
Kroegel, C1
Andoh, T; Honma, A; Kitazawa, K; Kuraishi, Y; Sakai, K; Urashima, M1
Amghar, H; Bouloumié, A; Bourlier, V; Féral, CC; Filloux, C; Galitzky, J; Grimaldi, PA; Mothe-Satney, I; Neels, JG; Pons, C; Van Obberghen, E1
Fang, SH; Huang, XQ; Lin, KN; Lu, YB; Wei, EQ; Zhang, WP1
Acikgoz, S; Baba, F; Banoglu, ZN; Dengiz, GO; Isikdemir, F; Kelek, S; Kurcer, Z; Sipahi, EY1
da Silva, NG; Gonçalves, LR; Sampaio, SC1
Chu, J; Giannopoulos, PF; Joshi, YB; Kirby, LG; Li, JG; Praticò, D; Sperow, M1
Chen, W; Han, H; Li, C; Wei, E; Zhang, L; Zhang, X; Zhao, J1
Atemnkeng, VA; Dong, LL; Kaiser, A; Langer, B; Laufer, S; May, C; Pink, M; Schmitz-Spanke, S; Wu, XJ; Zhao, KH1
Cuperlovic-Culf, M; Ferguson, D; Hébert, MJ; Jean-François, J; LeBlanc, LM; Morin, P; Paré, AF; Surette, ME; Touaibia, M1
Akpa, EG; Bosworth, BP; Boyle, JO; Brown, PH; Dannenberg, AJ; Duffield-Lillico, AJ; Kingsley, PJ; Knutson, A; Marnett, LJ; Milne, GL; Mohebati, A; Szabo, E; Zhou, XK1
Chen, CM; Chen, Y; Shi, SS; Tu, XK; Wang, CH; Yang, WZ1
Chu, J; Li, JG; Praticò, D1
Seow, CY; van Eeden, S1
Chang, FT; Chen, WJ; Liaw, SF; Lin, CC; Lin, MW1
Christians, U; Clavijo, CF; Galinkin, JL; Hoffman, K; Labovitz, E; Malik, P; Pian, P; Rzasa Lynn, R; Vinks, AA1
Cao, R; Liu, T; Meng, Z; Wang, X; Wang, Y; Yang, Z1
Fan, B; Gao, W; Li, B; Li, M; Liu, H; Qu, X; Shao, Q; Wang, Q; Wen, Z; Xie, Q; Yang, Y; Yu, J; Zhao, F1
Adesina, SE; Hart, CM; Kang, BY; Murphy, TC; Porter, KM; Sutliff, RL1
Andoh, T; Kuraishi, Y; Takayama, Y1
Di Meco, A; Lauretti, E; Praticò, D; Vagnozzi, AN1
Chen, L; Li, CT; Wang, XR; Wang, YF; Wei, EQ; Xu, DM; Zhang, LH; Zhang, XY1
Bujalska-Zadrozny, M; Gasinska, E; Maslinski, S; Rzodkiewicz, P1
Cao, W; Ding, XL; Qu, LS; Wu, SB; Zhang, H; Zhang, HF; Zhou, GX1
Bentrem, DJ; Blatner, NR; Cheon, EC; Gounaris, E; Grippo, PJ; Heiferman, JR; Heiferman, MJ; Khazaie, K; Knab, LM; Munshi, HG; Phillips, JD; Shrivastav, M; Vitello, D1
Abood, M; Chu, J; Giannopoulos, PF; Kirby, LG; Li, JG; Praticò, D; Sperow, M; Yu, WH1
Dahlin, A; Irvin, CG; Kubo, M; Lima, JJ; Litonjua, A; Peters, SP; Tamari, M; Tantisira, KG1
Bastiaans, DE; Fuijkschot, J; Roeleveld, N; Seyger, MM; Wevers, RA; Willemsen, MA1
Cheng, J; Jia, J; Li, Y; Liu, Y; Wang, W; Xiao, Y1
Barcelos, Lda S; de Miranda, AS; de Oliveira, AC; Machado, FS; Moraes, MF; Parreiras, PM; Rachid, MA; Resende, GH; Rodrigues, FG; Silva, BC; Silveira, AL; Teixeira, AL; Teixeira, MM1
Pasichnichenko, OM; Vinogradova, OO; Yanchuk, PI1
Arumugam, PI; Brandt, EB; Carmeliet, P; Eiymo Mwa Mpollo, MS; Hershey, GK; Jonck, B; Kalra, VK; Le Cras, TD; Lindsey, M; Loberg, A; Malik, P; Pillis, D; Ratner, N; Rizvi, T; Shanmukhappa, SK; Tiwari, S; Wills-Karp, M1
Dennis, EA; Mouchlis, VD1
Bretzke, S; Essig, S; Koeberle, A; Menche, D; Müller, R; Scherer, O; Schmalzbauer, B; Werz, O1
Chen, CM; Liang, RS; Shi, SS; Tu, XK; Wang, CH; Yang, WZ; Zhang, HB1
Hah, JH; Jeong, WJ; Oh, SM; Park, SW; Sung, MW1
Altavilla, D; Arcoraci, V; Bitto, A; Galfo, F; Irrera, N; Macrì, A; Minutoli, L; Pallio, G; Pizzino, G; Squadrito, F; Squadrito, G1
Antonov, VG; Krutetskaya, ZI; Milenina, LS; Naumova, AA; Nozdrachev, AD1
Chen, Y; DeSouza, N; Guo, Z; Hoffman, R; Li, S; Liang, A; Lu, M; Shan, Y1
Abueid, L; Alican, İ; Cumbul, A; Ercan, F; Uslu, Ü; Velioğlu Öğünç, A1
Gaboriaud-Kolar, N; Garscha, U; Halabalaki, M; Kouloura, E; Krauth, V; Pace, S; Pergola, C; Rossi, A; Sautebin, L; Skaltsounis, AL; Svouraki, A; Werz, O1
Barrero, C; Li, JG; Merali, S; Praticò, D1
Afenjar, A; Boespflug-Tanguy, O; Pichard, S; Sarret, C1
Gleitz, S; Hoffmann, DB; Komrakova, M; Kosinsky, RL; Menger, B; Nguyen, HH; Saul, D; Sehmisch, S; Wassmann, M1
Corrêa, JD; Cunha, TM; Garlet, GP; Machado, FS; Madeira, MFM; Queiroz-Junior, CM; Silva, TA; Souza, DG; Teixeira, MM; Werneck, SMC1
Blanchard, S; Boudreau, LH; Cormier, M; Doucet, MS; Lassalle-Claux, G; Surette, ME; Touaibia, M1
Cheon, HG; Choi, HE; Kwak, HJ1
Akyol, O; Huang, L; McBride, DW; Sherchan, P; Wang, Y; Zhang, JH1
Domon, H; Isono, T; Kawabata, S; Kurosawa, M; Maekawa, T; Oda, M; Terao, Y; Yamaguchi, M1
Dehm, F; Gerstmeier, J; Koeberle, A; Laufer, S; Maier, TJ; Northoff, H; Pace, S; Pein, H; Pergola, C; Rådmark, O; Rossi, A; Rummler, S; Samuelsson, B; Sautebin, L; Schaible, AM; Troisi, F; Weinigel, C; Werz, O1
Gasimov, T; Hoffmann, DB; Komrakova, M; Menger, B; Ninkovic, M; Rohde, V; Saul, D; Sehmisch, S; Simka, P; Wolff, L1
Du, YF; Hong, H; Hu, M; Li, DD; Long, Y; Reed, MN; Suppiramaniam, V; Tang, SS; Xie, H1
Mosser-Goldfarb, JL; Yanes, DA1
Dahlin, A; Irvin, CG; Kubo, M; Lima, JJ; Litonjua, AA; Peters, SP; Qiu, W; Tamari, M; Tantisira, KG; Weiss, ST; Wu, AC1
Hashim, AA; Helmy, MM; Mouneir, SM1
Arentson, E; Belikoff, B; Brooks, FJ; Byers, DE; Castro, M; Chen, DL; Engle, JT; Fujiwara, H; Huang, HJ; Isakow, W; Kemp, D; Phillips, S; Pierce, RA; Scherrer, DE; Shifren, A; Spayd, KJ1
Liao, D; Qian, B; Wu, K; Xu, M; Zhang, Y1
Chiu, J; Giannopoulos, PF; Praticò, D2
Ahmadieh, H; Hafezi-Moghadam, A; Ishibashi, T; Ishikawa, K; Kanavi, MR; Koga, T; Nakama, T; Nakao, S; Ohba, M; Okuno, T; Penninger, JM; Saeki, K; Sasaki, F; Sonoda, KH; Yokomizo, T; Yoshida, S1
Borges, RDS; Brasil, DDSB; Campos, JM; Costa, JDS; Costa, KDSL; Ferreira, EFB; Macêdo, WJDC; Ramos, RDS; Santos, CBRD; Silva, CHTPD1
Balamurali, MM; Basu, B; Doble, M; Munussami, P; Muthuraman, S; Saravana Kumar, R; Sinha, S; Vasavi, CS; Waidha, KM1
Butterfield, J; Castells, M1
Adams, KN; Ebert, CS; Farquhar, DR; Lee, SE; Masood, MM; Senior, BA; Thorp, BD; Zanation, AM1
Kwak, HJ; Lee, SS; Lim, HJ; Park, J; Um, JY1
Abasolo, I; Andrade, F; Arango, D; Díaz-Riascos, ZV; Gener, P; González, P; Manzano, A; Martínez-Trucharte, F; Montero, S; Rafael, D; Sayós, J; Schwartz, S; Seras-Franzoso, J; Xandri-Monje, H1
Cai, Z; Chen, JJ; Deng, W; Duan, M; Guo, Y; Liu, C; Tang, Q; Wang, J; Wu, QQ; Xiao, Y; Xie, S; Yuan, Y1
Bobade, PS; Dhumal, DM; Ganorkar, SB; Lokwani, DK; Shirkhedkar, AA; Vander Heyden, Y1
Alvarez, ML; Carrillo, MC; Ceballos, MP; Comanzo, CG; Lorenzetti, F; Lucci, A; Monti, JA; Pisani, GB; Quiroga, AD; Ronco, MT; Tordjmann, T; Vera, MC1
Holguin, F; Nouraie, M; Parikh, A; Thalanayar Muthukrishnan, P1
Enache, I; Kubick, N; Manda, G; Mickael, ME; Pajares, M1
Chen, X; Fan, W; Huang, C; Jacobson, O; Kang, F; Li, L; Ma, Y; Mu, Q; Tang, L; Wang, M; Wang, Z; Yang, W; Yu, Z; Zhou, Z1
Huang, CW; Hung, TY; Wu, SN1
Citron, F; Deem, AK; Genovese, G; Perelli, L; Viale, A1
Chiasson, AI; Hébert, MPA; Mbarik, M; Ndongou Moutombi, FJ; Robichaud, S; Surette, ME; Touaibia, M1
Chen, H; Deng, Y; Guo, Z; He, Z; Liang, Y; Liu, L; Sun, X; Zhang, P; Zhang, Z1
Baek, SE; Choi, JM; Jang, EJ; Jeon, EY; Kim, CD; Kim, JO1
Duan, P; Lin, J; Long, J; Tang, J; Zhang, C; Zhu, H1
Cavallaro, G; Craparo, EF; Drago, SE; Luxenhofer, R1
Franz, MK; Hohl, FE; Komrakova, M; Meyer, I; Roch, PJ; Saul, D; Sehmisch, S; Taudien, S1
Li, L; Wang, S; Xiao, Y; Xu, Z1
Chang-Chien, GP; Chen, A; Hsiao, YT; Ke, MC; Lee, JJ; Lin, S; Lin, TK1
Lin, CL; Su, HY; Tsai, HP; Tsai, YC1
Jang, H; Jang, WI; Jang, WS; Kim, H; Kwak, SY; Lee, SB; Lee, SJ; Na, J; Park, M; Park, S; Shim, S1

Reviews

40 review(s) available for zileuton and hydroxyurea

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor.
    International journal of immunopharmacology, 1992, Volume: 14, Issue:3

    Topics: Animals; Arachidonate 5-Lipoxygenase; Drug Design; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors

1992
[Allergy and leukotrienes].
    Klinicheskaia meditsina, 1995, Volume: 73, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Dermatitis, Atopic; Humans; Hydroxyurea; Hypersensitivity; Leukotrienes; Lipoxygenase Inhibitors; Receptors, Leukotriene

1995
Leukotriene antagonists and inhibitors: clinical applications.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Animals; Asthma; Glomerulonephritis; Humans; Hydroxyurea; Indoles; Inflammatory Bowel Diseases; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Propionates; Psoriasis; Quinolines; Receptors, Leukotriene

1995
Inhibition of CoA-independent transacylase reduces inflammatory lipid mediators.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Acyltransferases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Humans; Hydroxyurea; Imidazoles; Inflammation; Mast Cells; Monocytes; Neutrophils; Organophosphorus Compounds

1995
Zileuton.
    Lancet (London, England), 1996, Aug-24, Volume: 348, Issue:9026

    Topics: Arthritis, Rheumatoid; Asthma; Humans; Hydroxyurea; Lipoxygenase Inhibitors

1996
Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents.
    Archives of internal medicine, 1996, Oct-28, Volume: 156, Issue:19

    Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Hydroxyurea; Indoles; Inflammation; Inflammation Mediators; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds

1996
[5-lipoxygenase inhibitors in asthma therapy].
    Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:11

    Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acids; Asthma; Humans; Hydroxyurea; Lipoxygenase Inhibitors

1996
Antileukotriene therapy for asthma.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1996, Dec-01, Volume: 53, Issue:23

    Topics: Asthma; Humans; Hydroxyurea; Inflammation; Leukotrienes; Lipoxygenase Inhibitors

1996
Emerging treatments for rheumatoid arthritis.
    The American journal of medicine, 1997, Jan-27, Volume: 102, Issue:1A

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; CD4 Antigens; Collagen; Cyclosporine; Humans; Hydroxyurea; Immunosuppressive Agents; Interleukin-1; Minocycline; Mycophenolic Acid; Tumor Necrosis Factor-alpha

1997
Antileukotriene agents.
    Current opinion in pulmonary medicine, 1997, Volume: 3, Issue:3

    Topics: Anti-Asthmatic Agents; Asthma; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds

1997
New directions in asthma drug therapy.
    Hospital practice (1995), 1998, Feb-15, Volume: 33, Issue:2

    Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chromones; Humans; Hydroxyurea; Indoles; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds

1998
The role of antileukotrienes in asthma management.
    Current opinion in pulmonary medicine, 1998, Volume: 4, Issue:1

    Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Chromones; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds

1998
New approaches to anti-inflammatory therapy for asthma.
    The American journal of medicine, 1998, Volume: 104, Issue:3

    Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Dicarboxylic Acids; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Steroids; Sulfonamides; Tosyl Compounds

1998
The role of leukotriene modifiers in the treatment of asthma.
    American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:5 Pt 1

    Topics: Animals; Asthma; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds

1998
Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors.
    American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:6 Pt 2

    Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Phenylcarbamates; Randomized Controlled Trials as Topic; Sulfonamides; Tosyl Compounds; Treatment Outcome

1998
[Potential importance of antileukotrienes in the treatment of asthma and other inflammatory diseases: apropos of a new pharmacological class].
    La Revue de medecine interne, 1998, Volume: 19, Issue:2

    Topics: Acetophenones; Adult; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Asthma; Bronchoconstriction; Child; Clinical Trials as Topic; Crohn Disease; Cystic Fibrosis; Haplorhini; Humans; Hydroxyurea; Indazoles; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Psoriasis; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sulfonamides; Tetrazoles; Tosyl Compounds

1998
Leukotriene antagonism in asthma and rhinitis.
    Respiratory medicine, 1998, Volume: 92, Issue:6

    Topics: Acetates; Asthma; Bronchi; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene D4; Lipoxygenase Inhibitors; Membrane Proteins; Phenylcarbamates; Quinolines; Receptors, Leukotriene; Rhinitis; Sinusitis; Sulfides; Sulfonamides; Tosyl Compounds

1998
[Histopathologic diagnosis of the activity of chronic inflammatory bowel disease. Evaluation of the effect of drug treatment. Use of histological scores].
    Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:10

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Biopsy; Colitis, Ulcerative; Colon; Crohn Disease; Cyclosporine; Humans; Hydroxyurea; Ileum; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mesalamine; Microscopy; Sulfasalazine; Time Factors

1999
[The role of leukotrienes in inflammation and leukotriene inhibitors].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 1999, Volume: 7, Issue:39

    Topics: Acetates; Arachidonate 5-Lipoxygenase; Asthma; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds

1999
Leukotriene modifiers in pediatric asthma management.
    Pediatrics, 2001, Volume: 107, Issue:2

    Topics: Acetates; Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Child; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Phenylcarbamates; Quinolines; Receptors, Leukotriene; Sulfides; Sulfonamides; Tosyl Compounds

2001
Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma.
    Expert opinion on pharmacotherapy, 2001, Volume: 2, Issue:1

    Topics: Acetates; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Asthma; Bronchoconstriction; Child; Clinical Trials as Topic; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Phenylcarbamates; Phosphodiesterase Inhibitors; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome

