Page last updated: 2024-08-23

zidovudine and thymidine

zidovudine has been researched along with thymidine in 374 studies

Research

Studies (374)

TimeframeStudies, this research(%)All Research%
pre-1990222 (59.36)18.7374
1990's60 (16.04)18.2507
2000's64 (17.11)29.6817
2010's27 (7.22)24.3611
2020's1 (0.27)2.80

Authors

AuthorsStudies
Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E1
Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H1
Alvarez, R; Balzarini, J; Camarasa, MJ; De Clercq, E; Jimeno, ML; San-Félix, A; Velázquez, S1
Knaus, EE; Kumar, R; Wang, L; Wiebe, LI1
Busson, R; De Keukeleire, D; Dugué, L; Froeyen, M; Herdewijn, P; Heyerick, A; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Vanheusden, V1
Herdewijn, P; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Van Rompaey, P; Vanheusden, V1
Al-Madhoun, AS; Barth, RF; Byun, Y; Eriksson, S; Johnsamuel, J; Tjarks, W; Yan, J; Yang, W1
Björck, L; Clausen, AR; Piskur, J; Sandrini, MP; Shannon, O1
Li, Y; Liotta, DC; Liu, L; Lutz, S; Soni, PB; Zhang, X1
Agrofoglio, LA; Coats, SJ; Deville-Bonne, D; Eriksson, S; Lin, J; McBrayer, TR; Roy, V; Schinazi, RF; Wang, L; You, L1
Barr, P; Lewin, CS; Shepherd, AJ1
Arnér, ES; Eriksson, S; Spasokoukotskaja, T1
Baba, M; De Clercq, E; Debyser, Z; Desmyter, J; Pauwels, R1
Carson, DA; Hostetler, KY; Richman, DD; Stuhmiller, LM; van den Bosch, H; van Wijk, GM1
Albert, J; Cox, SW; Uhlén, M; Wahlberg, J; Wahren, B1
Bakhmedova, AA; Iartseva, IV; Iurkevich, AM; Mel'nik, SIa; Volosiuk, TP; Zhukova, OS1
Domin, BA; Hajian, G; Koszalka, GW; Mahony, WB; Porter, DJ; Zimmerman, TP1
Taniki, T; Weber, G; Zhen, YS1
Arnér, ES; Eriksson, S; Valentin, A1
Mitra, AK; Park, GB1
Ayisi, NK; Gupta, SV; Qualtiere, LF1
Bull, CO; Landry, ML; Milstone, LM; Reuveni, H; Schwartz, PM1
Kinkade, P; Leung, LK; Wu, JM1
Chen, MS; Prisbe, EJ; Suttmann, RT; Wu, JC1
Beabealash-villi, RS; Chidgeavadze, ZG; Yuzhakov, AA1
Agarwal, RP; Mian, AM1
Liu, PK; Norwood, TH1
Amyes, SG; Lewin, CS1
Hung, K; Patel, SS; Szebeni, J; Wahl, LM; Weinstein, JN1
Ahmed, AE; Jacob, S; Loh, JP; Nokta, M; Pollard, RB; Samra, SK1
Nagai, M; Nakamura, H; Olah, E; Prajda, N; Szekeres, T; Weber, G1
Allen, RA; Amyes, SG; Lewin, CS1
Eriksson, S; Törnevik, Y1
Herbert, V; Herzlich, BC; Nawabi, I; Ranginwala, M1
Ichikawa, S; Nagai, M; Natsumeda, Y; Weber, G1
Betageri, GV; Corcoran, M; Hung, K; Patel, SS; Szebeni, J; Wahl, LM; Weinstein, JN1
Barry, DW; Bolognesi, D; Broder, S; Furman, PA; Gallo, RC; Lehrman, SN; Mitsuya, H; St Clair, MH; Weinhold, KJ1
Bean, B1
De Clercq, E1
Bolognesi, DP; Broder, S; Freeman, GA; Furman, PA; Fyfe, JA; Lehrman, SN; Mitsuya, H; Rideout, JL; St Clair, MH; Weinhold, K1
Hirsch, MS; Schooley, RT; Vogt, M1
Harada, S; Kobayashi, N; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N1
Chou, TC; Coleman, LA; Crumpacker, C; Furman, PA; Fyfe, JA; Hartshorn, KL; Hirsch, MS; Schooley, RT; Vogt, MW1
Broder, S; Chabner, BA; DeVita, VT; Fauci, AS; Kovacs, JA1
Hirsch, MS; Kaplan, JC2
Kuno, S; Ueno, R2
Beveridge, A; Herzyk, P; Neidle, S1
Furman, P; Fyfe, JA; Olsen, JC; Swanstrom, R1
Pedersen, C1
Berenbaum, MC1
Lin, TS; Prusoff, WH; Schinazi, RF1
Gillis, JM; Hammer, SM1
Brian, EL; Pagano, JS; Smith, MS1
Camerman, A; Camerman, N; Mastropaolo, D1
Pomerantz, RJ; Schooley, RT1
Bibilashvili, RSh; Kavsan, VM; Kraevskiĭ, AA; Rudenko, NK; Shneĭder, MA1
Bryson, YJ1
Broder, S; Kuno, S; Looney, DJ; Mitsuya, H; Ueno, R; Wong-Staal, F1
Broder, S; Mitsuya, H; Webb, TR1
Bird, AG; Matthes, J; Walker, LA; Watson, JG1
Lietman, PS1
Clumeck, N; Hermans, P1
Krayevsky, AA; Kukhanova, MM; Kuzminova, EA; Pyrinova, GB; Salganik, RI1
August, EM; Brankovan, V; Ghazzouli, I; Hitchcock, MJ; Lin, TS; Mansuri, MM; Prusoff, WH; Sommadossi, JP; Starrett, JE; Sterzycki, RZ1
Balzarini, J; De Clercq, E; Herdewijn, P1
Chin, CD; Keilbaugh, SA; Lin, TS; Prusoff, WH; Simpson, MV1
Bajpai, PK; Barbaro, RM; Benghuzzi, HA1
Balzarini, J; De Clercq, E; Desmyter, J; Goubau, P; Herdewijn, P; Pauwels, R; Vandeputte, M; Vanderhaeghe, H1
Carson, DA; Kornbluth, RS; Richman, DD1
Kaplan, JC; Sandström, EG1
Miller, JL1
Baba, M; Balzarini, J; Broder, S; de Clercq, E; Herdewijn, P; Johns, DG; Pauwels, R1
Brady, RO; O'Neill, RR1
Berg, G; Dalakas, M; Fischl, M; Grafman, J; Klecker, RW; McAtee, N; Perno, CF; Thomas, RV; Wichman, A; Yarchoan, R1
Bovey, EH; Büchi, ER; Chave, JP; Erard, PA; Michel, AE1
Biron, K; Lin, JC; Pagano, JS; Smith, MC; Zhang, ZX1
Broder, S; Mitsuya, H1
Bozzette, S; Fay, MT; Freeman, WR; Hardy, D; Wiley, CA1
Broder, S; Yarchoan, R2
Chou, TC; Coleman, LA; Durno, AG; Hirsch, MS; Kaplan, JC; Paradis, TJ; Schooley, RT; Vogt, MW1
Balfour, HH; Henry, K; Thurn, JR1
Pardridge, WM; Terasaki, T1
D'Amico, DJ; Hirsch, MS; Kosloff, BR; Pinkston, P; Schooley, RT; Skolnik, PR1
Barry, DW; Blum, RM; Durack, DT; Gelmann, E; Klecker, RW; Lehrman, SN; Lyerly, HK; Markham, PD; Weinhold, KJ; Yarchoan, R1
Frame, PT; Hagler, DN1
Berg, G; Brouwers, P; Brunetti, A; Fischl, MA; Grafman, J; Safai, B; Spitzer, AR; Thomas, RV; Wichman, A; Yarchoan, R1
Carter, WA; Mitchell, WM; Montefiori, DC; Robinson, WE; Strayer, DR1
Davtyan, DG; Vinters, HV1
Ingeberg, S; Pedersen, C1
Brewton, GW; Duvic, M; Rios, A1
Bach, MC2
Helbert, M; Mitchell, D; Pinching, AJ; Stoneham, C1
Allain, JP; Dubinsky, R; Fischl, MA; Klecker, RW; McAtee, N; McNeely, MC; Perno, CF; Thomas, RV; Wills, RJ; Yarchoan, R1
Braun-Falco, O; Fröschl, M; Hohenleutner, U; Holzmann, H; Ruzicka, T1
Gama-Sosa, MA; Rosas, HD; Ruprecht, RM1
Cload, P; Coutinho, RA; de Gans, J; de Wolf, F; Fiddian, AP; Goudsmit, J; Lange, JM; Schellekens, PT; van der Noordaa, J1
Boucher, CA; Danner, SA; Goudsmit, J; Lange, JM; Reiss, P1
Chave, JP; Decrey, H; Francioli, P; Glauser, MP; Meylan, PR1
Delord, B; Faivre, R; Fleury, HJ; Morere, G1
Forster, S; Helbert, M; Jeffries, D; Kocsis, A; Peddle, B; Pinching, AJ; Robinson, D1
Ho, M; Lewis, JH; Ragni, MV; Tama, G1
Steel, M1
Loke, RH; Murray-Lyon, IM; Wade, JP1
Collins, P; Evans, R; Hawkins, DA; Lawrence, A; Oliver, N; Shanson, DC; Youle, MM1
Costello, C; Fuller, G; Gazzard, B; Hargreaves, M1
de Gans, J; Portegies, P; Tiessens, G1
Fletcher, T; Harris, JR; Helbert, M; Peddle, B; Pinching, AJ1
Sandström, E1
Weber, J1
Allain, JP; Blum, MR; Lehrman, SN; Leuther, M; Maha, M; McAtee, N; Mitsuya, H; Surbone, A; Thomas, RV; Yarchoan, R1
Chouc, PY; Disdier, P; Harle, JR; Weiller, PJ1
Clements, ML; Cohn, S; Miotti, P; Nelson, KE; Polk, BF1
Marwick, C; Riesenberg, DE1
Marx, JL1
Barnes, DM5
Baba, M; De Clercq, E; Desmyter, J; Herdewijn, P; Pauwels, R; Vandeputte, M1
Chen, MS; Kinney-Thomas, E; Lin, TS; Prusoff, WH; Schinazi, RF1
Harada, S; Nakashima, H; Yamamoto, N1
de Noronha, F; Johnston, K; Lehrman, SN; Roneker, C; Tavares, L1
Cantrill, H; Henry, K; Kish, MA1
Drucker, JL; King, DH1
Offerhaus, L1
Jaenisch, R; Ruprecht, RM; Sharpe, AH1
Broder, S; Matsushita, S; Mitsuya, H; Reitz, MS1
Hamamoto, Y; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N1
Barry, DW; LaFon, SW; Lehrman, SN1
Barry, DW; Furman, PA1
Hirsch, MS2
Ayers, KM1
Andrews, J; Richman, DD1
Koshland, DE1
Kobayashi, N; Matsuda, A; Nakashima, H; Tochikura, T; Ueda, T; Yamamoto, N1
Kaneko, Y; Kobayashi, N; Nakashima, H; Tochikura, TS; Yamamoto, N1
Chafey, S; Gottlieb, MS; Wolfe, PR1
Ikuta, K; Imai, H; Kato, S; Suehiro, S; Ueda, S; Yamamoto, N2
Souhrada, L1
Costello, C; Luckit, J; Mir, N1
Despotes, JC; Emeson, EE; Falk, LA; Jackson, GG; Knigge, M; Mack, D; Paul, DA; Rubenis, M1
Cload, P; Danner, SA; de Gans, J; de Wolf, F; Derix, MM; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Ongerboer de Visser, BW1
Courouce, AM; Lefrere, JJ; Salmon, C1
Berman, SM; Nakasato, S; Roberts, DE; Segal, GP; Wishnow, RM; Wyle, FA1
Dalakas, MC; Elder, G; Sever, JL; Spitzer, R; Yarchoan, R1
Fessas, P; Fourtounis, P; Karabinis, A; Kourtis, A; Mangakis, J; Vaiopoulos, G1
Pickus, OB1
Balfour, HH; Chinnock, BJ; de Miranda, P; Fletcher, CV; Henry, K; Quinn, RP1
Goldman, B1
Becker, P; Criner, GJ; Furth, P; Murray, RJ1
Busch, K; Kessler, HA; Maxwell, S; Scheftner, WA1
Dickmeiss, E; Permin, H1
Ersbøll, J; Krebs, HJ; Mathiesen, L; Petersen, CS1
Colarian, J1
de Miranda, P; Kessler, HA; Lehrman, SN; Spear, JB1
Glaser, V1
Langen, P; Lehmann, C; Matthes, E; Rosenthal, HA; Scholz, D1
Balzarini, J; De Clercq, E; Kinjo, J; Lesiak, K; Torrence, PF1
Farrell, PL; Gold, JW; Heinemann, MH; Mamelok, A; Polsky, B; Roberts, CW1
Frick, LW; Furman, PA; Krenitsky, TA; Nelson, DJ; St Clair, MH1
Nightingale, SL1
Klein, RS; Phelan, JA1
Hedaya, MA; Sawchuk, RJ1
Blum, MR; de Miranda, P; Good, SS; Liao, SH1
Blanche, S; Burgard, M; Caniglia, M; Duhamel, G; Fischer, A; Griscelli, C; Rouzioux, C; Tardieu, M1
Cesario, T; Packer, SJ; Williams, JH1
Anokhin, KV; Belotserkovskaia, NA; Kraevskiĭ, AA1
Gil Aguado, A; Lavilla, P; Pintado, V; Valencia, ME1
Balis, FM; Brouwers, P; Eddy, J; Falloon, J; Jarosinski, P; Moss, H; Murphy, RF; Pizzo, PA; Rubin, M; Wolters, P1
Ayela, P; Garnier, G; Thyss, A; Viens, P1
Barbaro, DJ; Coldiron, BM; Orcutt, VL1
Carlisle, R; Schinazi, RF; Sommadossi, JP; Zhou, Z1
Durno, AG; Eckstein, F; Hartmann, H; Hirsch, MS; Hunsmann, G; Vogt, MW1
Handlon, AL; Oppenheimer, NJ1
Blum, MR; de Miranda, P; Gordon, SM; Jacobson, MA; Mills, J; Volberding, P1
Dainiak, N; Goldman, L; Kreczko, S; Riordan, MA; Worthington, M1
Basgoz, N; Blumenfeld, W; Owen, WF; Schmidt, DM1
Azon-Masoliver, A; Castel, T; Gatell, J; Mallolas, J1
Buchanan, RJ1
Levitt, JA; Nightingale, SL; Norris, JA; Young, FE1
Barinaga, M1
Atkinson, H; Grant, I; Ostrow, D1
Balfour, HH; Chinnock, B; Dunn, DL; Erice, A; Rhame, FS1
Rada, B1
Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Schooley, RT; Volberding, PA1
Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Hirsch, MS; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Volberding, PA1
Brook, I1
Groopman, JE1
Harrington, JA; Miller, WH; Spector, T1
Harvengt, C1
Broder, S1
Marotta, RF; Perry, S1
Feeney, GF; Frazer, I1
Greene, JB; Hymes, KB; Karpatkin, S1
Carleton, S; Fauci, AS; Gralnick, HR; Kirk, LE; Kovacs, JA; Lane, HC; Masur, H; Parker, RI; Walker, RE1
Kennedy, CJ; Paradise, M; Wu, AW1
Bessen, LJ; Greene, JB; Louie, E; Seitzman, P; Weinberg, H1
Allain, JP; Chaisson, RE; Leuther, M; Volberding, PA1
Marwick, C1
Kolata, G2
DeHovitz, JA1
Blumberg, RS; Byington, R; Chou, TC; Hartshorn, KL; Hirsch, MS; Schooley, RT; Vogt, MW1
Mahony, WB; Prus, KL; Zimmerman, TP1
Weissman, JB1
Chandrasekar, PH1
Baba, M; De Clercq, E; Ito, M; Nakashima, H; Pauwels, R; Shigeta, S; Yamamoto, N1
De Clercq, E; Gil-Fernández, C1
Friedland, G; Macklin, R1
Cohen, SS1
Chattopadhyaya, J; Löfgren, B; Nordenfelt, E; Oberg, B1
Forester, G1
Brynes, RK; Causey, D; Gill, PS; Levine, AM; Loureiro, C; Rarick, M1
Armstrong, D; Campbell, SW; Gold, JW; Kleinberg, ML; Melamed, AJ; Muller, RJ1
Zuger, A1
Phillips, AJ; Spence, AA1
Jablon, L1
Andes, WA1
Panwalker, AP1
Mirsky, H1
Camsonne, R; Hurrault de Ligny, B; Letellier, P1
Beleslin, DB1
Carlisle, R; Sommadossi, JP1
Furth, PA; Kazakis, AM1
Cohen, OJ; Lyerly, HK; Weinhold, KJ1
Flanigan, T; Graham, R; Shapiro, E1
Cockerill, FR; Hermans, PE1
Richman, DD1
Gallo, RC1
Broder, S; Collins, JM; Jenkins, JF; Klecker, RW; Myers, CE; Thomas, R; Yarchoan, R1
Uretsky, SD1
Elwell, LP; Ferone, R; Freeman, GA; Fyfe, JA; Hill, JA; Knick, VB; Ray, PH; Richards, CA; Rideout, JL; Singer, SC1
Dosne Pasqualini, C1
Chen, MS; Prusoff, WH; Schinazi, RF; Shiau, GT1
Henson, E; McClarty, G; Wang, LL1
Honda, Y; Takahashi, Y; Tsuchiya, T1
Andrews, CW; Aulabaugh, AE; Painter, GR1
Back, DJ; Barry, MG; Veal, GJ; Wild, MJ1
Lerner-Tung, MB; Medina, DJ; Mellors, JW; Nelson, CJ; Strair, RK; Tung, PP1
Antonelli, G; Cianfriglia, M; Dianzani, F; Riva, E; Signoretti, C; Simeoni, E; Strosselli, S; Turriziani, O1
Bajpai, PK; Nagy, EA1
Bawdon, RE; Kaul, S; Sobhi, S1
Auclair, C; Carteau, S; Goulaouic, H; Mouscadet, JF; Subra, F1
Balzarini, J1
Domin, BA; Mahony, WB; Zimmerman, TP1
Breimer, DD; de Boer, AG; Jaehde, U; Langemeijer, MW; Masereeuw, R1
Neitzel, H; Nündel, M; Riedel, E; Schultis, HK; von Baeyer, H1
Cenacchi, A; Gamberi, B; Ottaviani, E; Tosi, P; Tura, S; Visani, G1
Hu, M1
Ellemunter, H; Gschwentner, M; Huemer, H; Laich, A; Nagl, UO; Pinggera, GM; Ritter, M; Schmarda, A; Susanna, A; Wöll, E1
Freeman, GA; Rideout, JL; Shaver, SR; Short, SA1
Antonelli, G; D'Offizi, G; Dianzani, F; Ferri, F; Narciso, P; Turriziani, O; Verri, A1
Joseph, PE; Nusbaum, NJ1
Baba, M; Hashimoto, KI; Okamoto, M; Shigeta, S; Tsunoda, R1
Munch-Petersen, B1
Back, DJ; Barry, MG; Hoggard, PG; Kewn, S; Khoo, SH1
Segal, MB; Thomas, SA2
Alekseeva, SG; Esipov, DS; Oskolkova, OV; Perepelov, AV; Shvets, VI; Zamiatina, AIu1
Clement, JG; Pardridge, WM; Wu, D1
Julias, JG; Pathak, VK1
Knaus, EE; Parang, K; Wiebe, LI1
Antony, AC; Gharehbaghi, K; Jayaram, HN; Li, QJ; Sun, XL; Xiao, X1
Balzarini, J; Camarasa, MJ; Chamorro, C; De Clercq, E; Jimeno, ML; Tuñón, V; Velázquez, S1
Bendayan, R; Hong, M; Schlichter, L1
Galegov, GA; Kraevskiĭ, AA; Selimova, LM1
Boretto, J; Canard, B; Deville-Bonne, D; Guerreiro, C; Janin, J; Meyer, P; Sarfati, S; Schneider, B; Véron, M1
Kong, F; Ning, J1
Agut, H; Angleraud, F; Bonmarchand, M; Brun-Vezinet, F; Calvez, V; Coutellier, A; Delaugerre, C; Descamps, D; Izopet, J; Katlama, C; Matheron, S; Mouroux, M; Valantin, MA; Yvon-Groussin, A1
Knecht, W; Munch-Petersen, B; Piskur, J1
Clark, R; Cohen, C; Cooley, T; Grosso, R; Gulick, R; Marlowe, SI; Mauney, J; Mulanovich, V; Santana, J; Schoellkopf, N; Squires, KE; Stevens, M; Tebas, P; Uffelman, K; Wright, D; Yangco, B1
Bellos, N; Eron, JJ; Esinhart, J; Grosso, R; Jemsek, J; Murphy, RL; Parenti, DM; Peterson, D; Pottage, J; Rashbaum, BC; Schoellkopf, N; Sepulveda, G; Stevens, M; Swindells, S1
Bower, M; Gazzard, BG; Mandalia, S; Matthews, GV; Moyle, GJ; Nelson, M1
Aquaro, S; Balzarini, J; Bianchi, V; De Clercq, E; Knispel, T; Meier, C; Perno, CF; Rampazzo, C1
D'Cruz, OJ; Uckun, FM; Venkatachalam, TK1
Becker, SL; Fusco, GP; Fusco, JS; Graham, NM; Hansen, NI; Igboko, EF; Raffanti, SR; Slatko, GH1
Becker, S; Fisher, R; Graham, N; Henry, K; Hernandez, J; Hirani, A; Liao, Q; Raffanti, S; Ross, L; Scarsella, A; St Clair, M1
Barber, GN; Boise, LH; Cabral, L; Deyev, VV; Harrington, WJ; Liu, LH; Podack, ER; Scott, D; Toomey, NL; Wood, C1
Congote, LF; DiFalco, MR1
Ait-Khaled, M; Amphlett, G; Clotet, B; Katlama, C; Staszewski, S; Stone, C; Tisdale, M1
Gajary, LC; Mansky, LM; Pearl, DK1
Pendergrass, S; Qazi, S; Richman, D; Uckun, FM; Venkatachalam, TK1
Bates, M; Hellmann, NS; Hughes, MD; Katzenstein, DA; Shafer, RW; Shulman, NS; Whitcomb, JM; Winters, MA; Zolopa, AR1
Carr, A; Cooper, DA; Hoy, J; Hudson, J; Law, M; Martin, A; Smith, DE1
Andrzejewska, M; Górska, A; Kamiński, J; Kazimierezuk, Z1
Aboulker, JP; Brun-Vézinet, F; Descamps, D; Flandre, P; Izopet, J; Joly, V; Meiffrédy, V; Tamalet, C1
Akbay, A; Aki-Sener, E; Oren, I; Temiz-Arpaci, O; Yalçin, I1
Belin, MF; Ghersi-Egea, JF; Strazielle, N1
Kidd, ME; Modica-Napolitano, JS; Nalbandian, A; Nalbandian, R; Nguyen, CC1
Biour, M; Djouadi, F; Fromenty, B; Guimont, MC; Igoudjil, A; Lettéron, P; Maisonneuve, C; Note, R; Pessayre, D; Peytavin, G1
Bölske, G; Carnrot, C; Eriksson, S; Wang, L; Wehelie, R1
Calvez, V; Delaugerre, C; Katlama, C; Marcelin, AG; Simon, A; Viegas, P; Wirden, M1
Ajana, F; Alcaraz, I; Bocket, L; Gerard, Y; Goffard, A; Mouton, Y; Viget, N; Wattré, P; Yazdanpanah, Y1
Franco, S; Martínez, MA; Mas, A; Matamoros, T; Menéndez-Arias, L; Vázquez-Alvarez, BM1
Konrad, M; Lavie, A1
Goldschmidt, V; Marquet, R1
Bates, M; Chappey, C; Clair, MS; Fisher, R; Lanier, ER; Parkin, N; Ross, L; Tisdale, M1
Mak, IT; Nedelec, LF; Weglicki, WB1
Bentley, AT; Gingerich, J; Hatch, M; McKee, EE; Susan-Resiga, D1
Antonelli, G; Antonelli, L; Butera, O; Gianotti, N; Girardi, E; Iaiani, G; Lazzarin, A; Mazzi, R; Parisi, SG; Turriziani, O1
Canard, B; Deval, J; Guerreiro, C; Matamoros, T; Menéndez-Arias, L; Mulard, L1
Brooks, JL; Cook, PD; Fagan, P; Hurd, T; Prhavc, M; Rajwanshi, VK; Wang, G1
Götte, M; Kuritzkes, DR; Liang, F; Miranda, LR1
Borderi, M1
Bentley, AT; Lynx, MD; McKee, EE1
Alexander, L; Collins, JA; Margolis, A; Paintsil, E1
Kiseleva, IaIu; Pliasunova, OA; Pokrovskaia, NV; Pokrovskiĭ, AG1
Bacheler, L; Koontz, D; Mellors, JW; Parikh, UM1
Lynx, MD; McKee, EE1
Cases-González, CE; Franco, S; Martínez, MA; Menéndez-Arias, L1
Averbuch, D; Einhorn, M; Engelhard, D; Gottesman, G; Gradstein, S; Grisaru-Soen, G; Grossman, Z; Kedem, E; Lanier, ER; Ofir, M; Schapiro, JM1
Bentley, AT; LaClair, DD; Lynx, MD; McKee, EE; Susan-Resiga, D1
Agarwal, HK; Parang, K1
Dauer, B; Doerr, HW; Haberl, A; Hanke, N; Knecht, G; Locher, L; Moesch, M; Mueller, A; Staszewski, S; Stürmer, M1
Clavel, F; Dam, E; Gerstoft, J; Joergensen, LB; Laursen, AL; Mathiesen, S; Roge, B1
Bussmann, H; DeGruttola, V; Essex, M; Gaseitsiwe, S; Marlink, RG; Moyo, S; Musonda, R; Novitsky, V; Thomas, A; Van Widenfelt, E; Wester, CW1
Kang, BK; Lynx, MD; McKee, EE1
Côté, HC; Gadawski, I; Papp, E1
Bonjoch, A; Clotet, B; Domingo, P; Galindo, MJ; Iribarren, J; Llibre, JM; Martinez-Picado, J; Negredo, E; Pérez-Alvarez, N; Schapiro, J1
Chishu, T; Kang, YS; Kose, N; Nakashima, E; Nishimura, T; Sai, Y; Sato, K; Seki, Y; Terasaki, T1
Bélec, L; Charpentier, C; Karmochkine, M; Laureillard, D; Piketty, C; Si-Mohamed, A; Sodqi, M; Weiss, L1
Portilla, J1
Baba, M; Cheng, YC; Tanaka, H; Wang, X1
Delviks-Frankenberry, KA; Hase, S; Maldarelli, F; Nikolenko, GN; Pathak, VK; Takebe, Y1
Martínez, MA; Matamoros, T; Menéndez-Arias, L; Nevot, M1
Back, DJ; Bray, PG; Janneh, O; Owen, A; Pirmohamed, M1
Amatore, C; Arbault, S; Jaouen, G; Koh, AC; Leong, WK; Top, S; Valleron, MA; Woo, CH1
Borojerdi, JP; Braun, HM; Cooch, CC; Keller, E; McKee, E; Ming, J; Olivero, OA; Poirier, MC; Vazquez, IL; Yu, M1
Chen, CM; Dornfeld, K; Johnson, M; Smith, BJ1
Radzio, J; Sluis-Cremer, N; Tachedjian, G; Yap, SH1
Alexander, V; Chandra, G; Choi, J; Choi, WJ; Chun, J; Jeon, JH; Jeong, LS; Kim, HO; Lee, HW; Tosh, DK1
Eriksson, S; Sun, R; Wang, L1
Adhikary, A; Khanduri, D; Pottiboyina, V; Rice, CT; Sevilla, MD1
Laclair, DD; McKee, EE; Morris, GW1
Curran, A; Ribera, E1
Baumann, J; Delviks-Frankenberry, KA; Lengruber, RB; Nikolenko, GN; Pathak, VK; Santos, AF; Soares, MA1
Menéndez-Arias, L1
Fessel, WJ; Israelski, D; Kagan, R; Kaufman, D; Melikian, GL; Rhee, SY; Robbins, GK; Shafer, RW; Taylor, J; Towner, W; Troia-Cancio, PV; Zolopa, A1
McCann, KA; McKee, EE; Williams, DW1
Bauerfeind, R; Behrens, GM; Binz, A; Leverkus, M; Panayotova-Dimitrova, D; Stankov, MV; Vondran, FW1
Chaiwarith, R; Kotarathitithum, W; Nuntachit, N; Praparattanapan, J; Sirisanthana, T; Supparatpinyo, K1
Antinori, A; Bansi, L; Boumis, E; Callegaro, A; Ceccherini-Silberstein, F; Dunn, D; Fearnhill, E; Forbici, F; Francisci, D; Maggiolo, F; Mussini, C; Nicastri, E; Palamara, G; Perno, CF; Sabin, C; Santoro, MM; Zazzi, M; Zoncada, A1
Chandrasekar, S; Idris, MM; Kavitha, M; Mahesh Kumar, J; Mainkar, PS; Meghah, V; Nagesh, N; Pal, B; Reddy, CR; Srinivas, G; Vinay Kumar, P1
Alcolea Palafox, M; Álvarez-Ros, MC; El-Sayed, AA; Tamara Molina, A1
Badia, R; Ballana, E; Clotet, B; Esté, JA; Martí, R; Pauls, E; Riveira-Muñoz, E; Ruiz, A; Terradas, G; Torres-Torronteras, J1
Palafox, MA1
Jin, Y; Li, M; Qi, S; Yao, W; Zhang, S; Zhao, J1
Hsiung, CH; Kamath, VG; Lizenby, ZJ; McKee, EE1
Ostermeier, M; Parhi, S; Shelat, NY1
Dunn, DT; Gilks, C; Goodall, RL; Gupta, RK; Kaleebu, P; Kityo, C; Mugarura, L; Munderi, P; Nkurunziza, P; Pattery, T; Pillay, D1
Hofer, A; Jiménez-González, A; Krakovka, S; Larsen, NB; Luján, HD; Luján, LA; Ranjbarian, F; Reggenti, A; Saura, A; Svärd, SG1

