Page last updated: 2024-08-24

zileuton and aspirin

zileuton has been researched along with aspirin in 25 studies

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (28.00)	18.2507
2000's	5 (20.00)	29.6817
2010's	12 (48.00)	24.3611
2020's	1 (4.00)	2.80

Authors

Authors	Studies
Hopper, AT; Witiak, DT; Ziemniak, J	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Achenbach, J; Barzen, S; Brüggerhoff, A; Hofmann, B; Ihlefeld, K; Kretschmer, SB; Proschak, E; Rödl, CB; Stark, H; Steinhilber, D; Vogt, D	1
Diaz, G; Espinosa, V; Holman, TR; Hoobler, EK; Mascayano, C; Perry, S; Sepúlveda-Boza, S	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Abid, OU; Ahmad, A; Ahmad, S; Ayaz, M; Hussain, F; Jan, MS; Mahmood, F; Rashid, U; Sadiq, A; Ullah, F	1
Chan, TC; Knapp, DW; Kuczek, T; Park, B; Reagan, WJ	1
Callery, JC; Cohn, J; Drazen, JM; Fischer, AR; Igarashi, Y; Kaliner, MA; Lilly, CM; Rosenberg, MA; Rubin, P; White, MV	1
Callery, JC; Cohn, J; Drazen, JM; Fischer, AR; Israel, E; Lilly, CM; Rosenberg, MA; Rubin, P; Shapiro, J	1
Ganey, PE; Peters-Golden, M; Schiamberg, E; Tithof, PK	1
Bochenek, G; Boodhoo, TI; Dahlén, B; Dahlén, SE; Dubé, LM; Kumlin, M; Mastalerz, L; Nizankowska, E; Pinis, G; Swanson, LJ; Szczeklik, A; Wright, S; Zetterström, O	1
Ellis, MH	1
Lang, DM	1
Daffern, PJ; Pauls, JD; Simon, RA; Stevenson, DD	1
Fiorucci, S; Hollenberg, MD; von der Weid, PY; Wallace, JL	1
Ludington, E; Mehra, P; Simon, RA; Stevenson, DD; White, A	1
Dennis, EA; Mouchlis, VD	1
Domon, H; Isono, T; Kawabata, S; Kurosawa, M; Maekawa, T; Oda, M; Terao, Y; Yamaguchi, M	1
Butterfield, J; Castells, M	1
Adams, KN; Ebert, CS; Farquhar, DR; Lee, SE; Masood, MM; Senior, BA; Thorp, BD; Zanation, AM	1

Reviews

3 review(s) available for zileuton and aspirin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Membrane and inhibitor interactions of intracellular phospholipases A2. Advances in biological regulation, 2016, Volume: 61 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Membrane; Eukaryotic Cells; Gene Expression Regulation; Humans; Hydroxyurea; Lipoxygenase; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Phospholipases A2; Phospholipids; Prostaglandin-Endoperoxide Synthases; Signal Transduction	2016
Mast Cell Activation Syndrome and Mastocytosis: Initial Treatment Options and Long-Term Management. The journal of allergy and clinical immunology. In practice, 2019, Volume: 7, Issue:4 Topics: Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cromolyn Sodium; Disease Management; Glucocorticoids; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Hydroxyurea; Interleukin-6; Leukotriene Antagonists; Leukotriene E4; Mastocytosis; Omalizumab; Prostaglandin D2; Tryptases	2019

Trials

4 trial(s) available for zileuton and aspirin

Article	Year
Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive asthma. The Journal of allergy and clinical immunology, 1994, Volume: 94, Issue:6 Pt 1 Topics: Adult; Aspirin; Asthma; Blood Proteins; Chymases; Cross-Over Studies; Double-Blind Method; Eosinophil Granule Proteins; Female; Histamine; Humans; Hydroxyurea; Leukotrienes; Male; Mast Cells; Middle Aged; Nasal Mucosa; Ribonucleases; Serine Endopeptidases; Tryptases	1994
The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. The American review of respiratory disease, 1993, Volume: 148, Issue:6 Pt 1 Topics: Adult; Arachidonate 5-Lipoxygenase; Aspirin; Asthma; Bronchoconstriction; Double-Blind Method; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged	1993
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:4 Pt 1 Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Glucocorticoids; Histamine; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene D4; Lipoxygenase Inhibitors; Male; Middle Aged; Peak Expiratory Flow Rate	1998
Effect of leukotriene modifier drugs on the safety of oral aspirin challenges. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:5 Topics: Acetates; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Asthmatic Agents; Aspirin; Asthma; Cyclopropanes; Desensitization, Immunologic; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Middle Aged; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome	2006