2001
Antileukotrienes in asthma: present situation.
    Expert opinion on pharmacotherapy, 2001, Volume: 2, Issue:3

    Topics: Acetates; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Chromones; Clinical Trials as Topic; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds

2001
[Leukotriene modifiers].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59, Issue:10

    Topics: Acetates; Asthma; Chromones; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Phenylcarbamates; Practice Guidelines as Topic; Quinolines; Receptors, Leukotriene; Sulfides; Sulfonamides; Tosyl Compounds

2001
Leukotriene modifiers. Expanded role may be on horizon.
    Advance for nurse practitioners, 2000, Volume: 8, Issue:10

    Topics: Acetates; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Cyclopropanes; Drug Interactions; Drug Therapy, Combination; Forced Expiratory Volume; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Patient Compliance; Phenylcarbamates; Quinolines; Safety; Steroids; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome

2000
[Anti-leukotriene drugs and Churg Strauss syndrome].
    Polskie Archiwum Medycyny Wewnetrznej, 2002, Volume: 107, Issue:2

    Topics: Churg-Strauss Syndrome; Humans; Hydroxyurea; Leukotriene Antagonists

2002
New treatments for asthma: the role of leukotriene modifier agents.
    Journal of the National Medical Association, 1999, Volume: 91, Issue:8 Suppl

    Topics: Acetates; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Asthma, Exercise-Induced; Cyclopropanes; Drug Evaluation; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome

1999
[Anti-leukotrienes in allergic diseases in children].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2003, Volume: 14, Issue:84

    Topics: Acetates; Asthma; Child; Cyclopropanes; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Quinolines; Receptors, Leukotriene; Sulfides

2003
Recent advances in the management of asthma using leukotriene modifiers.
    American journal of respiratory medicine : drugs, devices, and other interventions, 2003, Volume: 2, Issue:2

    Topics: Acetates; Administration, Inhalation; Adolescent; Adult; Asthma; Child; Child, Preschool; Chromones; Controlled Clinical Trials as Topic; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxyurea; Leukotriene Antagonists; Male; Middle Aged; Peak Expiratory Flow Rate; Quinolines; Respiratory Function Tests; Severity of Illness Index; Sulfides; Treatment Outcome

2003
Leukotrienes antagonists in the management of bronchial asthma.
    Romanian journal of internal medicine = Revue roumaine de medecine interne, 2003, Volume: 41, Issue:1

    Topics: Asthma; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotrienes

2003
Treatment of asthma with antileukotrienes: first line or last resort therapy?
    European journal of pharmacology, 2006, Mar-08, Volume: 533, Issue:1-3

    Topics: Acetates; Animals; Asthma; Clinical Trials as Topic; Cyclopropanes; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Lipoxygenase Inhibitors; Membrane Proteins; Quinolines; Receptors, Leukotriene; Respiratory System; Rhinitis; Sulfides

2006
Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends.
    Medicinal research reviews, 2007, Volume: 27, Issue:4

    Topics: Adult; Animals; Asthma; Cardiovascular Diseases; Child; Child, Preschool; Dermatitis, Atopic; Female; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Membrane Proteins; Pharmacogenetics; Receptors, Leukotriene; Receptors, Purinergic; Recombinant Proteins; Rhinitis, Allergic, Seasonal; SRS-A; Tissue Distribution

2007
Leukotriene inhibitors in the treatment of allergy and asthma.
    American family physician, 2007, Jan-01, Volume: 75, Issue:1

    Topics: Acetates; Anti-Asthmatic Agents; Asthma; Asthma, Exercise-Induced; Cyclopropanes; Dermatitis, Atopic; Humans; Hydroxyurea; Hypersensitivity; Indoles; Leukotriene Antagonists; Phenylcarbamates; Quinolines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sulfides; Sulfonamides; Tosyl Compounds

2007
Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease.
    International journal of clinical practice, 2007, Volume: 61, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Dermatitis, Atopic; Drug Administration Schedule; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Pulmonary Disease, Chronic Obstructive; Rhinitis

2007
Systemic therapies in managing sinonasal inflammation.
    Otolaryngologic clinics of North America, 2010, Volume: 43, Issue:3

    Topics: Anti-Inflammatory Agents; Combined Modality Therapy; Drug Therapy; Eosinophils; Histamine Antagonists; Humans; Hydroxyurea; Immunologic Factors; Indoles; Leukotriene Antagonists; Otorhinolaryngologic Surgical Procedures; Phenylcarbamates; Rhinitis; Sinusitis; Sulfonamides; Tosyl Compounds

2010
Association between leukotriene-modifying agents and suicide: what is the evidence?
    Drug safety, 2011, Jul-01, Volume: 34, Issue:7

    Topics: Acetates; Adverse Drug Reaction Reporting Systems; Cyclopropanes; Drug Labeling; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Phenylcarbamates; Quinolines; Suicide; Sulfides; Sulfonamides; Tosyl Compounds; United States; United States Food and Drug Administration

2011
[What helps for persistent symptoms of asthma during inhalative steroid therapy?].
    Deutsche medizinische Wochenschrift (1946), 2011, Volume: 136, Issue:42

    Topics: Acetates; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Child; Cyclopropanes; Drug Therapy, Combination; Ethanolamines; Formoterol Fumarate; Humans; Hydroxyurea; Leukotriene Antagonists; Quality of Life; Quinolines; Randomized Controlled Trials as Topic; Respiratory Function Tests; Salmeterol Xinafoate; Sulfides; Treatment Failure

2011
Membrane and inhibitor interactions of intracellular phospholipases A2.
    Advances in biological regulation, 2016, Volume: 61

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Membrane; Eukaryotic Cells; Gene Expression Regulation; Humans; Hydroxyurea; Lipoxygenase; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Phospholipases A2; Phospholipids; Prostaglandin-Endoperoxide Synthases; Signal Transduction

2016
Emerging therapies for atopic dermatitis: The prostaglandin/leukotriene pathway.
    Journal of the American Academy of Dermatology, 2018, Volume: 78, Issue:3 Suppl 1

    Topics: Acetates; Adult; Animals; Cyclopropanes; Dermatitis, Atopic; Female; Forecasting; Humans; Hydroxyurea; Leukotriene Antagonists; Male; Molecular Targeted Therapy; Prostaglandin Antagonists; Quinolines; Severity of Illness Index; Sulfides; Treatment Outcome

2018
Mast Cell Activation Syndrome and Mastocytosis: Initial Treatment Options and Long-Term Management.
    The journal of allergy and clinical immunology. In practice, 2019, Volume: 7, Issue:4

    Topics: Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cromolyn Sodium; Disease Management; Glucocorticoids; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Hydroxyurea; Interleukin-6; Leukotriene Antagonists; Leukotriene E4; Mastocytosis; Omalizumab; Prostaglandin D2; Tryptases

2019

Trials

62 trial(s) available for zileuton and hydroxyurea

ArticleYear
Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis.
    The Journal of rheumatology, 1992, Volume: 19, Issue:10

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Time Factors

1992
Phase II study of the safety and efficacy of a 5-lipoxygenase inhibitor in patients with ulcerative colitis.
    The American journal of gastroenterology, 1992, Volume: 87, Issue:3

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Drug Evaluation; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Sigmoidoscopy

1992
Effect of Zileuton (A-64077) on the 5-lipoxygenase activity of human whole blood ex vivo.
    Agents and actions, 1991, Volume: 34, Issue:1-2

    Topics: Adolescent; Adult; Arachidonate 5-Lipoxygenase; Calcimycin; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Hydroxyurea; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Radioimmunoassay

1991
Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor.
    The New England journal of medicine, 1990, Dec-20, Volume: 323, Issue:25

    Topics: Double-Blind Method; Female; Histamine Release; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Nasal Obstruction; Nasal Provocation Tests; Prostaglandin D2; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sneezing

1990
Pharmacokinetics, safety, and ability to diminish leukotriene synthesis by zileuton, an inhibitor of 5-lipoxygenase.
    Agents and actions. Supplements, 1991, Volume: 35

    Topics: Adolescent; Adult; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Thromboxanes

1991
Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients.
    Thorax, 1991, Volume: 46, Issue:3

    Topics: Adult; Allergens; Asthma; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; SRS-A; Time Factors

1991
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air.
    The New England journal of medicine, 1990, Dec-20, Volume: 323, Issue:25

    Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Calcimycin; Cold Temperature; Double-Blind Method; Eicosanoids; Humans; Humidity; Hydroxyurea; Lipoxygenase Inhibitors; Male

1990
Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects.
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:4 Pt 1

    Topics: Adult; Arachidonate 5-Lipoxygenase; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cold Temperature; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Single-Blind Method; Time Factors

1995
Population pharmacokinetics of zileution, a selective 5-lipoxygenase inhibitor, in patients with rheumatoid arthritis.
    European journal of clinical pharmacology, 1995, Volume: 48, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Male; Mathematics; Middle Aged; Time Factors

1995
Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma.
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:3

    Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Inflammation; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Middle Aged

1995
The effect of zileuton on antipyrine and indocyanine green disposition.
    Clinical pharmacology and therapeutics, 1995, Volume: 57, Issue:3

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Double-Blind Method; Humans; Hydroxyurea; Indocyanine Green; Lipoxygenase Inhibitors; Male

1995
A pilot study of zileuton, a novel selective 5-lipoxygenase inhibitor, in patients with systemic lupus erythematosus.
    The Journal of rheumatology, 1995, Volume: 22, Issue:3

    Topics: Adult; Aged; Double-Blind Method; Female; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene E4; Lipoxygenase Inhibitors; Lupus Erythematosus, Systemic; Male; Middle Aged; Pilot Projects; Prospective Studies; Treatment Outcome

1995
Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive asthma.
    The Journal of allergy and clinical immunology, 1994, Volume: 94, Issue:6 Pt 1

    Topics: Adult; Aspirin; Asthma; Blood Proteins; Chymases; Cross-Over Studies; Double-Blind Method; Eosinophil Granule Proteins; Female; Histamine; Humans; Hydroxyurea; Leukotrienes; Male; Mast Cells; Middle Aged; Nasal Mucosa; Ribonucleases; Serine Endopeptidases; Tryptases

1994
The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma.
    Annals of internal medicine, 1993, Dec-01, Volume: 119, Issue:11

    Topics: Adult; Albuterol; Asthma; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene E4; Lipoxygenase Inhibitors; Male; Single-Blind Method

1993
The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin.
    The American review of respiratory disease, 1993, Volume: 148, Issue:6 Pt 1

    Topics: Adult; Arachidonate 5-Lipoxygenase; Aspirin; Asthma; Bronchoconstriction; Double-Blind Method; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged

1993
Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor.
    Prostaglandins, 1995, Volume: 50, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cross-Over Studies; Dinoprost; Dinoprostone; Double-Blind Method; Eosinophils; Humans; Hydroxyurea; Leukotriene B4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Lung; Lung Injury; Placebos; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Proteins; Regression Analysis; Respiratory Hypersensitivity; Thromboxane B2

1995
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group.
    JAMA, 1996, Mar-27, Volume: 275, Issue:12

    Topics: Adrenergic beta-Agonists; Adult; Analysis of Variance; Asthma; Double-Blind Method; Drug Administration Schedule; Drug Monitoring; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Liver; Liver Function Tests; Male; Peak Expiratory Flow Rate; Quality of Life

1996
Pharmacokinetic interactions between zileuton and prednisone.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adult; Analysis of Variance; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Prednisone

1995
The pharmacokinetic and pharmacodynamic interactions between the 5-lipoxygenase inhibitor zileuton and the cyclo-oxygenase inhibitor naproxen in human volunteers.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Endoscopy; Humans; Hydroxyurea; Intestinal Mucosa; Leukotriene B4; Lipoxygenase Inhibitors; Male; Naproxen; Thromboxane B2

1995
Pharmacokinetics and pharmacodynamics of zileuton after oral administration of single and multiple dose regimens of zileuton 600mg in healthy volunteers.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fasting; Humans; Hydroxylation; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Stereoisomerism; Urea; White People

1995
The pharmacokinetics of zileuton in healthy young and elderly volunteers.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Chromatography, High Pressure Liquid; Coloring Agents; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Hydroxylation; Hydroxyurea; Indocyanine Green; Lipoxygenase Inhibitors; Liver Circulation; Male; Reproducibility of Results; Sex Characteristics

1995
The effect of food on the pharmacokinetics of zileuton.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Absorption; Adult; Analysis of Variance; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Eating; Fasting; Food-Drug Interactions; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Reproducibility of Results

1995
Pharmacodynamic and stereoselective pharmacokinetic interactions between zileuton and warfarin in humans.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adult; Analysis of Variance; Anticoagulants; Blood Coagulation; Blood Specimen Collection; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Prothrombin Time; Reproducibility of Results; Stereoisomerism; Warfarin

1995
Effect of zileuton on theophylline pharmacokinetics.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adult; Analysis of Variance; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Half-Life; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Theophylline

1995
Lack of pharmacokinetic interaction between zileuton and phenytoin in humans.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adult; Analysis of Variance; Anticonvulsants; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Linear Models; Lipoxygenase Inhibitors; Male; Phenytoin; Reproducibility of Results

1995
The pharmacokinetics of single oral doses of zileuton 200 to 800mg, its enantiomers, and its metabolites, in normal healthy volunteers.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Absorption; Administration, Oral; Adult; Analysis of Variance; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Glucuronates; Half-Life; Humans; Hydroxylation; Hydroxyurea; Kidney Tubules, Proximal; Lipoxygenase Inhibitors; Male; Middle Aged; Protein Binding; Stereoisomerism; Urea

1995
Assessment of the pharmacokinetic interaction between zileuton and digoxin in humans.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adult; Analysis of Variance; Blood Cell Count; Cardiotonic Agents; Cross-Over Studies; Digoxin; Double-Blind Method; Drug Interactions; Electrocardiography; Half-Life; Humans; Hydroxyurea; Isotope Labeling; Lipoxygenase Inhibitors; Male; Radioimmunoassay

1995
The influence of multiple oral doses of zileuton on the steady-state pharmacokinetics of sulfasalazine and its metabolites, sulfapyridine and N-acetylsulfapyridine.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Interactions; Half-Life; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Middle Aged; Sulfapyridine; Sulfasalazine

1995
A controlled trial of the effect of the 5-lipoxygenase inhibitor, zileuton, on lung inflammation produced by segmental antigen challenge in human beings.
    The Journal of allergy and clinical immunology, 1996, Volume: 97, Issue:2

    Topics: Adult; Antigens; Bronchoalveolar Lavage Fluid; Cell Count; Double-Blind Method; Eosinophils; Female; Humans; Hydroxyurea; Hypersensitivity; Leukotriene E4; Lipoxygenase Inhibitors; Male; Pneumonia; Pollen

1996
Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor.
    American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:3

    Topics: Adult; Albuterol; Anti-Asthmatic Agents; Asthma, Exercise-Induced; Bronchial Spasm; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Inflammation Mediators; Leukotriene Antagonists; Leukotriene B4; Leukotriene C4; Leukotrienes; Lipoxygenase Inhibitors; Vital Capacity

1996
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group.
    The Journal of allergy and clinical immunology, 1996, Volume: 98, Issue:5 Pt 1

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; Bronchoconstriction; Double-Blind Method; Drug Therapy, Combination; Eosinophils; Female; Forced Expiratory Volume; Histamine Antagonists; Humans; Hydroxyurea; Leukocyte Count; Leukotrienes; Lipoxygenase Inhibitors; Liver Function Tests; Male; Middle Aged; Time Factors; Treatment Outcome

1996
A trial of zileuton versus mesalazine or placebo in the maintenance of remission of ulcerative colitis. The European Zileuton Study Group For Ulcerative Colitis.
    Gastroenterology, 1997, Volume: 112, Issue:3

    Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Double-Blind Method; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Mesalamine; Middle Aged; Multivariate Analysis

1997
The pharmacokinetic and pharmacodynamic interaction between zileuton and terfenadine.
    European journal of clinical pharmacology, 1997, Volume: 52, Issue:1

    Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double-Blind Method; Drug Synergism; Electrocardiography; Histamine H1 Antagonists; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Terfenadine

1997
Evaluation of the diurnal variation in the pharmacokinetics of zileuton in healthy volunteers.
    Journal of clinical pharmacology, 1997, Volume: 37, Issue:5

    Topics: Adolescent; Adult; Circadian Rhythm; Cross-Over Studies; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Urea

1997
Pharmacokinetics of zileuton and its metabolites in patients with renal impairment.
    Journal of clinical pharmacology, 1997, Volume: 37, Issue:5

    Topics: Adult; Aged; Female; Humans; Hydroxyurea; Kidney Diseases; Kidney Failure, Chronic; Kidney Function Tests; Lipoxygenase Inhibitors; Male; Middle Aged; Renal Dialysis

1997
Drug interactions with zileuton.
    Lancet (London, England), 1997, May-17, Volume: 349, Issue:9063

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Bronchodilator Agents; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Theophylline; Warfarin

1997
A randomized controlled trial comparing zileuton with theophylline in moderate asthma. The Zileuton Study Group.
    Archives of internal medicine, 1998, Jan-26, Volume: 158, Issue:2

    Topics: Adult; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Lung Volume Measurements; Male; Middle Aged; Severity of Illness Index; Theophylline; Time Factors; Treatment Outcome