Reviews

25 review(s) available for zidovudine and thymidine

ArticleYear
Chemotherapeutic approaches to the treatment of the acquired immune deficiency syndrome (AIDS).
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Adsorption; Antibodies, Viral; Antigens, Viral; Aurintricarboxylic Acid; Deltaretrovirus; Deoxycytidine; Foscarnet; Genes, Viral; Glycoproteins; Humans; Interferons; Male; Phosphonoacetic Acid; Retroviridae Infections; Reverse Transcriptase Inhibitors; Ribavirin; RNA, Viral; Suramin; Thymidine; Transcription, Genetic; Viral Proteins; Virus Replication; Zalcitabine; Zidovudine

1986
Developmental therapeutics and the acquired immunodeficiency syndrome.
    Annals of internal medicine, 1987, Volume: 106, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Deoxyribonucleosides; HIV; Humans; Interferons; Interleukin-2; Opportunistic Infections; Pneumonia, Pneumocystis; Thymidine; Toxoplasmosis; Virus Replication; Zidovudine

1987
Therapy of human immunodeficiency virus infections.
    Clinics in laboratory medicine, 1987, Volume: 7, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Foscarnet; Humans; Immunotherapy; Interferons; Oligodeoxyribonucleotides; Phosphonoacetic Acid; Ribavirin; Suramin; Thymidine; Zidovudine

1987
Promising new antiviral drugs.
    Journal of the American Academy of Dermatology, 1988, Volume: 18, Issue:1 Pt 2

    Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Herpes Simplex; Herpes Zoster; Humans; Interferons; Phosphonoacetic Acid; Ribavirin; Thymidine; Zidovudine

1988
Antiviral drugs other than zidovudine and immunomodulating therapies in human immunodeficiency virus infection. An overview.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Antiviral Agents; Humans; Immunotherapy; Interferons; Thymidine; Zidovudine

1988
Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date.
    Drugs, 1987, Volume: 34, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Forecasting; Foscarnet; Immunotherapy; Phosphonoacetic Acid; Rifabutin; Rifamycins; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine

1987
Progress in the development of antiviral therapy for HTLV-III-associated diseases.
    Important advances in oncology, 1987

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; HIV; Humans; Phosphonoacetic Acid; Ribavirin; Rifabutin; Rifamycins; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine

1987
Antiviral drugs for AIDS. Current status and future prospects.
    Drugs, 1986, Volume: 31, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Humans; Interferon Type I; Phosphonoacetic Acid; Ribavirin; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine

1986
Spectrum of antiviral activity and mechanism of action of zidovudine. An overview.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Animals; Antiviral Agents; HIV; Humans; Retroviridae; Thymidine; Virus Replication; Zidovudine

1988
Antiviral drug development for the treatment of human immunodeficiency virus infections. An overview.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Humans; Thymidine; United States; Virus Replication; Zidovudine

1988
Preclinical toxicology of zidovudine. An overview.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Animals; Antiviral Agents; Drug Evaluation, Preclinical; Female; Male; Thymidine; Zidovudine

1988
AIDS commentary. Azidothymidine.
    The Journal of infectious diseases, 1988, Volume: 157, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Humans; Thymidine; Zidovudine

1988
Assessment and management of the AIDS patient with neuropsychiatric disturbances.
    The Journal of clinical psychiatry, 1988, Volume: 49 Suppl

