zidovudine triphosphate has been researched along with zidovudine in 175 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (6.86) | 18.7374 |
| 1990's | 86 (49.14) | 18.2507 |
| 2000's | 56 (32.00) | 29.6817 |
| 2010's | 19 (10.86) | 24.3611 |
| 2020's | 2 (1.14) | 2.80 |
| Authors | Studies |
|---|---|
| Hamzeh, FM; Kornhauser, DM; Kuwahara, SK; Lewis, LD; Lietman, PS; Slusher, JT | 1 |
| Britton, S; Eriksson, S; Jacobsson, B; Törnevik, Y | 1 |
| Kimura, S; Muramatsu, S; Shimada, K; Takahagi, H; Toyoshima, T | 1 |
| Joos, B; Kuster, H; Lüthy, R; Nadai, V; Vogt, M | 1 |
| Dhawan, RK; Kharbanda, S; Kufe, D; Nakamura, M; Ohno, T | 1 |
| Ashmun, R; Connelly, MC; Fridland, A | 1 |
| Darnowski, JW; Goulette, FA | 1 |
| Back, D; Barry, M; Beeching, N; Breckenridge, A; Carey, P; Fox, R; Nye, F; Timmins, D; Veal, G; Wild, M | 1 |
| Bebenek, K; Eckstein, F; Kunkel, TA; Roberts, JD; Thomas, DC | 1 |
| Back, DJ; Barry, MG; Breckenridge, AM; Gibbons, SE; Hoggard, PG; Khoo, SH; Veal, GJ; Wilkins, EG; Williams, O | 1 |
| Agou, F; Biondi, R; Deville-Bonne, D; Guerreiro, C; Sarfati, R; Schneider, B; Veron, M | 1 |
| August, EM; Brankovan, V; Ghazzouli, I; Hitchcock, MJ; Lin, TS; Mansuri, MM; Prusoff, WH; Sommadossi, JP; Starrett, JE; Sterzycki, RZ | 1 |
| Baba, M; De Clercq, E; Shi, M; Takao, S; Wang, X | 1 |
| Amblard, F; Bassit, L; Bondada, L; Coats, SJ; Detorio, M; Grier, J; Hernandez-Santiago, BI; Koontz, D; Mellors, JW; Rapp, KL; Schinazi, RF; Sluis-Cremer, N | 1 |
| Bassit, L; Coats, SJ; Detorio, M; Herman, BD; Mellors, JW; Nettles, JH; Obikhod, A; Schinazi, RF; Sluis-Cremer, N; Solomon, S; Tao, SJ; Zhang, HW | 1 |
| Ilina, T; Myshakina, NS; Parniak, MA; Sirivolu, VR; Vernekar, SK; Wang, Z | 1 |
| Abbotts, J; Wilson, SH | 1 |
| Barr, PJ; Bathurst, IC; Kenyon, GL; Ma, QF | 1 |
| Reardon, JE | 1 |
| Baba, M; De Clercq, E; Debyser, Z; Desmyter, J; Pauwels, R | 1 |
| Freeman, GA; Miller, WH; Reardon, JE; Rideout, JL | 1 |
| Emini, EA; Goldman, ME; Hoffman, JM; Nunberg, JH; O'Brien, JA; Quintero, JC; Ruffing, TL; Schleif, WA; Siegl, PK; Smith, AM | 1 |
| Antonelli, G; Capobianchi, MR; Dianzani, F; Dong, G; Riva, E; Turriziani, O | 1 |
| Chen, MS; Copeland, WC; Wang, TS | 1 |
| Abbotts, J; Kedar, PS; Kovács, T; Lesiak, K; Torrence, P; Wilson, SH | 1 |
| Farquhar, D; Huang, P; Plunkett, W | 1 |
| Miller, WH; Reardon, JE | 1 |
| Akesson-Johansson, A; Cox, S; Harmenberg, J; Vrang, L | 1 |
| Buckheit, RW; Germany, JM; Parker, WB; Ross, LJ; Secrist, JA; Shaddix, SC; Shannon, WM; Vince, R; White, EL | 1 |
| Kemp, SD; Larder, BA; Lowe, DM; Parmar, V | 1 |
| Quan, K; Tao, P; Zhang, X | 1 |
| Austermann, S; Bialek, G; Grosse, F; Nickel, W | 1 |
| Izuta, S; Kojima, K; Sakurai, T; Saneyoshi, M; Suzuki, M; Yoshida, S | 2 |
| Liu, PK; Norwood, TH | 1 |
| Bernaerts, R; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Votruba, I | 1 |
| Kovács, T; Torrence, PF | 1 |
| Bazin, H; Chattopadhyaya, J; Eriksson, B; Oberg, B; Vrang, L | 1 |
| Bazin, H; Chattopadhyaya, J; Oberg, B; Remaud, G; Vrang, L | 1 |
| Furman, PA; Langlois, AJ; Miller, WH; Richards, CA; Spector, T; St Clair, MH; Weinhold, KJ | 1 |
| Kim, H; Parthasarathy, R | 1 |
| Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R | 1 |
| Krayevsky, AA; Kukhanova, MM; Kuzminova, EA; Pyrinova, GB; Salganik, RI | 1 |
| Boehme, RE; Chen, MS; Chernow, M; Chuang, RY; Marx, PA; Matthews, TR; McRoberts, MJ; Prisbe, EJ; Suttmann, RT; Wu, JC | 1 |
| Kurth, R; Löwer, J; Oberg, B; Vrang, L | 1 |
| Brian, EL; De Clercq, E; Pagano, JS; Smith, MS | 1 |
| Behr, E; König, H; Kurth, R; Löwer, J | 1 |
| Chattopadhyaya, J; Löfgren, B; Nordenfelt, E; Oberg, B | 1 |
| Cheng, YC; Gonzalez, CJ; Im, GJ; Tramontano, E | 1 |
| Parker, WB; Ross, LJ; Shannon, WM; White, EL | 1 |
| Carroll, SS; Geib, J; Kuo, LC; Olsen, DB; Shafer, JA; Stahlhut, M | 1 |
| Kraut, J; Kumar, A; Pelletier, H; Sawaya, MR; Wilson, SH | 1 |
| Boone, LR; Borroto-Esoda, K | 1 |
| Dobrynin, VN; Esipov, DS; Gudima, SO; Kochetkov, SN; Memelova, LV; Pokholok, DK; Rechinskiĭ, VO | 1 |
| Busso, M; Resnick, L | 1 |
| Bakhanashvili, M; Hizi, A | 1 |
| Artico, M; de Montis, A; la Colla, P; Loi, AG; Mai, A; Marongiu, ME; Massa, S; Tramontano, E | 1 |
| Beard, WA; Jaju, M; Wilson, SH | 1 |
| Modak, MJ; Yadav, JS; Yadav, PN | 1 |
| Chavan, SJ; Prochaska, HJ | 1 |
| Mitsuya, H; Shirasaka, T; Ueno, T | 1 |
| Clayton, DA; Eriksson, S; Xu, B | 1 |
| Dobrynin, VN; Gudima, SO; Kochetkov, SN; Pokholok, DK; Rechinsky, VO; Yesipov, DS | 1 |
| Baba, M; Inouye, N; Sadakata, Y; Sekiya, K; Takashima, H; Ubasawa, M; Yuasa, S | 1 |
| Balzarini, J; Eriksson, S; Törnevik, Y; Ullman, B; Wahren, B | 1 |
| Arts, EJ; Wainberg, MA | 1 |
| Allen, SJ; Chen, MS; Cherrington, JM; McKee, BH | 1 |
| Caruso, M; Goff, SP; Klatzmann, D; Lowy, I | 1 |
| Blackburn, EH; Strahl, C | 2 |
| Hall, ET; Kuchta, RD; Melançon, P; Yan, JP | 1 |
| Crouch, RC; Reardon, JE; St John-Williams, L | 1 |
| Avramis, VI; Gomperts, E; Kwock, R; Solorzano, MM | 1 |
| Lewis, W; Meyer, RR; Simpson, JF | 1 |
| Bridges, EG; LeBoeuf, RB; Sommadossi, JP; Weidner, DA | 1 |
| Furman, PA; Haire, SE; Martin, JL; Painter, GR; Ray, PH; Wilson, JE; Wright, LL | 1 |
| Arts, EJ; Gu, Z; Li, Z; Quan, Y; Wainberg, MA | 1 |
| Arts, EJ; Gu, Z; Le Grice, SF; Marois, JP; Wainberg, MA | 1 |
| Buc, H; Buckle, M; Negroni, M; Williams, RM | 1 |
| Cox, S; Palmer, S | 1 |
| Hathaway, TR; Kim, B; Loeb, LA | 1 |
| Gu, Z; Li, X; Parniak, MA; Quan, Y; Wainberg, MA | 1 |
| Jagannadh, B; Kunwar, AC; Reddy, DV | 1 |
| Arzumanov, AA; Dyatkina, NB; Krayevsky, AA; Semizarov, DG; Victorova, LS | 1 |
| Garry, RF; Hart, DJ; Luo, H | 1 |
| Akimov, SS; Chernov, DN; Egorov, EE | 1 |
| Driscoll, JS; Fridland, A; Hui, FK; Kavlick, MF; Mitsuya, H; Srinivas, RV; Tanaka, M; Ueno, T | 1 |
| Albengres, E; Allain, V; Chauvet-Monges, AM; Crevat, A; Elimadi, A; Morin, D; Tillement, JP | 1 |
| Cabodevilla, F; Martinez-Irujo, JJ; Santiago, E; Villahermosa, ML | 1 |
| Bloom, J; Ortiz, J; Rodríguez, JF | 1 |
| Acel, A; Faust, EA; Udashkin, BE; Wainberg, MA | 1 |
| Deville-Bonne, D; Janin, J; Sarfati, R; Schneider, B; Sellam, O; Veron, M; Xu, YW | 1 |
| Canard, B; Richardson, CC; Sarfati, SR | 1 |
| Amacker, M; Hübscher, U | 1 |
| Anderson, KS; Vaccaro, JA | 1 |
| Barile, M; Passarella, S; Quagliariello, E; Valenti, D | 1 |
| Beard, WA; Bebenek, K; Darden, TA; Kunkel, TA; Li, L; Prasad, R; Wilson, SH | 1 |
| Amacker, M; Faraj, A; Gosselin, G; Hübscher, U; Imbach, JL; Maga, G; Mathé, C; Sommadossi, JP; Spadari, S | 1 |
| Amacker, M; Hübscher, U; Tasara, T | 1 |
| Murakami, J; Nagai, N; Ohama, K; Shigemasa, K | 1 |
| Bardeguez, AD; Blanchard, S; Flynn, PM; Fridland, A; Jimenez, E; Robbins, B; Rodman, JH; Rodriguez, JF | 1 |