1998
Effects of single-dose zileuton on bronchial hyperresponsiveness in asthmatic patients treated with inhaled corticosteroids.
    The European respiratory journal, 1997, Volume: 10, Issue:12

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Histamine; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Middle Aged; Reference Values; Respiratory Function Tests; Sensitivity and Specificity; Water

1997
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics.
    American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:4 Pt 1

    Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Glucocorticoids; Histamine; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene D4; Lipoxygenase Inhibitors; Male; Middle Aged; Peak Expiratory Flow Rate

1998
The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma.
    American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:5 Pt 1

    Topics: Adult; Airway Resistance; Asthma; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Neutropenia; Oxygen; Platelet Activating Factor; Pulmonary Gas Exchange; Respiratory Mechanics; Ventilation-Perfusion Ratio

1998
Randomized trial of zileuton in patients with moderate asthma: effect of reduced dosing frequency and amounts on pulmonary function and asthma symptoms. Zileuton Study Group.
    The American journal of managed care, 1997, Volume: 3, Issue:4

    Topics: Adolescent; Adult; Aged; Asthma; Double-Blind Method; Drug Administration Schedule; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Managed Care Programs; Middle Aged; Respiratory Function Tests; Respiratory System Agents; United States

1997
Safety and clinical efficacy of zileuton in patients with chronic asthma.
    The American journal of managed care, 1998, Volume: 4, Issue:6

    Topics: Asthma; Chronic Disease; Disease Management; Forced Expiratory Volume; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Managed Care Programs; Safety; Treatment Outcome; United States

1998
A pilot study examining the role of zileuton in atopic dermatitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:6 Pt 1

    Topics: Adult; Dermatitis, Atopic; Follow-Up Studies; Humans; Hydroxyurea; Leukotriene Antagonists; Patient Satisfaction; Pilot Projects

1999
Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics.
    American journal of respiratory and critical care medicine, 2000, Volume: 161, Issue:4 Pt 1

    Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxyurea; Inflammation Mediators; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Male; Skin Tests

2000
Double-blinded, placebo-controlled, cross-over pilot study on the efficacy of zileuton for canine atopic dermatitis.
    Veterinary dermatology, 2001, Volume: 12, Issue:4

    Topics: Administration, Oral; Animals; Cross-Over Studies; Dermatitis, Atopic; Dog Diseases; Dogs; Double-Blind Method; Female; Hydroxyurea; Leukotriene Antagonists; Male; Pilot Projects; Treatment Outcome

2001
Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma.
    Clinical & developmental immunology, 2004, Volume: 11, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Asthma; Dietary Supplements; Double-Blind Method; Fatty Acids; Female; gamma-Linolenic Acid; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Neutrophils; Plant Oils; Prospective Studies

2004
The effects of a 5-lipoxygenase inhibitor on acute mountain sickness and urinary leukotriene e4 after ascent to high altitude.
    Chest, 2005, Volume: 127, Issue:2

    Topics: Acclimatization; Administration, Oral; Adult; Alaska; Altitude Sickness; Arachidonate 5-Lipoxygenase; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hydroxyurea; Inflammation Mediators; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Mountaineering; Oximetry; Premedication; Statistics as Topic; Treatment Outcome

2005
Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects.
    Respiratory medicine, 2006, Volume: 100, Issue:2

    Topics: Adult; Animals; Bronchi; Bronchial Provocation Tests; Cytokines; Dust; Female; Humans; Hydroxyurea; Inhalation Exposure; Lipoxygenase Inhibitors; Male; Middle Aged; Nasal Lavage Fluid; Nitric Oxide; Respiratory Function Tests; Swine

2006
Effect of leukotriene modifier drugs on the safety of oral aspirin challenges.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:5

    Topics: Acetates; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Asthmatic Agents; Aspirin; Asthma; Cyclopropanes; Desensitization, Immunologic; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Middle Aged; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome

2006
Assessment of in vivo 5-lipoxygenase activity by analysis of leukotriene B4 in saliva: effects of treatment with zileuton.
    The Journal of allergy and clinical immunology, 2007, Volume: 119, Issue:5

    Topics: Adult; Arachidonate 5-Lipoxygenase; Chromatography, High Pressure Liquid; Double-Blind Method; Evaluation Studies as Topic; Female; Flow Cytometry; Humans; Hydroxyurea; Leukocytes, Mononuclear; Leukotriene Antagonists; Leukotriene B4; Male; Middle Aged; Saliva

2007
Zileuton added to low-dose inhaled beclomethasone for the treatment of moderate to severe persistent asthma.
    Respiratory medicine, 2007, Volume: 101, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Beclomethasone; Double-Blind Method; Drug Therapy, Combination; Forced Expiratory Volume; Glucocorticoids; Humans; Hydroxyurea; Middle Aged; Peak Expiratory Flow Rate; Severity of Illness Index; Single-Blind Method

2007
The safety and efficacy of zileuton controlled-release tablets as adjunctive therapy to usual care in the treatment of moderate persistent asthma: a 6-month randomized controlled study.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2007, Volume: 44, Issue:4

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Asthma; Child; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Middle Aged; Peak Expiratory Flow Rate; Quality of Life; Tablets

2007
Efficacy of zileuton controlled-release tablets administered twice daily in the treatment of moderate persistent asthma: a 3-month randomized controlled study.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2007, Volume: 99, Issue:2

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Forced Expiratory Volume; Humans; Hydroxyurea; Inhalation; Middle Aged; Tablets; Treatment Outcome

2007
Clinical pattern of zileuton-associated liver injury: results of a 12-month study in patients with chronic asthma.
    Drug safety, 2007, Volume: 30, Issue:9

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Asthma; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Liver Function Tests; Male; Prospective Studies

2007
Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Feb-20, Volume: 26, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carboplatin; Carcinoma, Non-Small-Cell Lung; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Deoxycytidine; Disease-Free Survival; Drug Administration Schedule; Eicosanoids; Female; Gemcitabine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyurea; Immunohistochemistry; Lipoxygenase Inhibitors; Logistic Models; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prognosis; Prospective Studies; Pyrazoles; Sulfonamides; Up-Regulation

2008
5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci.
    Pharmacogenetics and genomics, 2009, Volume: 19, Issue:3

    Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Cyclopropanes; Cysteine; Female; Forced Expiratory Volume; Genotype; Humans; Hydroxyurea; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Middle Aged; Polymorphism, Single Nucleotide; Quinolines; Receptors, Leukotriene; Sulfides

2009
Role of add-on zileuton on total exhaled, large airway, and small airway/alveolar nitric oxide in moderate-severe persistent adult asthmatics on fluticasone 250 microg/Salmeterol 50 microg.
    Pulmonary pharmacology & therapeutics, 2009, Volume: 22, Issue:6

    Topics: Adult; Albuterol; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Drug Therapy, Combination; Eosinophils; Female; Fluticasone; Humans; Hydroxyurea; Juniperus; Leukocyte Count; Male; Middle Aged; Nitric Oxide; Prospective Studies; Pulmonary Alveoli; Respiratory Function Tests; Respiratory System; Salmeterol Xinafoate; Spirometry

2009
Influence of leukotriene biosynthesis inhibition on heart rate in patients with atrial fibrillation.
    International journal of cardiology, 2010, Dec-03, Volume: 145, Issue:3

    Topics: Aged; Arachidonate 5-Lipoxygenase; Atrial Fibrillation; Female; Heart Rate; Humans; Hydroxyurea; Leukotriene Antagonists; Male; Middle Aged; Placebos

2010
Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization.
    COPD, 2011, Volume: 8, Issue:1

    Topics: Aged; Biomarkers; Double-Blind Method; Drug Administration Schedule; Female; Hospitalization; Humans; Hydroxyurea; Length of Stay; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Treatment Failure; Treatment Outcome

2011
Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:7

    Topics: Adult; Arachidonate 5-Lipoxygenase; Biomarkers; Celecoxib; Chromatography, Liquid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Humans; Hydroxyurea; Leukotriene E4; Lipoxygenase Inhibitors; Male; Maximum Tolerated Dose; Prognosis; Prostaglandins; Pyrazoles; Smoking; Sulfonamides; Tandem Mass Spectrometry

2013
Genome-wide association study of leukotriene modifier response in asthma.
    The pharmacogenomics journal, 2016, Volume: 16, Issue:2

    Topics: Acetates; Anti-Asthmatic Agents; Asthma; Cohort Studies; Cyclopropanes; Gene-Environment Interaction; Genetic Loci; Genome-Wide Association Study; Genotype; Humans; Hydroxyurea; Leukotrienes; Phenotype; Polymorphism, Single Nucleotide; Quinolines; Sulfides

2016
Zileuton for Pruritus in Sjögren-Larsson Syndrome: A Randomized Double-blind Placebo-controlled Crossover Trial.
    Acta dermato-venereologica, 2016, Volume: 96, Issue:2

    Topics: Adolescent; Adult; Antipruritics; Child; Double-Blind Method; Female; Humans; Hydroxyurea; Male; Netherlands; Pruritus; Sjogren's Syndrome; Time Factors; Treatment Outcome; Young Adult

2016

Other Studies

273 other study(ies) available for zileuton and hydroxyurea

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Drug Metabolism by the Mitochondrial Amidoxime Reducing Component (mARC): Rapid Assay and Identification of New Substrates.
    Journal of medicinal chemistry, 2020, 06-25, Volume: 63, Issue:12

    Topics: Biological Assay; Humans; Inactivation, Metabolic; Metabolic Clearance Rate; Mitochondria; Mitochondrial Proteins; Oxidation-Reduction; Oxidoreductases; Oximes; Substrate Specificity

2020
Nitroxide metabolites from alkylhydroxylamines and N-hydroxyurea derivatives resulting from reductive inhibition of soybean lipoxygenase.
    The Journal of biological chemistry, 1992, May-15, Volume: 267, Issue:14

    Topics: Benzeneacetamides; Electron Spin Resonance Spectroscopy; Free Radicals; Glycine max; Hydroxamic Acids; Hydroxylamines; Hydroxyurea; Lipoxygenase Inhibitors; Molecular Structure; Nitrogen Oxides; Oxidation-Reduction; Structure-Activity Relationship

1992
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.
    Inflammation, 1992, Volume: 16, Issue:3

    Topics: 5-Lipoxygenase-Activating Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Benzopyrans; Carrier Proteins; Free Radical Scavengers; Gastric Mucosa; Hydroxyurea; Indoles; Indomethacin; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Masoprocol; Membrane Proteins; Organic Chemicals; Permeability; Phenylcarbamates; Propionates; Quinolines; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene; Receptors, Leukotriene B4; Single-Blind Method; Stomach Ulcer; Sulfonamides; Tetrazoles; Tosyl Compounds

1992
The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep.
    European journal of pharmacology, 1992, Jul-07, Volume: 217, Issue:2-3

    Topics: Administration, Oral; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Dose-Response Relationship, Drug; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Sheep

1992
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2

1992
Effect of BI-L-239, A-64077 and MK-886 on leukotriene B4 synthesis by chopped guinea pig lung and on antigen-induced tracheal contraction in vitro.
    Prostaglandins, 1992, Volume: 44, Issue:6

    Topics: Animals; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phenols; Trachea

1992
Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity.
    The Journal of biological chemistry, 1992, Nov-05, Volume: 267, Issue:31

    Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Cell Compartmentation; Cell Membrane; Cytosol; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; In Vitro Techniques; Indoles; Leukotrienes; Neutrophils; Substrate Specificity

1992
Kinetics and mechanism of degradation of Zileuton, a potent 5-lipoxygenase inhibitor.
    Pharmaceutical research, 1992, Volume: 9, Issue:11

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Hydrolysis; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Oxidation-Reduction; Temperature

1992
Enantiomeric activation of glucuronidation in dog hepatic microsomes.
    The Journal of biological chemistry, 1992, Jul-05, Volume: 267, Issue:19

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Glucuronates; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Microsomes, Liver; Stereoisomerism

1992
Inhibition of leukotriene B4 biosynthesis by disulfiram and A-64077 during carrageenan-induced pleurisy in the rat.
    General pharmacology, 1991, Volume: 22, Issue:2

    Topics: Aldehyde Dehydrogenase; Animals; Carrageenan; Colitis, Ulcerative; Disulfiram; Exudates and Transudates; Humans; Hydroxyurea; In Vitro Techniques; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pleurisy; Rats; Rats, Inbred Strains

1991
Therapeutic approaches to reduce airway inflammation.
    Agents and actions. Supplements, 1991, Volume: 35

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Blood Platelets; Bronchi; Cell Adhesion Molecules; Humans; Hydroxyurea; Intercellular Adhesion Molecule-1; Interleukin-5; Lipoxygenase Inhibitors

1991
Pharmacologic evaluation of A23187-induced contractions of three distinct preparations of guinea pig lung parenchymal strips.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcimycin; Drug Interactions; Guinea Pigs; Histamine; Hydroxyurea; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth; Prostaglandin Endoperoxides, Synthetic; Pyrilamine; SRS-A

1992
Inhibition of leukotriene biosynthesis in the rat peritoneal cavity.
    European journal of pharmacology, 1991, Dec-03, Volume: 205, Issue:3

    Topics: Administration, Oral; Anaphylaxis; Animals; Disease Models, Animal; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Peritoneal Cavity; Rats; Rats, Inbred Strains; SRS-A

1991
5-lipoxygenase inhibitory activity of zileuton.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Chromatography, High Pressure Liquid; Dogs; Edema; Haplorhini; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Rats; Rats, Inbred Strains; Species Specificity

1991
Asthma: the molecular light at the end of the tracheal tunnel.
    Hospital practice (Office ed.), 1991, Feb-15, Volume: 26, Issue:2

    Topics: Asthma; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Propionates; Quinolines

1991
Selective 5-lipoxygenase inhibition in ulcerative colitis.
    Lancet (London, England), 1990, Mar-24, Volume: 335, Issue:8691

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arachidonate Lipoxygenases; Colitis, Ulcerative; Dialysis; Dinoprostone; Drug Evaluation; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Middle Aged; Recurrence; Time Factors

1990
Arachidonate 5-lipoxygenase inhibition and acute renal allograft rejection.
    Transplantation proceedings, 1991, Volume: 23, Issue:1 Pt 1

    Topics: Animals; Dogs; Graft Rejection; Hydroxyurea; Kidney Transplantation; Lipoxygenase Inhibitors; Transplantation, Autologous; Transplantation, Homologous

1991
From the National Institutes of Health.
    JAMA, 1991, Mar-06, Volume: 265, Issue:9

    Topics: Arthritis, Juvenile; Asthma; CD4 Antigens; Cells, Cultured; Exotoxins; HIV-1; HLA Antigens; Humans; Hydroxyurea; Immunotoxins; Lipoxygenase Inhibitors; National Institutes of Health (U.S.); Recombinant Proteins; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; T-Lymphocytes; United States

1991
Modulation of cytokine release from human monocytes by drugs used in the therapy of inflammatory bowel diseases.
    European journal of gastroenterology & hepatology, 1995, Volume: 7, Issue:8

    Topics: Aminosalicylic Acids; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Dexamethasone; Endotoxins; Humans; Hydroxyurea; In Vitro Techniques; Inflammatory Bowel Diseases; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Mesalamine; Sulfapyridine; Tumor Necrosis Factor-alpha

1995
Peptidoleukotriene (pLT) release from guinea pig lung mast cells.
    Inflammation, 1994, Volume: 18, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Female; Guinea Pigs; Histamine Release; Hydroxyurea; In Vitro Techniques; Leukotrienes; Lung; Mast Cells

1994
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
    Toxicology, 1995, Jun-26, Volume: 100, Issue:1-3

    Topics: 1-Naphthylisothiocyanate; Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Hydroxyurea; Indoles; Inflammation; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Liver; Liver Diseases; Male; Phenyl Ethers; Rats; Rats, Sprague-Dawley

1995
Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
    Prostaglandins, leukotrienes, and essential fatty acids, 1995, Volume: 52, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Bronchoconstriction; Capillary Permeability; Chromones; Fatty Acids, Unsaturated; Furans; Guinea Pigs; Hydrazines; Hydroxyurea; Leukotriene D4; Lipoxygenase Inhibitors; Lung; Male; Meclofenamic Acid; Plasma; Prostaglandin Endoperoxides, Synthetic; Pyrilamine; Receptors, Thromboxane; SRS-A; Thromboxane A2; Trachea; Vasoconstrictor Agents

1995
Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells.
    American journal of veterinary research, 1995, Volume: 56, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; Cell Line; Cell Survival; Dog Diseases; Dogs; Drug Screening Assays, Antitumor; Hydroxyurea; Indomethacin; Melanoma; Piroxicam; Sarcoma; Tumor Cells, Cultured; Tumor Stem Cell Assay

1995
Pharmacologic modulation of the influence of the epithelium on immunologic- and nonimmunologic-induced histamine release and contraction in guinea pig superfused tracheal strips.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Animals; Epithelium; Female; Guinea Pigs; Histamine Release; Hydroxyurea; In Vitro Techniques; Indazoles; Indomethacin; Muscle Contraction; Ovalbumin; Pyrilamine; Trachea; Tubocurarine

1993
Cyproheptadine-induced attenuation of type-I immediate-hypersensitivity reactions of airway smooth muscle from immune-sensitized cats.
    American journal of veterinary research, 1995, Volume: 56, Issue:1