    Topics: Acquired Immunodeficiency Syndrome; Anxiety; Humans; Male; Neurocognitive Disorders; Social Support; Thymidine; Zidovudine

1988
[Experimental chemotherapy of AIDS].
    Casopis lekaru ceskych, 1988, May-27, Volume: 127, Issue:22

    Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Antimony; Antiviral Agents; Humans; Oligopeptides; Peptide T; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine

1988
Treatment of human immunodeficiency virus infections.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Therapy, Combination; HIV; Humans; Ribavirin; Thymidine; Zidovudine

1987
AIDS-related Kaposi's sarcoma: therapeutic modalities.
    Seminars in hematology, 1987, Volume: 24, Issue:3 Suppl 2

    Topics: Acquired Immunodeficiency Syndrome; Bone Marrow Transplantation; Combined Modality Therapy; Doxorubicin; Humans; Interferon Type I; Opportunistic Infections; Sarcoma, Kaposi; Thymidine; Vinblastine; Zidovudine

1987
Strategies for the future chemotherapy of human immunodeficiency virus (HIV).
    Haematology and blood transfusion, 1987, Volume: 31

    Topics: Acquired Immunodeficiency Syndrome; Drug Evaluation; HIV; Humans; Thymidine; Zidovudine

1987
AIDS dementia: a review of the literature.
    Alzheimer disease and associated disorders, 1987, Volume: 1, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Brain; Counseling; Dementia; Humans; Nervous System Diseases; Neurocognitive Disorders; Social Support; Thymidine; Zidovudine

1987
Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. A progress report.
    The New England journal of medicine, 1987, Feb-26, Volume: 316, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Structure-Activity Relationship; Thymidine; Zidovudine

1987
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.
    Pharmacy world & science : PWS, 1994, Apr-15, Volume: 16, Issue:2

    Topics: Animals; Antiviral Agents; Dideoxyadenosine; Dideoxynucleosides; Humans; Lamivudine; Purines; Pyrimidines; Retroviridae; Spiro Compounds; Stavudine; Thymidine; Uridine; Zalcitabine; Zidovudine

1994
Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase.
    Mini reviews in medicinal chemistry, 2004, Volume: 4, Issue:4

    Topics: Anti-HIV Agents; Dideoxynucleotides; Humans; Nucleoside-Phosphate Kinase; Nucleotides; Phosphorylation; Prodrugs; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymine Nucleotides; Zidovudine

2004
Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs).
    The international journal of biochemistry & cell biology, 2004, Volume: 36, Issue:9

    Topics: Adenosine Triphosphate; DNA Primers; Drug Resistance, Multiple, Viral; Foscarnet; HIV; HIV Reverse Transcriptase; Humans; Point Mutation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine

2004
[Use of thymidine-sparing regimens in first-line therapy and in switches from thymidine analogues].
    Le infezioni in medicina, 2005, Volume: 13, Issue:3

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Stavudine; Thymidine; Treatment Outcome; Zidovudine

2005
[Tenofovir as a strategy to avoid or limit adverse effects].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 8

    Topics: Adenine; Anemia; Anti-HIV Agents; Antimetabolites; Clinical Trials as Topic; DNA, Mitochondrial; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Glucose Metabolism Disorders; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Multicenter Studies as Topic; Organophosphonates; Prospective Studies; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zidovudine

2008
From old to new nucleoside reverse transcriptase inhibitors: changes in body fat composition, metabolic parameters and mitochondrial toxicity after the switch from thymidine analogs to tenofovir or abacavir.
    Expert opinion on drug safety, 2011, Volume: 10, Issue:3

    Topics: Adenine; Adipose Tissue; Body Composition; Dideoxynucleosides; Drug Substitution; Humans; Metabolism; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zidovudine

2011

Trials

35 trial(s) available for zidovudine and thymidine

ArticleYear
[Chemotherapy and immunoprophylaxis of HIV infection].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Nov-25, Volume: 75, Issue:48

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Foscarnet; HIV; Humans; Phosphonoacetic Acid; Reverse Transcriptase Inhibitors; Ribavirin; Suramin; Thymidine; Viral Vaccines; Virus Replication; Zidovudine

1986
Progress in antiviral drug and vaccine development assessed at international AIDS conference.
    Clinical pharmacy, 1987, Volume: 6, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Evaluation; Drug Therapy, Combination; Humans; Ribavirin; Thymidine; Viral Vaccines; Zalcitabine; Zidovudine

1987
Long-term administration of 3'-azido-2',3'-dideoxythymidine to patients with AIDS-related neurological disease.
    Annals of neurology, 1988, Volume: 23 Suppl

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Clinical Trials as Topic; Dementia; Humans; Male; Middle Aged; Paraplegia; Peripheral Nervous System Diseases; Thymidine; Time Factors; Zidovudine

1988
AIDS. Treatment strategies and the Minnesota AIDS Clinical Trials Unit.
    Minnesota medicine, 1988, Volume: 71, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Humans; Opportunistic Infections; Thymidine; Zalcitabine; Zidovudine

1988
Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.
    Lancet (London, England), 1986, Mar-15, Volume: 1, Issue:8481

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Body Weight; Clinical Trials as Topic; Deltaretrovirus; Female; Humans; Infusions, Parenteral; Intestinal Absorption; Leukocyte Count; Lymphocytes; Male; Pneumonia, Pneumocystis; Sarcoma, Kaposi; T-Lymphocytes, Helper-Inducer; Thymidine; Virus Replication; Zidovudine

1986
Zidovudine (AZT)
    Lancet (London, England), 1987, Apr-25, Volume: 1, Issue:8539

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine

1987
Effect of zidovudine on serum human immunodeficiency virus antigen levels in symptom-free subjects.
    Lancet (London, England), 1988, Feb-20, Volume: 1, Issue:8582

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antigens, Viral; Antiviral Agents; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; HIV; Homosexuality; Humans; Male; Random Allocation; Thymidine; Zidovudine

1988
AIDS drug shows promise in preliminary clinical trial.
    Science (New York, N.Y.), 1986, Mar-28, Volume: 231, Issue:4745

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Deltaretrovirus; Humans; Thymidine; Virus Replication; Zidovudine

1986
[Azidothymidine and HIV infection].
    Nederlands tijdschrift voor geneeskunde, 1987, May-30, Volume: 131, Issue:22

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Interactions; Humans; Thymidine; Zalcitabine; Zidovudine

1987
Prophylactically administered Retrovir in health care workers potentially exposed to the human immunodeficiency virus.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Allied Health Personnel; Clinical Trials as Topic; Double-Blind Method; Humans; Occupational Diseases; Thymidine; Zidovudine

1988
Antiviral drug development for the treatment of human immunodeficiency virus infections. An overview.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Humans; Thymidine; United States; Virus Replication; Zidovudine

1988
Results of continued monitoring of participants in the placebo-controlled trial of zidovudine for serious human immunodeficiency virus infection.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; Follow-Up Studies; Humans; Opportunistic Infections; Placebos; Thymidine; Time Factors; Zidovudine

1988
Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT).
    Annals of internal medicine, 1988, Volume: 108, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antigens, Viral; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; HIV; HIV Antigens; HIV Core Protein p24; Humans; Lymphocytes; Retroviridae Proteins; Thymidine; Zidovudine

1988
AIDS commentary. Azidothymidine.
    The Journal of infectious diseases, 1988, Volume: 157, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Humans; Thymidine; Zidovudine

1988
The FDA's new procedures for the use of investigational drugs in treatment.
    JAMA, 1988, Apr-15, Volume: 259, Issue:15

    Topics: Acquired Immunodeficiency Syndrome; Catastrophic Illness; Clinical Protocols; Clinical Trials as Topic; Drug Information Services; Humans; Informed Consent; Orphan Drug Production; Pharmaceutical Preparations; Quality Control; Thymidine; United States; United States Food and Drug Administration; Zidovudine

1988
Commercial venture to speed up AIDS drug tests in California.
    Nature, 1988, May-19, Volume: 333, Issue:6170

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Drug Industry; Humans; San Francisco; Thymidine; Zidovudine

1988
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
    The New England journal of medicine, 1987, Jul-23, Volume: 317, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Opportunistic Infections; Pneumonia, Pneumocystis; Random Allocation; Sarcoma, Kaposi; Thymidine; Zidovudine

1987
The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
    The New England journal of medicine, 1987, Jul-23, Volume: 317, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; AIDS-Related Complex; Anemia; Antiviral Agents; Blood Transfusion; Bone Marrow; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Count; Female; Hemoglobins; Humans; Leukocyte Count; Male; Neutropenia; Platelet Count; Random Allocation; Thymidine; Vitamin B 12; Zidovudine

1987
Approval of zidovudine (AZT) for acquired immunodeficiency syndrome. A challenge to the medical and pharmaceutical communities.
    JAMA, 1987, Sep-18, Volume: 258, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Drug Utilization; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine

1987
"On the shelf" AIDS drug in clinical trial.
    Science (New York, N.Y.), 1987, Oct-16, Volume: 238, Issue:4825

    Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Fusidic Acid; HIV; Humans; Thymidine; Virus Replication; Zidovudine

1987
Zidovudine approved by FDA for treatment of AIDS.
    Clinical pharmacy, 1987, Volume: 6, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Clinical Trials as Topic; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine

1987
Anemia and erythropoiesis in patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi sarcoma treated with zidovudine.
    Annals of internal medicine, 1988, Volume: 108, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anemia; Antiviral Agents; Drug Evaluation; Erythrocyte Indices; Erythropoiesis; Hemoglobins; Humans; Male; Middle Aged; Prospective Studies; Random Allocation; Sarcoma, Kaposi; Thymidine; Zidovudine

1988
Senate votes to expand anti-AIDS drug trials.
    Science (New York, N.Y.), 1986, Sep-26, Volume: 233, Issue:4771

    Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Government Agencies; Humans; National Institutes of Health (U.S.); Thymidine; United States; Zidovudine

1986
Promising results halt trial of anti-AIDS drug.
    Science (New York, N.Y.), 1986, Oct-03, Volume: 234, Issue:4772

    Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Humans; Thymidine; Zidovudine

1986
Azidothymidine for AIDS.
    The Medical letter on drugs and therapeutics, 1986, Nov-07, Volume: 28, Issue:726

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Bone Marrow Diseases; Clinical Trials as Topic; Humans; Kinetics; Thymidine; Zidovudine

1986
Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases.
    Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Biological Availability; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Drug Evaluation; Half-Life; Humans; Infusions, Intravenous; Kinetics; Thymidine; Zidovudine

1987
Report from the war zone.
    American journal of hospital pharmacy, 1987, Volume: 44, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Humans; New York City; Pharmacy Service, Hospital; Thymidine; Zidovudine

1987
[Clinical trial with a new drug in acquired immunodeficiency syndrome].
    Medicina, 1986, Volume: 46, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; Humans; Thymidine; Zidovudine

1986
A comparison of stavudine plus lamivudine versus zidovudine plus lamivudine in combination with indinavir in antiretroviral naive individuals with HIV infection: selection of thymidine analog regimen therapy (START I).
    AIDS (London, England), 2000, Jul-28, Volume: 14, Issue:11

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lamivudine; Male; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Zidovudine

2000
A comparison of stavudine, didanosine and indinavir with zidovudine, lamivudine and indinavir for the initial treatment of HIV-1 infected individuals: selection of thymidine analog regimen therapy (START II).
    AIDS (London, England), 2000, Jul-28, Volume: 14, Issue:11

    Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Didanosine; Dideoxynucleosides; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lamivudine; Male; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Viral Load; Zidovudine

2000
Zidovudine and stavudine sequencing in HIV treatment planning: findings from the CHORUS HIV cohort.
    Journal of acquired immune deficiency syndromes (1999), 2001, Jan-01, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Homosexuality; Humans; Logistic Models; Longitudinal Studies; Male; Middle Aged; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; White People; Zidovudine

2001
Subtle decreases in stavudine phenotypic susceptibility predict poor virologic response to stavudine monotherapy in zidovudine-experienced patients.
    Journal of acquired immune deficiency syndromes (1999), 2002, Oct-01, Volume: 31, Issue:2

    Topics: Adult; Anti-HIV Agents; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Phenotype; Predictive Value of Tests; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Time Factors; Treatment Outcome; Viral Load; Zidovudine

2002
Thymidine analogue withdrawal for lipoatrophic patients on protease-sparing therapy improves lipoatrophy but compromises antiviral control: the PIILR extension study.
    AIDS (London, England), 2002, Dec-06, Volume: 16, Issue:18

    Topics: Anti-HIV Agents; HIV-Associated Lipodystrophy Syndrome; Humans; Male; Middle Aged; Stavudine; Substance Withdrawal Syndrome; Thymidine; Zidovudine

2002
Predictive factors and selection of thymidine analogue mutations by nucleoside reverse transcriptase inhibitors according to initial regimen received.
    Antiviral therapy, 2003, Volume: 8, Issue:1

    Topics: Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Predictive Value of Tests; Reverse Transcriptase Inhibitors; Selection, Genetic; Thymidine; Zalcitabine; Zidovudine

2003
Thymidine analogue mutations in antiretroviral-naive HIV-1 patients on triple therapy including either zidovudine or stavudine.
    The Journal of antimicrobial chemotherapy, 2004, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Resistance, Multiple, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Stavudine; Thymidine; Viral Load; Zidovudine

2004

Other Studies

316 other study(ies) available for zidovudine and thymidine

ArticleYear
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Kinetics; Molecular Structure; Phosphorylation; Pyrimidine Nucleosides; Rabbits; Stavudine; T-Lymphocytes; Thymidine Kinase; Thymus Gland; Zidovudine

1990
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication

1987
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.
    Journal of medicinal chemistry, 1995, May-12, Volume: 38, Issue:10

    Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Polymers; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine; Uridine; Zidovudine

1995
Synthesis, in vitro biological stability, and anti-HIV activity of 5-halo-6-alkoxy(or azido)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs to 3'-azido-3'-deoxythymidine (AZT).
    Journal of medicinal chemistry, 1994, Dec-09, Volume: 37, Issue:25

    Topics: Animals; Antiviral Agents; Blood-Brain Barrier; Brain; Bromides; Chlorides; Cysteine; Glutathione; HIV-1; Iodides; Mice; Molecular Structure; Prodrugs; Rats; Stereoisomerism; Structure-Activity Relationship; Zidovudine

1994
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
    Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18

    Topics: Antitubercular Agents; Azides; Enzyme Inhibitors; Humans; Kinetics; Models, Molecular; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Nucleosides; Nucleotides; Structure-Activity Relationship; Thymidine Monophosphate

2003
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
    Bioorganic & medicinal chemistry letters, 2003, Sep-15, Volume: 13, Issue:18

    Topics: Antitubercular Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Structure-Activity Relationship; Thymidine; Thymine Nucleotides

2003
Synthesis and biological evaluation of neutral and zwitterionic 3-carboranyl thymidine analogues for boron neutron capture therapy.
    Journal of medicinal chemistry, 2005, Feb-24, Volume: 48, Issue:4

    Topics: Animals; Binding Sites; Biological Availability; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Humans; Ions; Mice; Mice, Nude; Phosphorylation; Solubility; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase; Tissue Distribution; Xenograft Model Antitumor Assays

2005
Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Deoxycytidine; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Sequence Data; Nucleosides; Phosphotransferases (Alcohol Group Acceptor); Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes

2007
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
    Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3

    Topics: Animals; Drosophila melanogaster; Fluorescent Dyes; Nucleosides; Phosphotransferases (Alcohol Group Acceptor)

2010
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.
    Bioorganic & medicinal chemistry, 2010, May-01, Volume: 18, Issue:9

    Topics: Amino Acid Sequence; Anti-Infective Agents; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Molecular Sequence Data; Molecular Structure; Sequence Alignment; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase; Triazoles; Ureaplasma; Zidovudine

2010
The effect of thymidine on the antibacterial and antiviral activity of zidovudine.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:8

    Topics: Deoxyadenosines; Escherichia coli; HIV-1; Salmonella typhimurium; SOS Response, Genetics; Thymidine; Zidovudine

1992
Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.
    Biochemical and biophysical research communications, 1992, Oct-30, Volume: 188, Issue:2

    Topics: Arabinonucleosides; Cladribine; Deoxycytidine; Deoxycytidine Kinase; Humans; Isoenzymes; Kinetics; Leukemia; Leukocytes; Mitochondria; Organ Specificity; Phosphorylation; Radioisotope Dilution Technique; Reference Values; Substrate Specificity; Thymidine; Thymidine Kinase; Tritium; Tumor Cells, Cultured; Zidovudine

1992
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.
    Molecular pharmacology, 1992, Volume: 41, Issue:5

    Topics: Antiviral Agents; Benzodiazepines; Dideoxynucleotides; HIV-1; Imidazoles; Kinetics; Molecular Structure; Recombinant Proteins; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Templates, Genetic; Thymidine; Thymine Nucleotides; Uracil; Zidovudine