| Font, E; García, H; Rodriguez, JF; Rosario, O; Santana, J; Sommadossi, JP | 1 |
| Klarmann, GJ; North, TW; Preston, BD; Schinazi, RF; Smith, RA | 1 |
| Maga, G; Pregnolato, M; Salvetti, R; Spadari, S; Ubiali, D | 1 |
| Ehresmann, B; Ehresmann, C; Lanchy, JM; Le Grice, SF; Marquet, R; Rigourd, M | 1 |
| Boretto, J; Canard, B; Capony, JP; Lazaro, JB; Selmi, B | 1 |
| Adman, ET; Isaacs, SJ; Kim, B; Tran, NH; Weiss, KK | 1 |
| El Alaoui, AM; Faraj, A; Gosselin, G; Imbach, JL; Morrow, C; Sommadossi, JP | 1 |
| García, H; Rodriguez, JF; Rodriguez, JL; Rosario, O; Santana, J | 1 |
| Anderson, PL; Brundage, RC; Bushman, LR; Fletcher, CV; Kakuda, TN; Kawle, SP; Remmel, RP; Weller, D | 1 |
| Darque, A; Moore, JD; Sommadossi, JP; Valette, G; Zhou, XJ | 1 |
| Back, DJ; Barry, MG; Dann, L; Gibbons, SE; Hoggard, PG; Khoo, SH; Lloyd, J; Loveday, C; Wilkins, EG | 1 |
| Gosselin, G; Hübscher, U; Maga, G; Pregnolato, M; Spadari, S; Ubiali, D | 1 |
| Copeland, WC; Lim, SE | 1 |
| Baker, RC; Brady, MT; Hunkler, JA; McOwen, NM; Nahata, MC; Sobol, BJ; Wintermeyer, SM | 1 |
| Akeb, F; Creminon, C; Duval, D; Grassi, J; Guedj, R | 1 |
| Hertogs, K; Larder, BA; Lennerstrand, J; Stammers, DK | 1 |
| Duan, C; Kuritzkes, DR; McHenry, CS; Petropoulos, CJ; Poticha, D; Stoeckli, TC; Whitcomb, JM | 1 |
| Blomberg, J; Gronowitz, JS; Hjalmarsson, S; Källander, CF; Lennerstrand, J; Shao, XW; Svennerholm, B | 1 |
| Boretto, J; Canard, B; Deval, J; Egloff, MP; Guerreiro, C; Sarfati, S; Selmi, B | 1 |
| Becher, F; Benech, H; Brossette, T; Créminon, C; Goujard, C; Grassi, J; Guerreiro, C; Jorajuria, S; Lebeau, L; Nevers, MC; Pruvost, A; Schlemmer, D | 1 |
| Heneine, W; Merigan, T; Qari, SH; Vandamme, AM; Winters, M | 1 |
| Hurwitz, SJ; Schinazi, RF | 1 |
| Anderson, KS; Feng, JY; Furman, PA; Jeffrey, JL; Qi, CC | 1 |
| DeRose, EF; Kirby, TW; London, RE; Pitcher, WH | 1 |
| Akbay, A; Aki-Sener, E; Oren, I; Temiz-Arpaci, O; Yalçin, I | 1 |
| Arissawa, M; Felcman, J; Herrera, JO | 1 |
| Gronowitz, JS; Källander, CF; Lennerstrand, J; Malmsten, A; Shao, XW; Sönnerborg, A; Unge, T | 1 |
| Ishikawa, F; Saito, M; Saneyoshi, M; Takayama, Y; Yamaguchi, T | 1 |
| Andréola, M; Cruchaga, C; Dollé, V; Martínez-Irujo, JJ; Nguyen, CH; Odriozola, L; Pérez-Mediavilla, A; Tarrago-Litvak, L | 1 |
| Behforouz, M; Behforouz, NC; Briere, D; Cai, W; Jung, JY; Katen, KS; Lucas, JS; Stocksdale, MG; Wang, A | 1 |
| Beard, WA; Hou, EW; Prasad, R; Wilson, SH | 1 |
| de Groot, R; Fraaij, PL; Hartwig, NG; Hira, V; Luider, TM; van Kampen, JJ; van Rossum, AM | 1 |
| Hall, JM; Komarov, AM; Weglicki, WB | 1 |
| Cases-González, CE; Menéndez-Arias, L | 1 |
| Feuston, B; Getty, K; Hazuda, DJ; Krueger, J; Lewis, D; Miller, MD; Munshi, V; Parniak, MA; Shaw-Reid, CA | 1 |
| Andréola, M; Cruchaga, C; Martínez-Irujo, JJ; Odriozola, L; Tarrago-Litvak, L | 1 |
| Canard, B; Deval, J; Guerreiro, C; Matamoros, T; Menéndez-Arias, L; Mulard, L | 1 |
| Brooks, JL; Cook, PD; Fagan, P; Hurd, T; Prhavc, M; Rajwanshi, VK; Wang, G | 1 |
| Guo, D; Jamburuthugoda, VK; Kim, B; Wedekind, JE | 1 |
| Anderson, PL; Bushman, L; Delahunty, T; Fletcher, CV; King, T; Ray, M | 1 |
| Ansó, E; Cruchaga, C; Martínez-Irujo, JJ; Rouzaut, A | 1 |
| Acheampong, E; Argyris, EG; Dornadula, G; Mehlman, K; Nunnari, G; Pomerantz, RJ; Zhang, C; Zhang, H | 1 |
| Appel, M; Couvreur, P; Hillaireau, H; Le Doan, T | 1 |
| Chacun, H; Couvreur, P; Hillaireau, H; Janin, J; Le Doan, T | 1 |
| Vinogradov, SV | 1 |
| Benech, H; Compain, S; Durand-Gasselin, L; Grassi, J | 1 |
| Han, HY; Kohli, E; Vinogradov, SV; Zeman, AD | 1 |
| Anderson, PL; Bushman, LR; Fletcher, CV; Gerber, J; King, T; Meditz, A; Predhomme, J; Zheng, JH | 1 |
| Baba, M; Cheng, YC; Dutschman, GE; Grill, SP; Hu, R; Lam, W; Paintsil, E; Tanaka, H | 1 |
| Acosta, EP; Bassett, R; Eron, JJ; Fischl, MA; Johnson, VA; Kuritzkes, DR; Long, MC; Moore, JD; Sommadossi, JP | 1 |
| Frohn, A; Hartl, MJ; Kretzschmar, B; Nowrouzi, A; Rethwilm, A; Wöhrl, BM | 1 |
| Kore, AR; Krebs, JF | 1 |
| Bénech, H; Dehée, A; Dollfus, C; Durand-Gasselin, L; Garbarg-Chenon, A; Grassi, J; Leverger, G; Pruvost, A; Tabone, MD; Vaudre, G | 1 |
| Hsu, CH; Taylor, JM | 1 |
| Gandhi, NH; Nair, MP; Saiyed, ZM | 2 |
| Azoulay, S; Burger, A; Créminon, C; Duval, D; Golebiowski, J; Grassi, J; Nevers, MC; Roucairol, C | 1 |
| Arnold, E; Bauman, JD; Boyer, PL; Clark, AD; Das, K; Frenkel, YV; Gaffney, BL; Han, Q; Hou, X; Hughes, SH; Jones, RA; Sarafianos, SG; Tu, X | 1 |
| Marquet, R; Metzner, P; Schütte, C; von Kleist, M | 1 |
| Anderson, PL; Bushman, LR; Gardner, EM; Klein, B; Lichtenstein, K; Mawhinney, S; Meditz, A; Predhomme, J; Rower, JE; Zheng, JH | 1 |
| Didierlaurent, L; Ducloux, C; Goldschmidt, V; Isel, C; Marquet, R; Mougel, M | 1 |
| Chen, J; Flexner, C; Fuchs, EJ; Hendrix, CW; Liberman, RG; Louissaint, NA; Skipper, PL; Tannenbaum, SR | 1 |
| Agostoni, V; Anand, R; Baati, T; Bouchemal, K; Chacun, H; Chalati, T; Clayette, P; Couvreur, P; Gref, R; Hall, S; Horcajada, P; Martineau, C; Maurin, G; Monti, S; Rogez-Kreuz, C; Semiramoth, N; Serre, C; Taulelle, F; Willaime, H | 1 |
| Barreto-de-Souza, V; Frolova, S; Karpenko, I; Khandazhinskaya, A; Kochetkov, S; Margolis, L; Vanpouille, C; Zicari, S | 1 |
| Baiborodin, SI; Levina, AS; Li-Zhulanov, NS; Mazurkova, NA; Repkova, MN; Shatskaya, NV; Silnikov, VN; Vasilyeva, SV; Zarytova, VF | 1 |
| Gatanaga, H; Kato, S; Kikuchi, Y; Kinai, E; Oka, S | 1 |
| Bridges, AS; Cohen, MS; Dumond, JB; Fiscus, SA; Forrest, A; Kashuba, AD; Kendrick, R; Reddy, YS; Troiani, L; Yang, KH | 1 |
| Bhatnagar, S; Gupta, A; Mohanty, P | 1 |
| Bodem, J; Buchholz, B; Corona, A; Di Santo, R; Jordan, M; Maccioni, E; Schneider, A; Spöring, I; Tramontano, E; Wöhrl, BM | 1 |
| Gatanaga, H; Ha, do Q; Hosokawa, S; Kato, S; Kikuchi, Y; Kinai, E; Kinh, NV; Lam, NV; Liem, NT; Oka, S; Sadatsuki, M | 1 |
| Agostoni, V; Anand, R; Borghi, F; Gref, R; Marassi, V; Monti, S; Reschiglian, P; Roda, B; Zattoni, A | 1 |
| Ablaeva, J; Antoch, MP; Cohen, HY; De Cecco, M; Gladyshev, VN; Gonzalez, RS; Gorbunova, V; Gudkov, AV; Helfand, SL; Ke, Z; Kogan, V; Leonova, KI; Meer, MV; Neretti, N; Roichman, A; Sedivy, JM; Seluanov, A; Simon, M; Taguchi, T; Van Meter, M | 1 |
| Armijos Rivera, JI; Badia, R; Brambilla, A; Catalano, M; Cinquina, E; Coluccia, A; Crespan, E; Esté, JA; Falasca, F; La Regina, G; Limatola, C; Maga, G; Masci, D; Nalli, M; Riveira-Muñoz, E; Silvestri, R; Turriziani, O | 1 |
| Chien, M; Jockusch, S; Ju, J; Kalachikov, S; Kirchdoerfer, RN; Kumar, S; Li, X; Morozova, I; Russo, JJ; Tao, C | 1 |
3 review(s) available for zidovudine triphosphate and zidovudine
| Article | Year |
|---|---|
Inhibitors of HIV-1 reverse transcriptase and fidelity of in vitro DNA replication.