    Topics: Airway Resistance; Analysis of Variance; Animals; Ascaris suum; Cat Diseases; Cats; Cyproheptadine; Female; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Muscle, Smooth; Respiratory Hypersensitivity; Serotonin

1995
Stereoselective glucuronidation of zileuton isomers by human hepatic microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Chromosomes, Human; Glucuronates; Humans; Hydroxyurea; In Vitro Techniques; Microsomes, Liver; Stereoisomerism

1995
Properties of LTA4 synthase in human neutrophil preparations.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Arachidonate 5-Lipoxygenase; Calcimycin; Cell Membrane; Cytosol; Humans; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Neutrophils

1995
Suppression of NF kappa B activation and NF kappa B-dependent gene expression by tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase.
    Journal of cellular biochemistry, 1995, Volume: 57, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cell Line; Chloramphenicol O-Acetyltransferase; Cyclooxygenase Inhibitors; DNA Primers; Gene Expression; HeLa Cells; Humans; Hydroxyurea; Interleukin-6; Ionomycin; Kinetics; Lipoxygenase Inhibitors; Mice; Molecular Sequence Data; Naproxen; NF-kappa B; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Proto-Oncogene Proteins c-myc; Pyrazoles; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured

1995
Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Haplorhini; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Rats; Stereoisomerism

1995
Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats.
    Agents and actions, 1993, Volume: 39, Issue:3-4

    Topics: Animals; Colitis; Colon; Eicosanoids; Hydroxyurea; Inflammatory Bowel Diseases; Leukocytes; Lipoxygenase Inhibitors; Male; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid

1993
Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005.
    European journal of pharmacology, 1994, Jun-02, Volume: 258, Issue:1-2

    Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Animals; Benzoquinones; Bronchoconstriction; Carrier Proteins; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Injections, Intravenous; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Membrane Proteins; Ovalbumin; Pyrans; Quinolines; Quinolones; Trachea

1994
Eosinophil 15-lipoxygenase is a leukotriene A4 synthase.
    The Journal of biological chemistry, 1994, Oct-28, Volume: 269, Issue:43

    Topics: Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell-Free System; Cytosol; Dose-Response Relationship, Drug; Eosinophils; Granulocytes; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Leukotriene A4; Leukotrienes; Lipoxygenase Inhibitors; Models, Chemical; Neutrophils; Recombinant Proteins

1994
Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Aug-16, Volume: 91, Issue:17

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Adhesion; Chemotaxis, Leukocyte; Cytochrome c Group; Dose-Response Relationship, Drug; Humans; Hydroxyurea; In Vitro Techniques; Indoles; Interleukin-8; Kinetics; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate

1994
The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
    Pulmonary pharmacology, 1994, Volume: 7, Issue:2

    Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; Hydroxyurea; Indazoles; Lipoxygenase Inhibitors; Male; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth; Pyrilamine; SRS-A; Trachea

1994
Preclinical and clinical activity of zileuton and A-78773.
    Annals of the New York Academy of Sciences, 1993, Nov-30, Volume: 696

    Topics: Animals; Bronchial Spasm; Guinea Pigs; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Rats

1993
Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1

    Topics: Bronchi; Chlorpheniramine; Dicarboxylic Acids; Female; Histamine; Humans; Hydroxyurea; In Vitro Techniques; Indazoles; Isometric Contraction; Isotonic Solutions; Leukotriene D4; Lipoxygenase Inhibitors; Male; Middle Aged; Muscle Tonus; Muscle, Smooth; Pyrilamine; SRS-A

1994
Use of a continuous assay of oxygen consumption to evaluate the pharmacology of 5-lipoxygenase inhibitors.
    Prostaglandins, leukotrienes, and essential fatty acids, 1993, Volume: 49, Issue:6

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Drug Evaluation, Preclinical; Humans; Hydroxyurea; Imidazoles; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Monocytes; Oxygen Consumption; Rats; Tumor Cells, Cultured

1993
Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
    Agents and actions, 1993, Volume: 40, Issue:1-2

    Topics: Animals; Calcimycin; Chromatography, High Pressure Liquid; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Quinolines

1993
Effects of the arachidonate 5-lipoxygenase synthesis inhibitor A-64077 in intestinal ischemia-reperfusion injury.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Dogs; Hydroxyurea; Intestinal Mucosa; Intestines; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Models, Biological; Neutrophils; Reperfusion Injury

1994
The properties of A-69412: a small hydrophilic 5-lipoxygenase inhibitor.
    Agents and actions, 1993, Volume: 38, Issue:3-4

    Topics: Anaphylaxis; Animals; Biological Availability; Blood Proteins; Dogs; Half-Life; Humans; Hydroxyurea; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Macaca fascicularis; Male; Microsomes, Liver; Protein Binding; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured

1993
Effect of 5-lipoxygenase inhibitors on the anti-IgE-induced contraction of passively sensitized human bronchus in vitro.
    Journal of lipid mediators, 1993, Volume: 8, Issue:2

    Topics: Antibodies, Anti-Idiotypic; Bronchoconstriction; Humans; Hydroxyurea; Immunoglobulin E; In Vitro Techniques; Indoles; Leukotrienes; Lipoxygenase Inhibitors; Pyrilamine

1993
Effect of 5-lipoxygenase inhibitors on in situ LTB4 biosynthesis following calcium ionophore stimulation in the rat pleural cavity.
    Agents and actions, 1993, Volume: 39 Spec No

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Carrageenan; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene B4; Lipoxygenase Inhibitors; Pleura; Radioimmunoassay; Rats

1993
Inhibition of endotoxin-induced hypothermia and serum TNF-alpha levels in CD-1 mice by various pharmacological agents.
    Agents and actions, 1993, Volume: 39 Spec No

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endotoxins; Hydroxyurea; Hypothermia; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Mice; Naphthaleneacetic Acids; Quinolines; Shock, Septic; Tromethamine; Tumor Necrosis Factor-alpha

1993
Irreversible inactivation of 5-lipoxygenase by leukotriene A4. Characterization of product inactivation with purified enzyme and intact leukocytes.
    The Journal of biological chemistry, 1994, Jan-28, Volume: 269, Issue:4

    Topics: Arachidonate 5-Lipoxygenase; Cell Differentiation; Cell Line; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Kinetics; Leukemia, Promyelocytic, Acute; Leukocytes; Leukotriene A4; Lipoxygenase Inhibitors; Neutrophils; Tumor Cells, Cultured

1994
Leukotrienes mediate antigen-induced airway hyper-reactivity in guinea pigs.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:1

    Topics: Acetophenones; Animals; Antigens; Bronchoconstriction; Eosinophilia; Guinea Pigs; Hydroxyurea; Indoles; Leukotriene D4; Leukotrienes; Lipoxygenase Inhibitors; Male; Naphthaleneacetic Acids; Quinolines; Tetrazoles

1994
LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists.
    Journal of pharmacological and toxicological methods, 1993, Volume: 30, Issue:3

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dexamethasone; Hydroxyurea; Indomethacin; Leukocyte Count; Leukotriene B4; Male; Models, Biological; Naproxen; Neutropenia; Neutrophils; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene B4

1993
WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity.
    European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2

    Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Female; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Naphthaleneacetic Acids; Prostaglandin-Endoperoxide Synthases; Quinolines; Rabbits; Rats; Rats, Wistar

1993
Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat.
    Life sciences, 1993, Volume: 53, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Disease Models, Animal; Drug Evaluation, Preclinical; Eicosanoids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley

1993
Oxidative modification of low-density lipoproteins by mesangial cells.
    Journal of the American Society of Nephrology : JASN, 1993, Volume: 4, Issue:2

    Topics: Antioxidants; Arachidonic Acid; Butylated Hydroxytoluene; Catalase; Cell Division; Cells, Cultured; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Deferoxamine; DNA Replication; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Humans; Hydroxyurea; Indomethacin; Ketoconazole; Lipoproteins, LDL; Lipoxygenase Inhibitors; Masoprocol; Oxidation-Reduction; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

1993
Criteria for the identification of non-redox inhibitors of 5-lipoxygenase.
    Biochemical pharmacology, 1993, Feb-24, Volume: 45, Issue:4

    Topics: Arachidonate 5-Lipoxygenase; Benzeneacetamides; Benzofurans; Enzyme Inhibitors; Humans; Hydroxamic Acids; Hydroxyurea; Indoles; Leukotrienes; Lipid Peroxides; Lipoxygenase Inhibitors; Naphthalenes; Oxidation-Reduction; Thiazoles

1993
Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.
    European journal of pharmacology, 1993, Apr-06, Volume: 234, Issue:2-3

    Topics: Acetophenones; Animals; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Naphthaleneacetic Acids; Quinolines; SRS-A; Tetrazoles; Trachea

1993
Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3

    Topics: Animals; Antigens; Blood Vessels; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Guinea Pigs; Humans; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Rats; Skin

1995
CGS 26529: the biological profile of a novel, orally active 5-lipoxygenase inhibitor with an extended duration of action.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2

    Topics: Animals; Dogs; Female; Guinea Pigs; Humans; Hydroxyurea; In Vitro Techniques; Injections, Intravenous; Isoquinolines; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred AKR; Pleurisy; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines

1995
Pulmonary pharmacology of WAY-126299A: a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2

    Topics: Acetamides; Anesthesia; Animals; Benzothiazoles; Bronchoconstriction; Guinea Pigs; Humans; Hydroxyurea; In Vitro Techniques; Leukotriene D4; Lipoxygenase Inhibitors; Lung; Naphthaleneacetic Acids; Quinolines; Respiration, Artificial; Thiazoles

1995
Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.
    European journal of immunology, 1996, Volume: 26, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Base Sequence; Binding, Competitive; Cell Movement; E-Selectin; Hydroxyurea; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Naproxen; Neutrophils; Pyrazoles; Skin; Tumor Necrosis Factor-alpha

1996
Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5-lipoxygenase.
    Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Bronchoconstriction; Guinea Pigs; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Molecular Structure; Monocytes; Oxazoles; Rats; Structure-Activity Relationship; Thiazoles

1996
Lipid mediators in the rat retina: light exposure and trauma elicit leukotriene B4 release in vitro.
    Current eye research, 1995, Volume: 14, Issue:11

    Topics: Animals; Arachidonate 5-Lipoxygenase; Eicosanoids; Enzyme Activation; Hydroxyurea; Leukotriene B4; Light; Lipid Metabolism; Lipoxygenase Inhibitors; Male; Radiation Injuries, Experimental; Radioimmunoassay; Rats; Retina; Rhodopsin

1995
The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation.
    Arthritis and rheumatism, 1996, Volume: 39, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disease; Disease Models, Animal; Drug Combinations; Exudates and Transudates; Female; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Naproxen; Prostaglandin-Endoperoxide Synthases; Quinolines; Time Factors; Zymosan

1996
Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity.
    Toxicology letters, 1996, Volume: 84, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Azepines; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Liver; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

1996
Determination of a new 5-lipoxygenase inhibitor, zileuton, and its inactive N-dehydroxylated metabolite in plasma by high performance liquid chromatography.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Haplorhini; Humans; Hydroxylation; Hydroxyurea; Lipoxygenase Inhibitors; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism; Urea

1995
In vitro plasma protein binding of zileuton and its N-dehydroxylated metabolite.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Adult; Anti-Allergic Agents; Anti-Inflammatory Agents; Anticoagulants; Blood Proteins; Chromatography, High Pressure Liquid; Drug Interactions; Female; Hematocrit; Humans; Hydroxylation; Hydroxyurea; Ibuprofen; In Vitro Techniques; Isotope Labeling; Lipoxygenase Inhibitors; Male; Naproxen; Prednisolone; Protein Binding; Salicylates; Stereoisomerism; Terfenadine; Theophylline; Warfarin

1995
The effect of mild or moderate hepatic impairment (cirrhosis) on the pharmacokinetics of zileuton.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Administration, Oral; Adult; Aging; Blood Proteins; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucuronates; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Liver Cirrhosis; Male; Middle Aged; Protein Binding

1995
Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:10

    Topics: Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Hydroxyurea; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Microsomes, Liver; Propranolol; Theophylline; Urea

1995
Hepatic peroxisomal and drug metabolizing activity in CD-1 mice after oral treatment with a novel 5-lipoxygenase inhibitor.
    Toxicology and applied pharmacology, 1996, Volume: 137, Issue:2

    Topics: Administration, Oral; Animals; Body Weight; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; Hepatomegaly; Hydroxyurea; Isoenzymes; Lipoxygenase Inhibitors; Liver; Male; Mice; Mice, Inbred Strains; Microbodies; Microsomes, Liver; Organ Size

1996
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:1

    Topics: Animals; Benzofurans; Enzyme-Linked Immunosorbent Assay; Hip Joint; Humans; Hydroxyurea; Indoles; Interleukin-1; Knee Joint; Lipoxygenase Inhibitors; Naphthalenes; Organ Culture Techniques; Oxindoles; Pyrazoles; Quinolines; Structure-Activity Relationship; Swine; Synovial Membrane; Tarsus, Animal; Thiazoles; Thiophenes

1996
Determination of 1-benzo[b]thien-2-ylethanone and related impurities by high performance liquid chromatography.
    Journal of pharmaceutical and biomedical analysis, 1996, Volume: 14, Issue:4

    Topics: Chromatography, High Pressure Liquid; Hydroxyurea; Lipoxygenase Inhibitors

1996
Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase.
    Journal of medicinal chemistry, 1996, Aug-02, Volume: 39, Issue:16

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Blood Platelets; Cells, Cultured; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Methacrylates; Molecular Structure; Neutrophils; Pyridines; Rats; Structure-Activity Relationship; Thromboxane B2; Thromboxane-A Synthase

1996
Inhibition of tumour growth by lipoxygenase inhibitors.
    British journal of cancer, 1996, Volume: 74, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Analysis of Variance; Animals; Benzeneacetamides; Cell Division; Colonic Neoplasms; Hydroxamic Acids; Hydroxyurea; Lipoxygenase Inhibitors; Male; Mice; Neoplasm Transplantation; Treatment Outcome; Tumor Cells, Cultured

1996
The effect of a selective 5-lipoxygenase inhibitor, zileuton, on tissue damage in acute colonic inflammation in rats.
    Inflammation, 1996, Volume: 20, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Hydroxyurea; Intestinal Mucosa; Leukocyte Count; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mitomycin; Neutrophils; Peroxidase; Rats; Rats, Sprague-Dawley

1996
The effect of 5-lipoxygenase inhibition on Ascaris antigen (Ag)-induced responses in atopic monkeys.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Helminth; Ascaris suum; Bronchoalveolar Lavage Fluid; Hydroxyurea; Inflammation; Leukocyte Count; Lipoxygenase Inhibitors; Macaca fascicularis; Male; Neutrophils; Pyrans; Quinolones

1996
Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls.
    Environmental health perspectives, 1996, Volume: 104, Issue:1

    Topics: Animals; Arachidonic Acid; Aroclors; Aspirin; Cyclooxygenase Inhibitors; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phospholipases A; Phospholipases A2; Polychlorinated Biphenyls; Quinacrine; Rats; Superoxides; Terpenes; Tetradecanoylphorbol Acetate

1996
Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats.
    European journal of pharmacology, 1996, Nov-07, Volume: 315, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Calcimycin; Dextrans; Eosinophils; Hydroxyurea; Ionophores; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pulmonary Eosinophilia; Rats; Theophylline

1996
Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis.
    Gut, 1996, Volume: 38, Issue:6

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Colon; Eicosanoids; Female; Hydroxyurea; Lipoxygenase Inhibitors; Mesalamine; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid

1996
Depletion of human monocyte 85-kDa phospholipase A2 does not alter leukotriene formation.
    The Journal of biological chemistry, 1997, Jan-10, Volume: 272, Issue:2

    Topics: Arachidonic Acids; Binding Sites; Calcimycin; Enzyme Inhibitors; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Molecular Weight; Monocytes; Oligonucleotides, Antisense; Phagocytosis; Phospholipases A; Phospholipases A2; Sulfonamides; Zymosan

1997
Zileuton for asthma.
    The Medical letter on drugs and therapeutics, 1997, Feb-28, Volume: 39, Issue:995

    Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Intestinal Absorption; Leukotrienes; Lipoxygenase Inhibitors; Propranolol; Theophylline; Warfarin

1997
Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism.
    American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:4

    Topics: Animals; Cell Movement; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene B4; Leukotriene D4; Lipoxygenase Inhibitors; Male; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Phenylcarbamates; Receptors, Leukotriene; Receptors, Leukotriene B4; Sulfonamides; Tosyl Compounds; Trachea

1997
Effects of the 5-lipoxygenase inhibitor A-64077 on intestinal hypothermic organ preservation injury.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:2

    Topics: Animals; Cryopreservation; Dinoprostone; Dogs; Hydroxyurea; Ileum; Leukotriene B4; Lipoxygenase Inhibitors; Organ Preservation; Peroxidase

1997
Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration.
    Toxicology, 1997, Sep-05, Volume: 121, Issue:3

    Topics: Administration, Oral; Alanine Transaminase; Animals; Azepines; Blood Platelets; Chemical and Drug Induced Liver Injury; Female; Fibrinogen; Hydroxyurea; Injections, Intraperitoneal; Injections, Intravenous; Leukotrienes; Lipopolysaccharides; Lipoxygenase Inhibitors; Liver; Liver Diseases; Necrosis; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombocytopenia; Triazoles