1992
Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:9

    Topics: Antiviral Agents; Cell Line; HIV-1; Humans; Phospholipids; Prodrugs; T-Lymphocytes; Thymidine; Thymine Nucleotides; Viral Plaque Assay; Virus Replication; Zidovudine

1992
Loss of synergistic response to combinations containing AZT in AZT-resistant HIV-1.
    AIDS research and human retroviruses, 1992, Volume: 8, Issue:7

    Topics: Antiviral Agents; Cells, Cultured; Didanosine; Drug Resistance, Microbial; Drug Synergism; HIV-1; Humans; Thymidine; Zidovudine

1992
[Synthesis and cytotoxic properties of anomeric 5-substituted 3'-azido-2',3'-dideoxyuridines].
    Bioorganicheskaia khimiia, 1992, Volume: 18, Issue:3

    Topics: Antiviral Agents; Cell Line; Cell Survival; Chromatography, Thin Layer; DNA; Glycosylation; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thymidine; Zidovudine

1992
Membrane permeation characteristics of 5'-modified thymidine analogs.
    Molecular pharmacology, 1992, Volume: 41, Issue:5

    Topics: Antiviral Agents; Biological Transport; Dilazep; Dipyridamole; Erythrocyte Membrane; Erythrocytes; Humans; Kinetics; Nucleosides; Purines; Pyrimidines; Radioisotope Dilution Technique; Thymidine; Tritium; Zidovudine

1992
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
    Oncology research, 1992, Volume: 4, Issue:2

    Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; DNA Replication; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Methotrexate; Pancreatic Neoplasms; Thymidine; Tumor Stem Cell Assay; Zidovudine

1992
Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways.
    The Journal of biological chemistry, 1992, Jun-05, Volume: 267, Issue:16

    Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; Humans; Isoenzymes; Lymphocytes; Macrophages; Phosphorylation; Phytohemagglutinins; Substrate Specificity; Thymidine; Thymidine Kinase; Zidovudine

1992
Mechanism and site dependency of intestinal mucosal transport and metabolism of thymidine analogues.
    Pharmaceutical research, 1992, Volume: 9, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Colon; Intestinal Absorption; Intestinal Mucosa; Male; Perfusion; Rats; Rats, Inbred Strains; Thymidine; Zidovudine

1992
Modified tetrazolium-based colorimetric method for determining the activities of anti-HIV compounds.
    Journal of virological methods, 1991, Volume: 33, Issue:3

    Topics: Antiviral Agents; Cell Line; Colorimetry; Didanosine; Foscarnet; HIV-1; Humans; Phosphonoacetic Acid; Tetrazolium Salts; Thymidine; Zalcitabine; Zidovudine

1991
Antiviral activity of 5-iodo-2'-deoxyuridine and related drugs in human keratinocytes infected in vitro with herpes simplex virus type 1.
    Skin pharmacology : the official journal of the Skin Pharmacology Society, 1991, Volume: 4, Issue:4

    Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Drug Interactions; Guinea Pigs; Herpes Simplex; Humans; Idoxuridine; Keratinocytes; Simplexvirus; Thymidine; Thymidine Phosphorylase; Thymine; Zidovudine

1991
Biochemical changes in ethanol-treated HL-60 cells.
    Progress in clinical and biological research, 1990, Volume: 325

    Topics: Acquired Immunodeficiency Syndrome; Alcoholism; Biological Transport, Active; DNA; Ethanol; Humans; Interferons; Models, Biological; Receptors, Immunologic; Receptors, Interferon; Thymidine; Tumor Cells, Cultured; Zidovudine

1990
Metabolism of 4'-azidothymidine. A compound with potent and selective activity against the human immunodeficiency virus.
    The Journal of biological chemistry, 1992, Jan-05, Volume: 267, Issue:1

    Topics: Cell Line; DNA; HIV; Humans; Kinetics; Phosphorylation; Substrate Specificity; T-Lymphocytes; Thymidine; Thymidine Kinase; Thymidine Phosphorylase; Virus Replication; Zidovudine

1992
A new method of synthesis of 3'-mercapto-3'-deoxythymidine.
    Nucleic acids symposium series, 1991, Issue:24

    Topics: Antiviral Agents; Cell Line; HIV; Humans; T-Lymphocytes; Thymidine; Zidovudine

1991
Thymidine and zidovudine metabolism in chronically zidovudine-exposed cells in vitro.
    Biochemical pharmacology, 1991, Jul-25, Volume: 42, Issue:4

    Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Phosphorylation; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Time Factors; Zidovudine

1991
Mutants from V79 fibroblasts exhibiting hypersensitivity to aphidicolin and 3'-azido-3'-deoxythymidine.
    Somatic cell and molecular genetics, 1991, Volume: 17, Issue:1

    Topics: Animals; Aphidicolin; Cell Division; Cell Line; Cell Survival; Cricetinae; Cricetulus; Deoxyribonucleotides; Dideoxynucleotides; Diterpenes; DNA Replication; DNA-Directed DNA Polymerase; Mutation; Temperature; Thymidine; Thymine Nucleotides; Zidovudine

1991
The role of the SOS response in bacteria exposed to zidovudine or trimethoprim.
    Journal of medical microbiology, 1991, Volume: 34, Issue:6

    Topics: beta-Galactosidase; Cell Survival; DNA Repair; Dose-Response Relationship, Drug; Escherichia coli; SOS Response, Genetics; Thymidine; Trimethoprim; Zidovudine

1991
Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:1

    Topics: Bone Marrow; Bone Marrow Cells; Dose-Response Relationship, Drug; Humans; Leukocytes, Mononuclear; Macrophages; Phosphorylation; Thymidine; Thymidine Kinase; Tritium; Uridine; Zidovudine

1991
Comparative disposition and whole-body autoradiographic distribution of [2-14C]azidothymidine and [2-14C]thymidine in mice.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1

    Topics: Animals; Autoradiography; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Male; Mice; Thymidine; Tissue Distribution; Zidovudine

1991
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
    Cancer communications, 1991, Volume: 3, Issue:4

    Topics: Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Methotrexate; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine

1991
Mechanisms of zidovudine resistance in bacteria.
    Journal of medical microbiology, 1990, Volume: 33, Issue:4

    Topics: DNA, Bacterial; Drug Resistance, Microbial; Edetic Acid; Enterobacteriaceae; Escherichia coli; Phosphorylation; Pseudomonas aeruginosa; Salmonella typhimurium; Staphylococcus; Staphylococcus aureus; Staphylococcus epidermidis; Thymidine; Thymidine Kinase; Zidovudine

1990
2',3'-Dideoxycytidine toxicity in cultured human CEM T lymphoblasts: effects of combination with 3'-azido-3'-deoxythymidine and thymidine.
    Molecular pharmacology, 1990, Volume: 38, Issue:2

    Topics: Cell Division; Cell Line; Cell Survival; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Interactions; Humans; Phosphorylation; T-Lymphocytes; Thymidine; Zalcitabine; Zidovudine

1990
Synergy of inhibition of DNA synthesis in human bone marrow by azidothymidine plus deficiency of folate and/or vitamin B12?
    American journal of hematology, 1990, Volume: 33, Issue:3

    Topics: Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Humans; Pyrimidines; Tetrahydrofolates; Thymidine; Vitamin B 12 Deficiency; Zidovudine

1990
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
    Cancer communications, 1990, Volume: 2, Issue:4

    Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics; Liver Neoplasms, Experimental; Methotrexate; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine

1990
Effect of dipyridamole on transport and phosphorylation of thymidine and 3'-azido-3'-deoxythymidine in human monocyte/macrophages.
    Biochemical pharmacology, 1990, Aug-15, Volume: 40, Issue:4

    Topics: Biological Transport; Cells, Cultured; Dipyridamole; Humans; Macrophages; Monocytes; Phosphorylation; Thymidine; Zidovudine

1990
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:20

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Deltaretrovirus; Gene Products, gag; Humans; Retroviridae Proteins; RNA-Directed DNA Polymerase; Thymidine; Transcription, Genetic; Zidovudine

1985
Antiviral therapy. New drugs and their uses.
    Postgraduate medicine, 1986, Volume: 80, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Chickenpox; Common Cold; Cytomegalovirus Infections; Herpes Simplex; Herpes Zoster; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Influenza, Human; Interferons; Ribavirin; Rimantadine; Thymidine; Vidarabine; Virus Diseases; Zidovudine

1986
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:21

    Topics: Antiviral Agents; Cell Survival; HIV; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Reverse Transcriptase Inhibitors; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Virus Replication; Zidovudine

1986
Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitro.
    Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:6

    Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; HIV; HIV Antigens; Humans; Reverse Transcriptase Inhibitors; Thymidine; Viral Plaque Assay; Virus Replication; Zidovudine

1986
Ribavirin antagonizes the effect of azidothymidine on HIV replication.
    Science (New York, N.Y.), 1987, Mar-13, Volume: 235, Issue:4794

    Topics: Cell Line; HIV; Humans; Lymphocytes; Monocytes; Phosphorylation; Phytohemagglutinins; Ribavirin; Ribonucleosides; RNA-Directed DNA Polymerase; Thymidine; Virus Replication; Zidovudine

1987
Antiviral therapy.
    Scientific American, 1987, Volume: 256, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cytomegalovirus; DNA, Viral; Drug Resistance, Microbial; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV; Humans; Interferons; Nucleosides; Reverse Transcriptase Inhibitors; Ribavirin; RNA, Messenger; RNA, Viral; Simplexvirus; Thymidine; Virus Diseases; Virus Physiological Phenomena; Virus Replication; Zidovudine

1987
Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine.
    Lancet (London, England), 1987, Jun-13, Volume: 1, Issue:8546

    Topics: Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Thymidine; Zidovudine

1987
Conformational properties of 3'-azido-3'deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase.
    Biochemical and biophysical research communications, 1987, Jun-30, Volume: 145, Issue:3

    Topics: Antiviral Agents; HIV; Models, Molecular; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine

1987
3'-Azido-3'-deoxythymidine inhibits the replication of avian leukosis virus.
    Journal of virology, 1987, Volume: 61, Issue:9

    Topics: Animals; Antiviral Agents; Avian Leukosis Virus; Chick Embryo; DNA, Viral; Phosphorylation; Reverse Transcriptase Inhibitors; Thymidine; Thymine Nucleotides; Virus Replication; Zidovudine

1987
[We can perhaps hold AIDS in check but we cannot cure it].
    Sygeplejersken, 1987, May-20, Volume: 87, Issue:21

    Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Antiviral Agents; Humans; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine

1987
Anti-HIV synergy between dextran sulphate and zidovudine.
    Lancet (London, England), 1987, Aug-22, Volume: 2, Issue:8556

    Topics: Dextran Sulfate; Dextrans; Drug Synergism; HIV; Thymidine; Zidovudine

1987
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.
    Biochemical pharmacology, 1987, Sep-01, Volume: 36, Issue:17

    Topics: Antiviral Agents; Deoxycytidine; HIV; Humans; Monocytes; Retroviridae Proteins; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Virus Replication; Zidovudine

1987
Anti-HIV synergism between dextran sulphate and zidovudine.
    Lancet (London, England), 1987, Oct-03, Volume: 2, Issue:8562

    Topics: Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Thymidine; Zidovudine

1987
Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:7

    Topics: Antiviral Agents; Cell Line; Drug Synergism; Fluorescent Antibody Technique; HIV; Humans; Interleukin-3; Recombinant Proteins; RNA-Directed DNA Polymerase; Thymidine; Virus Replication; Zidovudine

1987
Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine.
    Journal of virology, 1987, Volume: 61, Issue:12

    Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; DNA, Viral; Drug Resistance, Microbial; HIV; Humans; RNA-Directed DNA Polymerase; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine

1987
Azidothymidine: crystal structure and possible functional role of the azido group.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:23

    Topics: Crystallography; Models, Molecular; RNA-Directed DNA Polymerase; Stereoisomerism; Structure-Activity Relationship; Thymidine; Zidovudine

1987
[Inhibition of the avian leukosis-sarcoma complex with 3'-azido-3'-deoxythymidine (AzT); a model for screening and evaluation of chemotherapeutic agents against retrovirus infections].
    Doklady Akademii nauk SSSR, 1987, Volume: 296, Issue:6

    Topics: Alpharetrovirus; Animals; Antiviral Agents; Avian Leukosis; Chick Embryo; Chickens; Drug Evaluation, Preclinical; Mice; Retroviridae Infections; Reverse Transcriptase Inhibitors; Thymidine; Virus Replication; Zidovudine

1987
Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.
    Science (New York, N.Y.), 1988, Apr-29, Volume: 240, Issue:4852

    Topics: Antigens, Differentiation, T-Lymphocyte; Cell Line; Dextran Sulfate; Dextrans; Dideoxynucleosides; DNA, Viral; Fluorescent Antibody Technique; HIV; HIV Envelope Protein gp120; Immunologic Techniques; Retroviridae Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Suramin; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Fusion Proteins; Virion; Zidovudine

1988
1-(2,3-Anhydro-beta-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:7

    Topics: Ancitabine; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; HIV; Magnetic Resonance Spectroscopy; Mass Spectrometry; Thymidine; Uracil; Zidovudine

1988
AIDS encephalopathy with response to treatment.
    Archives of disease in childhood, 1988, Volume: 63, Issue:5

    Topics: Antiviral Agents; Brain Diseases; Child, Preschool; gamma-Globulins; HIV Seropositivity; Humans; Male; Opportunistic Infections; Thymidine; Zidovudine

1988
Antiviral chemotherapy.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Herpes Simplex; Herpes Zoster; Humans; Interferons; Thymidine; Zidovudine

1988
Inhibition of reverse transcription in rat liver intracisternal A-particles by thymidine derivatives.
    FEBS letters, 1989, Apr-10, Volume: 247, Issue:1

    Topics: Animals; Dideoxynucleotides; DNA; Genes, Intracisternal A-Particle; Microsomes, Liver; Proto-Oncogenes; Rats; Rats, Inbred Strains; Retroviridae; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Templates, Genetic; Thymidine; Thymine Nucleotides; Zidovudine

1989
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:2

    Topics: Antiviral Agents; Bone Marrow; Dideoxynucleosides; HIV; Stavudine; Thymidine; Zidovudine

1989
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.
    The Journal of biological chemistry, 1989, Apr-15, Volume: 264, Issue:11

    Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Deoxycytidine; Deoxyribonucleotides; Dideoxynucleosides; Dose-Response Relationship, Drug; HIV; Humans; Mice; Phosphorylation; Sarcoma Viruses, Murine; Solubility; Stavudine; Thymidine; Zidovudine

1989
Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication.
    Biochemical pharmacology, 1989, Apr-01, Volume: 38, Issue:7

    Topics: Animals; Dideoxynucleosides; DNA Replication; HIV-1; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains; Thymidine; Virus Replication; Zidovudine

1989
Sustained delivery of 3H-thymidine by means of ceramic capsules in rats.
    Biomedical sciences instrumentation, 1989, Volume: 25

    Topics: Animals; Capsules; Ceramics; Delayed-Action Preparations; Drug Implants; Male; Rats; Rats, Inbred Strains; Thymidine; Zidovudine

1989
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.
    Journal of virological methods, 1987, Volume: 16, Issue:3

    Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Deoxycytidine; Flow Cytometry; Fluorescent Antibody Technique; HIV; Humans; Thymidine; Zalcitabine; Zidovudine

1987
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.
    The Journal of experimental medicine, 1987, Oct-01, Volume: 166, Issue:4

    Topics: Adenosine Kinase; Cell Line; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dideoxyadenosine; HIV; Humans; Macrophages; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Uridine Kinase; Virus Replication; Zalcitabine; Zidovudine

1987
The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.
    Biochemical pharmacology, 1988, Mar-01, Volume: 37, Issue:5

    Topics: Animals; Antiviral Agents; Cell Line; Deoxycytidine; HIV; Humans; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Retroviridae; Thymidine; Zalcitabine; Zidovudine

1988
Therapy for neurological involvement in AIDS.
    Annals of neurology, 1988, Volume: 23 Suppl

    Topics: Acquired Immunodeficiency Syndrome; Blood-Brain Barrier; Central Nervous System Diseases; Deoxycytidine; Humans; Immunotherapy; Molecular Biology; Retroviridae; Thymidine; Zalcitabine; Zidovudine

1988
Can AZT treatment in AIDS patients aggravate pre-existing CMV retinitis?
    The British journal of ophthalmology, 1988, Volume: 72, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cytomegalovirus Infections; Humans; Male; Retinitis; Thymidine; Zidovudine

1988
Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:2

    Topics: Cell Line; Cytomegalovirus; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV; Simplexvirus; Thymidine; Virus Replication; Zidovudine

1988
Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro.
    AIDS research and human retroviruses, 1988, Volume: 4, Issue:2

    Topics: Cytopathogenic Effect, Viral; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; HIV; In Vitro Techniques; Nucleosides; Retroviridae; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Proteins; Virus Replication; Zalcitabine; Zidovudine