Topics: Dideoxynucleosides; Dideoxynucleotides; DNA Replication; HIV Reverse Transcriptase; HIV-1; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Virus Replication; Zidovudine | 1992 |
Mitochondria as cell targets of AZT (zidovudine).
Topics: Acquired Immunodeficiency Syndrome; Animals; Cells, Cultured; Dideoxynucleotides; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Humans; In Vitro Techniques; Mitochondria; Thymine Nucleotides; Zidovudine | 1998 |
Polymeric nanogel formulations of nucleoside analogs.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Dideoxynucleotides; Drug Delivery Systems; Humans; Nanogels; Nucleotides; Polyethylene Glycols; Polyethyleneimine; Thymine Nucleotides; Zidovudine | 2007 |
4 trial(s) available for zidovudine triphosphate and zidovudine
| Article | Year |
|---|---|
Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biotransformation; Dideoxynucleotides; HIV Infections; HIV Seronegativity; Humans; Leukocytes, Mononuclear; Middle Aged; Phosphorylation; Reference Values; Thymine Nucleotides; Zidovudine | 1994 |
Determination of zidovudine triphosphate intracellular concentrations in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals by tandem mass spectrometry.
Topics: Adult; Aged; Anti-HIV Agents; Calibration; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Female; HIV Infections; Humans; Male; Mass Spectrometry; Middle Aged; Monocytes; Nucleotides; Reference Standards; Thymine Nucleotides; Zidovudine | 1999 |
Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons.
Topics: Adolescent; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Cytidine Triphosphate; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Therapy, Combination; HIV; HIV Infections; Humans; Lamivudine; Leukocytes, Mononuclear; Middle Aged; Prospective Studies; Regression Analysis; Reverse Transcriptase Inhibitors; RNA, Viral; Thymine Nucleotides; Zidovudine | 2000 |
Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study.
Topics: Adenine; Adult; Anti-HIV Agents; Biological Availability; Carbon Radioisotopes; CD4-Positive T-Lymphocytes; Dideoxynucleotides; Female; Humans; Male; Mass Spectrometry; Middle Aged; Organophosphonates; Phosphorylation; Reverse Transcriptase Inhibitors; Tenofovir; Thymine Nucleotides; Zidovudine | 2012 |
168 other study(ies) available for zidovudine triphosphate and zidovudine
| Article | Year |
|---|---|
Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dideoxynucleotides; Drug Stability; HIV Infections; Humans; Intracellular Fluid; Leukocytes, Mononuclear; Phosphorylation; Radioimmunoassay; Reproducibility of Results; Sensitivity and Specificity; Thymine Nucleotides; Tritium; Zidovudine | 1992 |
Intracellular metabolism of 3'-azidothymidine in isolated human peripheral blood mononuclear cells.
Topics: Adult; Dideoxynucleotides; Female; Half-Life; HIV Infections; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Male; Middle Aged; Phosphorylation; Phytohemagglutinins; Thymine Nucleotides; Zidovudine | 1991 |
A sensitive nonisotopic method for the determination of intracellular azidothymidine 5'-mono-, 5'-di-, and 5'-triphosphate.
Topics: Acquired Immunodeficiency Syndrome; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Intracellular Fluid; Leukocytes, Mononuclear; Microchemistry; Phosphorylation; Thymine Nucleotides; Zidovudine | 1991 |
A method for the quantification of intracellular zidovudine nucleotides.
Topics: Alkaline Phosphatase; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Leukocytes, Mononuclear; Phosphorylation; Radioimmunoassay; Thymine Nucleotides; Zidovudine | 1991 |
Effects of granulocyte-macrophage colony-stimulating factor on 3'-azido-3'-deoxythymidine uptake, phosphorylation and nucleotide retention in human U-937 cells.
Topics: Biological Transport; Cell Division; Dideoxynucleotides; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Monocytes; Phosphorylation; Thioinosine; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine | 1990 |
Relationship of deoxynucleotide changes to inhibition of DNA synthesis induced by the antiretroviral agent 3'-azido-3'-deoxythymidine and release of its monophosphate by human lymphoid cells (CCRF-CEM).
Topics: Cell Division; Cell Line; Chromatography, High Pressure Liquid; Deoxyribonucleotides; Dideoxynucleotides; DNA Replication; Flow Cytometry; Kinetics; T-Lymphocytes; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine | 1990 |
3'-Azido-3'-deoxythymidine cytotoxicity and metabolism in the human colon tumor cell line HCT-8.
Topics: Cell Death; Colonic Neoplasms; Dideoxynucleotides; Humans; Thymidine Kinase; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine | 1994 |
Effects of 3'-azido-3'-deoxythymidine metabolites on simian virus 40 origin-dependent replication and heteroduplex repair in HeLa cell extracts.
Topics: Antiviral Agents; Dideoxynucleotides; DNA; DNA Repair; HeLa Cells; Humans; Simian virus 40; Thymine Nucleotides; Virus Replication; Zidovudine | 1993 |
The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites.
Topics: Adult; Antiviral Agents; Chromatography, High Pressure Liquid; Dideoxynucleotides; Dose-Response Relationship, Drug; HIV-1; Humans; Male; Phosphorylation; Radioimmunoassay; Thymine Nucleotides; Virus Replication; Zidovudine | 1996 |
The mechanism of phosphorylation of anti-HIV D4T by nucleoside diphosphate kinase.
Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; HIV Reverse Transcriptase; Humans; Kinetics; Nucleoside-Diphosphate Kinase; Phosphorylation; Stavudine; Thymine Nucleotides; Zidovudine | 2000 |
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
Topics: Antiviral Agents; Bone Marrow; Dideoxynucleosides; HIV; Stavudine; Thymidine; Zidovudine | 1989 |
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Catalysis; Cell Line; Dose-Response Relationship, Drug; Endogenous Retroviruses; HIV-1; Humans; Kidney; Molecular Sequence Data; Organophosphonates; Polymerase Chain Reaction; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Stavudine; Swine; Swine, Miniature; Tenofovir; Virus Replication; Zidovudine | 2007 |
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Topics: Anti-HIV Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Molecular Structure; Reverse Transcriptase Inhibitors | 2009 |
Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
Topics: Antiviral Agents; Cell Line; Glycosylation; Hepatitis B virus; HIV-1; Humans; Kinetics; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microwaves; Models, Molecular; Nucleosides; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Electrospray Ionization | 2011 |
Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.
Topics: Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; HIV; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Zidovudine | 2013 |
The observed inhibitory potency of 3'-azido-3'-deoxythymidine 5'-triphosphate for HIV-1 reverse transcriptase depends on the length of the poly(rA) region of the template.
Topics: Base Sequence; Binding, Competitive; Dideoxynucleotides; HIV Reverse Transcriptase; HIV-1; Kinetics; Molecular Sequence Data; Poly A; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1992 |
Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation.
Topics: Antiviral Agents; Base Sequence; Binding, Competitive; Dideoxynucleotides; HIV; Molecular Sequence Data; Oligonucleotide Probes; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thionucleotides; Thymine Nucleotides; Zidovudine | 1992 |
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.
Topics: Antiviral Agents; Benzodiazepines; Dideoxynucleotides; HIV-1; Imidazoles; Kinetics; Molecular Structure; Recombinant Proteins; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Templates, Genetic; Thymidine; Thymine Nucleotides; Uracil; Zidovudine | 1992 |
3'-Azido-3',5'-dideoxythymidine-5'-methylphosphonic acid diphosphate: synthesis and HIV-1 reverse transcriptase inhibition.
Topics: Antiviral Agents; Base Sequence; Dideoxynucleotides; HIV Reverse Transcriptase; HIV-1; Kinetics; Molecular Sequence Data; Molecular Structure; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1992 |
L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro.
Topics: Benzoxazoles; Cells, Cultured; Dideoxynucleotides; Dose-Response Relationship, Drug; HIV-1; Proteins; Pyridones; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 1992 |
In vitro selection of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine.
Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Dideoxynucleotides; DNA, Viral; Drug Resistance, Microbial; Genetic Variation; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Selection, Genetic; Thymine Nucleotides; Virus Replication; Zidovudine | 1992 |
Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA.
Topics: Antiviral Agents; Base Sequence; Deoxycytosine Nucleotides; Dideoxynucleotides; DNA; DNA Polymerase I; DNA Polymerase II; HIV; Humans; Kinetics; Molecular Sequence Data; Terminator Regions, Genetic; Thymine Nucleotides; Zidovudine | 1992 |
Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP.
Topics: Antiviral Agents; Bacteriophages; Chemical Phenomena; Chemistry; Dideoxynucleotides; DNA; DNA-Directed DNA Polymerase; HIV; Kinetics; Models, Molecular; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1990 |
Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases.