1997
Inherent tone of human bronchus: role of eicosanoids and the epithelium.
    British journal of pharmacology, 1997, Volume: 121, Issue:6

    Topics: Adult; Aged; Bronchi; Carbachol; Cyclooxygenase Inhibitors; Eicosanoids; Epithelium; Female; Humans; Hydroxyurea; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Middle Aged; Muscle Tonus

1997
Improving the in vivo duration of 5-lipoxygenase inhibitors: application of an in vitro glucuronosyltransferase assay.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:9

    Topics: Animals; Glucuronosyltransferase; Half-Life; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Macaca fascicularis; Metabolic Clearance Rate; Microsomes, Liver; Structure-Activity Relationship

1997
Effect of mast cell deficiency and leukotriene inhibition on the influx of eosinophils induced by eotaxin.
    Journal of leukocyte biology, 1997, Volume: 62, Issue:5

    Topics: Animals; Chemokine CCL11; Chemokines, CC; Cytokines; Eosinophils; Hydroxyurea; Injections, Intraperitoneal; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Mast Cells; Mice; Mice, Inbred BALB C; Peritoneal Cavity

1997
Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages.
    The Biochemical journal, 1998, Feb-01, Volume: 329 ( Pt 3)

    Topics: Animals; Arachidonate 5-Lipoxygenase; Biological Transport; Calcimycin; Cell Membrane; Enzyme Activation; Female; Hydroxyurea; Interphase; Leukemia, Basophilic, Acute; Leukotrienes; Lipoxygenase Inhibitors; Macrophages, Alveolar; Mast Cells; Rats; Rats, Wistar; Tumor Cells, Cultured

1998
The relevance of resting tension to responsiveness and inherent tone of human bronchial smooth muscle.
    British journal of pharmacology, 1998, Volume: 123, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Bronchi; Bronchodilator Agents; Carbachol; Electric Stimulation; Humans; Hydroxyurea; In Vitro Techniques; Isoproterenol; Lipoxygenase Inhibitors; Middle Aged; Muscle Tonus; Muscle, Smooth

1998
Aqueous stability of SB 210661: kinetics and primary degradation mechanisms of an N-hydroxyurea-containing 5-lipoxygenase inhibitor.
    The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:2

    Topics: Benzofurans; Drug Stability; Hydrogen-Ion Concentration; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Urea; Water

1998
Formulation development of sustained-release hydrophilic matrix tablets of zileuton.
    Pharmaceutical development and technology, 1997, Volume: 2, Issue:3

    Topics: Biological Availability; Chemistry, Pharmaceutical; Compressive Strength; Delayed-Action Preparations; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Osmolar Concentration; Polymers; Rotation; Solubility; Surface-Active Agents; Tablets; Viscosity; Water

1997
Antileukotrienes in chronic urticaria.
    The Journal of allergy and clinical immunology, 1998, Volume: 101, Issue:4 Pt 1

    Topics: Adult; Chronic Disease; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Male; Phenylcarbamates; Sulfonamides; Tosyl Compounds; Urticaria

1998
The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis.
    Biochimica et biophysica acta, 1998, May-20, Volume: 1392, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Granuloma; Hydroxyurea; Inflammation Mediators; Leukotrienes; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Phenanthridines; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Sulfonamides; Triazines

1998
Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells.
    The American journal of physiology, 1998, Volume: 274, Issue:6

    Topics: Bronchi; Cell Line; Cell Line, Transformed; Epithelial Cells; Histamine; Humans; Hydroxyurea; Indoles; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; NF-kappa B; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Quinolines; RNA, Messenger; Transfection

1998
Allergen-stimulated leukotriene B4 and interleukin-8 levels in patients with asthma and allergic rhinitis-modulation by a lipid pathway inhibitor.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 81, Issue:4

    Topics: Adult; Aged; Allergens; Asthma; Female; Humans; Hydroxyurea; Interleukin-8; Leukocytes, Mononuclear; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal

1998
Successful treatment of chronic urticaria with leukotriene antagonists.
    The Journal of allergy and clinical immunology, 1998, Volume: 102, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Controlled Clinical Trials as Topic; Double-Blind Method; Humans; Hydroxyurea; Leukotriene Antagonists; Male; Urticaria

1998
Mechanism of pyocyanin- and 1-hydroxyphenazine-induced lung neutrophilia in sheep airways.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Female; Hydroxyurea; In Vitro Techniques; Interleukin-8; Leukotriene B4; Lung; Macrophages, Alveolar; Neutrophils; Phenazines; Pseudomonas aeruginosa; Pyocyanine; Sheep

1998
In vivo correlation of neutrophil receptor expression, ischemia-reperfusion injury, and selective 5-lipoxygenase inhibition in guinea pigs.
    Archives of otolaryngology--head & neck surgery, 1998, Volume: 124, Issue:12

    Topics: Animals; CD18 Antigens; Female; Guinea Pigs; Hydroxyurea; Lipoxygenase Inhibitors; Neutrophil Activation; Neutrophils; Receptors, Cell Surface; Reperfusion Injury; Skin; Wound Healing

1998
Drugs for asthma.
    The Medical letter on drugs and therapeutics, 1999, Jan-15, Volume: 41, Issue:1044

    Topics: Acetates; Administration, Inhalation; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bone Density; Bronchial Spasm; Bronchodilator Agents; Child; Child, Preschool; Choice Behavior; Cromolyn Sodium; Cyclopropanes; Exercise; Female; Growth; Humans; Hydroxyurea; Indoles; Infant, Newborn; Ipratropium; Lactation; Leukotriene Antagonists; Phenylcarbamates; Pregnancy; Pregnancy Complications; Quinolines; Salmeterol Xinafoate; Sulfides; Sulfonamides; Tachycardia; Theophylline; Tosyl Compounds

1999
The effects of multiple dosing with zileuton on antigen-induced responses in sheep.
    Pulmonary pharmacology & therapeutics, 1998, Volume: 11, Issue:4

    Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxyurea; Leukotriene Antagonists; Random Allocation; Sheep

1998
WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 60, Issue:1

    Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Eicosanoids; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Naphthaleneacetic Acids; Neutrophils; Quinolines; Rats; Serum Albumin

1999
Selective effects of antileukotrienes on leukotriene and histamine release in human dispersed lung cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 1

    Topics: Histamine H1 Antagonists; Histamine Release; Humans; Hydroxyurea; Indazoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Lung; Lung Neoplasms; Pyrilamine; Quinolines

1999
Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells.
    Biology of reproduction, 1999, Volume: 61, Issue:1

    Topics: 11-beta-Hydroxysteroid Dehydrogenases; Choriocarcinoma; Dinoprost; Dinoprostone; Enzyme Inhibitors; Humans; Hydroxysteroid Dehydrogenases; Hydroxyurea; Indomethacin; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Masoprocol; Placenta; Prostaglandins; Tumor Cells, Cultured

1999
Leukotriene modifiers--a new treatment option for asthma.
    Medicine and health, Rhode Island, 1999, Volume: 82, Issue:7

    Topics: Acetates; Anti-Asthmatic Agents; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome

1999
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
    British journal of pharmacology, 2000, Volume: 129, Issue:2

    Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone

2000
Drugs for asthma.
    The Medical letter on drugs and therapeutics, 2000, Mar-06, Volume: 42, Issue:1073

    Topics: Acetates; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Spasm; Child; Cromolyn Sodium; Cyclopropanes; Exercise; Female; Growth Disorders; Humans; Hydroxyurea; Indoles; Ipratropium; Lactation; Leukotriene Antagonists; Nebulizers and Vaporizers; Nedocromil; Phenylcarbamates; Pregnancy; Pregnancy Complications; Quinolines; Salmeterol Xinafoate; Sulfides; Sulfonamides; Theophylline; Tosyl Compounds

2000
5-Lipoxygenase inhibition: a new treatment strategy for Sjögren-Larsson syndrome.
    Neuropediatrics, 2000, Volume: 31, Issue:1

    Topics: Aldehyde Oxidoreductases; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Sjogren-Larsson Syndrome

2000
The use of newer asthma and allergy medications during pregnancy. The American College of Obstetricians and Gynecologists (ACOG) and The American College of Allergy, Asthma and Immunology (ACAAI).
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 84, Issue:5

    Topics: Abnormalities, Drug-Induced; Acetates; Administration, Inhalation; Administration, Intranasal; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Budesonide; Chlorpheniramine; Cyclopropanes; Ephedrine; Female; Histamine H1 Antagonists; Humans; Hydroxyurea; Hypersensitivity; Indoles; Ipratropium; Leukotriene Antagonists; Metaproterenol; Nasal Decongestants; Nebulizers and Vaporizers; Nedocromil; Phenylcarbamates; Pregnancy; Pregnancy Complications; Quinolines; Salmeterol Xinafoate; Sulfides; Sulfonamides; Terbutaline; Tosyl Compounds; Tripelennamine

2000
Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents.
    Mayo Clinic proceedings, 2000, Volume: 75, Issue:6

    Topics: Acetates; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cyclopropanes; Diagnosis, Differential; Erythema Induratum; Humans; Hydroxyurea; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Middle Aged; Panniculitis, Nodular Nonsuppurative; Quinolines; Sulfides

2000
Antileukotriene agents and aspirin-sensitive asthma: are we removing the second bassoonist or skating to where the puck is gonna be?
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 85, Issue:1

    Topics: Aspirin; Asthma; Bronchial Spasm; Humans; Hydroxyurea; Leukotriene Antagonists; Therapeutic Equivalency

2000
Lack of effect of the 5-lipoxygenase inhibitor zileuton in blocking oral aspirin challenges in aspirin-sensitive asthmatics.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 85, Issue:1

    Topics: Administration, Oral; Aspirin; Asthma; Desensitization, Immunologic; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors

2000
Nasal secretion in ragweed-sensitized dogs: effect of leukotriene synthesis inhibition.
    Acta oto-laryngologica, 2000, Volume: 120, Issue:6

    Topics: Animals; Dogs; Hydroxyurea; Hypersensitivity; Leukotriene Antagonists; Leukotriene B4; Nasal Mucosa; Nasal Obstruction; Nasal Provocation Tests; Neutrophils; Plants; Pollen; Rhinitis, Allergic, Seasonal; Time Factors

2000
Modulation of alveolar macrophage phagocytosis by leukotrienes is Fc receptor-mediated and protein kinase C-dependent.
    American journal of respiratory cell and molecular biology, 2000, Volume: 23, Issue:6

    Topics: Acetophenones; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Female; Hydroxyurea; Immune Sera; Immunoglobulin G; Klebsiella pneumoniae; Leukotriene Antagonists; Leukotrienes; Macrophages, Alveolar; Microspheres; Naphthalenes; Phagocytosis; Protein Kinase C; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Fc; Receptors, Leukotriene B4; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Tetrazoles

2000
N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.
    Bioorganic & medicinal chemistry letters, 2001, Mar-26, Volume: 11, Issue:6

    Topics: Antioxidants; Arachidonate 5-Lipoxygenase; Hydroxyurea; Indoles; Lipoxygenase Inhibitors; Pyrazoles

2001
Clinical predictors of health-related quality of life depend on asthma severity.
    American journal of respiratory and critical care medicine, 2001, Volume: 163, Issue:4

    Topics: Adult; Albuterol; Analysis of Variance; Asthma; Female; Follow-Up Studies; Humans; Hydroxyurea; Male; Predictive Value of Tests; Probability; Quality of Life; Respiratory Function Tests; Retrospective Studies; Severity of Illness Index; Sickness Impact Profile; Treatment Outcome

2001
Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus.
    Biochemical pharmacology, 2001, Apr-15, Volume: 61, Issue:8

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Calcium; Complement C5a; Cysteine; Eosinophils; Humans; Hydroxyurea; In Vitro Techniques; Leukotriene B4; Leukotrienes; Macrophages; Neutrophils; Plant Extracts; Platelet Activating Factor; Sesquiterpenes; Signal Transduction

2001
Safety of antileukotriene agents in asthma management.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 86, Issue:6 Suppl 1

    Topics: Acetates; Asthma; Churg-Strauss Syndrome; Clinical Trials as Topic; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds

2001
In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production.
    European journal of pharmacology, 2001, Jun-22, Volume: 422, Issue:1-3

    Topics: Animals; Arachidonate 5-Lipoxygenase; Benzothiazoles; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Humans; Hydroxyurea; Indomethacin; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mesalamine; Methacrylates; Neutrophils; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred F344; Sheep; Sulfasalazine; Thiazoles; Thromboxane B2; Thromboxane-A Synthase

2001
Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages.
    British journal of pharmacology, 2001, Volume: 133, Issue:6

    Topics: Amidines; Animals; Benzylamines; Cell Line; Chick Embryo; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxyurea; Indomethacin; Isoenzymes; Leukotriene B4; Leukotriene C4; Leukotrienes; Macrophage Activation; Macrophages; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrans; Quinolones; Sulfonamides; Time Factors; Transcription Factor AP-1; Zymosan

2001
Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 63, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hydroxyurea; Lipoxygenase Inhibitors; Liver; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Microsomes, Liver; NADH Dehydrogenase; Organ Size; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley

2001
Zileuton and atopic dermatitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 87, Issue:2

    Topics: Dermatitis, Atopic; Humans; Hydroxyurea; Immunoglobulin E; T-Lymphocytes; Treatment Outcome

2001
Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1

    Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Nitrates; omega-N-Methylarginine; Precipitin Tests; Proteins; Rats; Rats, Wistar; Tyrosine

2001
Leukotrienes play protective roles early during experimental VSV encephalitis.
    Journal of neuroimmunology, 2001, Nov-01, Volume: 120, Issue:1-2

    Topics: Animals; Arachidonate 5-Lipoxygenase; Blood-Brain Barrier; Brain; CD4-Positive T-Lymphocytes; CHO Cells; Cricetinae; Encephalitis, Viral; Hydroxyurea; Immunohistochemistry; Interferon-gamma; Interleukin-12; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophil Activation; Nitric Oxide; Nitric Oxide Synthase; Vesicular stomatitis Indiana virus; Viral Load

2001
Clinical and biochemical effects of zileuton in patients with the Sjögren-Larsson syndrome.
    European journal of pediatrics, 2001, Volume: 160, Issue:12

    Topics: Adolescent; Adult; Brain; Electroencephalography; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Sjogren-Larsson Syndrome

2001
Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:2

    Topics: Administration, Oral; Administration, Topical; Animals; Arthus Reaction; beta-Alanine; Dermatitis; Edema; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Hydroxyurea; In Vitro Techniques; Leukotriene A4; Leukotriene Antagonists; Lipoxygenase Inhibitors; Mice; Peritoneum; Rats; Skin

2002
Treatment of disseminated granuloma annulare with a 5-lipoxygenase inhibitor and vitamin E.
    The British journal of dermatology, 2002, Volume: 146, Issue:4

    Topics: Drug Therapy, Combination; Female; Follow-Up Studies; Granuloma Annulare; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Middle Aged; Vitamin E

2002
Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:1

    Topics: Adult; Cell Count; Exercise; Female; Histamine H1 Antagonists; Humans; Hydroxyurea; Hypoxia; Inflammation Mediators; Leukotriene Antagonists; Leukotriene E4; Lung; Male; Oxygen Consumption; Pulmonary Gas Exchange; Respiratory Function Tests; Sports; Sputum; Terfenadine

2002
Effects of Celebrex and Zyflo on BOP-induced pancreatic cancer in Syrian hamsters.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2002, Volume: 2, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Celecoxib; Cricetinae; Glutathione; Hydroxyurea; Incidence; Lipoxygenase Inhibitors; Male; Mesocricetus; Pancreas; Pancreatic Neoplasms; Pyrazoles; Sulfonamides; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2002
Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice.
    Cancer research, 2002, Aug-01, Volume: 62, Issue:15

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Dose-Response Relationship, Drug; Female; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred A; Phenylcarbamates; Sulfonamides; Tosyl Compounds; Urethane

2002
Interaction between nitric oxide, reactive oxygen intermediates, and peroxynitrite in the regulation of 5-lipoxygenase metabolism.
    Biochimica et biophysica acta, 2002, Oct-10, Volume: 1584, Issue:2-3

    Topics: Animals; Arachidonate 5-Lipoxygenase; Down-Regulation; Female; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyurea; Leukotrienes; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages, Alveolar; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Xanthine Oxidase

2002
Effects of Celebrex and Zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in Syrian hamsters.
    Clinical & experimental metastasis, 2002, Volume: 19, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cricetinae; Hydroxyurea; Lipid Peroxidation; Lipoxygenase Inhibitors; Liver Neoplasms; Male; Mesocricetus; Neoplasm Metastasis; Pancreatic Neoplasms; Pyrazoles; Sulfonamides; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2002
Anti-leukotriene drugs in the prevention and treatment of hepatorenal syndrome.
    Prostaglandins, leukotrienes, and essential fatty acids, 2003, Volume: 68, Issue:4

    Topics: Acetates; Arachidonic Acid; Cyclopropanes; Hepatorenal Syndrome; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Liver; Phenylcarbamates; Protein Structure, Tertiary; Quinolines; Sulfides; Sulfonamides; Thromboxanes; Tosyl Compounds