Other Studies

18 other study(ies) available for zileuton and aspirin

Article	Year
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid. Journal of medicinal chemistry, 1998, Feb-12, Volume: 41, Issue:4 Topics: Animals; Antioxidants; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Line, Transformed; Cell Nucleus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Indicators and Reagents; Isoenzymes; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Malondialdehyde; Membrane Proteins; Models, Molecular; Molecular Conformation; Molecular Structure; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship	1998
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism. European journal of medicinal chemistry, 2014, Sep-12, Volume: 84 Topics: 5-Lipoxygenase-Activating Proteins; Aminophenols; Cyclooxygenase 2; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; HeLa Cells; Humans; Molecular Structure; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured; U937 Cells	2014
Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase. Chemical biology & drug design, 2015, Volume: 86, Issue:1 Topics: Animals; Arachidonate 5-Lipoxygenase; Flavonoids; Humans; Leukocytes; Lipoxygenase Inhibitors; Molecular Dynamics Simulation; Sheep	2015
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents. European journal of medicinal chemistry, 2020, Jan-15, Volume: 186 Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Design; Edema; Enzyme Inhibitors; Female; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Molecular Structure; Pyrrolidines; Structure-Activity Relationship	2020
Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells. American journal of veterinary research, 1995, Volume: 56, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; Cell Line; Cell Survival; Dog Diseases; Dogs; Drug Screening Assays, Antitumor; Hydroxyurea; Indomethacin; Melanoma; Piroxicam; Sarcoma; Tumor Cells, Cultured; Tumor Stem Cell Assay	1995
Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls. Environmental health perspectives, 1996, Volume: 104, Issue:1 Topics: Animals; Arachidonic Acid; Aroclors; Aspirin; Cyclooxygenase Inhibitors; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phospholipases A; Phospholipases A2; Polychlorinated Biphenyls; Quinacrine; Rats; Superoxides; Terpenes; Tetradecanoylphorbol Acetate	1996
Successful treatment of chronic urticaria with leukotriene antagonists. The Journal of allergy and clinical immunology, 1998, Volume: 102, Issue:5 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Controlled Clinical Trials as Topic; Double-Blind Method; Humans; Hydroxyurea; Leukotriene Antagonists; Male; Urticaria	1998
Antileukotriene agents and aspirin-sensitive asthma: are we removing the second bassoonist or skating to where the puck is gonna be? Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 85, Issue:1 Topics: Aspirin; Asthma; Bronchial Spasm; Humans; Hydroxyurea; Leukotriene Antagonists; Therapeutic Equivalency	2000
Lack of effect of the 5-lipoxygenase inhibitor zileuton in blocking oral aspirin challenges in aspirin-sensitive asthmatics. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 85, Issue:1 Topics: Administration, Oral; Aspirin; Asthma; Desensitization, Immunologic; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors	2000
Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone. Circulation, 2004, Sep-07, Volume: 110, Issue:10 Topics: Acetylcholine; Animals; Aorta; Aspirin; Blood Pressure; Celecoxib; Cyclooxygenase 2 Inhibitors; Endothelium, Vascular; Hydroxyurea; Lipoxins; Lipoxygenase Inhibitors; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Oligopeptides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Lipoxin; Sulfonamides; Vascular Resistance; Vasodilation; Vasodilator Agents	2004
Frontiers in cellular and infection microbiology, 2017, Volume: 7 Topics: Animals; Aorta; Arachidonic Acid; Aspirin; Cell Adhesion Molecules; DNA, Bacterial; Endothelial Cells; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred BALB C; Monocytes; Mutation; Phospholipases A2; Recombinant Proteins; Signal Transduction; Streptococcus pyogenes; THP-1 Cells; Vascular Cell Adhesion Molecule-1	2017
Effect of Zileuton Treatment on Sinonasal Quality of Life in Patients with Aspirin-Exacerbated Respiratory Disease. American journal of rhinology & allergy, 2019, Volume: 33, Issue:6 Topics: Adult; Aged; Allergens; Anti-Asthmatic Agents; Arachidonate 5-Lipoxygenase; Aspirin; Asthma, Aspirin-Induced; Chronic Disease; Female; Humans; Hydroxyurea; Male; Middle Aged; Quality of Life; Retrospective Studies; Sinusitis; Surveys and Questionnaires; Treatment Outcome	2019