Topics: Antiviral Agents; Avian Myeloblastosis Virus; Base Sequence; Cell Line; Dideoxynucleotides; DNA Polymerase II; DNA Polymerase III; DNA-Directed DNA Polymerase; HIV; Humans; Molecular Sequence Data; Moloney murine leukemia virus; Nucleic Acid Synthesis Inhibitors; Oligonucleotide Probes; Reverse Transcriptase Inhibitors; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1990 |
Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate.
Topics: Antiviral Agents; Base Sequence; Dideoxynucleotides; DNA, Viral; HIV-1; Kinetics; Molecular Sequence Data; Plasmids; Protein Binding; Recombinant Proteins; Restriction Mapping; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Templates, Genetic; Thymine Nucleotides; Tritium; Zidovudine | 1990 |
Synergistic inhibition of human immunodeficiency virus replication in vitro by combinations of 3'-azido-3'-deoxythymidine and 3'-fluoro-3'-deoxythymidine.
Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; Dideoxynucleotides; Drug Synergism; HIV-1; Humans; In Vitro Techniques; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Virus Replication; Zidovudine | 1990 |
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RN
Topics: Antiviral Agents; Base Sequence; Deoxyguanine Nucleotides; Dideoxynucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; HIV-1; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Reverse Transcriptase Inhibitors; RNA; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1991 |
Mutational analysis of two conserved sequence motifs in HIV-1 reverse transcriptase.
Topics: Amino Acid Sequence; Dideoxynucleotides; DNA Mutational Analysis; Foscarnet; HIV-1; In Vitro Techniques; Kinetics; Molecular Sequence Data; Phosphonoacetic Acid; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine Nucleotides; Zidovudine | 1991 |
The characterization of EIAV reverse transcriptase and its inhibition by 5'-triphosphates of 2'-deoxyuridine analogs, PFA and PAA.
Topics: Antiviral Agents; Dideoxynucleotides; Foscarnet; HIV; Infectious Anemia Virus, Equine; Phosphonoacetic Acid; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1990 |
Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase.
Topics: Animals; Cattle; Chromatography, Liquid; Dideoxynucleotides; DNA Primase; DNA Replication; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Kinetics; Nucleic Acid Synthesis Inhibitors; Poly dA-dT; RNA Nucleotidyltransferases; Templates, Genetic; Thymine Nucleotides; Thymus Gland; Zidovudine | 1992 |
Mechanisms of inhibitions of DNA polymerase gamma by nucleotide analogues having anti-HIV activities.
Topics: Animals; Antiviral Agents; Cattle; Dideoxynucleotides; DNA Polymerase III; HIV; Male; Thymine Nucleotides; Zidovudine | 1991 |
The 5'-triphosphates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms.
Topics: Animals; Antiviral Agents; Base Sequence; Cattle; Dideoxynucleosides; Dideoxynucleotides; DNA Polymerase III; DNA, Single-Stranded; Electrophoresis, Polyacrylamide Gel; Male; Mitochondria; Molecular Sequence Data; Oligonucleotides; Testis; Thymine Nucleotides; Zidovudine | 1991 |
Mutants from V79 fibroblasts exhibiting hypersensitivity to aphidicolin and 3'-azido-3'-deoxythymidine.
Topics: Animals; Aphidicolin; Cell Division; Cell Line; Cell Survival; Cricetinae; Cricetulus; Deoxyribonucleotides; Dideoxynucleotides; Diterpenes; DNA Replication; DNA-Directed DNA Polymerase; Mutation; Temperature; Thymidine; Thymine Nucleotides; Zidovudine | 1991 |
Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Dideoxynucleotides; DNA Polymerase I; DNA Polymerase II; DNA Replication; HeLa Cells; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Thymine Nucleotides; Zidovudine | 1990 |
A swift and facile radiosynthesis of [alpha-32P]-3'-azido-3'-deoxythymidine 5'-triphosphate (AZT triphosphate).
Topics: Dideoxynucleotides; Isotope Labeling; Phosphorus Radioisotopes; Thymine Nucleotides; Zidovudine | 1990 |
Different patterns of inhibition of avian myeloblastosis virus reverse transcriptase activity by 3'-azido-3'-deoxythymidine 5'-triphosphate and its threo isomer.
Topics: Avian Leukosis Virus; Avian Myeloblastosis Virus; Binding, Competitive; Dideoxynucleotides; Isomerism; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Viral Proteins; Zidovudine | 1987 |
Inhibition of the reverse transcriptase from HIV by 3'-azido-3'-deoxythymidine triphosphate and its threo analogue.
Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Dideoxynucleotides; HIV; Humans; Kinetics; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1987 |
3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase.
Topics: Anti-Bacterial Agents; Autoradiography; Cells, Cultured; Dideoxynucleotides; Electrophoresis, Polyacrylamide Gel; HIV; Nucleic Acid Synthesis Inhibitors; Peptide Chain Termination, Translational; Reverse Transcriptase Inhibitors; Substrate Specificity; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1987 |
Conformation and sandwiching of bases by azido groups in the crystal structure of 3'-azido-3'-deoxy-thymidine (AZT), an antiviral agent that inhibits HIV reverse transcriptase.
Topics: Azides; Dideoxynucleotides; HIV; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 1988 |
Alpha, beta- and beta, gamma-methylene 5'-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine-5'-triphosphate. Correlation between affinity for reverse transcriptase, susceptibility to hydrolysis by phosphodiesterases and anti-retrovirus activity.
Topics: Antiviral Agents; Cell Division; Dideoxynucleotides; Hydrolysis; Phosphoric Diester Hydrolases; Retroviridae; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine Nucleotides; Zidovudine | 1988 |
Inhibition of reverse transcription in rat liver intracisternal A-particles by thymidine derivatives.
Topics: Animals; Dideoxynucleotides; DNA; Genes, Intracisternal A-Particle; Microsomes, Liver; Proto-Oncogenes; Rats; Rats, Inbred Strains; Retroviridae; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Templates, Genetic; Thymidine; Thymine Nucleotides; Zidovudine | 1989 |
Kinetics and inhibition of reverse transcriptase from human and simian immunodeficiency viruses.
Topics: Deoxyguanine Nucleotides; Dideoxynucleotides; HIV; Humans; Kinetics; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Thymine Nucleotides; Zidovudine | 1988 |
Reverse transcriptases from human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIVMAC) are susceptible to inhibition by foscarnet and 3'-azido-3'-deoxythymidine triphosphate.
Topics: Animals; Dideoxynucleotides; Foscarnet; HIV-1; HIV-2; Humans; Organophosphorus Compounds; Phosphonoacetic Acid; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Thymine Nucleotides; Zidovudine | 1988 |
Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Dideoxynucleotides; Drug Synergism; HIV-1; Organophosphonates; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thymine Nucleotides; Virus Replication; Zidovudine | 1989 |
Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type 1 reverse transcriptase and DNA polymerase gamma.
Topics: Dideoxynucleotides; DNA Polymerase III; DNA Primase; DNA, Viral; Electrophoresis, Polyacrylamide Gel; HIV-1; Kinetics; Nucleic Acid Synthesis Inhibitors; Nucleotides; Reverse Transcriptase Inhibitors; RNA Nucleotidyltransferases; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1989 |
Inhibition of hepatitis B virus DNA polymerase by 3'-azido-3'-deoxythymidine triphosphate but not by its threo analog.
Topics: Antiviral Agents; Carrier State; Dideoxynucleotides; Hepatitis B; Hepatitis B virus; Humans; Nucleic Acid Synthesis Inhibitors; Thymidine; Thymine Nucleotides; Zidovudine | 1987 |
Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance.
Topics: Amino Acids; Antiviral Agents; Binding Sites; Dideoxynucleotides; Diphosphates; Drug Resistance, Microbial; Foscarnet; HIV Reverse Transcriptase; HIV-1; Kinetics; Recombinant Proteins; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1993 |
Lack of synergy in the inhibition of HIV-1 reverse transcriptase by combinations of the 5'-triphosphates of various anti-HIV nucleoside analogs.
Topics: Antiviral Agents; Base Sequence; Deoxyadenine Nucleotides; Dideoxynucleosides; Dideoxynucleotides; DNA-Directed DNA Polymerase; DNA, Viral; Drug Synergism; HIV Reverse Transcriptase; Molecular Sequence Data; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 1993 |
Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate.
Topics: Antiviral Agents; Base Sequence; Dideoxynucleotides; Diphosphates; DNA Primers; HIV Reverse Transcriptase; HIV-1; Hydrolysis; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Substrate Specificity; Templates, Genetic; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine | 1994 |
Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP.
Topics: Animals; Base Sequence; Binding Sites; Crystallization; Crystallography, X-Ray; Deoxycytosine Nucleotides; Dideoxynucleotides; DNA; DNA Polymerase I; DNA Primers; DNA-Directed RNA Polymerases; HIV Reverse Transcriptase; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Rats; Recombinant Proteins; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Viral Proteins; Zidovudine | 1994 |
Development of a human immunodeficiency virus-1 in vitro DNA synthesis system to study reverse transcriptase inhibitors.
Topics: Dideoxynucleotides; DNA, Viral; HIV Reverse Transcriptase; HIV-1; Hydrogen-Ion Concentration; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Time Factors; Zidovudine | 1994 |
[Studies of the resistance of the human immunodeficiency virus to azidothymidine. I. Kinetic studies of the interaction between reverse transcriptase and a series of its mutant forms with substrates and azidothymidine-5'-trisphosphate].
Topics: Amino Acid Sequence; Base Sequence; Dideoxynucleotides; DNA, Viral; Drug Resistance, Microbial; Genes, pol; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Molecular Sequence Data; Point Mutation; RNA-Directed DNA Polymerase; RNA, Viral; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1994 |
Development of an assay that detects transcriptionally competent human immunodeficiency virus type one particles.
Topics: Antiviral Agents; Benzodiazepines; Dideoxynucleotides; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sensitivity and Specificity; Thymine Nucleotides; Zidovudine | 1994 |
Interaction of the reverse transcriptase of human immunodeficiency virus type 1 with DNA.