2003
Inhibition of 5-LO activating protein (FLAP) activity decreases proteinuria in streptozotocin (STZ)-induced diabetic rats.
    Advances in experimental medicine and biology, 2002, Volume: 507

    Topics: 5-Lipoxygenase-Activating Proteins; Animals; Blood Glucose; Blood Urea Nitrogen; Carrier Proteins; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diuresis; Hydroxyurea; Lipoxygenase Inhibitors; Male; Membrane Proteins; Proteinuria; Quinolines; Rats; Rats, Sprague-Dawley

2002
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.
    Toxicon : official journal of the International Society on Toxinology, 2003, Volume: 41, Issue:6

    Topics: Animals; Bothrops; Bradykinin; Carrageenan; Celecoxib; Crotalid Venoms; Heparin; Hindlimb; Histamine Antagonists; Hydroxyurea; Hyperalgesia; Male; omega-N-Methylarginine; Peptides; Phospholipases A; Pyrazoles; Rats; Rats, Wistar; Serotonin Antagonists; Sulfonamides; Time Factors

2003
Zileuton reduces respiratory illness and lung inflammation, during respiratory syncytial virus infection, in mice.
    The Journal of infectious diseases, 2003, Jun-01, Volume: 187, Issue:11

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Hydroxyurea; Inflammation; Leukotriene Antagonists; Leukotrienes; Lung; Mice; Mice, Inbred BALB C; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Time Factors; Virus Replication; Weight Loss

2003
A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor.
    Archives of dermatology, 2003, Volume: 139, Issue:5

    Topics: Acne Vulgaris; Administration, Oral; Adolescent; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Pilot Projects

2003
Tenofovir, COX inhibitors and zileuton during cancer immunotherapies: up-regulated TNF-alpha increases antigen driven lymphocyte proliferation.
    Molecular immunology, 2003, Volume: 40, Issue:5

    Topics: Adenine; Adenylyl Cyclases; Anti-HIV Agents; Cell Division; Cyclooxygenase Inhibitors; Humans; Hydroxyurea; Immunotherapy; Lipoxygenase Inhibitors; Lymphocytes; Neoplasms; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Necrosis Factor-alpha; Up-Regulation

2003
Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma.
    American journal of hematology, 2003, Volume: 74, Issue:1

    Topics: Adult; Aged; Asthma; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2

2003
Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:11

    Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Microsomes, Liver

2003
Generalized granuloma annulare in a patient with adult onset diabetes mellitus.
    Journal of drugs in dermatology : JDD, 2003, Volume: 2, Issue:6

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arm; Diabetes Mellitus, Type 2; Diagnosis, Differential; Granuloma Annulare; Hand; Humans; Hydroxyurea; Male; Vitamin E

2003
Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway.
    Blood, 2004, May-15, Volume: 103, Issue:10

    Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Fetal Hemoglobin; Gene Expression Regulation; Humans; Hydroxyurea; K562 Cells; Nitric Oxide; Nitric Oxide Synthase; Signal Transduction

2004
In vitro metabolism of 2-acetylbenzothiophene: relevance to zileuton hepatotoxicity.
    Chemical research in toxicology, 2004, Volume: 17, Issue:2

    Topics: Animals; Cell Line; Glutathione; Half-Life; Humans; Hydroxyurea; Liver; Magnetic Resonance Spectroscopy; Rats; Spectrometry, Mass, Electrospray Ionization; Thiophenes

2004
Leukotriene modifier use and asthma severity: how is a new medication being used by adults with asthma?
    Archives of internal medicine, 2004, Mar-22, Volume: 164, Issue:6

    Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Cyclopropanes; Female; Health Status Indicators; Hospitalization; Humans; Hydroxyurea; Leukotriene Antagonists; Logistic Models; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Quinolines; Sulfides

2004
Effect of zileuton in radicular pain induced by herniated nucleus pulposus in rats.
    Inflammopharmacology, 2004, Volume: 12, Issue:2

    Topics: Animals; Female; Hydroxyurea; Intervertebral Disc Displacement; Pain; Pain Measurement; Rats; Rats, Wistar

2004
Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
    Molecular pharmacology, 2004, Volume: 66, Issue:2

    Topics: Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Ischemia; Kidney Diseases; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Mice, Knockout; Neutrophils; Peroxidase; Reperfusion Injury

2004
Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone.
    Circulation, 2004, Sep-07, Volume: 110, Issue:10

    Topics: Acetylcholine; Animals; Aorta; Aspirin; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Endothelium, Vascular; Hydroxyurea; Lipoxins; Lipoxygenase Inhibitors; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Oligopeptides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Lipoxin; Sulfonamides; Vascular Resistance; Vasodilation; Vasodilator Agents

2004
Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
    Journal of leukocyte biology, 2004, Volume: 76, Issue:5

    Topics: Animals; Arachidonate 5-Lipoxygenase; CD11 Antigens; CD18 Antigens; Chemotaxis, Leukocyte; Disease Models, Animal; Endotoxemia; Enzymes; Gene Targeting; Hydroxyurea; Leukocytes; Lipopolysaccharides; Lipoxygenase Inhibitors; Liver; Lung; Male; Mice; Mice, Knockout; Multiple Organ Failure; Pancreas; Rats; Rats, Wistar; Viscera

2004
The improved survival of experimental animals fed with fish oil is suppressed by a leukotriene inhibitor.
    Scandinavian journal of immunology, 2004, Volume: 60, Issue:4

    Topics: Animals; Dietary Fats, Unsaturated; Female; Fish Oils; Hydroxyurea; Klebsiella Infections; Klebsiella pneumoniae; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Mice

2004
Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Oct-01, Volume: 10, Issue:19

    Topics: Adenocarcinoma; Anastomosis, Surgical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Body Weight; Celecoxib; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Esophageal Neoplasms; Humans; Hydroxyurea; Immunohistochemistry; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors

2004
Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production.
    Dermatology (Basel, Switzerland), 2005, Volume: 210, Issue:1

    Topics: Administration, Oral; Adult; Dermatitis, Seborrheic; Drug Administration Schedule; Face; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Neck; Scalp; Sebaceous Gland Diseases; Sebum

2005
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Mar-01, Volume: 11, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogens; Carcinoma, Squamous Cell; Celecoxib; Cell Transformation, Neoplastic; Chemoprevention; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Hydroxyurea; Immunohistochemistry; In Situ Hybridization; Lipoxygenase Inhibitors; Male; Membrane Proteins; Mesocricetus; Mouth Neoplasms; Neoplasms, Experimental; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Up-Regulation

2005
Differential effects of hydroxyurea and zileuton on interleukin-13 secretion by activated murine spleen cells: implication on the expression of vascular cell adhesion molecule-1 and vasoocclusion in sickle cell anemia.
    Cytokine, 2005, Jun-07, Volume: 30, Issue:5

    Topics: Anemia, Sickle Cell; Animals; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Female; Hydroxyurea; Interleukin-13; Lymphocytes; Mice; Mice, Inbred C57BL; Spleen; Vascular Cell Adhesion Molecule-1; Vasoconstriction

2005
Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3

    Topics: Acetates; Acetic Acid; Analgesics; Animals; Capillary Permeability; Carrageenan; Cyclopropanes; Dose-Response Relationship, Drug; Female; Hindlimb; Hydroxyurea; Hyperalgesia; Indoles; Inflammation; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Mice; Pain; Pain Measurement; Phenylcarbamates; Quinolines; Rats; Rats, Wistar; Receptors, Leukotriene B4; Sulfides; Sulfonamides; Tosyl Compounds

2005
Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster.
    Prostaglandins, leukotrienes, and essential fatty acids, 2005, Volume: 73, Issue:2

    Topics: Animals; Carcinoma, Pancreatic Ductal; Celecoxib; Cricetinae; Cyclooxygenase Inhibitors; Dinoprostone; Drug Therapy, Combination; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Liver; Liver Neoplasms; Pancreas; Pancreatic Neoplasms; Prostaglandins; Prostaglandins F; Pyrazoles; Sulfonamides

2005
Modification of eicosanoid profile in human blood treated by dual COX/LOX inhibitors.
    Prostaglandins, leukotrienes, and essential fatty acids, 2005, Volume: 73, Issue:6

    Topics: Arachidonic Acid; Calcimycin; Celecoxib; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Eicosanoids; Humans; Hydroxyurea; Indomethacin; Inhibitory Concentration 50; Lipopolysaccharides; Lipoxygenase Inhibitors; Pyrazoles; Sulfonamides

2005
Effect of 5-lipoxygenase inhibitor against lipopolysaccharide-induced hypothermia in mice.
    Indian journal of experimental biology, 2005, Volume: 43, Issue:12

    Topics: Animals; Colon; Dinoprostone; Female; Hydroxyurea; Hypothalamus; Hypothermia; Hypothermia, Induced; Indomethacin; Leukotriene B4; Leukotrienes; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Mice

2005
Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages.
    Journal of leukocyte biology, 2006, Volume: 79, Issue:6

    Topics: Animals; Antigen Presentation; Bone Marrow Cells; Calcium Signaling; Cells, Cultured; Dendritic Cells; Endocytosis; Enzyme Activation; Erythrocytes; Hydroxyurea; Immunoglobulin G; Indoles; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophages; Macrophages, Alveolar; Macrophages, Peritoneal; Mice; Mice, Inbred CBA; Mice, Knockout; Opsonin Proteins; Phagocytosis; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, IgG; Receptors, Leukotriene B4; Sheep; Syk Kinase

2006
Activated neutrophil-mediated sickle red blood cell adhesion to lung vascular endothelium: role of phosphatidylserine-exposed sickle red blood cells.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:4

    Topics: Anemia, Sickle Cell; Animals; Annexin A5; Arachidonate 5-Lipoxygenase; Cell Adhesion; Endothelium, Vascular; Enzyme Inhibitors; Erythrocytes, Abnormal; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Neutrophil Activation; Neutrophils; Phosphatidylserines; Rats; Rats, Sprague-Dawley

2006
Quantum chemical design of hydroxyurea derivatives for the treatment of sickle-cell anemia.
    The journal of physical chemistry. B, 2005, Jul-14, Volume: 109, Issue:27

    Topics: Anemia, Sickle Cell; Antisickling Agents; Free Radicals; Humans; Hydroxyurea; Nitric Oxide Donors; Quantum Theory

2005
Effects of novel 5-lipoxygenase inhibitors on the incidence of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation.
    Carcinogenesis, 2007, Volume: 28, Issue:5

    Topics: Adenoma; Administration, Inhalation; Administration, Oral; Animals; Benzo(a)pyrene; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hydroxamic Acids; Hydroxyurea; Incidence; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred Strains; Phenylurea Compounds

2007
Effects of ertiprotafib on hepatic cytochrome P450 and peroxisomal enzymes in rats and dogs, and in rat and human primary hepatocytes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:1

    Topics: Animals; Cytochrome P-450 Enzyme System; Dogs; Enzyme Induction; Female; Glucuronosyltransferase; Hepatocytes; Humans; Hydroxyurea; Hypoglycemic Agents; Liver; Male; Microsomes, Liver; Organ Size; Peroxisomes; Phenylpropionates; Rats; RNA, Messenger; Thiazolidinediones; Thiophenes; Thyroid Gland

2007
Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ascitic Fluid; Benzothiazoles; Dogs; Ear; Edema; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Female; Humans; Hydroxyurea; Inflammation; Leukotriene B4; Leukotriene C4; Lipoxins; Lipoxygenase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neutrophil Infiltration; Peritonitis; Piperidines; Recombinant Proteins

2007
Effects of leukotriene inhibition on pulmonary morphology in rat pup lungs exposed to hyperoxia.
    Comparative medicine, 2007, Volume: 57, Issue:2

    Topics: Animals; Animals, Newborn; Female; Hydroxyurea; Hyperoxia; Indoles; Leukotriene Antagonists; Lung; Lung Diseases; Male; Oxygen; Phenylcarbamates; Rats; Rats, Sprague-Dawley; Sulfonamides; Tosyl Compounds

2007
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Betamethasone Valerate; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Chromones; Cimetidine; Culicidae; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Hydroxyurea; Hypersensitivity; Indoles; Indomethacin; Ketoprofen; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Phenylpropionates; Phospholipid Ethers; Propionates; Pruritus; Quinolines; Terfenadine

2007
Irreversible alkylation of human serum albumin by zileuton metabolite 2-acetylbenzothiophene-S-oxide: a potential model for hepatotoxicity.
    Chemical research in toxicology, 2007, Volume: 20, Issue:12

    Topics: Alkylation; Anti-Asthmatic Agents; Binding, Competitive; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Half-Life; Humans; Hydroxyurea; Ibuprofen; Models, Biological; Serum Albumin; Tandem Mass Spectrometry; Thiophenes; Warfarin

2007
Effects of zileuton and montelukast in mouse experimental spinal cord injury.
    British journal of pharmacology, 2008, Volume: 153, Issue:3

    Topics: Acetates; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cyclooxygenase 2; Cyclopropanes; Cysteine; Dinoprostone; Disease Models, Animal; Gene Expression Regulation; Hydroxyurea; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Neutrophil Infiltration; Quinolines; Recovery of Function; Spinal Cord Injuries; Sulfides; Tumor Necrosis Factor-alpha

2008
Reactions of in situ generated N-Boc nitrones with aromatic and heteroaromatic grignard reagents: application to the synthesis of zileuton.
    The Journal of organic chemistry, 2008, Mar-07, Volume: 73, Issue:5

    Topics: Hydroxyurea; Indicators and Reagents; Nitrogen Oxides

2008
Novel strategies for the treatment of lung cancer: modulation of eicosanoids.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Feb-20, Volume: 26, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Eicosanoids; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Lung Neoplasms; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Up-Regulation

2008
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
    European journal of pharmacology, 2008, Apr-14, Volume: 584, Issue:1

    Topics: Air; Animals; Arachidonate 5-Lipoxygenase; Biological Assay; Calcimycin; Carrageenan; Cell Line, Tumor; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyurea; Imidazoles; Immunoglobulin E; Inflammation; Ionophores; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Oxidation-Reduction; Rats; Rats, Inbred Lew; Reproducibility of Results; Sulfides; Tandem Mass Spectrometry

2008
Pharmacological intervention to the inflammatory response from decompression sickness in rats.
    Aviation, space, and environmental medicine, 2008, Volume: 79, Issue:2

    Topics: Animals; Cyclooxygenase Inhibitors; Decompression Sickness; Hydroxyurea; Indoles; Indomethacin; Inflammation; Isoproterenol; Lipoxygenase Inhibitors; Lysine; Male; Phenylcarbamates; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Sulfonamides; Tosyl Compounds

2008
Crotoxin alters lymphocyte distribution in rats: Involvement of adhesion molecules and lipoxygenase-derived mediators.
    Toxicon : official journal of the International Society on Toxinology, 2008, Jun-15, Volume: 51, Issue:8

    Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Crotoxin; Eicosanoids; Endothelial Cells; Hydroxyurea; Lipoxygenase; Lipoxygenase Inhibitors; Lymph; Lymph Nodes; Lymphatic Vessels; Lymphocyte Count; Lymphocytes; Male; Phospholipases A2; Rats; Rats, Wistar; Spleen; Thoracic Duct

2008
Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells.
    Cancer research, 2008, Sep-15, Volume: 68, Issue:18

    Topics: Apoptosis; Cell Line, Tumor; Fibroblast Growth Factor 2; Golgi Apparatus; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Masoprocol; Multiple Myeloma; Phosphorylation; Receptor, Fibroblast Growth Factor, Type 3; Signal Transduction; Thanatophoric Dysplasia; Transfection

2008
Blockade of cytosolic phospholipase A2 alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses.
    Journal of neuroimmunology, 2008, Nov-15, Volume: 204, Issue:1-2

    Topics: Analysis of Variance; Animals; Benzoates; Cell Proliferation; Cells, Cultured; Cyclooxygenase Inhibitors; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Glycoproteins; Group IV Phospholipases A2; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Myelin-Oligodendrocyte Glycoprotein; Naproxen; Peptide Fragments; Severity of Illness Index; Seveso Accidental Release; Sulfonamides; Th1 Cells; Time Factors

2008
Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells.
    Journal of neuroscience research, 2009, Volume: 87, Issue:4

    Topics: 5-Lipoxygenase-Activating Proteins; Animals; Antioxidants; Antipyrine; Arachidonate 5-Lipoxygenase; Caffeic Acids; Carrier Proteins; Cell Hypoxia; Edaravone; Enzyme Activation; Enzyme Inhibitors; Glucose; Hydrogen Peroxide; Hydroxyurea; Imidazoles; Indoles; Leukotrienes; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Membrane Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Pyridines; Rats; Reactive Oxygen Species; Transfection

2009
Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea.
    Chest, 2009, Volume: 135, Issue:5

    Topics: Acetates; Adenoids; Apoptosis; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Cyclopropanes; Dose-Response Relationship, Drug; Humans; Hydroxyurea; Immunohistochemistry; Interleukins; Leukotriene Antagonists; Leukotriene D4; Palatine Tonsil; Polysomnography; Quinolines; Sleep Apnea, Obstructive; SRS-A; Sulfides

