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zileuton and abbott 66193

zileuton has been researched along with abbott 66193 in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bell, RL; Bhatia, PA; Bouska, JB; Brooks, CD; Carter, GW; Craig, RA; DeNinno, SL; Holms, JH; Kerdesky, FA; Kolasa, T; Lanni, C; Maki, RG; Martin, JG; Martin, MB; Mazdiyasni, H; Moore, JL; Ratajczyk, JD; Rodriques, KE; Stewart, AO; Summers, JB; Young, PR1
Braeckman, RA; Erdman, KA; Granneman, GR1
Awni, WM; Braeckman, RA; Dubé, LM; Granneman, GR; Witt, G1
Awni, WM; Cavanaugh, JH; Dubé, LM; el-Shourbagy, T; Locke, CS; Wong, SL1
Ferrero, JL; Machinist, JM; Mayer, MD; Rodrigues, AD; Shet, MS1
Awni, WM; Cavanaugh, JH; Dube, LM; Locke, C1

Trials

3 trial(s) available for zileuton and abbott 66193

ArticleYear
Pharmacokinetics and pharmacodynamics of zileuton after oral administration of single and multiple dose regimens of zileuton 600mg in healthy volunteers.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fasting; Humans; Hydroxylation; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Stereoisomerism; Urea; White People

1995
The pharmacokinetics of single oral doses of zileuton 200 to 800mg, its enantiomers, and its metabolites, in normal healthy volunteers.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Absorption; Administration, Oral; Adult; Analysis of Variance; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Glucuronates; Half-Life; Humans; Hydroxylation; Hydroxyurea; Kidney Tubules, Proximal; Lipoxygenase Inhibitors; Male; Middle Aged; Protein Binding; Stereoisomerism; Urea

1995
Evaluation of the diurnal variation in the pharmacokinetics of zileuton in healthy volunteers.
    Journal of clinical pharmacology, 1997, Volume: 37, Issue:5

    Topics: Adolescent; Adult; Circadian Rhythm; Cross-Over Studies; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Urea

1997

Other Studies

3 other study(ies) available for zileuton and abbott 66193

ArticleYear
Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.
    Journal of medicinal chemistry, 1997, Jun-20, Volume: 40, Issue:13

    Topics: Animals; Cells, Cultured; Drug Design; Enzyme Inhibitors; Furans; Glucuronates; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Macaca fascicularis; Models, Chemical; Rats; Structure-Activity Relationship; Templates, Genetic; Thiophenes

1997
Determination of a new 5-lipoxygenase inhibitor, zileuton, and its inactive N-dehydroxylated metabolite in plasma by high performance liquid chromatography.
    Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

    Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Haplorhini; Humans; Hydroxylation; Hydroxyurea; Lipoxygenase Inhibitors; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism; Urea

1995
Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:10

    Topics: Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Hydroxyurea; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Microsomes, Liver; Propranolol; Theophylline; Urea

1995