Topics: Antiviral Agents; Autoradiography; Base Sequence; Benzodiazepines; Binding, Competitive; Dideoxynucleotides; DNA-Binding Proteins; DNA, Viral; Electrophoresis, Polyacrylamide Gel; HIV Reverse Transcriptase; HIV-1; Imidazoles; Molecular Sequence Data; Oligodeoxyribonucleotides; Quinolones; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1994 |
Characterization of the anti-HIV-1 activity of 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), new non-nucleoside reverse transcriptase inhibitors.
Topics: Antiviral Agents; Cells, Cultured; Dideoxynucleotides; Drug Interactions; HIV Reverse Transcriptase; HIV-1; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Virus Replication; Zidovudine | 1994 |
Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer.
Topics: Antiviral Agents; Dideoxynucleotides; DNA Primers; HIV Reverse Transcriptase; HIV-1; Kinetics; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1995 |
Nucleoside drug resistance in HIV-1 reverse transcriptase.
Topics: Antiviral Agents; Binding Sites; Dideoxynucleotides; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Mutation; Nucleosides; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1995 |
Fluorometric measurement of reverse transcriptase activity with 4',6-diamidino-2-phenylindole.
Topics: Antiviral Agents; Dideoxynucleotides; Fluorescent Dyes; HIV Reverse Transcriptase; HIV-1; Indicators and Reagents; Indoles; Kinetics; Nevirapine; Phosphorus Radioisotopes; Pyrazines; Pyridines; Radioisotope Dilution Technique; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spectrometry, Fluorescence; Thiones; Thiophenes; Thymine Nucleotides; Zidovudine | 1995 |
Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates.
Topics: Antiviral Agents; Base Sequence; Binding Sites; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; Dideoxynucleotides; DNA Primers; DNA, Viral; Drug Resistance, Multiple; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1995 |
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase.
Topics: Antiviral Agents; Base Sequence; Deoxyribonucleotides; Dideoxynucleotides; DNA-Directed DNA Polymerase; HIV; Mitochondria; Molecular Sequence Data; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1995 |
Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.
Topics: Antiviral Agents; Dideoxynucleotides; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Mutagenesis, Site-Directed; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1993 |
Selective and synergistic inhibition of human immunodeficiency virus type 1 reverse transcriptase by a non-nucleoside inhibitor, MKC-442.
Topics: Antiviral Agents; Dideoxynucleotides; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Kinetics; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Uracil; Virus Replication; Zidovudine | 1993 |
Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T-lymph
Topics: Blotting, Northern; Cell Cycle; Cell Division; Cell Line, Transformed; Cell Survival; Dideoxynucleotides; Half-Life; HIV-1; HIV-2; Humans; T-Lymphocytes; Thymine Nucleotides; Virus Replication; Zidovudine | 1995 |
Preferential incorporation of nucleoside analogs after template switching during human immunodeficiency virus reverse transcription.
Topics: Antiviral Agents; Base Sequence; CD4-Positive T-Lymphocytes; Cell Line; Didanosine; Dideoxynucleotides; DNA, Viral; HIV-1; Humans; Molecular Sequence Data; Nucleosides; Polymerase Chain Reaction; RNA, Transfer, Lys; Templates, Genetic; Thymine Nucleotides; Transcription, Genetic; Zidovudine | 1994 |
Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gamma.
Topics: Antiviral Agents; Arabinofuranosyluracil; Cidofovir; Cytosine; Dideoxynucleotides; DNA Polymerase I; DNA Polymerase III; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Thymine Nucleotides; Zalcitabine; Zidovudine | 1994 |
Cellular thymidine kinase activity is required for the inhibition of HIV-1 replication by AZT in lymphocytes.
Topics: Dideoxynucleotides; Drug Resistance, Microbial; HIV-1; Lymphocytes; Thymidine Kinase; Thymine Nucleotides; Virus Replication; Zidovudine | 1994 |
The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena.
Topics: Animals; Arabinonucleotides; Base Sequence; Cell Survival; Deoxyguanine Nucleotides; Dideoxynucleotides; DNA Nucleotidylexotransferase; Guanosine Triphosphate; Molecular Sequence Data; Nucleotides; Telomere; Tetrahymena thermophila; Thymine Nucleotides; Zidovudine | 1994 |
3'-Azido-3'-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity.
Topics: Animals; CHO Cells; Cricetinae; Cytidine Monophosphate N-Acetylneuraminic Acid; Dideoxynucleotides; Glycosylation; Golgi Apparatus; HIV; HIV Infections; Humans; Intracellular Membranes; Kinetics; Membrane Proteins; Nucleoside Diphosphate Sugars; Protein Processing, Post-Translational; Thymine Nucleotides; Uridine Diphosphate Galactose; Uridine Diphosphate N-Acetylglucosamine; Zidovudine | 1994 |
Reduction of 3'-azido-3'-deoxythymidine (AZT) and AZT nucleotides by thiols. Kinetics and product identification.
Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Dideoxynucleotides; Hydrogen-Ion Concentration; Models, Chemical; Nucleotides; Oxidation-Reduction; Sulfhydryl Compounds; Thymine Nucleotides; Zidovudine | 1994 |
Evidence of in vitro development of drug resistance to azidothymidine in T-lymphocytic leukemia cell lines (Jurkat E6-1/AZT-100) and in pediatric patients with HIV-1 infection.
Topics: Adolescent; Adult; Antiviral Agents; Cell Division; Child; Child, Preschool; Clone Cells; Dideoxynucleotides; DNA, Neoplasm; Drug Resistance; Drug Resistance, Microbial; HIV Infections; HIV-1; Humans; Infant; Leukemia, T-Cell; T-Lymphocytes; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine | 1993 |
Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine.
Topics: Animals; Cattle; Dideoxynucleotides; DNA Polymerase III; Kinetics; Mitochondria, Heart; Phosphorylation; Thymine Nucleotides; Zidovudine | 1994 |
Influence of template primary structure on 3'-azido-3'-deoxythymidine triphosphate incorporation into DNA.
Topics: Antiviral Agents; Bacteriophage M13; Base Sequence; Dideoxynucleotides; DNA; DNA-Directed DNA Polymerase; DNA, Viral; Globins; Molecular Sequence Data; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1993 |
Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines.
Topics: Antiviral Agents; Arabinonucleosides; Cell Division; Cell Line; Dideoxynucleosides; Dideoxynucleotides; DNA; Drug Interactions; Foscarnet; Humans; Oligonucleotide Probes; Repetitive Sequences, Nucleic Acid; Reverse Transcriptase Inhibitors; Telomerase; Telomere; Thymine Nucleotides; Zidovudine | 1996 |
Recombinant human immunodeficiency virus type 1 reverse transcriptase is heterogeneous.
Topics: Antiviral Agents; Chromatography, Affinity; Chromatography, Gel; Dideoxynucleotides; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Escherichia coli; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Protein Conformation; Protein Denaturation; Recombinant Fusion Proteins; RNA-Directed DNA Polymerase; Spectrometry, Fluorescence; Thymine Nucleotides; Urea; Zidovudine | 1996 |
Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays.
Topics: Cell-Free System; Delavirdine; Deoxycytosine Nucleotides; Dideoxynucleotides; Drug Antagonism; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Indoles; Nevirapine; Piperazines; Pyridines; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1995 |
Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA.
Topics: Antiviral Agents; Base Sequence; Cells, Cultured; Didanosine; Dideoxynucleotides; DNA, Viral; HIV-1; Humans; Lamivudine; Molecular Sequence Data; Nucleic Acid Conformation; Nucleosides; Nucleotides; Phytohemagglutinins; RNA, Viral; Thymine Nucleotides; Transcription, Genetic; Zalcitabine; Zidovudine | 1996 |
Real time measurements of elongation by a reverse transcriptase using surface plasmon resonance.
Topics: Bacterial Proteins; Base Sequence; Biosensing Techniques; Biotin; Dideoxynucleotides; DNA; Molecular Sequence Data; Moloney murine leukemia virus; Nucleic Acid Heteroduplexes; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Streptavidin; Thymine Nucleotides; Zidovudine | 1996 |
Intracellular activation and cytotoxicity of three different combinations of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine.
Topics: Antiviral Agents; Cell Division; Cell Line; Didanosine; Dideoxynucleotides; Drug Interactions; Humans; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 1995 |
Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli.
Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Cloning, Molecular; Dideoxynucleotides; DNA Polymerase I; Escherichia coli; Genetic Complementation Test; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Point Mutation; Random Allocation; Recombinant Proteins; RNA-Directed DNA Polymerase; Selection, Genetic; Thymine Nucleotides; Zidovudine | 1996 |
Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively.
Topics: Animals; Antibodies, Monoclonal; Antiviral Agents; Delavirdine; Deoxycytosine Nucleotides; Dideoxynucleotides; DNA; HIV Antibodies; HIV Reverse Transcriptase; Humans; Indoles; Mice; Neutralization Tests; Nevirapine; Peptide Chain Elongation, Translational; Piperazines; Pyridines; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1996 |
NMR study of dideoxynucleotides with anti-human immunodeficiency virus (HIV) activity.
Topics: Antiviral Agents; Dideoxynucleotides; HIV; Humans; Inosine Triphosphate; Magnetic Resonance Spectroscopy; Models, Theoretical; Molecular Conformation; Molecular Structure; Thymine Nucleotides; Zidovudine | 1996 |
Gamma-phosphate-substituted 2'-deoxynucleoside 5'-triphosphates as substrates for DNA polymerases.
Topics: Animals; Antiviral Agents; Dideoxynucleotides; DNA-Directed DNA Polymerase; Drug Stability; Humans; Phosphates; Substrate Specificity; Thymine Nucleotides; Zidovudine | 1996 |
Biochemical characterization of the reverse transcriptase of a human intracisternal A-type particle (HIAP).
Topics: Antiviral Agents; Dideoxynucleotides; Genes, Intracisternal A-Particle; HIV Reverse Transcriptase; Humans; RNA-Directed DNA Polymerase; Sjogren's Syndrome; Thymine Nucleotides; Zidovudine | 1996 |
[Telomerase activity in murine cells during spontaneous transformation].
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Dideoxynucleotides; Embryo, Mammalian; Fibroblasts; Mice; Reverse Transcriptase Inhibitors; Telomerase; Thymine Nucleotides; Zidovudine | 1996 |
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine.