2009
Topical chemoprevention of skin cancer in mice, using combined inhibitors of 5-lipoxygenase and cyclo-oxygenase-2.
    The Journal of laryngology and otology, 2009, Volume: 123, Issue:8

    Topics: Administration, Topical; Analysis of Variance; Animals; Anticarcinogenic Agents; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Combinations; Head and Neck Neoplasms; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Mice, Nude; Pyrazoles; Random Allocation; Skin Neoplasms; Sulfonamides

2009
2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: implications for toxicity associated with zileuton.
    Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:3

    Topics: Chromatography, Liquid; Glutathione Transferase; Hydroxyurea; Inactivation, Metabolic; Isoenzymes; Kinetics; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Thiophenes; Toxicity Tests

2009
5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9.
    Neurological research, 2009, Volume: 31, Issue:8

    Topics: Animals; Arachidonate 5-Lipoxygenase; Body Water; Brain; Brain Edema; Brain Ischemia; Dose-Response Relationship, Drug; Down-Regulation; Hydroxyurea; Infarction, Middle Cerebral Artery; Lipoxygenase Inhibitors; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2009
Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions.
    The Journal of allergy and clinical immunology, 2009, Volume: 124, Issue:2

    Topics: Allergens; Anaphylaxis; Animals; Arachis; Cholera Toxin; Cimetidine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Female; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Hydroxyurea; Immunoglobulin E; Immunoglobulin G; Lipoxygenase Inhibitors; Mice; Mice, Inbred C57BL; Peanut Hypersensitivity; Platelet Membrane Glycoproteins; Pyrilamine; Receptors, G-Protein-Coupled; Receptors, Histamine

2009
Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor.
    Journal of cellular physiology, 2009, Volume: 221, Issue:1

    Topics: Acetates; Animals; Arachidonate 5-Lipoxygenase; Cell Proliferation; Chondrocytes; Cyclopropanes; Fracture Healing; Fractures, Bone; Gene Expression Regulation; Hydroxyurea; Hypertrophy; Leukotriene Antagonists; Leukotriene B4; Mice; Models, Biological; Osteogenesis; Quinolines; Radiography; Receptors, Leukotriene; Sulfides

2009
CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain.
    European journal of pharmacology, 2009, Sep-01, Volume: 617, Issue:1-3

    Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Blotting, Western; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Humans; Hydroxyurea; Imidazoles; Immunohistochemistry; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Male; Osteoarthritis; Pain; Rats; Rats, Sprague-Dawley; Substrate Specificity; Sulfides

2009
Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis.
    Experimental dermatology, 2010, Volume: 19, Issue:2

    Topics: Arachidonic Acid; Cell Count; Cell Line; Humans; Hydroxyurea; Interleukin-6; Interleukin-8; Leukotriene Antagonists; Leukotriene B4; Lipogenesis; Sebaceous Glands

2010
Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation.
    Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:11

    Topics: Cyclic GMP; Erythroid Cells; Fetal Hemoglobin; gamma-Globins; Humans; Hydrogen Peroxide; Hydroxyurea; K562 Cells; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Signal Transduction; Stem Cells; Transcription, Genetic; Transcriptional Activation

2009
Induction of leukotriene B(4) and prostaglandin E(2) release from keratinocytes by protease-activated receptor-2-activating peptide in ICR mice.
    International immunopharmacology, 2009, Volume: 9, Issue:11

    Topics: Animals; Cetirizine; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Hydroxyurea; Indomethacin; Injections, Intradermal; Keratinocytes; Leukotriene B4; Male; Mice; Mice, Inbred ICR; Oligopeptides; Pruritus; Skin; Tacrolimus

2009
The cardioprotective effects of zileuton, a 5-lipoxygenase inhibitor, are mediated by COX-2 via activation of PKC delta.
    Cellular signalling, 2010, Volume: 22, Issue:1

    Topics: Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Enzyme Activation; Hydrogen Peroxide; Hydroxyurea; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Myocytes, Cardiac; Protein Kinase C-delta; Rats

2010
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
    Cell cycle (Georgetown, Tex.), 2009, Nov-01, Volume: 8, Issue:21

    Topics: 5-Lipoxygenase-Activating Proteins; Animals; Benzamides; Carrier Proteins; Genes, abl; Humans; Hydroxyurea; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lipoxygenase Inhibitors; Membrane Proteins; Mice; Mice, Knockout; Myeloproliferative Disorders; Neoplastic Stem Cells; Piperazines; Protein Kinase Inhibitors; Pyrimidines

2009
Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis.
    The Journal of allergy and clinical immunology, 2009, Volume: 124, Issue:5

    Topics: Acetates; Arachidonate 5-Lipoxygenase; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cyclopropanes; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene C4; Mast Cells; Nasal Polyps; Quinolines; Receptors, Leukotriene; Sulfides; Thapsigargin

2009
Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Gene Expression; Hydroxyurea; Lipoxygenase Inhibitors; Male; Mouth Neoplasms; Naproxen; Piroxicam; Pyrazoles; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Up-Regulation

2010
Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model.
    AAPS PharmSciTech, 2010, Volume: 11, Issue:1

    Topics: Adenoma; Administration, Inhalation; Animals; Benzo(a)pyrene; Chemistry, Pharmaceutical; Dosage Forms; Ethanol; Female; Hydroxyurea; Inhalation; Lung; Lung Neoplasms; Mice; Mice, Inbred A

2010
Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats.
    Inflammation, 2010, Volume: 33, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Brain; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Hydroxyurea; Immunohistochemistry; Interleukin-1beta; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Malondialdehyde; Neuroprotective Agents; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley; Time Factors; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2010
Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.
    ChemMedChem, 2010, Sep-03, Volume: 5, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Drug Design; Edema; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Nitric Oxide; Rats; Structure-Activity Relationship

2010
The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages.
    British journal of pharmacology, 2010, Volume: 161, Issue:3

    Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carrageenan; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Humans; Hydroxyurea; Interferon-gamma; Intramolecular Oxidoreductases; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages; Mice; Mice, Inbred Strains; Pleurisy; Prostaglandin-E Synthases; Prostaglandins F; Rats; Rats, Wistar; Zymosan

2010
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase.
    The American journal of pathology, 2011, Volume: 178, Issue:4

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Female; Fibroblasts; Humans; Hydroxyurea; Immunohistochemistry; Lipoxygenase Inhibitors; Mice; Mice, Transgenic; Models, Biological; Mutation; Phenotype; Receptors, Notch

2011
[5-lipoxygenase is involved in rotenone-induced injury in PC12 cells].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2011, Volume: 40, Issue:2

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Survival; Hydroxyurea; Lipoxygenase Inhibitors; PC12 Cells; Rats; Rotenone

2011
Involvement of leukotriene B4 in itching in a mouse model of ocular allergy.
    Experimental eye research, 2012, Volume: 98

    Topics: Allergens; Ambrosia; Animals; Conjunctivitis, Allergic; Disease Models, Animal; Glucocorticoids; Histamine; Histamine H1 Antagonists, Non-Sedating; Hydroxyurea; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Injections, Intraocular; Injections, Subcutaneous; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mast Cells; Mice; Mice, Inbred ICR; Phenylpropionates; Pollen; Terfenadine

2012
Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice.
    Diabetes, 2012, Volume: 61, Issue:9

    Topics: Adipocytes; Adipose Tissue; Animals; Arachidonate 5-Lipoxygenase; Cell Line; Chemokines; Cytokines; Diet, High-Fat; Female; Humans; Hydroxyurea; Inflammation; Insulin Resistance; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Obesity; Subcutaneous Fat

2012
Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:12

    Topics: Apoptosis; Brain Ischemia; Cell Culture Techniques; Cell Hypoxia; Cell Line; Cell Membrane; Cell Nucleus; Cell Survival; Chromones; Endothelial Cells; Glucose; Humans; Hydroxyurea; Ligands; Models, Biological; Nuclear Localization Signals; Oxygen; Protein Transport; Receptors, Leukotriene

2012
Effects of montelukast and zileuton on testicular torsion/detorsion injury in rats.
    Andrologia, 2014, Volume: 46, Issue:1

    Topics: Acetates; Animals; Cyclopropanes; Hydroxyurea; Male; Malondialdehyde; Quinolines; Rats; Rats, Wistar; Spermatic Cord Torsion; Sulfides

2014
Inhibitory effect of Crotalus durissus terrificus venom on chronic edema induced by injection of bacillus Calmette-Guérin into the footpad of mice.
    Toxicon : official journal of the International Society on Toxinology, 2013, Mar-01, Volume: 63

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BCG Vaccine; Chronic Disease; Crotalid Venoms; Crotalus; Crotoxin; Dexamethasone; Edema; Foot; Hindlimb; Hydroxyurea; Inflammation; Injections, Subcutaneous; Lipoxygenase; Male; Mice; Mycobacterium bovis

2013
5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.
    Neurobiology of aging, 2013, Volume: 34, Issue:6

    Topics: Animals; Arachidonate 5-Lipoxygenase; Brain; Cyclin-Dependent Kinase 5; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Mice, Transgenic; Phosphorylation; Random Allocation; tau Proteins

2013
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.
    Molecular psychiatry, 2014, Volume: 19, Issue:4

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arachidonate 5-Lipoxygenase; Brain; Conditioning, Classical; Disease Models, Animal; Excitatory Postsynaptic Potentials; Fear; Gene Expression Regulation; Humans; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Memory Disorders; Mice; Mice, Transgenic; Mutation; Presenilin-1; Synapses; tau Proteins

2014
[Expression of 5-lipoxygenase in hippocampal CA1 neuronal damage following global cerebral ischemia in rats].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2013, Volume: 42, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Brain Ischemia; CA1 Region, Hippocampal; Disease Models, Animal; Hydroxyurea; Lipoxygenase Inhibitors; Male; Neurons; Rats; Rats, Sprague-Dawley

2013
Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Amino Acid Sequence; Animals; Arachidonate 5-Lipoxygenase; Cloning, Molecular; Cluster Analysis; Enzyme Activation; Gene Expression; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Malaria, Vivax; Mixed Function Oxygenases; Molecular Sequence Data; Phycocyanin; Plasmodium vivax; Sequence Alignment; Transcription, Genetic

2013
NMR metabolomics analysis of the effects of 5-lipoxygenase inhibitors on metabolism in glioblastomas.
    Journal of proteome research, 2013, May-03, Volume: 12, Issue:5

    Topics: Antineoplastic Agents; Arachidonate 5-Lipoxygenase; Caffeic Acids; Cell Line, Tumor; Drug Screening Assays, Antitumor; Free Radical Scavengers; Glioblastoma; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxyurea; Leukotrienes; Lipid Metabolism; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Metabolome; Metabolomics; Phenylethyl Alcohol; Principal Component Analysis

2013
5-Lipoxygenase inhibitor zileuton inhibits neuronal apoptosis following focal cerebral ischemia.
    Inflammation, 2013, Volume: 36, Issue:6

    Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain; Brain Injuries; Caspase 1; Caspase 3; Hydroxyurea; Infarction, Middle Cerebral Artery; Lipoxygenase Inhibitors; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2013
Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arachidonate 5-Lipoxygenase; Cognition; Cyclin-Dependent Kinase 5; Female; Humans; Hydroxyurea; Immunoblotting; Immunohistochemistry; Lipoxygenase Inhibitors; Male; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; Synapses; tau Proteins

2013
Airway remodeling in asthma: tumor of the airway?
    Respiration; international review of thoracic diseases, 2013, Volume: 86, Issue:5

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Hydroxyurea; Leukotriene Antagonists; Lung; Male

2013
Effects of zileuton on airway smooth muscle remodeling after repeated allergen challenge in brown Norway rats.
    Respiration; international review of thoracic diseases, 2013, Volume: 86, Issue:5

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Drug Evaluation, Preclinical; Hydroxyurea; Leukotriene Antagonists; Lung; Male; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Rats; Respiratory Function Tests; T-Lymphocytes

2013
Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Oct-15, Volume: 937

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Hydroxyurea; Linear Models; Lipoxygenase Inhibitors; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2013
Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin.
    Urology, 2013, Volume: 82, Issue:6

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cadherins; Cell Migration Assays; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Immunohistochemistry; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Paxillin; Prostatic Neoplasms; Up-Regulation

2013
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration.
    Oncogene, 2015, Mar-05, Volume: 34, Issue:10

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Line; Cell Line, Tumor; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Heparin-binding EGF-like Growth Factor; Heterografts; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukotriene B4; Macrophages; MAP Kinase Signaling System; Matrix Metalloproteinase 7; Mice; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Necrosis Factor-alpha

2015
Chronic hypoxia promotes pulmonary artery endothelial cell proliferation through H2O2-induced 5-lipoxygenase.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Arachidonate 5-Lipoxygenase; Cell Hypoxia; Cell Line; Cell Proliferation; Endothelial Cells; Humans; Hydrogen Peroxide; Hydroxyurea; Indoles; Lipoxygenase Inhibitors; Oxygen; Pulmonary Artery

2014
Involvement of leukotriene B4 in dermatophyte-related itch in mice.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Arthrodermataceae; Dermatomycoses; Hydroxyurea; Keratinocytes; Leukotriene Antagonists; Leukotriene B4; Male; Mice, Inbred Strains; Oligopeptides; Pruritus; Receptor, PAR-2

2014
Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice.
    Neurobiology of aging, 2014, Volume: 35, Issue:11

    Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Amyloidogenic Proteins; Animals; Arachidonate 5-Lipoxygenase; Cyclin-Dependent Kinase 5; Hydroxyurea; Lipoxygenase Inhibitors; Memory; Mice, Transgenic; Molecular Targeted Therapy; Phosphorylation; Protein Aggregates; Protein Aggregation, Pathological; tau Proteins; Up-Regulation

2014
[Zileuton, a 5-lipoxygenase inhibitor, attenuates mouse microglial cell-mediated rotenone toxicity in PC12 cells].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2014, Volume: 43, Issue:3

    Topics: Animals; Cell Death; Cells, Cultured; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Microglia; PC12 Cells; Rats; Rotenone

2014
Antinociceptive properties of esculetin in non-inflammatory and inflammatory models of pain in rats.
    Clinical and experimental pharmacology & physiology, 2015, Volume: 42, Issue:2

    Topics: Analgesia; Analgesics; Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Hyperalgesia; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pain; Pain Threshold; Rats; Umbelliferones

2015
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells.
    Oncology reports, 2015, Volume: 33, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Lymphatic Metastasis; Male; Middle Aged; Pancreatic Neoplasms

2015
Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Animals; Colonic Neoplasms; Disease Models, Animal; Female; Humans; Hydroxyurea; Inflammatory Bowel Diseases; Intestinal Polyposis; Lipoxygenase Inhibitors; Male; Mice; Mice, Mutant Strains

2015
Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.
    Biological psychiatry, 2015, Nov-15, Volume: 78, Issue:10

    Topics: Animals; Arachidonate 5-Lipoxygenase; Brain; Cerebellum; Cerebral Cortex; Cyclin-Dependent Kinase 5; Disease Models, Animal; Encephalitis; Excitatory Postsynaptic Potentials; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Phenotype; Phosphorylation; Synapses; tau Proteins; Tauopathies

2015
The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:8

    Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Line; Cyclohexylamines; Glutamic Acid; Hydroxyurea; Iron; Lipoxygenase Inhibitors; Mice; Neurons; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Phenylenediamines; Reactive Oxygen Species

2015
The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia.
    Current neurovascular research, 2015, Volume: 12, Issue:4

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Infarction; Carotid Stenosis; Cytokines; Disease Models, Animal; Down-Regulation; Encephalitis; Enzyme-Linked Immunosorbent Assay; Hydroxyurea; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Nervous System Diseases

2015
[ROLE OF THROMBOXANE AND LEUKOTRIENES IN MECHANISMS OF CONTRACTILE REACTIONS OF PORTAL VEIN, INDUCED BY ACETYLCHLINE AND PHENYLEPHRINE].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2015, Volume: 61, Issue:3

    Topics: Acetylcholine; Animals; Endothelium, Vascular; Female; Hydroxyurea; In Vitro Techniques; Leukotriene Antagonists; Leukotrienes; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phthalic Acids; Portal Vein; Rats; Receptors, Thromboxane; Thromboxanes

2015
Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13.
    The Journal of clinical investigation, 2016, Volume: 126, Issue:2

    Topics: Anemia, Sickle Cell; Animals; Asthma; Disease Models, Animal; Hydroxyurea; Interleukin-13; Leukotrienes; Mice; Mice, Knockout; Placenta Growth Factor; Pregnancy Proteins; Th2 Cells

2016
Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B.
    The Journal of organic chemistry, 2016, Feb-19, Volume: 81, Issue:4

    Topics: Arachidonate 5-Lipoxygenase; Biological Products; Computational Biology; Coumarins; Humans; Hydroxyurea; Stereoisomerism

2016
5-LOX Inhibitor Zileuton Reduces Inflammatory Reaction and Ischemic Brain Damage Through the Activation of PI3K/Akt Signaling Pathway.
    Neurochemical research, 2016, Volume: 41, Issue:10

    Topics: Animals; Arachidonate 5-Lipoxygenase; Brain; Brain Ischemia; Hydroxyurea; Infarction, Middle Cerebral Artery; Inflammation; Lipoxygenase Inhibitors; Male; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction

2016
5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells.
    BMC cancer, 2016, 07-13, Volume: 16