1988
Atypical retinitis in patients with the acquired immunodeficiency syndrome.
    American journal of ophthalmology, 1988, May-15, Volume: 105, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Cytomegalovirus Infections; Fluorescein Angiography; Fundus Oculi; Humans; Male; Retinitis; Ribavirin; Thymidine; Zidovudine

1988
Synergistic interaction of 2',3'-dideoxycytidine and recombinant interferon-alpha-A on replication of human immunodeficiency virus type 1.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:2

    Topics: Antiviral Agents; Cell Line; Deoxycytidine; Drug Synergism; HIV; Humans; Interferon Type I; Leukocytes; Recombinant Proteins; Thymidine; Virus Replication; Zalcitabine; Zidovudine

1988
Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:3

    Topics: Animals; Antiviral Agents; Blood-Brain Barrier; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; Liver; Male; Rats; Rats, Inbred Strains; Thymidine; Zalcitabine; Zidovudine

1988
Resolution of cytomegalovirus retinitis with zidovudine therapy. Case report.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1988, Volume: 106, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Adult; Cytomegalovirus Infections; Fundus Oculi; Humans; Male; Retinitis; Thymidine; Zidovudine

1988
Azidothymidine neurotoxicity.
    Lancet (London, England), 1986, Dec-13, Volume: 2, Issue:8520

    Topics: Acquired Immunodeficiency Syndrome; Adult; Epilepsies, Partial; Humans; Male; Opportunistic Infections; Thymidine; Zidovudine

1986
Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine.
    Lancet (London, England), 1987, Jan-17, Volume: 1, Issue:8525

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Humans; Male; Middle Aged; Nervous System Diseases; Thymidine; Zidovudine

1987
Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus.
    Lancet (London, England), 1987, Apr-18, Volume: 1, Issue:8538

    Topics: Antiviral Agents; Cell Line; HIV; Humans; Poly I-C; Poly U; Polyribonucleotides; Thymidine; Virus Replication; Zidovudine

1987
Wernicke's encephalopathy in AIDS patient treated with zidovudine.
    Lancet (London, England), 1987, Apr-18, Volume: 1, Issue:8538

    Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Thymidine; Wernicke Encephalopathy; Zidovudine

1987
Serum thymidine kinase in AIDS patients treated with zidovudine.
    Lancet (London, England), 1987, Aug-22, Volume: 2, Issue:8556

    Topics: Acquired Immunodeficiency Syndrome; Humans; Thymidine; Thymidine Kinase; Zidovudine

1987
Remission of AIDS-associated psoriasis with zidovudine.
    Lancet (London, England), 1987, Sep-12, Volume: 2, Issue:8559

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Humans; Male; Psoriasis; Thymidine; Zidovudine

1987
Zidovudine for lymphocytic interstitial pneumonia associated with AIDS.
    Lancet (London, England), 1987, Oct-03, Volume: 2, Issue:8562

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Humans; Male; Middle Aged; Pulmonary Fibrosis; Thymidine; Zidovudine

1987
Zidovudine for lymphocytic interstitial pneumonitis in AIDS.
    Lancet (London, England), 1987, Dec-05, Volume: 2, Issue:8571

    Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Pulmonary Fibrosis; Thymidine; Zidovudine

1987
Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).
    Lancet (London, England), 1988, Jan-16, Volume: 1, Issue:8577

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Deoxycytidine; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; HIV; Humans; Male; Middle Aged; Thymidine; Zalcitabine; Zidovudine

1988
Treatment of HIV-induced retinoid-resistant psoriasis with zidovudine.
    Lancet (London, England), 1987, Dec-19, Volume: 2, Issue:8573

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Drug Resistance; Etretinate; Homosexuality; Humans; Male; Psoriasis; Thymidine; Zidovudine

1987
Combination therapy after retroviral inoculation.
    Lancet (London, England), 1988, Jan-30, Volume: 1, Issue:8579

    Topics: Animals; Antiviral Agents; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Interferon Type I; Mice; Mice, Inbred BALB C; Recombinant Proteins; Retroviridae Infections; Thymidine; Zidovudine

1988
Resumption of HIV antigen production during continuous zidovudine treatment.
    Lancet (London, England), 1988, Feb-20, Volume: 1, Issue:8582

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Antiviral Agents; HIV; Humans; Thymidine; Zidovudine

1988
Post-exposure prophylaxis against HIV infection in health care workers.
    Lancet (London, England), 1988, Feb-27, Volume: 1, Issue:8583

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Female; Humans; Laboratory Infection; Thymidine; Zidovudine

1988
Isolation of HIV from mononuclear cells of patients receiving zidovudine.
    Lancet (London, England), 1988, Apr-16, Volume: 1, Issue:8590

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antiviral Agents; HIV; Humans; Leukocytes, Mononuclear; Thymidine; Zidovudine

1988
Necrotising myopathy and zidovudine.
    Lancet (London, England), 1988, May-07, Volume: 1, Issue:8593

    Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Muscular Diseases; Necrosis; Thymidine; Zidovudine

1988
Update on AIDS--new video cassette.
    Annals of allergy, 1988, Volume: 60, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Congresses as Topic; Drug Therapy; Humans; Immunotherapy; Thymidine; Videotape Recording; Zidovudine

1988
Acute meningo-encephalitis on dose reduction of zidovudine.
    Lancet (London, England), 1988, Jun-04, Volume: 1, Issue:8597

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Complex; Antiviral Agents; Follow-Up Studies; HIV; Homosexuality; Humans; Male; Meningoencephalitis; Middle Aged; Neutropenia; Thrombocytopenia; Thymidine; Virus Replication; Zidovudine

1988
Increased frequency of haemarthroses in haemophilic patient treated with zidovudine.
    Lancet (London, England), 1988, Jun-25, Volume: 1, Issue:8600

    Topics: Acquired Immunodeficiency Syndrome; Hemarthrosis; Hemophilia A; Humans; Male; Middle Aged; Thymidine; Zidovudine

1988
IVth international AIDS conference.
    Lancet (London, England), 1988, Jul-02, Volume: 2, Issue:8601

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Child; Congresses as Topic; Female; Health Education; HIV; HIV Antibodies; Humans; Male; Sweden; Thymidine; Zidovudine

1988
Myelopathy after stopping zidovudine.
    Lancet (London, England), 1988, Jul-30, Volume: 2, Issue:8605

    Topics: Humans; Male; Middle Aged; Spinal Cord Diseases; Substance Withdrawal Syndrome; Thymidine; Zidovudine

1988
Acyclovir-resistant herpes in AIDS treated with foscarnet.
    Lancet (London, England), 1988, Aug-06, Volume: 2, Issue:8606

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Drug Resistance, Microbial; Female; Foscarnet; Herpes Genitalis; Humans; Organophosphorus Compounds; Phosphonoacetic Acid; Simplexvirus; Thymidine; Zidovudine

1988
Zidovudine overdose.
    Lancet (London, England), 1988, Aug-27, Volume: 2, Issue:8609

    Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Thymidine; Zidovudine

1988
Acute meningoencephalitis on dose reduction of zidovudine.
    Lancet (London, England), 1988, Sep-03, Volume: 2, Issue:8610

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; HIV; Humans; Meningoencephalitis; Thymidine; Virus Replication; Zidovudine

1988
Zidovudine-associated myopathy.
    Lancet (London, England), 1988, Sep-17, Volume: 2, Issue:8612

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Muscular Diseases; Thymidine; Zidovudine

1988
AIDS: the virus, antivirals and vaccines.
    British journal of hospital medicine, 1987, Volume: 37, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Genes, Viral; HIV; Humans; Phosphonoacetic Acid; Suramin; Thymidine; Tungsten; Tungsten Compounds; Viral Vaccines; Virus Replication; Zidovudine

1987
Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study.
    Annals of internal medicine, 1988, Volume: 108, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; AIDS-Related Complex; Antiviral Agents; Drug Interactions; Drug Therapy, Combination; Hematologic Diseases; Humans; Male; Middle Aged; Nervous System Diseases; Pilot Projects; T-Lymphocytes, Helper-Inducer; Thymidine; Zidovudine

1988
[Dysautonomic orthostatic hypotension in human immunodeficiency virus infection. Remission in azidovudine therapy].
    Presse medicale (Paris, France : 1983), 1988, May-14, Volume: 17, Issue:18

    Topics: Acquired Immunodeficiency Syndrome; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Humans; Hypotension, Orthostatic; Male; Thymidine; Zidovudine

1988
The influence of human immunodeficiency virus (HIV) infection on antibody responses to influenza vaccines.
    Annals of internal medicine, 1988, Sep-01, Volume: 109, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antibodies, Viral; Antiviral Agents; Hemagglutination Inhibition Tests; HIV Core Protein p24; HIV Seropositivity; Humans; Influenza A virus; Influenza B virus; Influenza Vaccines; Leukocyte Count; Male; Prospective Studies; Retroviridae Proteins; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Core Proteins; Zidovudine

1988
Anti-AIDS agents show varying early results in vitro and in vivo.
    JAMA, 1985, Nov-08, Volume: 254, Issue:18

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Deltaretrovirus; Humans; Ribavirin; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine

1985
In search of the best drugs against AIDS.
    Science (New York, N.Y.), 1986, Jul-25, Volume: 233, Issue:4762

    Topics: Acquired Immunodeficiency Syndrome; Deltaretrovirus; Humans; Ribavirin; Suramin; Thymidine; Zidovudine

1986
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
    Biochemical and biophysical research communications, 1987, Jan-15, Volume: 142, Issue:1

    Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Structure-Activity Relationship; Thymidine; Virus Replication; Zidovudine

1987
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
    Biochemical pharmacology, 1987, Feb-01, Volume: 36, Issue:3

    Topics: Antiviral Agents; Deoxycytidine; Fluorescence; HIV; Humans; In Vitro Techniques; Monocytes; Thymidine; Zalcitabine; Zidovudine

1987
Substances affecting the infection and replication of human immunodeficiency virus (HIV).
    AIDS research, 1986, Volume: 2 Suppl 1

    Topics: Cell Line; Cytopathogenic Effect, Viral; Deltaretrovirus; Dinoprostone; HIV; Humans; Interferon-gamma; Prostaglandins E; Tetradecanoylphorbol Acetate; Thymidine; Tretinoin; Virus Replication; Zidovudine

1986
3'-Azido-3'-deoxythymidine in feline leukemia virus-infected cats: a model for therapy and prophylaxis of AIDS.
    Cancer research, 1987, Jun-15, Volume: 47, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Viral; Antineoplastic Agents; Antiviral Agents; Cats; Leukemia Virus, Feline; Leukemia, Experimental; Thymidine; Zidovudine

1987
Intravitreous ganciclovir for patients receiving zidovudine.
    JAMA, 1987, Jun-12, Volume: 257, Issue:22

    Topics: Acyclovir; Adult; Antiviral Agents; Cytomegalovirus Infections; Ganciclovir; Humans; Injections; Male; Retinitis; Thymidine; Vitreous Body; Zidovudine

1987
Management of viral infections in AIDS patients.
    Infection, 1987, Volume: 15 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cytomegalovirus Infections; Herpes Simplex; Herpes Zoster; Herpesvirus 4, Human; Humans; Leukoplakia, Oral; Opportunistic Infections; Thymidine; Tumor Virus Infections; Virus Diseases; Zidovudine

1987
Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy.
    Science (New York, N.Y.), 1987, Jun-26, Volume: 236, Issue:4809

    Topics: Animals; Animals, Newborn; Antiviral Agents; Central Nervous System Diseases; Female; Fetal Diseases; Gestational Age; Maternal-Fetal Exchange; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Retroviridae; Thymidine; Tumor Virus Infections; Virulence; Zidovudine

1987
Pharmacological inhibition of in vitro infectivity of human T lymphotropic virus type I.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:2

    Topics: Deltaretrovirus; Deoxycytidine; DNA, Viral; Humans; Lymphocyte Activation; T-Lymphocytes, Helper-Inducer; Tetanus Toxoid; Thymidine; Virus Replication; Zalcitabine; Zidovudine

1987
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:6

    Topics: Antigens, Viral; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Thymidine; Viral Plaque Assay; Virus Replication; Zalcitabine; Zidovudine

1987
Brain damage by AIDS under active study.
    Science (New York, N.Y.), 1987, Mar-27, Volume: 235, Issue:4796

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Cell Line; Cell Transformation, Viral; Encephalitis; Glioma; Histocytochemistry; Humans; Macrophages; Membrane Proteins; Microscopy, Electron; Neuroglia; T-Lymphocytes; Thymidine; Viral Proteins; Zidovudine

1987
TPA and PDQ.
    Science (New York, N.Y.), 1987, Jul-24, Volume: 237, Issue:4813

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Quality Control; Thymidine; Tissue Plasminogen Activator; United States; United States Food and Drug Administration; Zidovudine

1987
Effect of 3'-azido-2',3'-dideoxythymidine (AZT) and neutralizing antibody on human immunodeficiency virus (HIV)-induced cytopathic effects: implication of giant cell formation for the spread of virus in vivo.
    Virology, 1987, Volume: 159, Issue:1

    Topics: Antibodies, Viral; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Antiviral Agents; Cell Fusion; Cytopathogenic Effect, Viral; HIV; Neutralization Tests; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine

1987
Suppression of human immunodeficiency virus replication by 3'-azido-3'-deoxythymidine in various human hematopoietic cell lines in vitro: augmentation of the effect by lentinan.
    Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:6

    Topics: Cell Line; Drug Synergism; Hematopoietic Stem Cells; HIV; Humans; Lentinan; Polysaccharides; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine

1987
Response of AIDS-related thrombocytopenia to intravenous and oral azidothymidine (3'-azido-3'-deoxythymidine).
    AIDS research and human retroviruses, 1987,Summer, Volume: 3, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Humans; Injections, Intravenous; Leukocyte Count; Platelet Count; T-Lymphocytes; Thrombocytopenia; Thymidine; Zidovudine

1987
Amplification of human immuno-deficiency virus production from a virus-producing cell line in culture at high cell density.
    Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:7

    Topics: Cell Line; Culture Media; Electrophoresis, Polyacrylamide Gel; HIV; Humans; Membrane Proteins; Thymidine; Viral Proteins; Virion; Virology; Virus Replication; Zidovudine

1987
Suppression by neurotropin of production of human immuno-deficiency virus by the virus-producing MOLT-4 cell line.
    Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Surface; Antigens, Viral; Cell Line; HIV; Humans; Polysaccharides; Thymidine; Virion; Virus Replication; Zidovudine

1987
AIDS, cardiovascular drugs approved in 1987.
    Hospitals, 1987, Dec-20, Volume: 61, Issue:24

    Topics: Drug and Narcotic Control; Humans; Thymidine; Tissue Plasminogen Activator; United States; United States Food and Drug Administration; Zidovudine

1987
The blood transfusion service and zidovudine treatment for AIDS.
    British medical journal (Clinical research ed.), 1987, Dec-05, Volume: 295, Issue:6611

    Topics: Acquired Immunodeficiency Syndrome; Anemia; Antiviral Agents; Blood Transfusion; Humans; Thymidine; Zidovudine

1987
Decline of HIV antigen levels in cerebrospinal fluid during treatment with low-dose zidovudine.
    AIDS (London, England), 1988, Volume: 2, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Central Nervous System Diseases; HIV; HIV Antigens; Humans; Male; Thymidine; Time Factors; Virus Replication; Zidovudine

1988
HIV antigenemia and zidovudine.
    AIDS (London, England), 1988, Volume: 2, Issue:3

    Topics: Antigens, Viral; Antiviral Agents; HIV; HIV Antigens; Humans; Thymidine; Zidovudine

1988
Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome.
    The American journal of medicine, 1988, Volume: 85, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Agranulocytosis; Humans; Leukocyte Count; Lithium; Lithium Carbonate; Male; Middle Aged; Neutropenia; Neutrophils; Thymidine; Zidovudine

1988
Treatment of human immunodeficiency virus-related polyneuropathy with 3'-azido-2',3'-dideoxythymidine.
    Annals of neurology, 1988, Volume: 23 Suppl

    Topics: Acquired Immunodeficiency Syndrome; Aged; Female; Humans; Leg; Nervous System Diseases; Neural Conduction; Paralysis; Sural Nerve; Thymidine; Zidovudine

1988
Nail pigmentation and azidothymidine.
    Annals of internal medicine, 1988, Volume: 108, Issue:5

    Topics: Antiviral Agents; Humans; Male; Middle Aged; Nails; Pigmentation; Thymidine; Zidovudine

1988
Overdose of zidovudine.
    The New England journal of medicine, 1988, May-05, Volume: 318, Issue:18

    Topics: Adult; Humans; Male; Thymidine; Zidovudine

1988
AZT helpful in HIV infection.
    The New Zealand medical journal, 1988, Apr-27, Volume: 101, Issue:844

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine

1988
Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex.
    JAMA, 1988, May-27, Volume: 259, Issue:20

