zileuton has been researched along with arachidonic acid in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER | 1 |
| Henson, PM; Hill, E; Maclouf, J; Murphy, RC | 1 |
| Ado, VA; Mokronosova, MA; Perlamutrov, IuN | 1 |
| Henson, PM; Hill, E; MacMillan, DK; Murphy, RC; Sala, A; Shuman, T; Sigal, E | 1 |
| Berkenkopf, JW; Carlson, RP; Grimes, D; Kreft, AF; Marinari, LR; Musser, JH; Sturm, RJ; Weichman, BM | 1 |
| Kasiske, BL; Keane, WF; Kim, Y; O'Donnell, MP | 1 |
| Ganey, PE; Peters-Golden, M; Schiamberg, E; Tithof, PK | 1 |
| Hirasawa, N; Kushihara, M; Ohuchi, K; Takahagi, H; Takasaki, W; Takayanagi, M; Yamashita, M | 1 |
| Capella, GL | 1 |
| Chen, X; Fang, M; Li, N; Sood, S; Sun, Z; Wang, P; Wang, S; Yang, CS | 1 |
| Hénichart, JP; Pommery, J; Pommery, N | 1 |
| Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Jiang, X; Karlsson, L; Lundeen, KA; Rao, NL; Riley, JP; Williams, KN; Xue, X | 1 |
| Alestas, T; Seltmann, H; Zouboulis, CC | 1 |
| Bramanti, P; Cuzzocrea, S; Dehm, F; Hoffmann, M; Koeberle, A; Pergola, C; Rossi, A; Sautebin, L; Werz, O | 1 |
| Dennis, EA; Mouchlis, VD | 1 |
| Domon, H; Isono, T; Kawabata, S; Kurosawa, M; Maekawa, T; Oda, M; Terao, Y; Yamaguchi, M | 1 |
| Citron, F; Deem, AK; Genovese, G; Perelli, L; Viale, A | 1 |
2 review(s) available for zileuton and arachidonic acid
| Article | Year |
|---|---|
[Allergy and leukotrienes].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Dermatitis, Atopic; Humans; Hydroxyurea; Hypersensitivity; Leukotrienes; Lipoxygenase Inhibitors; Receptors, Leukotriene | 1995 |
Membrane and inhibitor interactions of intracellular phospholipases A2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Membrane; Eukaryotic Cells; Gene Expression Regulation; Humans; Hydroxyurea; Lipoxygenase; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Phospholipases A2; Phospholipids; Prostaglandin-Endoperoxide Synthases; Signal Transduction | 2016 |
15 other study(ies) available for zileuton and arachidonic acid
| Article | Year |
|---|---|
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2 | 1992 |
Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Cell Compartmentation; Cell Membrane; Cytosol; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; In Vitro Techniques; Indoles; Leukotrienes; Neutrophils; Substrate Specificity | 1992 |
Eosinophil 15-lipoxygenase is a leukotriene A4 synthase.
Topics: Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell-Free System; Cytosol; Dose-Response Relationship, Drug; Eosinophils; Granulocytes; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Leukotriene A4; Leukotrienes; Lipoxygenase Inhibitors; Models, Chemical; Neutrophils; Recombinant Proteins | 1994 |
WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity.
Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Female; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Naphthaleneacetic Acids; Prostaglandin-Endoperoxide Synthases; Quinolines; Rabbits; Rats; Rats, Wistar | 1993 |
Oxidative modification of low-density lipoproteins by mesangial cells.
Topics: Antioxidants; Arachidonic Acid; Butylated Hydroxytoluene; Catalase; Cell Division; Cells, Cultured; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Deferoxamine; DNA Replication; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Humans; Hydroxyurea; Indomethacin; Ketoconazole; Lipoproteins, LDL; Lipoxygenase Inhibitors; Masoprocol; Oxidation-Reduction; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 1993 |
Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls.
Topics: Animals; Arachidonic Acid; Aroclors; Aspirin; Cyclooxygenase Inhibitors; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phospholipases A; Phospholipases A2; Polychlorinated Biphenyls; Quinacrine; Rats; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1996 |
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Anti-leukotriene drugs in the prevention and treatment of hepatorenal syndrome.
Topics: Acetates; Arachidonic Acid; Cyclopropanes; Hepatorenal Syndrome; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Liver; Phenylcarbamates; Protein Structure, Tertiary; Quinolines; Sulfides; Sulfonamides; Thromboxanes; Tosyl Compounds | 2003 |
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogens; Carcinoma, Squamous Cell; Celecoxib; Cell Transformation, Neoplastic; Chemoprevention; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Hydroxyurea; Immunohistochemistry; In Situ Hybridization; Lipoxygenase Inhibitors; Male; Membrane Proteins; Mesocricetus; Mouth Neoplasms; Neoplasms, Experimental; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Up-Regulation | 2005 |
Modification of eicosanoid profile in human blood treated by dual COX/LOX inhibitors.
Topics: Arachidonic Acid; Calcimycin; Celecoxib; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Eicosanoids; Humans; Hydroxyurea; Indomethacin; Inhibitory Concentration 50; Lipopolysaccharides; Lipoxygenase Inhibitors; Pyrazoles; Sulfonamides | 2005 |
Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ascitic Fluid; Benzothiazoles; Dogs; Ear; Edema; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Female; Humans; Hydroxyurea; Inflammation; Leukotriene B4; Leukotriene C4; Lipoxins; Lipoxygenase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neutrophil Infiltration; Peritonitis; Piperidines; Recombinant Proteins | 2007 |
Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis.
Topics: Arachidonic Acid; Cell Count; Cell Line; Humans; Hydroxyurea; Interleukin-6; Interleukin-8; Leukotriene Antagonists; Leukotriene B4; Lipogenesis; Sebaceous Glands | 2010 |
The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carrageenan; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Humans; Hydroxyurea; Interferon-gamma; Intramolecular Oxidoreductases; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages; Mice; Mice, Inbred Strains; Pleurisy; Prostaglandin-E Synthases; Prostaglandins F; Rats; Rats, Wistar; Zymosan | 2010 |
Topics: Animals; Aorta; Arachidonic Acid; Aspirin; Cell Adhesion Molecules; DNA, Bacterial; Endothelial Cells; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred BALB C; Monocytes; Mutation; Phospholipases A2; Recombinant Proteins; Signal Transduction; Streptococcus pyogenes; THP-1 Cells; Vascular Cell Adhesion Molecule-1 | 2017 |
Leukotrienes, a potential target for Covid-19.
Topics: Acetates; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Betacoronavirus; Coronavirus Infections; COVID-19; Cyclopropanes; Cytokine Release Syndrome; Humans; Hydroxyurea; Immunologic Factors; Indoles; Leukotrienes; Pandemics; Phenylcarbamates; Pneumonia, Viral; Quinolines; SARS-CoV-2; Severity of Illness Index; Sulfides; Sulfonamides; Tosyl Compounds | 2020 |