    Topics: Alanine; Antineoplastic Agents; Apoptosis; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Azoles; Benzoquinones; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Endocannabinoids; Head and Neck Neoplasms; Humans; Hydroxyurea; Isoindoles; Lipoxygenase Inhibitors; Organoselenium Compounds; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; TRPV Cation Channels

2016
Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis.
    European journal of pharmacology, 2016, Oct-15, Volume: 789

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Body Weight; Catechin; CD3 Complex; Celecoxib; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Combinations; Eating; Gene Expression Regulation; Hydroxyurea; Leukotriene B4; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Neutrophil Infiltration; Rats; Rats, Sprague-Dawley; Thromboxane B2; Tumor Necrosis Factor-alpha

2016
5-Lipoxygenase inhibitor zileuton inhibits Ca(2+)-responses induced by glutoxim and molixan in macrophages.
    Doklady. Biochemistry and biophysics, 2016, Volume: 469, Issue:1

    Topics: Animals; Anti-Asthmatic Agents; Arachidonate 5-Lipoxygenase; Calcium; Calcium Signaling; Cations, Divalent; Cells, Cultured; Cytophotometry; Drug Combinations; Drug Interactions; Fura-2; Hydroxyurea; Inosine; Intracellular Space; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Microscopy, Fluorescence; Oligopeptides; Rats, Wistar

2016
Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice.
    Cancer research, 2017, 01-01, Volume: 77, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Hydroxyurea; Janus Kinase 2; Leukotriene Antagonists; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Polycythemia Vera; Polymerase Chain Reaction

2017
Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction.
    Anatolian journal of cardiology, 2017, Volume: 17, Issue:4

    Topics: Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Leukotriene Antagonists; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2017
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.
    Journal of natural products, 2017, 03-24, Volume: 80, Issue:3

    Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Humans; Hydroxyurea; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Mice; Molecular Structure; Prenylation; Prostaglandin-E Synthases; Rutaceae; Structure-Activity Relationship

2017
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
    Scientific reports, 2017, 04-06, Volume: 7

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Diet; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hydroxyurea; Inflammation; Lipoxygenase; Male; Mice, Transgenic; Phenotype; Phosphorylation; Synapses; tau Proteins; Up-Regulation; Vitamin B Complex; Vitamin B Deficiency

2017
Lack of Long-Term Neurologic Efficacy of Zileuton in Sjögren-Larsson's Syndrome.
    Neuropediatrics, 2017, Volume: 48, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hydroxyurea; Infant; Lipoxygenase Inhibitors; Male; Outcome Assessment, Health Care; Sjogren-Larsson Syndrome

2017
Effect of the lipoxygenase-inhibitors baicalein and zileuton on the vertebra in ovariectomized rats.
    Bone, 2017, Volume: 101

    Topics: Animals; Bone Density; Bone Diseases, Metabolic; Cancellous Bone; Female; Flavanones; Hydroxyurea; Lipoxygenase Inhibitors; Lumbar Vertebrae; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley

2017
The role of 5-lipoxygenase in Aggregatibacter actinomycetemcomitans-induced alveolar bone loss.
    Journal of clinical periodontology, 2017, Volume: 44, Issue:8

    Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Arachidonate 5-Lipoxygenase; Cell Differentiation; Cells, Cultured; Hydroxyurea; Interleukin-6; Mice; Osteoclasts; Real-Time Polymerase Chain Reaction; Tumor Necrosis Factor-alpha

2017
New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis.
    Mediators of inflammation, 2017, Volume: 2017

    Topics: Arachidonate 5-Lipoxygenase; Caffeic Acids; Coumaric Acids; Enzyme Activation; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Phenylethyl Alcohol; Structure-Activity Relationship

2017
5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes.
    Scientific reports, 2017, 07-10, Volume: 7, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Arachidonate 5-Lipoxygenase; Cell Line; Endoplasmic Reticulum Stress; Hydroxyurea; Insulin Resistance; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Muscle Fibers, Skeletal; Oxidative Stress; Palmitic Acid; Phosphorylation

2017
Naja sputatrix Venom Preconditioning Attenuates Neuroinflammation in a Rat Model of Surgical Brain Injury via PLA2/5-LOX/LTB4 Cascade Activation.
    Scientific reports, 2017, 07-14, Volume: 7, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Biomarkers; Brain; Brain Edema; Brain Injuries; Elapid Venoms; Hydroxyurea; Inflammation; Intraoperative Complications; Leukocyte Count; Leukotriene B4; Lipoxygenase Inhibitors; Naja; Phospholipase A2 Inhibitors; Phospholipases A2; Rats; Signal Transduction; Skin; Subcutaneous Tissue; Terpenes

2017
    Frontiers in cellular and infection microbiology, 2017, Volume: 7

    Topics: Animals; Aorta; Arachidonic Acid; Aspirin; Cell Adhesion Molecules; DNA, Bacterial; Endothelial Cells; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred BALB C; Monocytes; Mutation; Phospholipases A2; Recombinant Proteins; Signal Transduction; Streptococcus pyogenes; THP-1 Cells; Vascular Cell Adhesion Molecule-1

2017
Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.
    The Journal of clinical investigation, 2017, Aug-01, Volume: 127, Issue:8

    Topics: 5-Lipoxygenase-Activating Proteins; Androgens; Animals; Arachidonate 5-Lipoxygenase; Dihydrotestosterone; Female; Humans; Hydroxyurea; Leukocytes; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Pyrroles; Rats; Rats, Wistar; Sex Factors; Sulindac; Testosterone

2017
Effect of zileuton on osteoporotic bone and its healing, expression of bone, and brain genes in rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2018, 01-01, Volume: 124, Issue:1

    Topics: Animals; Brain; Drug Evaluation, Preclinical; Female; Hydroxyurea; Lipoxygenase Inhibitors; Osteoporosis; Ovariectomy; Rats, Sprague-Dawley; Tibia; X-Ray Microtomography

2018
Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice.
    Journal of affective disorders, 2018, Volume: 227

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP; Depression; Depressive Disorder; Disease Models, Animal; Fluoxetine; Hippocampus; Hydroxyurea; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation

2018
The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma.
    The pharmacogenomics journal, 2018, Volume: 18, Issue:5

    Topics: Asthma; Cell Line; Humans; Hydroxyurea; Leukotrienes; Phosphatidylinositol 3-Kinases; Polymorphism, Single Nucleotide; Quantitative Trait Loci; RNA, Messenger; Signal Transduction

2018
Zileuton alleviates acute cisplatin nephrotoxicity: Inhibition of lipoxygenase pathway favorably modulates the renal oxidative/inflammatory/caspase-3 axis.
    Prostaglandins & other lipid mediators, 2018, Volume: 135

    Topics: Animals; Caspase 3; Cisplatin; Hydroxyurea; Kidney; Leukotriene B4; Leukotriene D4; Lipoxygenases; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley

2018
The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study.
    PloS one, 2018, Volume: 13, Issue:2

    Topics: Adult; Arachidonate 5-Lipoxygenase; Female; Healthy Volunteers; Humans; Hydroxyurea; Male; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Placebos; Positron-Emission Tomography; Single-Blind Method; Thiazolidinediones; Young Adult

2018
Inhibition of 5-lipoxygenase represses neutrophils activation and activates apoptosis in pancreatic tissues during acute necrotizing pancreatitis.
    Biochemical and biophysical research communications, 2018, 03-25, Volume: 498, Issue:1

    Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Biomarkers; Caspase 3; Enzyme Activation; Hydroxyurea; Male; Neutrophil Activation; Neutrophils; Pancreas; Pancreatitis, Acute Necrotizing; Rats, Sprague-Dawley; RNA, Messenger

2018
Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.
    Aging cell, 2018, Volume: 17, Issue:3

    Topics: Animals; Cognition; Disease Models, Animal; Hydroxyurea; Leukotriene Antagonists; Mice; Mice, Transgenic; Phosphorylation; tau Proteins

2018
Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway.
    Molecular neurobiology, 2019, Volume: 56, Issue:2

    Topics: Animals; Behavior, Animal; Brain; Cyclin-Dependent Kinase 5; Hydroxyurea; Leukotriene Antagonists; Leukotrienes; Memory Disorders; Mice; Mice, Transgenic; Phosphorylation; Signal Transduction; Spatial Learning; tau Proteins; Tauopathies

2019
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models.
    JCI insight, 2018, 09-20, Volume: 3, Issue:18

    Topics: Animals; Benzopyrans; Carboxylic Acids; Choroidal Neovascularization; Disease Models, Animal; Eye; Eye Injuries; Hydroxyurea; Indoles; Lasers; Leucine; Leukotriene B4; Macrophages; Macular Degeneration; Male; Mice; Mice, Knockout; Neovascularization, Pathologic; Receptors, Leukotriene B4; Signal Transduction

2018
An In Silico Study of the Antioxidant Ability for Two Caffeine Analogs Using Molecular Docking and Quantum Chemical Methods.
    Molecules (Basel, Switzerland), 2018, Oct-29, Volume: 23, Issue:11

    Topics: Antioxidants; Caffeine; Catalytic Domain; Computer Simulation; Enzymes; Febuxostat; Fluorouracil; Hydroxyurea; Molecular Docking Simulation; Quantum Theory

2018
Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies.
    Bioorganic & medicinal chemistry, 2019, 02-15, Volume: 27, Issue:4

    Topics: Antioxidants; Arachidonate 5-Lipoxygenase; Catalytic Domain; Drug Design; Enzyme Assays; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Molecular Docking Simulation; Molecular Structure; Peroxidases; Piperidines; Structure-Activity Relationship

2019
Effect of Zileuton Treatment on Sinonasal Quality of Life in Patients with Aspirin-Exacerbated Respiratory Disease.
    American journal of rhinology & allergy, 2019, Volume: 33, Issue:6

    Topics: Adult; Aged; Allergens; Anti-Asthmatic Agents; Arachidonate 5-Lipoxygenase; Aspirin; Asthma, Aspirin-Induced; Chronic Disease; Female; Humans; Hydroxyurea; Male; Middle Aged; Quality of Life; Retrospective Studies; Sinusitis; Surveys and Questionnaires; Treatment Outcome

2019
Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation.
    Cells, 2019, 09-30, Volume: 8, Issue:10

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyurea; Large-Conductance Calcium-Activated Potassium Channels; Lipoxygenase Inhibitors; Mice; Mice, Inbred C57BL

2019
Zileuton™ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells.
    Nanomedicine : nanotechnology, biology, and medicine, 2020, Volume: 24

    Topics: Animals; Breast Neoplasms; Female; Humans; Hydroxyurea; MCF-7 Cells; Mice; Mice, Inbred NOD; Mice, SCID; Micelles; Neoplastic Cells, Circulating; Neoplastic Stem Cells; Xenograft Model Antitumor Assays

2020
The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPAR
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyurea; Lipoxygenase Inhibitors; Male; Mice; Myocytes, Cardiac; NF-E2-Related Factor 2; PPAR alpha; Rats; Signal Transduction; Ventricular Remodeling

2019
Pharmaceutical analysis combined with in-silico therapeutic and toxicological profiling on zileuton and its impurities to assist in modern drug discovery.
    Journal of pharmaceutical and biomedical analysis, 2020, Feb-05, Volume: 179

    Topics: Arachidonate 5-Lipoxygenase; Chromatography, Liquid; Computer Simulation; Drug Contamination; Drug Discovery; Hydrolysis; Hydroxyurea; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Molecular Structure; Oxidative Stress; Software; Tandem Mass Spectrometry

2020
Participation of 5-lipoxygenase and LTB4 in liver regeneration after partial hepatectomy.
    Scientific reports, 2019, 12-03, Volume: 9, Issue:1

    Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Proliferation; Cyclin D1; Eicosanoids; Hepatectomy; Hydrogen-Ion Concentration; Hydroxyurea; Leukotriene B4; Leukotrienes; Liver; Liver Regeneration; Macrophages; Male; Neutrophils; NF-kappa B; Rats; Rats, Wistar; Signal Transduction

2019
Zileuton use and phenotypic features in asthma.
    Pulmonary pharmacology & therapeutics, 2020, Volume: 60

    Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Lung; Male; Middle Aged; Phenotype; Respiratory Function Tests; Retrospective Studies; Severity of Illness Index

2020
Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach.
    Molecules (Basel, Switzerland), 2020, May-05, Volume: 25, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Artificial Intelligence; Cells, Cultured; Data Mining; Drug Repositioning; Hydroxyurea; Lipopolysaccharides; Macrophages; Mice; Neural Networks, Computer; NF-E2-Related Factor 2; RAW 264.7 Cells; Semantics; Sequence Analysis, RNA; Signal Transduction

2020
Targeting Neutrophils for Enhanced Cancer Theranostics.
    Advanced materials (Deerfield Beach, Fla.), 2020, Volume: 32, Issue:33

    Topics: Cell Line, Tumor; Drug Design; Drug Liberation; Humans; Hydroxyurea; Molecular Targeted Therapy; Nanoparticles; Neoplasms; Neutrophils; Photosensitizing Agents; Serotonin; Tumor Microenvironment

2020
High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate I
    European journal of pharmacology, 2020, Nov-15, Volume: 887

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Line; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Hippocampus; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Potassium Channels, Calcium-Activated

2020
Leukotrienes, a potential target for Covid-19.
    Prostaglandins, leukotrienes, and essential fatty acids, 2020, Volume: 161

    Topics: Acetates; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Betacoronavirus; Coronavirus Infections; COVID-19; Cyclopropanes; Cytokine Release Syndrome; Humans; Hydroxyurea; Immunologic Factors; Indoles; Leukotrienes; Pandemics; Phenylcarbamates; Pneumonia, Viral; Quinolines; SARS-CoV-2; Severity of Illness Index; Sulfides; Sulfonamides; Tosyl Compounds

2020
New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition.
    Molecules (Basel, Switzerland), 2020, Oct-14, Volume: 25, Issue:20

    Topics: Arachidonate 5-Lipoxygenase; Computer Simulation; Coumaric Acids; Drug Evaluation, Preclinical; Free Radical Scavengers; HEK293 Cells; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Molecular Docking Simulation; Neutrophils; Structure-Activity Relationship

2020
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
    Aging, 2021, 04-20, Volume: 13, Issue:8

    Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Disease Models, Animal; Humans; Hydroxyurea; Inflammation; Infusions, Intraventricular; Lipoxygenase Inhibitors; Male; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Subarachnoid Hemorrhage

2021
5-LO-derived LTB4 plays a key role in MCP-1 expression in HMGB1-exposed VSMCs via a BLTR1 signaling axis.
    Scientific reports, 2021, 05-27, Volume: 11, Issue:1

    Topics: Animals; Aorta; Arachidonate 5-Lipoxygenase; Chemokine CCL2; Fatty Alcohols; Glycols; HMGB1 Protein; Hydroxyurea; Leukotriene B4; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Signal Transduction

2021
ALOX5-5-HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation.
    Cancer medicine, 2021, Volume: 10, Issue:15

    Topics: Analysis of Variance; Antineoplastic Agents; Arachidonate 5-Lipoxygenase; Cell Proliferation; Cell Survival; Disease Progression; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Phosphorylation; Stomach Neoplasms; Up-Regulation

2021
Development of polymer-based nanoparticles for zileuton delivery to the lung: PMeOx and PMeOzi surface chemistry reduces interactions with mucins.
    Nanomedicine : nanotechnology, biology, and medicine, 2021, Volume: 37

    Topics: Administration, Inhalation; Bronchi; Bronchial Diseases; Cells, Cultured; Drug Carriers; Drug Delivery Systems; Epithelial Cells; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxyurea; Mucins; Nanoparticles; Polyamines; Polyesters; Polymers

2021
Inhibition of Lipoxygenases Showed No Benefit for the Musculoskeletal System in Estrogen Deficient Rats.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Animals; Bone Diseases, Metabolic; Estrogens; Female; Flavanones; Hydroxyurea; Lipoxygenase Inhibitors; Lipoxygenases; Musculoskeletal System; Osteoporosis; Rats; Rats, Sprague-Dawley

2021
Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models.
    Cancer chemotherapy and pharmacology, 2021, Volume: 88, Issue:6

    Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Proliferation; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Mice, SCID; Tumor Cells, Cultured; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2021
5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Line; Disease Models, Animal; Ferroptosis; Gene Knockdown Techniques; Humans; Hydroxyurea; Iodates; Lipoxygenase Inhibitors; Macular Degeneration; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Retinal Pigment Epithelium; Signal Transduction; Transfection

2022
Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway.
    International journal of molecular sciences, 2022, Apr-28, Volume: 23, Issue:9

    Topics: Animals; Hydroxyurea; Lipopolysaccharides; Lipoxygenase Inhibitors; Microglia; Myeloid Differentiation Factor 88; NF-kappa B; Signal Transduction; Subarachnoid Hemorrhage

2022
Zileuton Alleviates Radiation-Induced Cutaneous Ulcers via Inhibition of Senescence-Associated Secretory Phenotype in Rodents.
    International journal of molecular sciences, 2022, Jul-29, Volume: 23, Issue:15

    Topics: Animals; Cellular Senescence; Fibroblasts; Hydroxyurea; Phenotype; Rodentia; Senescence-Associated Secretory Phenotype; Ulcer

2022