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Chromatography, High Pressure Liquid; Humans; Male; Radioimmunoassay; Semen; Thymidine; Zidovudine

1988
Health of Toronto's street kids disturbing, study reveals.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1988, Jun-01, Volume: 138, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Behavior; Antiviral Agents; Attitude to Health; Chlamydia Infections; Female; Humans; Ill-Housed Persons; Male; Ontario; Pregnancy; Pregnancy in Adolescence; Thymidine; Zidovudine

1988
Recovery from cryptococcemia and the adult respiratory distress syndrome in the acquired immunodeficiency syndrome.
    Chest, 1988, Volume: 93, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Amphotericin B; Antiviral Agents; Cryptococcosis; Humans; Intubation, Intratracheal; Male; Radiography; Respiratory Distress Syndrome; Thymidine; Zidovudine

1988
Manic syndrome associated with zidovudine treatment.
    JAMA, 1988, Jun-17, Volume: 259, Issue:23

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Bipolar Disorder; Cognition Disorders; Humans; Male; Thymidine; Zidovudine

1988
[HIV infection and AIDS. Paris, 25-29 January 1988].
    Ugeskrift for laeger, 1988, Apr-18, Volume: 150, Issue:16

    Topics: Acquired Immunodeficiency Syndrome; Antibody Formation; HIV; Humans; Thymidine; Zidovudine

1988
[Zidovudin (Retrovir). A new antiviral agents against human immunodeficiency viruses (HIV)].
    Ugeskrift for laeger, 1988, Jan-25, Volume: 150, Issue:4

    Topics: Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Thymidine; Zidovudine

1988
Clostridium difficile colitis following antiviral therapy in the acquired immunodeficiency syndrome.
    The American journal of medicine, 1988, Volume: 84, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Enterocolitis, Pseudomembranous; Humans; Male; Middle Aged; Thymidine; Zidovudine

1988
Zidovudine overdosage.
    Annals of internal medicine, 1988, Jul-01, Volume: 109, Issue:1

    Topics: Adult; Antiviral Agents; Ataxia; Humans; Male; Nystagmus, Pathologic; Suicide, Attempted; Thymidine; Zidovudine

1988
The effect of zidovudine on antigen levels in HIV infection.
    New York state journal of medicine, 1988, Volume: 88, Issue:5

    Topics: Acyclovir; Antigens, Viral; Antiviral Agents; Drug Therapy, Combination; HIV; HIV Antigens; HIV Seropositivity; Humans; Male; Thymidine; Zidovudine

1988
Prophylactic Retrovir study for health care workers.
    The American journal of nursing, 1988, Volume: 88, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Health Occupations; Humans; Thymidine; Zidovudine

1988
Update on AIDS--new video cassette.
    Annals of allergy, 1988, Volume: 60, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Forecasting; Humans; Research; Thymidine; Videotape Recording; Zidovudine

1988
Phosphorylation, anti-HIV activity and cytotoxicity of 3'-fluorothymidine.
    Biochemical and biophysical research communications, 1988, Jun-16, Volume: 153, Issue:2

    Topics: Animals; Antiviral Agents; Cell Division; Cell Line; Cell Survival; Cytidine Diphosphate; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Mice; Phosphorylation; Rats; Thymidine; Virus Replication; Zidovudine

1988
AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system.
    FEBS letters, 1988, Jul-04, Volume: 234, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Animals; Brain; Cell Line; Chemical Phenomena; Chemistry; Dementia; Dihydropyridines; HIV; Humans; Male; Mice; Moloney murine sarcoma virus; Pharmaceutical Preparations; Prodrugs; Rats; Rats, Inbred Strains; Thymidine; Virus Replication; Zidovudine

1988
Response of human immunodeficiency virus-associated uveitis to zidovudine.
    American journal of ophthalmology, 1988, Jul-15, Volume: 106, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Humans; Male; Thymidine; Uveitis; Visual Acuity; Zidovudine

1988
Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells.
    Biochemical and biophysical research communications, 1988, Jul-15, Volume: 154, Issue:1

    Topics: Antiviral Agents; Cell Line; Deoxyribonucleotides; Humans; Kinetics; Leukemia; Thymidine; Zidovudine

1988
From the Food and Drug Administration. Update on zidovudine.
    JAMA, 1988, Aug-19, Volume: 260, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine

1988
Resolution of oral hairy leukoplakia during treatment with azidothymidine.
    Oral surgery, oral medicine, and oral pathology, 1988, Volume: 65, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Homosexuality; Humans; Leukoplakia, Oral; Male; Thymidine; Tongue Neoplasms; Zidovudine

1988
A sensitive liquid-chromatographic method for determination of 3'-azido-3'-deoxythymidine (AZT) in plasma and urine.
    Clinical chemistry, 1988, Volume: 34, Issue:8

    Topics: Chromatography, High Pressure Liquid; Humans; Reference Values; Thymidine; Zidovudine

1988
Study to examine use of retrovir.
    Pennsylvania medicine, 1988, Volume: 91, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Evaluation; Humans; Occupational Diseases; Thymidine; Zidovudine

1988
Pharmacokinetics and bioavailability of zidovudine in humans.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antiviral Agents; Biological Availability; Drug Evaluation; Humans; Thymidine; Zidovudine

1988
Zidovudine therapy in children with acquired immunodeficiency syndrome.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Male; Thymidine; Zidovudine

1988
Mycobacterium avium complex infection presenting as endobronchial lesions in immunosuppressed patients.
    Annals of internal medicine, 1988, Sep-01, Volume: 109, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Bronchial Diseases; Bronchoscopy; Female; Humans; Male; Middle Aged; Mycobacterium avium; Mycobacterium Infections; Opportunistic Infections; Radiography; Thymidine; Zidovudine

1988
[Disordered long-term memory in mice as affected by azidothymidine].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 106, Issue:8

    Topics: Animals; Antiviral Agents; Avoidance Learning; Dose-Response Relationship, Drug; Male; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Reaction Time; Thymidine; Time Factors; Zidovudine

1988
[Severe anemia after administration of zidovudine].
    Medicina clinica, 1988, May-21, Volume: 90, Issue:20

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anemia; Humans; Male; Thymidine; Zidovudine

1988
Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection.
    The New England journal of medicine, 1988, Oct-06, Volume: 319, Issue:14

    Topics: Acquired Immunodeficiency Syndrome; Brain; Brain Diseases; Child; Child, Preschool; Follow-Up Studies; Glucose; Humans; Infant; Infusions, Intravenous; Intelligence Tests; Opportunistic Infections; Thymidine; Tomography, X-Ray Computed; Zidovudine

1988
AIDS update--a roundup of news and trends.
    Nursing, 1988, Volume: 18, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine

1988
Thrombocytopenia, the acquired immunodeficiency syndrome (AIDS), and zidovudine.
    Annals of internal medicine, 1988, Oct-15, Volume: 109, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Thrombocytopenia; Thymidine; Zidovudine

1988
Resolution of resistant chronic herpetic lesions with zidovudine in a patient with the acquired immunodeficiency syndrome.
    Archives of dermatology, 1988, Volume: 124, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adult; Chronic Disease; Herpes Simplex; Humans; Male; Opportunistic Infections; Thymidine; Zidovudine

1988
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:7

    Topics: Antiviral Agents; Cytidine; HIV; Humans; In Vitro Techniques; Macrophages; Stem Cells; Thymidine; Uridine; Virus Replication; Zidovudine

1988
Enhanced in vitro inhibition of HIV-1 replication by 3'-fluoro-3'-deoxythymidine compared to several other nucleoside analogs.
    AIDS research and human retroviruses, 1988, Volume: 4, Issue:6

    Topics: Cell Line; Dideoxynucleosides; HIV-1; In Vitro Techniques; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Structure-Activity Relationship; Thymidine; Virus Replication; Zidovudine

1988
Thiol reduction of 3'-azidothymidine to 3'-aminothymidine: kinetics and biomedical implications.
    Pharmaceutical research, 1988, Volume: 5, Issue:5

    Topics: Chromatography, High Pressure Liquid; Dideoxynucleosides; Dithiothreitol; Kinetics; Oxidation-Reduction; Sulfhydryl Compounds; Thymidine; Zidovudine

1988
Treatment of pneumocystis pneumonia in AIDS.
    The New England journal of medicine, 1988, Apr-14, Volume: 318, Issue:15

    Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Humans; Pneumonia, Pneumocystis; Thymidine; Zidovudine

1988
Prolonged pancytopenia due to combined ganciclovir and zidovudine therapy.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:2

    Topics: Acyclovir; Antiviral Agents; Drug Therapy, Combination; Ganciclovir; Humans; Male; Middle Aged; Pancytopenia; Thymidine; Zidovudine

1988
3'-Azido-3'-deoxythymidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells.
    British journal of haematology, 1988, Volume: 69, Issue:3

    Topics: Antiviral Agents; Cell Division; Colony-Forming Units Assay; Depression, Chemical; Hematopoiesis; Hematopoietic Stem Cells; Humans; Interleukin-3; Thymidine; Zidovudine

1988
Granulomatous pulmonary lesions in patients with the acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii infection.
    Annals of internal medicine, 1988, Sep-15, Volume: 109, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Antiviral Agents; Granuloma; Humans; Male; Pentamidine; Pneumonia, Pneumocystis; Thymidine; Zidovudine

1988
Zidovudine-induced nail pigmentation.
    Archives of dermatology, 1988, Volume: 124, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Nail Diseases; Opportunistic Infections; Pigmentation Disorders; Pneumonia, Pneumocystis; Thymidine; Zidovudine

1988
State Medicaid coverage of AZT and AIDS-related policies.
    American journal of public health, 1988, Volume: 78, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Hospices; Humans; Insurance Benefits; Insurance, Health, Reimbursement; Medicaid; Thymidine; United States; Zidovudine

1988
Neutropenia in an HIV-1-infected renal transplant recipient treated with zidovudine.
    JAMA, 1988, Jun-17, Volume: 259, Issue:23

    Topics: Acquired Immunodeficiency Syndrome; Adult; Agranulocytosis; Antiviral Agents; Humans; Kidney Transplantation; Male; Neutropenia; Thymidine; Zidovudine

1988
Effector studies of 3'-azidothymidine nucleotides with human ribonucleotide reductase.
    Biochemical pharmacology, 1987, Nov-01, Volume: 36, Issue:21

    Topics: Antiviral Agents; Cytidine Diphosphate; Guanosine Diphosphate; Humans; Kinetics; Nucleotides; Oxidation-Reduction; Ribonucleotide Reductases; Thymidine; Thymine Nucleotides; Zidovudine

1987
Drugs recently released in Belgium. Carboplatin, cefmenoxime, zidovudine.
    Acta clinica Belgica, 1987, Volume: 42, Issue:6

    Topics: Antineoplastic Agents; Antiviral Agents; Carboplatin; Cefmenoxime; Cefotaxime; Humans; Organoplatinum Compounds; Thymidine; Zidovudine

1987
Azidothymidine in the treatment of AIDS.
    The New England journal of medicine, 1988, Jan-28, Volume: 318, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Humans; Male; Thymidine; Zidovudine

1988
AIDS-associated psoriasis responds to azidothymidine.
    The Medical journal of Australia, 1988, Feb-01, Volume: 148, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Psoriasis; Thymidine; Zidovudine

1988
The effect of azidothymidine on HIV-related thrombocytopenia.
    The New England journal of medicine, 1988, Feb-25, Volume: 318, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Platelet Count; Thrombocytopenia; Thymidine; Zidovudine

1988
AIDS drug patent.
    Nature, 1988, Feb-18, Volume: 331, Issue:6157

    Topics: Acquired Immunodeficiency Syndrome; Humans; Patents as Topic; Thymidine; United States; Zidovudine

1988
Factitious false-positive test for HIV.
    JAMA, 1988, Mar-18, Volume: 259, Issue:11

    Topics: Adult; Factitious Disorders; False Positive Reactions; HIV Seropositivity; Humans; Male; Thymidine; Zidovudine

1988
Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC.
    The New England journal of medicine, 1988, Mar-17, Volume: 318, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Humans; Myositis; Thymidine; Zidovudine

1988
AIDS drug assistance program.
    New York state journal of medicine, 1988, Volume: 88, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Medical Assistance; New York; Thymidine; Zidovudine

1988
Significant changes in HIV antigen level in the serum of patients treated with azidothymidine.
    The New England journal of medicine, 1986, Dec-18, Volume: 315, Issue:25

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Antiviral Agents; HIV; HIV Antigens; Humans; Thymidine; Zidovudine

1986
Possible drug interaction during therapy with azidothymidine and acyclovir for AIDS.
    The New England journal of medicine, 1987, Feb-26, Volume: 316, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Drug Interactions; Herpes Simplex; Humans; Male; Sleep Stages; Thymidine; Zidovudine

1987
AZT (zidovudine) just a step away from FDA approval for AIDS therapy.
    JAMA, 1987, Mar-13, Volume: 257, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine

1987
Imminent marketing of AZT raises problems.
    Science (New York, N.Y.), 1987, Mar-20, Volume: 235, Issue:4795

    Topics: Acquired Immunodeficiency Syndrome; Humans; Thymidine; Zidovudine

1987
FDA approves AZT.
    Science (New York, N.Y.), 1987, Mar-27, Volume: 235, Issue:4796

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine

1987
Azidothymidine and human immunodeficiency virus infection.
    New York state journal of medicine, 1987, Volume: 87, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine

1987
Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:2

    Topics: Antiviral Agents; Drug Synergism; HIV; Humans; Interferon Type I; Recombinant Proteins; Thymidine; Virus Replication; Zidovudine

1987
3'-azido-3'-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion.
    The Journal of biological chemistry, 1987, Apr-25, Volume: 262, Issue:12

    Topics: Antiviral Agents; Biological Transport; Cell Membrane Permeability; Diffusion; Erythrocytes; Humans; Kinetics; Lymphocytes; Thymidine; Zidovudine

1987
Availability of AZT for treatment of AIDS.
    The New England journal of medicine, 1987, Apr-30, Volume: 316, Issue:18

    Topics: Acquired Immunodeficiency Syndrome; Humans; Thymidine; United States; Zidovudine

1987
"Cure" of chronic cryptosporidiosis during treatment with azidothymidine in a patient with the acquired immune deficiency syndrome.
    The American journal of medicine, 1987, Volume: 83, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Chronic Disease; Cryptosporidiosis; Diarrhea; Humans; Male; Opportunistic Infections; Thymidine; Zidovudine

1987
Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)].
    Antiviral research, 1987, Volume: 7, Issue:3

    Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Drug Interactions; Glycyrrhetinic Acid; Glycyrrhizic Acid; HIV; Humans; Thymidine; Zidovudine

1987
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro.
    Antiviral research, 1987, Volume: 7, Issue:3

    Topics: Adenine; African Swine Fever Virus; Amides; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Iridoviridae; Organophosphonates; Organophosphorus Compounds; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tubercidin; Vero Cells; Virus Replication; Zidovudine

1987
AIDS research: the ethics of clinical trials.
    Law, medicine & health care : a publication of the American Society of Law & Medicine, 1986, Volume: 14, Issue:5-6

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Beneficence; Clinical Trials as Topic; Control Groups; Ethical Analysis; Ethics, Professional; Human Experimentation; Humans; Patient Advocacy; Patient Selection; Personal Autonomy; Research; Research Subjects; Risk Assessment; Social Justice; Thymidine; Zidovudine

1986
Antiretroviral therapy for AIDS.
    The New England journal of medicine, 1987, Sep-03, Volume: 317, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; DNA, Viral; Humans; Thymidine; Zidovudine

1987
Inhibition of hepatitis B virus DNA polymerase by 3'-azido-3'-deoxythymidine triphosphate but not by its threo analog.
    Journal of medical virology, 1987, Volume: 22, Issue:3

    Topics: Antiviral Agents; Carrier State; Dideoxynucleotides; Hepatitis B; Hepatitis B virus; Humans; Nucleic Acid Synthesis Inhibitors; Thymidine; Thymine Nucleotides; Zidovudine

1987
Profound cytopenia secondary to azidothymidine.
    The New England journal of medicine, 1987, Sep-17, Volume: 317, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Pancytopenia; Thymidine; Zidovudine

1987
Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS).
    Annals of internal medicine, 1987, Volume: 107, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Bone Marrow Diseases; Humans; Male; Middle Aged; Pancytopenia; Random Allocation; Thymidine; Zidovudine

1987
Possible zidovudine-induced hepatotoxicity.
    JAMA, 1987, Oct-16, Volume: 258, Issue:15

    Topics: Adult; Antiviral Agents; Humans; Liver; Liver Function Tests; Male; Thymidine; Zidovudine

1987
Promoting Retrovir.
    The New England journal of medicine, 1987, Oct-29, Volume: 317, Issue:18

    Topics: Acquired Immunodeficiency Syndrome; Advertising; Drug Industry; Humans; Thymidine; United States; Zidovudine