Topics: Animals; Anti-HIV Agents; COS Cells; Deoxyadenine Nucleotides; Dideoxyadenosine; Dideoxynucleotides; Drug Resistance, Microbial; Genes, pol; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 1997 |
Differential effects of zidovudine and zidovudine triphosphate on mitochondrial permeability transition and oxidative phosphorylation.
Topics: Adenosine Triphosphate; Animals; Antiviral Agents; Calcium; Dideoxynucleotides; Dose-Response Relationship, Drug; Male; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Phosphorylation; Rats; Rats, Wistar; Thymine Nucleotides; Zidovudine | 1997 |
Synergistic inhibition of HIV-1 reverse transcriptase by combinations of chain-terminating nucleotides.
Topics: Anti-HIV Agents; Binding Sites; Dideoxynucleotides; DNA Primers; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Drug Synergism; HIV Reverse Transcriptase; Oligodeoxyribonucleotides; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1997 |
Azidothymidine triphosphate determination using micellar electrokinetic capillary chromatography.
Topics: Anti-HIV Agents; Chromatography; Dideoxynucleotides; Electrophoresis, Capillary; Micelles; Thymine Nucleotides; Zidovudine | 1997 |
Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 integrase.
Topics: Animals; Antibodies, Monoclonal; Catalysis; Cattle; Dideoxynucleotides; DNA Primers; DNA Repair; DNA-Directed DNA Polymerase; HIV Integrase; HIV-1; Humans; Molecular Weight; Neutralization Tests; Sequence Deletion; Substrate Specificity; Templates, Genetic; Thymine Nucleotides; Time Factors; Zidovudine | 1998 |
Pre-steady state of reaction of nucleoside diphosphate kinase with anti-HIV nucleotides.
Topics: Animals; Anti-HIV Agents; Binding Sites; Deoxyribonucleotides; Dictyostelium; Dideoxynucleosides; Dideoxynucleotides; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nucleoside-Diphosphate Kinase; Phosphorylation; Structure-Activity Relationship; Thymine Nucleotides; Zidovudine | 1998 |
Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer.
Topics: Cross-Linking Reagents; Dideoxynucleotides; DNA Primers; Drug Resistance; Exodeoxyribonucleases; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine | 1998 |
Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases.
Topics: Antiviral Agents; Dideoxynucleotides; Dimerization; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Immunodeficiency Virus, Feline; Nevirapine; Protein Conformation; Recombinant Fusion Proteins; Reverse Transcriptase Inhibitors; Ribonuclease H; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 1998 |
Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3'-azido-3'-deoxythymidine (AZT) resistance.
Topics: Dideoxynucleotides; DNA Primers; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Peptide Chain Initiation, Translational; RNA; RNA, Transfer, Lys; Templates, Genetic; Thymine Nucleotides; Virus Replication; Zidovudine | 1998 |
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions.
Topics: Antiviral Agents; Catalytic Domain; Crystallography, X-Ray; Dideoxynucleotides; DNA; Frameshift Mutation; HIV Reverse Transcriptase; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Mutagenesis; Nucleic Acid Conformation; Protein Conformation; Thymine Nucleotides; Tryptophan; Zidovudine | 1998 |
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.
Topics: Anti-HIV Agents; Carbohydrates; Catalysis; Deoxycytosine Nucleotides; Deoxyribonucleosides; Dideoxynucleosides; Dideoxynucleotides; DNA; Drug Resistance, Microbial; HIV Reverse Transcriptase; Humans; Hydroxyl Radical; Isoleucine; Kinetics; Nevirapine; Recombinant Fusion Proteins; Reverse Transcriptase Inhibitors; Ribose; Templates, Genetic; Thymine Nucleotides; Tyrosine; Zidovudine | 1999 |
Intramolecular chimeras of the p51 subunit between HIV-1 and FIV reverse transcriptases suggest a stabilizing function for the p66 subunit in the heterodimeric enzyme.
Topics: Amino Acid Sequence; Animals; Cats; Dideoxynucleotides; Dimerization; DNA, Viral; Enzyme Activation; Enzyme Stability; Genetic Vectors; HIV Reverse Transcriptase; Humans; Immunodeficiency Virus, Feline; Molecular Sequence Data; Nevirapine; Peptide Fragments; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Reverse Transcriptase Inhibitors; Ribonuclease H; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine Nucleotides; Zidovudine | 1999 |
Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines.
Topics: Blotting, Southern; Cell Division; Cystadenocarcinoma; Didanosine; Dideoxynucleotides; Endometrial Neoplasms; Female; HIV Reverse Transcriptase; Humans; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Telomerase; Thymine Nucleotides; Tumor Cells, Cultured; Uterine Neoplasms; Zidovudine | 1999 |
Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants.
Topics: Adolescent; Adult; Anti-HIV Agents; Dideoxynucleotides; Female; Fetal Blood; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Phosphorylation; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 1999 |
Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.
Topics: Catalytic Domain; Cytidine Triphosphate; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Resistance; HIV Reverse Transcriptase; HIV-1; Lamivudine; Mutation; Proline; Reverse Transcriptase Inhibitors; Thionucleosides; Thiophenes; Thymine Nucleotides; Transcription, Genetic; Zalcitabine; Zidovudine | 2000 |
Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes.
Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Binding, Competitive; Catalytic Domain; Cyclopropanes; Dideoxynucleotides; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Oxazines; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 2000 |
Inhibition of the initiation of HIV-1 reverse transcription by 3'-azido-3'-deoxythymidine. Comparison with elongation.
Topics: Base Sequence; Dideoxynucleotides; Diphosphates; DNA Primers; HIV Reverse Transcriptase; HIV-1; Humans; Hydrolysis; Kinetics; Lymphocytes; Peptide Chain Elongation, Translational; Thymine Nucleotides; Transcription, Genetic; Zidovudine | 2000 |
Phosphorylation of AZT-resistant human immunodeficiency virus type 1 reverse transcriptase by casein kinase II in vitro: effects on inhibitor sensitivity.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Casein Kinase II; Consensus Sequence; Dideoxynucleotides; DNA; DNA Repair; Drug Resistance, Microbial; Enzyme Activation; Foscarnet; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Peptide Mapping; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Recombinant Proteins; Reverse Transcriptase Inhibitors; Substrate Specificity; Thymine Nucleotides; Zidovudine | 2000 |
Molecular architecture of the mutagenic active site of human immunodeficiency virus type 1 reverse transcriptase: roles of the beta 8-alpha E loop in fidelity, processivity, and substrate interactions.
Topics: Amino Acid Substitution; Anti-HIV Agents; Base Pair Mismatch; Binding Sites; Dideoxynucleotides; DNA Mutational Analysis; DNA Primers; Glutamine; Glycine; HIV Reverse Transcriptase; Humans; Lac Operon; Lysine; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Protein Structure, Secondary; RNA; Substrate Specificity; Templates, Genetic; Thymine Nucleotides; Tryptophan; Zidovudine | 2000 |
Effects of beta-L-3'-azido-3'-deoxythymidine 5'-triphosphate on host and viral DNA polymerases.
Topics: Anti-HIV Agents; Autoradiography; Dideoxynucleotides; DNA Polymerase beta; DNA Polymerase gamma; DNA Polymerase I; DNA-Directed DNA Polymerase; HIV Reverse Transcriptase; HIV-1; Humans; Point Mutation; Stereoisomerism; Thymine Nucleotides; Zidovudine | 2000 |
Simultaneous quantitation of intracellular zidovudine and lamivudine triphosphates in human immunodeficiency virus-infected individuals.
Topics: Anti-HIV Agents; Chromatography, Ion Exchange; Cytidine Triphosphate; Dideoxynucleotides; HIV Infections; Humans; Lamivudine; Reference Standards; Thymine Nucleotides; Zidovudine | 2000 |
Simultaneous quantitation of the 5'-triphosphate metabolites of zidovudine, lamivudine, and stavudine in peripheral mononuclear blood cells of HIV infected patients by high-performance liquid chromatography tandem mass spectrometry.
Topics: Anti-HIV Agents; Calibration; Chromatography, High Pressure Liquid; Cytidine Triphosphate; Dideoxynucleotides; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Mass Spectrometry; Monocytes; Reference Standards; Sensitivity and Specificity; Stavudine; Thymine Nucleotides; Zidovudine | 2000 |
Zidovudine phosphorylation determined sequentially over 12 months in human immunodeficiency virus-infected patients with or without previous exposure to antiretroviral agents.
Topics: Adult; Anti-HIV Agents; Dideoxynucleotides; Female; HIV; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Phosphorylation; Thymine Nucleotides; Zidovudine | 2001 |
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs.
Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Dideoxynucleotides; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Drug Synergism; HIV Reverse Transcriptase; Humans; Inhibitory Concentration 50; Mutation; Nevirapine; Oxazines; Reverse Transcriptase Inhibitors; Stereoisomerism; Thymine Nucleotides; Zidovudine | 2001 |
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.
Topics: Anti-HIV Agents; Cytidine Triphosphate; Deoxyguanine Nucleotides; Deoxyribonucleotides; Dideoxynucleotides; DNA; DNA Polymerase gamma; DNA Replication; DNA-Directed DNA Polymerase; Exodeoxyribonucleases; Humans; Kinetics; Lamivudine; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; Stavudine; Substrate Specificity; Thymine Nucleotides; Zalcitabine; Zidovudine | 2001 |
Phosphorylated zidovudine concentrations in mononuclear cells in pediatric patients with human immunodeficiency virus infections.
Topics: Adolescent; Anti-HIV Agents; Biological Availability; Child; Child, Preschool; Dideoxynucleotides; Dose-Response Relationship, Drug; Female; HIV Infections; Humans; Male; Monocytes; Phosphorylation; Thymine Nucleotides; Treatment Outcome; Zidovudine | 1997 |
The production and evaluation of antibodies for enzyme immunoassay of AZTTP.
Topics: Acetylcholinesterase; Animals; Anti-HIV Agents; Antibodies; Calibration; Dideoxynucleotides; Enzyme-Linked Immunosorbent Assay; Hemocyanins; Molecular Structure; Rabbits; Sensitivity and Specificity; Thymine Nucleotides; Zidovudine | 2001 |
Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants.
Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; Drug Resistance, Microbial; Guanosine Triphosphate; HIV Reverse Transcriptase; HIV-1; Mutagenesis, Site-Directed; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 2001 |
Inhibition of purified recombinant reverse transcriptase from wild-type and zidovudine-resistant clinical isolates of human immunodeficiency virus type 1 by zidovudine, stavudine, and lamivudine triphosphates.
Topics: Anti-HIV Agents; Cytidine Triphosphate; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Escherichia coli; HIV Infections; HIV-1; Lamivudine; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Stavudine; Thymine Nucleotides; Transfection; Zidovudine | 2001 |
Application of a colorimetric chain-termination assay for characterization of reverse transcriptase from 3'-azido-2',3'-deoxythymidine-resistant HIV isolates.
Topics: Anti-HIV Agents; Cells, Cultured; Colorimetry; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Resistance, Viral; Enzyme-Linked Immunosorbent Assay; HIV-1; Humans; Leukocytes, Mononuclear; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 2002 |
The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues.
Topics: Anti-HIV Agents; Deoxyadenine Nucleotides; Dideoxynucleotides; Drug Resistance, Multiple; HIV Reverse Transcriptase; Models, Molecular; Mutation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 2002 |
Development of a direct assay for measuring intracellular AZT triphosphate in humans peripheral blood mononuclear cells.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Immunoenzyme Techniques; Leukocytes, Mononuclear; Mass Spectrometry; Reproducibility of Results; Thymine Nucleotides; Zidovudine | 2002 |
A rapid phenotypic assay for detecting multiple nucleoside analogue reverse transcriptase inhibitor-resistant HIV-1 in plasma.
Topics: Adenosine Monophosphate; Dideoxynucleotides; Drug Evaluation, Preclinical; Drug Resistance, Multiple, Viral; HIV Infections; HIV-1; Humans; Mutation; Phenotype; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 2002 |
Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Cytidine Triphosphate; Dideoxynucleotides; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Models, Statistical; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Viral Load; Zidovudine | 2002 |
Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses.
Topics: Acquired Immunodeficiency Syndrome; Cytidine Triphosphate; Deoxycytidine Monophosphate; Deoxyguanine Nucleotides; Dideoxynucleotides; Dioxolanes; DNA, Viral; Drug Resistance, Viral; Guanosine; Guanosine Triphosphate; HIV Reverse Transcriptase; HIV-1; Lamivudine; Mutation; Reverse Transcriptase Inhibitors; Substrate Specificity; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine | 2003 |
Metabolic transformation of AZTp4A by Ap4A hydrolase regenerates AZT triphosphate.
Topics: Acid Anhydride Hydrolases; Biotransformation; Dideoxynucleotides; HIV Reverse Transcriptase; Humans; Kinetics; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Thymine Nucleotides; Zidovudine | 2003 |
Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives.
Topics: Benzimidazoles; Benzoxazoles; Dideoxynucleotides; HIV Reverse Transcriptase; Indicators and Reagents; Magnetic Resonance Spectroscopy; Pyridines; Reverse Transcriptase Inhibitors; Spectrophotometry, Infrared; Thiazoles; Thymidine; Thymine Nucleotides; Zidovudine | 2003 |
Theoretical investigation of the triphosphate forms of azidothymidine and thymidine.
Topics: Dideoxynucleotides; Models, Theoretical; Stereoisomerism; Thymine Nucleotides; Zidovudine | 2003 |
Use of HIV-1 reverse transcriptase recovered from human plasma for phenotypic drug susceptibility testing.
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleotides; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Reproducibility of Results; Stavudine; Thymine Nucleotides; Virion; Zidovudine | 2003 |
Telomerase-inhibitory effects of the triphosphate derivatives of some biologically active nucleosides.
Topics: Acyclovir; Dideoxynucleotides; HeLa Cells; Humans; Nucleosides; Reverse Transcriptase Inhibitors; Telomerase; Thymine Nucleotides; Zidovudine | 2001 |
Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate.
Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; Diphosphates; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; HIV Reverse Transcriptase; Humans; Mutation, Missense; Nevirapine; Phosphorylation; Protein Subunits; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 2003 |
Novel lavendamycin analogues as potent HIV-reverse transcriptase inhibitors: synthesis and evaluation of anti-reverse transcriptase activity of amide and ester analogues of lavendamycin.
Topics: Amides; Animals; Cells, Cultured; Dideoxynucleotides; Drug Synergism; Esters; HIV Reverse Transcriptase; Humans; Mice; Reverse Transcriptase Inhibitors; Streptonigrin; Structure-Activity Relationship; Thymine Nucleotides; Zidovudine | 2003 |
High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase.
Topics: Anti-HIV Agents; Chromatography, Affinity; Chromatography, Gel; Dideoxynucleotides; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; Genetic Vectors; Histidine; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Molecular Weight; Protein Engineering; Protein Subunits; Recombinant Fusion Proteins; Recombinant Proteins; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thymine Nucleotides; Zidovudine | 2004 |
A new method for analysis of AZT-triphosphate and nucleotide-triphosphates.
Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; Guanosine Triphosphate; Humans; Leukocytes, Mononuclear; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thymine Nucleotides; Zidovudine | 2004 |
Azidothymidine promotes free radical generation by activated macrophages and hydrogen peroxide-iron-mediated oxidation in a cell-free system.
Topics: Animals; Anti-HIV Agents; Cell-Free System; Dideoxynucleotides; Free Radicals; Hydrogen Peroxide; Iron; Macrophage Activation; Macrophages, Peritoneal; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Respiratory Burst; Thymine Nucleotides; Zidovudine | 2004 |
Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114.
Topics: Alanine; Amino Acid Substitution; Dideoxynucleosides; Dideoxynucleotides; Dinucleoside Phosphates; DNA; DNA, Viral; HIV Reverse Transcriptase; Mutagenesis, Site-Directed; Mutation; Nucleotides; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine | 2005 |
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.
Topics: Anti-HIV Agents; Binding Sites; Butyrates; Catalysis; Dideoxynucleotides; DNA-Directed DNA Polymerase; Drug Combinations; Drug Synergism; Foscarnet; HIV Reverse Transcriptase; Hydrolysis; Kinetics; Nucleic Acid Synthesis Inhibitors; Oxazines; Reverse Transcriptase Inhibitors; Ribonuclease H; Thiophenes; Thymine Nucleotides; Zidovudine | 2005 |
Inhibition of phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3'-azido-3'-deoxythymidine with nonnucleoside inhibitors.
Topics: Alkynes; Benzoxazines; Binding Sites; Catalysis; Cyclopropanes; Dideoxynucleotides; DNA Primers; Drug Combinations; Drug Synergism; Enzyme Stability; HIV Reverse Transcriptase; Nevirapine; Oxazines; Phosphoric Acids; Pyridones; Reverse Transcriptase Inhibitors; Templates, Genetic; Thymine Nucleotides; Zidovudine | 2005 |
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues.
Topics: Adenosine Triphosphate; Boron Compounds; Dideoxynucleotides; Drug Resistance, Multiple, Viral; HIV-1; Humans; Kinetics; Mutation; Phosphorylation; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine | 2005 |
Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors.
Topics: Dideoxynucleotides; HIV Reverse Transcriptase; Molecular Mimicry; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymidine; Thymine Nucleotides; Zidovudine | 2005 |
Kinetic evidence for interaction of human immunodeficiency virus type 1 reverse transcriptase with the 3'-OH of the incoming dTTP substrate.
Topics: Acyclovir; Amino Acid Substitution; Asparagine; Dideoxynucleotides; Glutamine; HIV Reverse Transcriptase; Hydroxyl Radical; Isoleucine; Kinetics; Models, Molecular; Protein Binding; Substrate Specificity; Thymine Nucleotides; Valine; Zidovudine | 2005 |
Quantitation of zidovudine triphosphate concentrations from human peripheral blood mononuclear cells by anion exchange solid phase extraction and liquid chromatography-tandem mass spectroscopy; an indirect quantitation methodology.
Topics: Chemical Fractionation; Chromatography, Liquid; Dideoxynucleotides; Drug Stability; Enzyme-Linked Immunosorbent Assay; HIV Infections; Humans; Ion Exchange; Leukocytes, Mononuclear; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Thymine Nucleotides; Zidovudine | 2006 |
Selective excision of chain-terminating nucleotides by HIV-1 reverse transcriptase with phosphonoformate as substrate.
Topics: Antiviral Agents; Binding Sites; Catalysis; Dideoxynucleotides; Foscarnet; HIV Reverse Transcriptase; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 2006 |
Inhibition of endogenous reverse transcription of human and nonhuman primate lentiviruses: potential for development of lentivirucides.
Topics: Antiviral Agents; Cells, Cultured; Dideoxynucleotides; Disease Transmission, Infectious; HIV-1; Humans; Lentivirus Infections; Nevirapine; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; T-Lymphocytes; Thymine Nucleotides; Transcription, Genetic; Zidovudine | 2006 |
Hybrid polymer nanocapsules enhance in vitro delivery of azidothymidine-triphosphate to macrophages.
Topics: Animals; Cell Line; Dideoxynucleotides; Drug Carriers; Drug Compounding; Macrophages; Mice; Microscopy, Electron, Transmission; Nanocapsules; Particle Size; Polymers; Reverse Transcriptase Inhibitors; Solubility; Surface Properties; Thymine Nucleotides; Zidovudine | 2006 |
Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.
Topics: Cations; Chitosan; Cidofovir; Cyanoacrylates; Cytosine; Dideoxynucleotides; Drug Carriers; Enbucrilate; Materials Testing; Nanocapsules; Nucleotides; Oligonucleotides; Organophosphonates; Permeability; Polyethyleneimine; Polymers; Solubility; Thymine Nucleotides; Water; Zidovudine | 2007 |
Improved method to quantify intracellular zidovudine mono- and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Leukocytes, Mononuclear; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Thymine Nucleotides; Zidovudine | 2007 |
Formulations of biodegradable Nanogel carriers with 5'-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity.
