zileuton has been researched along with abbott 66193 in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, RL; Bhatia, PA; Bouska, JB; Brooks, CD; Carter, GW; Craig, RA; DeNinno, SL; Holms, JH; Kerdesky, FA; Kolasa, T; Lanni, C; Maki, RG; Martin, JG; Martin, MB; Mazdiyasni, H; Moore, JL; Ratajczyk, JD; Rodriques, KE; Stewart, AO; Summers, JB; Young, PR | 1 |
| Braeckman, RA; Erdman, KA; Granneman, GR | 1 |
| Awni, WM; Braeckman, RA; Dubé, LM; Granneman, GR; Witt, G | 1 |
| Awni, WM; Cavanaugh, JH; Dubé, LM; el-Shourbagy, T; Locke, CS; Wong, SL | 1 |
| Ferrero, JL; Machinist, JM; Mayer, MD; Rodrigues, AD; Shet, MS | 1 |
| Awni, WM; Cavanaugh, JH; Dube, LM; Locke, C | 1 |
3 trial(s) available for zileuton and abbott 66193
| Article | Year |
|---|---|
Pharmacokinetics and pharmacodynamics of zileuton after oral administration of single and multiple dose regimens of zileuton 600mg in healthy volunteers.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fasting; Humans; Hydroxylation; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Stereoisomerism; Urea; White People | 1995 |
The pharmacokinetics of single oral doses of zileuton 200 to 800mg, its enantiomers, and its metabolites, in normal healthy volunteers.
Topics: Absorption; Administration, Oral; Adult; Analysis of Variance; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Glucuronates; Half-Life; Humans; Hydroxylation; Hydroxyurea; Kidney Tubules, Proximal; Lipoxygenase Inhibitors; Male; Middle Aged; Protein Binding; Stereoisomerism; Urea | 1995 |
Evaluation of the diurnal variation in the pharmacokinetics of zileuton in healthy volunteers.
Topics: Adolescent; Adult; Circadian Rhythm; Cross-Over Studies; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Urea | 1997 |
3 other study(ies) available for zileuton and abbott 66193
| Article | Year |
|---|---|
Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.
Topics: Animals; Cells, Cultured; Drug Design; Enzyme Inhibitors; Furans; Glucuronates; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Macaca fascicularis; Models, Chemical; Rats; Structure-Activity Relationship; Templates, Genetic; Thiophenes | 1997 |
Determination of a new 5-lipoxygenase inhibitor, zileuton, and its inactive N-dehydroxylated metabolite in plasma by high performance liquid chromatography.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Haplorhini; Humans; Hydroxylation; Hydroxyurea; Lipoxygenase Inhibitors; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism; Urea | 1995 |
Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193.
Topics: Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Hydroxyurea; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Microsomes, Liver; Propranolol; Theophylline; Urea | 1995 |