1987
Zidovudine and the anaesthetist.
    Anaesthesia, 1987, Volume: 42, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Anesthesiology; Anesthetics; Antiviral Agents; Drug Interactions; Humans; Thymidine; Zidovudine

1987
Azidothymidine (AZT).
    Connecticut medicine, 1987, Volume: 51, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; HIV; Humans; Thymidine; Zidovudine

1987
AZT in hemophilia.
    Thrombosis and haemostasis, 1987, Aug-04, Volume: 58, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Blood Platelets; Hemophilia A; Humans; Male; Thymidine; Zidovudine

1987
Update on AZT for AIDS.
    The Medical letter on drugs and therapeutics, 1987, Dec-18, Volume: 29, Issue:755

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Drug Interactions; Hematologic Diseases; Humans; Thymidine; Zidovudine

1987
Nail pigmentation in the acquired immunodeficiency syndrome (AIDS)
    Annals of internal medicine, 1987, Volume: 107, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Humans; Male; Nail Diseases; Pigmentation Disorders; Thymidine; Zidovudine

1987
A pinch of will is better than a pound of perhaps.
    American pharmacy, 1987, Volume: NS27, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Attitude to Health; Humans; Male; Social Support; Thymidine; Zidovudine

1987
A little more to improve safety and efficiency of AZT in AIDS therapy.
    International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine

1987
[AIDS and antiretroviral agents: specificity of azidothymidine].
    Srpski arhiv za celokupno lekarstvo, 1987, Volume: 115, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Humans; Thymidine; Zidovudine

1987
Zidovudine for AIDS.
    The New Zealand medical journal, 1987, May-27, Volume: 100, Issue:824

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Humans; Thymidine; Zidovudine

1987
Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:3

    Topics: Acyclovir; Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Ganciclovir; Hematopoietic Stem Cells; Humans; Thymidine; Zidovudine

1987
Nail pigmentation changes associated with azidothymidine (zidovudine).
    Annals of internal medicine, 1987, Volume: 107, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Black People; Female; Humans; Male; Nail Diseases; Pigmentation Disorders; Pneumonia, Pneumocystis; Thymidine; Zidovudine

1987
Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.
    AIDS research and human retroviruses, 1987,Spring, Volume: 3, Issue:1

    Topics: Antigen-Presenting Cells; Antiviral Agents; Cell Line; Cell Survival; HIV; Humans; Lymphocyte Activation; Models, Biological; Radioimmunoassay; T-Lymphocytes; Tetanus Toxoid; Thymidine; Zidovudine

1987
Prophylaxis against Pneumocystis carinii pneumonia in patients receiving azidothymidine.
    The New England journal of medicine, 1987, Oct-29, Volume: 317, Issue:18

    Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Middle Aged; Pneumonia, Pneumocystis; Thymidine; Zidovudine

1987
Antiviral agents.
    Mayo Clinic proceedings, 1987, Volume: 62, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Herpes Simplex; Humans; Idoxuridine; Influenza A virus; Influenza, Human; Ribavirin; Rimantadine; Thymidine; Vidarabine; Viruses; Zidovudine

1987
Dideoxynucleosides are less inhibitory in vitro against human immunodeficiency virus type 2 (HIV-2) than against HIV-1.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:12

    Topics: Antiviral Agents; Cell Line; Drug Resistance, Microbial; HIV; Humans; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine

1987
The AIDS virus.
    Scientific American, 1987, Volume: 256, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Animals; Chlorocebus aethiops; Genes, Viral; History, 20th Century; HIV; Humans; Lymphocytes; Thymidine; Viral Envelope Proteins; Viral Vaccines; Zidovudine

1987
Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U).
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:2

    Topics: Antiviral Agents; DNA Replication; DNA, Bacterial; Drug Resistance, Microbial; Enterobacteriaceae; Escherichia coli; HIV; Kinetics; Microbial Sensitivity Tests; Mutation; Thymidine; Thymidine Kinase; Vibrio; Zidovudine

1987
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:2

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Deoxyribonucleosides; Female; Kinetics; Leukemia L1210; Mice; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus; Structure-Activity Relationship; Thymidine; Zidovudine

1980
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
    Molecular microbiology, 1994, Volume: 14, Issue:2

    Topics: Adenosine Triphosphate; Animals; Chlamydia trachomatis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; Guanosine Triphosphate; L Cells; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; RNA, Bacterial; Sulfisoxazole; Thymidine; Trimethoprim; Uracil; Zidovudine

1994
Synthesis of (3'R)-3'-deoxy-3'-C-nitromethylthymidine.
    Carbohydrate research, 1995, Apr-18, Volume: 270, Issue:1

    Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; HIV-1; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Thymidine; Zidovudine

1995
A comparison of the conformations of the 5'-triphosphates of zidovudine (AZT) and thymidine bound to HIV-1 reverse transcriptase.
    Biochemical and biophysical research communications, 1993, Mar-31, Volume: 191, Issue:3

    Topics: HIV Reverse Transcriptase; HIV-1; Magnetic Resonance Spectroscopy; Molecular Structure; Protein Binding; Recombinant Proteins; RNA-Directed DNA Polymerase; Thymidine; Zidovudine

1993
Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells.
    British journal of clinical pharmacology, 1994, Volume: 38, Issue:4

    Topics: Analysis of Variance; B-Lymphocytes; Cell Line; Cells, Cultured; Didanosine; Drug Interactions; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Phosphorylation; Phytohemagglutinins; Thymidine; Zalcitabine; Zidovudine

1994
Sanctuary growth of human immunodeficiency virus in the presence of 3'-azido-3'-deoxythymidine.
    Journal of virology, 1995, Volume: 69, Issue:3

    Topics: Cell Line; Dose-Response Relationship, Drug; Drug Resistance; HIV-1; Humans; In Vitro Techniques; Phosphorylation; Thymidine; Virus Replication; Zidovudine

1995
Zidovudine induces the expression of cellular resistance affecting its antiviral activity.
    AIDS research and human retroviruses, 1994, Volume: 10, Issue:11

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; DNA, Viral; Drug Resistance, Microbial; HIV-1; Humans; Thymidine; Thymidine Kinase; Zidovudine

1994
Development of a ceramic matrix system for continuous delivery of azidothymidine.
    Biomedical sciences instrumentation, 1994, Volume: 30

    Topics: Calcium Phosphates; Ceramics; Drug Implants; Thymidine; Zidovudine

1994
The ex vivo transfer of the anti-HIV nucleoside compound d4T in the human placenta.
    Gynecologic and obstetric investigation, 1994, Volume: 38, Issue:1

    Topics: Diffusion; Dipyridamole; Female; Fetal Blood; Gestational Age; Humans; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Stavudine; Thymidine; Zidovudine

1994
Potentiation of 2',3'-dideoxycytidine (ddC) by hydroxyurea and thymidine on the Moloney murine leukemia virus (MoMLV) early replicative steps.
    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1994, Volume: 317, Issue:5

    Topics: 3T3 Cells; Animals; Drug Synergism; Hydroxyurea; Mice; Moloney murine leukemia virus; Thymidine; Transcription, Genetic; Virus Replication; Zalcitabine; Zidovudine

1994
Inhibition of thymidine transport by 3'-azido-3'-deoxythymidine and its metabolites.
    Oncology research, 1993, Volume: 5, Issue:12

    Topics: Biological Transport; Dideoxynucleosides; Erythrocytes; Humans; Thymidine; Zidovudine

1993
In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors.
    Pharmaceutical research, 1994, Volume: 11, Issue:2

    Topics: Analysis of Variance; Animals; Azides; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Central Nervous System; Deoxyglucose; Diffusion; Endothelium, Vascular; Injections, Intravenous; Injections, Intraventricular; Male; Probenecid; Rats; Rats, Wistar; Sodium Azide; Thymidine; Zidovudine

1994
Covalent coupling of nucleosides to low density lipoprotein (LDL) generates macrophage specific (drug)-carriers.
    International journal of clinical pharmacology, therapy, and toxicology, 1993, Volume: 31, Issue:8

    Topics: Animals; Apolipoproteins B; Autoradiography; Biological Transport; Cells, Cultured; Drug Carriers; Endocytosis; Humans; Lipoproteins, LDL; Lysine; Macrophages; Mice; Thymidine; Zidovudine

1993
Synergistic cytotoxicity of AZT plus alpha and gamma interferon in chronic myeloid leukemia cell line K562.
    European journal of haematology, 1993, Volume: 51, Issue:4

    Topics: Cell Division; Cell Line; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Humans; Interferon alpha-2; Interferon-alpha; Interferon-gamma; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Recombinant Proteins; Thymidine; Tumor Cells, Cultured; Zidovudine

1993
Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model system.
    Journal of pharmaceutical sciences, 1993, Volume: 82, Issue:8

    Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Drug Interactions; Epithelium; Humans; Intestinal Mucosa; Intestines; Nucleosides; Thymidine; Zidovudine

1993
Antiviral drugs from the nucleoside analog family block volume-activated chloride channels.
    Molecular medicine (Cambridge, Mass.), 1995, Volume: 1, Issue:4

    Topics: 3T3 Cells; Acyclovir; Animals; Antiviral Agents; Cell Size; Chloride Channels; Humans; Mice; Patch-Clamp Techniques; Thymidine; Tumor Cells, Cultured; Uridine; Zidovudine

1995
2-amino-9-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)-6-substituted-9H-purines: synthesis and anti-HIV activity.
    Bioorganic & medicinal chemistry, 1995, Volume: 3, Issue:4

    Topics: Antiviral Agents; Cell Line, Transformed; Cytopathogenic Effect, Viral; Dideoxynucleosides; Guanosine; HIV-1; Humans; Lactobacillus; Pentosyltransferases; Purines; Structure-Activity Relationship; T-Lymphocytes; Thymidine; Zidovudine

1995
Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase.
    AIDS research and human retroviruses, 1996, Feb-10, Volume: 12, Issue:3

    Topics: Cell Line; HIV Infections; HIV-1; Humans; Kinetics; Leukocytes, Mononuclear; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Time Factors; Tritium; Zidovudine

1996
AZT incorporation into mitochondria: study in a human myeloid cell line.
    DNA and cell biology, 1996, Volume: 15, Issue:5

    Topics: Antimetabolites; HL-60 Cells; Humans; Mitochondria; Scintillation Counting; Thymidine; Zidovudine

1996
Stavudine selectively induces apoptosis in HIV type 1-infected cells.
    AIDS research and human retroviruses, 1997, Jan-20, Volume: 13, Issue:2

    Topics: Anti-HIV Agents; Apoptosis; Cell Line; Didanosine; DNA Fragmentation; Down-Regulation; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reverse Transcriptase Inhibitors; Stavudine; T-Lymphocytes; Thymidine; Zalcitabine; Zidovudine

1997
Thymidine in the micromolar range promotes rejoining of UVC-induced DNA strand breaks and prevents azidothymidine from inhibiting the rejoining in quiescent human lymphocytes.
    Mutation research, 1997, Mar-12, Volume: 383, Issue:2

    Topics: Adult; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; DNA Damage; DNA Repair; Humans; Lymphocytes; Methyl Methanesulfonate; Middle Aged; Reproducibility of Results; Thymidine; Ultraviolet Rays; Zidovudine

1997
Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:6

    Topics: Anti-HIV Agents; Cells, Cultured; Drug Interactions; Humans; Leukemia, Monocytic, Acute; Leukocytes, Mononuclear; Phosphorylation; Phytohemagglutinins; Stavudine; Stimulation, Chemical; Thymidine; Zidovudine

1997
The passage of azidodeoxythymidine into and within the central nervous system: does it follow the parent compound, thymidine?
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:3

    Topics: Animals; Central Nervous System; Guinea Pigs; Thymidine; Zidovudine

1997
[Synthesis of phosphoceramide azidothymidine and phosphoceramide didehydrodeoxythymidine].
    Bioorganicheskaia khimiia, 1997, Volume: 23, Issue:7

    Topics: Anti-HIV Agents; Ceramides; Dideoxynucleotides; Esterification; Magnetic Resonance Spectroscopy; Prodrugs; Thymidine; Zidovudine

1997
Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat.
    Brain research, 1998, Apr-27, Volume: 791, Issue:1-2

    Topics: Animals; Anti-HIV Agents; Blood-Brain Barrier; Drug Evaluation, Preclinical; Lamivudine; Male; Rats; Rats, Sprague-Dawley; Thymidine; Zidovudine

1998
Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate.
    Journal of virology, 1998, Volume: 72, Issue:10

    Topics: Cell Line; Deoxyribonucleotides; Genetic Vectors; Hydroxyurea; Mutation; Retroviridae; Thymidine; Zidovudine

1998
The transport of the anti-HIV drug, 2',3'-didehydro-3'-deoxythymidine (D4T), across the blood-brain and blood-cerebrospinal fluid barriers.
    British journal of pharmacology, 1998, Volume: 125, Issue:1

    Topics: Analysis of Variance; Animals; Anti-HIV Agents; Biological Transport; Blood-Brain Barrier; Brain; Guinea Pigs; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine

1998
Pharmacokinetics and tissue distribution of (+/-)-3'-azido-2',3'-dideoxy-5'-O-(2-bromomyristoyl)thymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine (AZT) in mice.
    The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:9

    Topics: Animals; Anti-HIV Agents; Area Under Curve; Brain; Chromatography, High Pressure Liquid; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred BALB C; Myristic Acids; Prodrugs; Thymidine; Tissue Distribution; Zidovudine

1998
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.
    Cancer research, 1999, Feb-15, Volume: 59, Issue:4

    Topics: Antimetabolites, Antineoplastic; Carrier Proteins; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Gene Transfer Techniques; Humans; Methotrexate; Receptors, Cell Surface; Thymidine; Thymidine Kinase; Uterine Cervical Neoplasms; Zidovudine

1999
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region.
    Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25

    Topics: Anti-HIV Agents; Cell Line; Dimerization; HIV-1; HIV-2; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Fast Atom Bombardment; Spiro Compounds; Stavudine; Thymidine; Uridine; Zidovudine

1999
A Na(+)-dependent nucleoside transporter in microglia.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:1

    Topics: Adenosine; Animals; Carrier Proteins; Cell Size; Cells, Cultured; Cytidine; Dideoxynucleosides; Dose-Response Relationship, Drug; Guanosine; Membrane Proteins; Microglia; Nucleic Acid Probes; Nucleoside Transport Proteins; Rats; Rats, Wistar; Sodium; Thymidine; Time Factors; Uridine; Zidovudine

2000
[Combination of phosphazide and crixivan inhibit replication of HIV-1 strains that are resistant to azidothymidine].
    Doklady Akademii nauk, 1999, Volume: 369, Issue:6

    Topics: Anti-HIV Agents; Azides; Cell Line; Drug Resistance, Microbial; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Microbial Sensitivity Tests; Organophosphonates; Reverse Transcriptase Inhibitors; Thymidine; Virus Replication; Zidovudine

1999
Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
    The EMBO journal, 2000, Jul-17, Volume: 19, Issue:14

    Topics: Anti-HIV Agents; Boron Compounds; Crystallography, X-Ray; DNA Repair; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Models, Molecular; Molecular Conformation; Nucleoside-Diphosphate Kinase; Protein Binding; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Thymidine; Transcription, Genetic; Zidovudine

2000
A facile synthesis of 1-(5'-O-acetyl-3'-O-benzyl-beta-D-xylofuranosyl)thymidine: a potentially viable intermediate for the preparation of the anti-AIDS drugs, AZT and D4T.
    Carbohydrate research, 2000, Jun-16, Volume: 326, Issue:3

    Topics: Anti-HIV Agents; Stavudine; Thymidine; Zidovudine

2000
[Conditions of "thymidine analog mutations" (TAMs) in naive patients treated with different combinations of d4T].
    Pathologie-biologie, 2000, Volume: 48, Issue:5

    Topics: Anti-HIV Agents; Drug Resistance; Humans; Lamivudine; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine

2000
Identification of residues involved in the specificity and regulation of the highly efficient multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster.
    Journal of molecular biology, 2000, Aug-25, Volume: 301, Issue:4

    Topics: Animals; Cytarabine; Dideoxyadenosine; Directed Molecular Evolution; Drosophila melanogaster; Enzyme Activation; Feedback; Inhibitory Concentration 50; Kinetics; Mutation; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Substrate Specificity; Thymidine; Thymine Nucleotides; Zalcitabine; Zidovudine

2000
Absence of association between individual thymidine analogues or nonnucleoside analogues and lipid abnormalities in HIV-1-infected persons on initial therapy.
    Journal of acquired immune deficiency syndromes (1999), 2000, Aug-01, Volume: 24, Issue:4

    Topics: Adult; Alkynes; Anti-HIV Agents; Arteriosclerosis; Benzoxazines; Cholesterol; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lipids; Male; Nevirapine; Oxazines; Risk Factors; Stavudine; Thymidine; Triglycerides; Zidovudine