Topics: Adenosine Triphosphate; Animals; Antiviral Agents; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Survival; Dideoxynucleotides; Dogs; Dose-Response Relationship, Drug; Drug Carriers; Female; Fluorescent Dyes; Formazans; Humans; Influenza A virus; Inhibitory Concentration 50; Kidney; L-Lactate Dehydrogenase; Luminescent Measurements; Membrane Potentials; Mitochondria; Nanogels; Nanotechnology; Polyethylene Glycols; Polyethyleneimine; Rhodamines; Ribavirin; Sensitivity and Specificity; Tetrazolium Salts; Thymine Nucleotides; Zidovudine | 2007 |
Concentrations of zidovudine- and lamivudine-triphosphate according to cell type in HIV-seronegative adults.
Topics: Adult; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cytidine Triphosphate; Dideoxynucleotides; Drug Administration Schedule; Female; HIV Seronegativity; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Phosphorylation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine | 2007 |
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.
Topics: Anti-HIV Agents; Cell Line; Dideoxynucleotides; Dose-Response Relationship, Drug; HeLa Cells; HIV; Humans; Phosphorylation; Reverse Transcriptase Inhibitors; Stavudine; Thymine Nucleotides; Virus Replication; Zidovudine | 2007 |
Intracellular nucleoside triphosphate concentrations in HIV-infected patients on dual nucleoside reverse transcriptase inhibitor therapy.
Topics: Anti-HIV Agents; Cytidine Triphosphate; Dideoxynucleotides; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Reverse Transcriptase Inhibitors; Stavudine; Thymine Nucleotides; Zidovudine | 2007 |
AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Dideoxynucleotides; DNA; Drug Resistance, Viral; Escherichia coli; Kinetics; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA; RNA-Directed DNA Polymerase; Sequence Alignment; Spumavirus; Thymine Nucleotides; Zidovudine | 2008 |
Novel FRET-based assay to detect reverse transcriptase activity using modified dUTP analogues.
Topics: Animals; Avian Myeloblastosis Virus; Deoxyuracil Nucleotides; Dideoxynucleotides; Enzyme Stability; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; HIV-1; Hot Temperature; Humans; Mice; Moloney murine leukemia virus; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine | 2008 |
High levels of zidovudine (AZT) and its intracellular phosphate metabolites in AZT- and AZT-lamivudine-treated newborns of human immunodeficiency virus-infected mothers.
Topics: Anti-HIV Agents; Dideoxynucleotides; Female; Follow-Up Studies; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Leukocytes, Mononuclear; Male; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Thymine Nucleotides; Zidovudine | 2008 |
Nonparametric comparison of two survival functions with dependent censoring via nonparametric multiple imputation.
Topics: Anti-HIV Agents; Clinical Trials as Topic; Data Interpretation, Statistical; Dideoxynucleotides; HIV Infections; Humans; Placebos; Statistics, Nonparametric; Survival Analysis; Thymine Nucleotides; Zidovudine | 2009 |
AZT 5'-triphosphate nanoformulation suppresses human immunodeficiency virus type 1 replication in peripheral blood mononuclear cells.
Topics: Anti-HIV Agents; Blood-Brain Barrier; Cells, Cultured; Dideoxynucleotides; Drug Carriers; Drug Compounding; Electromagnetic Fields; Ferrosoferric Oxide; Humans; Leukocytes, Mononuclear; Nanomedicine; Thymine Nucleotides; Virus Replication; Zidovudine | 2009 |
Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies.
Topics: Animals; Antibody Formation; Dideoxynucleotides; Drug Design; Polyphosphates; Rabbits; Thymine Nucleotides; Zidovudine | 2010 |
Magnetic nanoformulation of azidothymidine 5'-triphosphate for targeted delivery across the blood-brain barrier.
Topics: Antiviral Agents; Blood-Brain Barrier; Cells, Cultured; Dideoxynucleotides; Diffusion; Drug Carriers; Drug Compounding; Electromagnetic Fields; Humans; Materials Testing; Nanomedicine; Nanostructures; Thymine Nucleotides; Zidovudine | 2010 |
Structural basis of HIV-1 resistance to AZT by excision.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Binding Sites; Crystallography, X-Ray; Deoxyribonucleotides; Dideoxynucleotides; DNA, Viral; Drug Design; Drug Resistance, Viral; Genes, rev; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Mutation, Missense; Point Mutation; Protein Conformation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine Nucleotides; Zidovudine | 2010 |
HIV-1 polymerase inhibition by nucleoside analogs: cellular- and kinetic parameters of efficacy, susceptibility and resistance selection.
Topics: Anti-HIV Agents; Base Sequence; Dideoxynucleotides; DNA, Viral; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Nucleosides; pol Gene Products, Human Immunodeficiency Virus; Reverse Transcriptase Inhibitors; RNA, Viral; Thymine Nucleotides; Zidovudine | 2012 |
Effect of HIV-1 infection and sex on the cellular pharmacology of the antiretroviral drugs zidovudine and lamivudine.
Topics: Adult; Anti-HIV Agents; Black or African American; Cytidine Triphosphate; Dideoxynucleotides; Female; HIV Infections; Humans; Lamivudine; Longitudinal Studies; Male; Prospective Studies; Sex Factors; Thymine Nucleotides; Zidovudine | 2012 |
A pyrophosphatase activity associated with purified HIV-1 particles.
Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; Diphosphates; DNA, Viral; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Kinetics; Mutation; Pyrophosphatases; Stavudine; Substrate Specificity; Thymine Nucleotides; Virion; Zidovudine | 2012 |
Towards an improved anti-HIV activity of NRTI via metal-organic frameworks nanoparticles.
Topics: Anti-Retroviral Agents; Cells, Cultured; Dideoxynucleotides; Ferric Compounds; HIV-1; Humans; Leukocytes, Mononuclear; Nanocomposites; Thymine Nucleotides; Zidovudine | 2013 |
A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.
Topics: Anti-HIV Agents; Dideoxynucleotides; Drug Evaluation, Preclinical; HIV Infections; HIV-1; Humans; In Vitro Techniques; Lamivudine; Palatine Tonsil; Thymine Nucleotides; Virus Replication; Zidovudine | 2014 |
SiO₂ nanoparticles as platform for delivery of 3'-triazole analogues of AZT-triphosphate into cells.
Topics: Animals; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Click Chemistry; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Delivery Systems; Microbial Sensitivity Tests; Molecular Structure; Nanoparticles; Silicon Dioxide; Simplexvirus; Structure-Activity Relationship; Thymine Nucleotides; Triazoles; Variola virus; Vero Cells; Zidovudine | 2015 |
Ultrasensitive method to quantify intracellular zidovudine mono-, di- and triphosphate concentrations in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry.
Topics: Aged; Chromatography, High Pressure Liquid; Dideoxynucleotides; Female; Humans; Leukocytes, Mononuclear; Limit of Detection; Male; Middle Aged; Reproducibility of Results; Tandem Mass Spectrometry; Thymine Nucleotides; Zidovudine | 2015 |
Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells.
Topics: Adult; Anti-HIV Agents; Biological Availability; Biological Transport; Blood Cells; Computer Simulation; Cytidine Triphosphate; Dideoxynucleotides; HIV Infections; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Models, Statistical; Semen; Thymine Nucleotides; Time Factors; Zidovudine | 2015 |
Modeling of Plasmodium falciparum Telomerase Reverse Transcriptase Ternary Complex: Repurposing of Nucleoside Analog Inhibitors.
Topics: Amino Acid Sequence; Antimalarials; Antimetabolites; Deoxyguanine Nucleotides; Dideoxynucleotides; Drug Repositioning; Humans; Magnesium; Models, Molecular; Molecular Docking Simulation; Molecular Sequence Data; Nucleosides; Plasmodium falciparum; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telomerase; Thymine Nucleotides; Vidarabine; Zidovudine | 2015 |
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
Topics: Amino Acid Sequence; Amino Acid Substitution; Anti-HIV Agents; Cloning, Molecular; Dideoxynucleotides; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Escherichia coli; Gene Expression; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Recombinant Proteins; Ribonuclease H, Human Immunodeficiency Virus; Thymine Nucleotides; Zidovudine | 2016 |
High Plasma Concentrations of Zidovudine (AZT) Do Not Parallel Intracellular Concentrations of AZT-Triphosphates in Infants During Prevention of Mother-to-Child HIV-1 Transmission.
Topics: Adult; Anti-HIV Agents; Chromatography, High Pressure Liquid; Dideoxynucleotides; Female; HIV Infections; HIV-1; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Longitudinal Studies; Male; Mothers; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Thymine Nucleotides; Treatment Outcome; Young Adult; Zidovudine | 2016 |
Flow field-flow fractionation and multi-angle light scattering as a powerful tool for the characterization and stability evaluation of drug-loaded metal-organic framework nanoparticles.
Topics: Anti-HIV Agents; Antimetabolites; Coordination Complexes; Dideoxynucleotides; Drug Carriers; Dynamic Light Scattering; Fractionation, Field Flow; Metal-Organic Frameworks; Models, Molecular; Nanoparticles; Particle Size; Refractometry; Spectrophotometry, Ultraviolet; Thymine Nucleotides; Zidovudine | 2018 |
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.
Topics: Age Factors; Animals; Dideoxynucleotides; Female; Inflammation; Male; Mice; Mice, Inbred Strains; Mice, Knockout; RNA-Binding Proteins; Sirtuins; Stavudine; Thymine Nucleotides; Zidovudine | 2019 |
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains.
Topics: Anti-HIV Agents; Cell Line, Tumor; Drug Design; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Indoles; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Mutation; Protein Binding; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfones; Zidovudine | 2020 |
Nucleotide analogues as inhibitors of SARS-CoV Polymerase.
Topics: Antiviral Agents; Betacoronavirus; Carbamates; Coronavirus Infections; COVID-19; Dideoxynucleotides; Drug Combinations; Heterocyclic Compounds, 4 or More Rings; Humans; Pandemics; Pneumonia, Viral; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sofosbuvir; Thymine Nucleotides; Zidovudine | 2020 |