2000
Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP.
    Molecular pharmacology, 2000, Volume: 58, Issue:5

    Topics: 5'-Nucleotidase; Anti-HIV Agents; Culture Media; Dideoxynucleotides; Half-Life; Humans; Hydrogen-Ion Concentration; Leukocytes, Mononuclear; Macrophages; Monocytes; Stavudine; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Time Factors; Tritium; Tumor Cells, Cultured; Zidovudine

2000
Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm.
    Biology of reproduction, 2001, Volume: 64, Issue:1

    Topics: Cervix Uteri; Chromatography, High Pressure Liquid; Dideoxynucleotides; Epithelial Cells; Female; Flow Cytometry; Genitalia, Female; Humans; Male; Nucleotides; Phosphorylation; Sperm Motility; Spermatozoa; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Vagina; Zidovudine

2001
Thymidine analog and multinucleoside resistance mutations are associated with decreased phenotypic susceptibility to stavudine in HIV type 1 isolated from zidovudine-naive patients experiencing viremia on stavudine-containing regimens.
    AIDS research and human retroviruses, 2001, Aug-10, Volume: 17, Issue:12

    Topics: Anti-HIV Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; HIV Infections; HIV Protease; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Viremia; Zidovudine

2001
Induction of a TRAIL-mediated suicide program by interferon alpha in primary effusion lymphoma.
    Oncogene, 2001, Oct-25, Volume: 20, Issue:48

    Topics: Antimetabolites, Antineoplastic; Antiviral Agents; Apoptosis; Apoptosis Regulatory Proteins; Arabidopsis Proteins; bcl-X Protein; Biopolymers; Cysteine Endopeptidases; Drug Synergism; Enzyme Activation; Epstein-Barr Virus Infections; Etoposide; Fatty Acid Desaturases; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Herpesviridae Infections; Herpesvirus 4, Human; Herpesvirus 8, Human; HIV Infections; Humans; Immunocompromised Host; Immunologic Factors; Interferon-alpha; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Membrane Glycoproteins; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Thymidine; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tumor Virus Infections; Zidovudine

2001
Antagonism between interleukin 3 and erythropoietin in mice with azidothymidine-induced anemia and in bone marrow endothelial cells.
    Cytokine, 2002, Apr-07, Volume: 18, Issue:1

    Topics: Anemia; Animals; Antimetabolites; Bone Marrow Cells; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium; Erythropoietin; HL-60 Cells; Humans; Insulin-Like Growth Factor II; Interleukin-3; Jurkat Cells; Liver; Mice; Recombinant Fusion Proteins; Thymidine; Zidovudine

2002
M184V is associated with a low incidence of thymidine analogue mutations and low phenotypic resistance to zidovudine and stavudine.
    AIDS (London, England), 2002, Aug-16, Volume: 16, Issue:12

    Topics: Drug Resistance, Microbial; Genotype; HIV Infections; HIV-1; Humans; Mutation; Phenotype; Retrospective Studies; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Viral Load; Zidovudine

2002
Combination of drugs and drug-resistant reverse transcriptase results in a multiplicative increase of human immunodeficiency virus type 1 mutant frequencies.
    Journal of virology, 2002, Volume: 76, Issue:18

    Topics: Animals; Anti-HIV Agents; COS Cells; Dose-Response Relationship, Drug; Drug Resistance, Viral; Genetic Vectors; HeLa Cells; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Lamivudine; Mutation; Reverse Transcriptase Inhibitors; Thymidine; Virus Replication; Zidovudine

2002
Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:11

    Topics: Anti-HIV Agents; Dideoxynucleotides; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nucleosides; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Thymidine; Thymidine Monophosphate; Zidovudine

2002
Microwave-assisted synthesis of O'-adamantylated uracil-derived nucleosides.
    Nucleosides, nucleotides & nucleic acids, 2003, Volume: 22, Issue:1

    Topics: Adamantane; Deoxyuridine; Hot Temperature; HSP70 Heat-Shock Proteins; Microwaves; Molecular Chaperones; Nucleosides; Saccharomyces cerevisiae Proteins; Thymidine; Uracil; Zidovudine

2003
Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:4

    Topics: Benzimidazoles; Benzoxazoles; Dideoxynucleotides; HIV Reverse Transcriptase; Indicators and Reagents; Magnetic Resonance Spectroscopy; Pyridines; Reverse Transcriptase Inhibitors; Spectrophotometry, Infrared; Thiazoles; Thymidine; Thymine Nucleotides; Zidovudine

2003
Choroid plexus controls brain availability of anti-HIV nucleoside analogs via pharmacologically inhibitable organic anion transporters.
    AIDS (London, England), 2003, Jul-04, Volume: 17, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biological Availability; Blood-Brain Barrier; Choroid Plexus; Epithelial Cells; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Thymidine; Viral Load; Zidovudine

2003
The selective in vitro cytotoxicity of carcinoma cells by AZT is enhanced by concurrent treatment with delocalized lipophilic cations.
    Cancer letters, 2003, Jul-30, Volume: 198, Issue:1

    Topics: Adenosine Triphosphate; Carcinoma; Cations; Cell Survival; Colony-Forming Units Assay; Humans; Male; Pyridines; Thiazoles; Thymidine; Tumor Cells, Cultured; Zidovudine

2003
Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:11

    Topics: Aminoisobutyric Acids; Animals; Blotting, Northern; Cholesterol; DNA; Fatty Acids; Immunoblotting; Ketone Bodies; Lactic Acid; Lipid Metabolism; Liver; Male; Metabolism; Mice; Mitochondria; Oxidation-Reduction; Phospholipids; Pyruvic Acid; Reverse Transcriptase Inhibitors; Thymidine; Triglycerides; Zidovudine

2003
Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth.
    Molecular microbiology, 2003, Volume: 50, Issue:3

    Topics: Amino Acid Sequence; Cell Division; Cloning, Molecular; Deoxyuridine; Escherichia coli; Feedback, Physiological; Molecular Sequence Data; Molecular Weight; Mycoplasma pneumoniae; Nucleosides; Phosphates; Pyrimidine Nucleosides; Recombinant Proteins; Sequence Homology, Amino Acid; Stavudine; Substrate Specificity; Tetrahydrouridine; Thymidine; Thymidine Kinase; Thymine Nucleotides; Ureaplasma urealyticum; Zidovudine

2003
Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure.
    Journal of medical virology, 2004, Volume: 72, Issue:1

    Topics: Anti-HIV Agents; Base Sequence; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Treatment Failure; Viral Load; Zidovudine

2004
Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNA prim
    The Journal of biological chemistry, 2004, Jun-04, Volume: 279, Issue:23

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Base Sequence; Codon; DNA; DNA Primers; Drug Resistance, Viral; Gene Deletion; HIV Reverse Transcriptase; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Phenotype; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Sequence Homology, Amino Acid; Stavudine; Thymidine; Time Factors; Tyrosine; Zidovudine

2004
Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.
    AIDS (London, England), 2004, Aug-20, Volume: 18, Issue:12

    Topics: Adenine; Algorithms; Anti-HIV Agents; Databases, Genetic; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV; HIV Infections; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zalcitabine; Zidovudine

2004
Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT.
    Cardiovascular toxicology, 2004, Volume: 4, Issue:2

    Topics: Animals; Aorta; Cattle; Cell Survival; Cells, Cultured; Dideoxynucleotides; Endothelial Cells; Endothelium, Vascular; Free Radicals; Glutathione; In Vitro Techniques; Intracellular Membranes; Lipid Peroxidation; Magnesium; Microsomes, Liver; Molsidomine; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides; Zidovudine

2004
Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity.
    Cardiovascular toxicology, 2004, Volume: 4, Issue:2

    Topics: Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biological Transport; Chromatography, High Pressure Liquid; Dideoxynucleotides; DNA, Mitochondrial; In Vitro Techniques; Mitochondria, Heart; Phosphorylation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine

2004
Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients.
    AIDS (London, England), 2005, Mar-25, Volume: 19, Issue:5

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine Kinase; Female; HIV; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Middle Aged; RNA, Viral; Thymidine; Thymidine Kinase; Zidovudine

2005
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues.
    Journal of molecular biology, 2005, Jun-10, Volume: 349, Issue:3

    Topics: Adenosine Triphosphate; Boron Compounds; Dideoxynucleotides; Drug Resistance, Multiple, Viral; HIV-1; Humans; Kinetics; Mutation; Phosphorylation; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine

2005
Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors.
    Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:3

    Topics: Dideoxynucleotides; HIV Reverse Transcriptase; Molecular Mimicry; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymidine; Thymine Nucleotides; Zidovudine

2005
The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:7

    Topics: Adenosine Triphosphate; Anti-HIV Agents; Base Sequence; Didanosine; DNA Primers; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine

2005
3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity.
    Biochemical pharmacology, 2006, Apr-28, Volume: 71, Issue:9

    Topics: Animals; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Kinetics; Liver Diseases; Mitochondria, Liver; Phosphorylation; Rats; Rats, Sprague-Dawley; Thymidine; Zidovudine

2006
The contribution of HIV fitness to the evolution pattern of reverse transcriptase inhibitor resistance.
    Journal of medical virology, 2006, Volume: 78, Issue:4

    Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; Evolution, Molecular; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Nevirapine; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine

2006
[In vitro selection and phenotyping of HIV-1 mutants resistant to azidothymidine and didanosine].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2005, Volume: 50, Issue:5-6

    Topics: Didanosine; Drug Resistance, Viral; HIV-1; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine

2005
The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations.
    Journal of virology, 2006, Volume: 80, Issue:10

    Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Arginine; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Lysine; Organophosphonates; Phenotype; Point Mutation; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine; Zalcitabine; Zidovudine

2006
3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.
    Biochemical pharmacology, 2006, Jul-14, Volume: 72, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Mitochondria, Heart; Mitochondria, Liver; Phosphorylation; Rats; Thymidine; Zidovudine

2006
Mutational patterns associated with the 69 insertion complex in multi-drug-resistant HIV-1 reverse transcriptase that confer increased excision activity and high-level resistance to zidovudine.
    Journal of molecular biology, 2007, Jan-12, Volume: 365, Issue:2

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Anti-HIV Agents; Base Sequence; Drug Resistance, Multiple, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutagenesis, Insertional; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Thymidine; Zidovudine

2007
Diminished selection for thymidine-analog mutations associated with the presence of M184V in Ethiopian children infected with HIV subtype C receiving lamivudine-containing therapy.
    The Pediatric infectious disease journal, 2006, Volume: 25, Issue:11

    Topics: Anti-HIV Agents; Child; Child, Preschool; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Inhibitory Concentration 50; Lamivudine; Male; Microbial Sensitivity Tests; Mutation; Phenotype; Reverse Transcriptase Inhibitors; Selection, Genetic; Thymidine; Virus Replication; Zidovudine

2006
Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Animals; Heart; Mitochondria, Heart; Perfusion; Phosphorylation; Rats; Rats, Sprague-Dawley; Thymidine; Zidovudine

2007
Application of solid-phase chemistry for the synthesis of 3'-fluoro-3'-deoxythymidine.
    Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:3

    Topics: Anti-HIV Agents; Chemistry, Pharmaceutical; Dideoxynucleosides; Drug Design; Models, Chemical; Molecular Structure; Polymers; Thymidine; Trifluoroacetic Acid; Zidovudine

2007
Evolution of resistance mutations during low-level viral replication in HIV-1-infected patients treated with zidovudine/lamivudine/abacavir as a first-line regimen.
    Antiviral therapy, 2007, Volume: 12, Issue:1

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Dideoxynucleosides; DNA, Viral; Drug Combinations; Drug Monitoring; Drug Resistance, Viral; Follow-Up Studies; Genotype; Germany; HIV Infections; HIV-1; Humans; Lamivudine; Methionine; Mutation; Reverse Transcriptase Inhibitors; Thymidine; Time Factors; Treatment Failure; Valine; Viral Load; Virus Replication; Zidovudine

2007
Long-term foscarnet therapy remodels thymidine analogue mutations and alters resistance to zidovudine and lamivudine in HIV-1.
    Antiviral therapy, 2007, Volume: 12, Issue:3

    Topics: Amino Acid Substitution; Anti-HIV Agents; Drug Resistance, Multiple, Viral; Evolution, Molecular; Foscarnet; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Point Mutation; Reverse Transcriptase Inhibitors; Species Specificity; Thymidine; Time Factors; Zidovudine

2007
The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in southern Africa.
    AIDS research and human retroviruses, 2007, Volume: 23, Issue:7

    Topics: Africa, Southern; Antiretroviral Therapy, Highly Active; Didanosine; Drug Resistance, Multiple, Viral; Evolution, Molecular; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymidine; Treatment Failure; Zidovudine

2007
Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines.
    Biochemical pharmacology, 2008, Apr-15, Volume: 75, Issue:8

    Topics: Animals; Anti-HIV Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Humans; Phosphorylation; Rats; Thymidine; U937 Cells; Zidovudine

2008
Longitudinal effects of thymidine analogues on mtDNA, mtRNA and multidrug resistance (MDR-1) induction in cultured cells.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 61, Issue:5

    Topics: Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA, Mitochondrial; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; K562 Cells; RNA; RNA, Mitochondrial; Stavudine; Thymidine; Time Factors; Zidovudine

2008
Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study.
    HIV medicine, 2008, Volume: 9, Issue:7

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Thymidine; Viral Load; Zidovudine

2008
Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:10

    Topics: Animals; Cell Line; Dehydroepiandrosterone Sulfate; Drug Interactions; Models, Theoretical; Rats; Reverse Transcriptase Inhibitors; Thymidine; Trophoblasts; Zidovudine

2008
Foscarnet salvage therapy efficacy is associated with the presence of thymidine-associated mutations (TAMs) in HIV-infected patients.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2008, Volume: 43, Issue:2

    Topics: Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Foscarnet; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Mutation; Reverse Transcriptase Inhibitors; Salvage Therapy; Stavudine; Thymidine; Treatment Outcome; Zidovudine

2008
Retention of metabolites of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel anti-human immunodeficiency virus type 1 thymidine analog, in cells.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8

    Topics: Anti-HIV Agents; Biological Transport; Cell Line; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dipyridamole; Humans; Multidrug Resistance-Associated Proteins; Phosphodiesterase Inhibitors; Phosphorylation; Stavudine; Thymidine; Zidovudine

2009
Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine.
    Journal of virology, 2009, Volume: 83, Issue:17

    Topics: Anti-HIV Agents; Cell Line; DNA Repair; Drug Resistance, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Point Mutation; Ribonuclease H; RNA, Viral; Thymidine; Viral Proteins; Zidovudine

2009
Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.
    The Journal of biological chemistry, 2009, Nov-20, Volume: 284, Issue:47

    Topics: Acyclovir; Adenosine Triphosphate; Anti-HIV Agents; DNA Mutational Analysis; DNA Primers; Drug Resistance, Multiple; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Stavudine; Thymidine; Valine; Zidovudine

2009
The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes.
    British journal of pharmacology, 2010, Jan-01, Volume: 159, Issue:2

    Topics: 3T3 Cells; Adipocytes; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytosol; HIV Protease Inhibitors; Hydrogen-Ion Concentration; Mice; Multidrug Resistance-Associated Proteins; Nigericin; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine

2010
Pro-oxidant properties of AZT and other thymidine analogues in macrophages: implication of the azido moiety in oxidative stress.
    ChemMedChem, 2010, Feb-01, Volume: 5, Issue:2

    Topics: Animals; Anti-HIV Agents; Azides; Cell Line, Tumor; Coordination Complexes; Humans; Macrophages; Mice; Osmium; Oxidants; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Thymidine; Zidovudine

2010
Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 115, Issue:1

    Topics: Anti-HIV Agents; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA; DNA Adducts; Down-Regulation; Drug Resistance, Neoplasm; Humans; Micronuclei, Chromosome-Defective; Micronucleus Tests; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Zidovudine

2010
Azidothymidine enhances fluorodeoxyuridine-mediated radiosensitization.
    International journal of radiation oncology, biology, physics, 2010, Mar-01, Volume: 76, Issue:3

    Topics: Antimetabolites; Cell Cycle; Cell Line, Tumor; Cell Survival; Colony-Forming Units Assay; Deoxyuracil Nucleotides; DNA Breaks, Single-Stranded; DNA Damage; DNA Mismatch Repair; Drug Synergism; Flow Cytometry; Floxuridine; Humans; MutS Homolog 2 Protein; Poisson Distribution; Radiation Tolerance; Thymidine; Thymine Nucleotides; Zidovudine

2010
N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations.
    AIDS (London, England), 2010, Mar-13, Volume: 24, Issue:5

    Topics: Drug Resistance, Multiple, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Phenotype; Reverse Transcriptase Inhibitors; Thymidine; Viral Load; Zidovudine

2010
A new DNA building block, 4'-selenothymidine: synthesis and modification to 4'-seleno-AZT as a potential anti-HIV agent.
    Organic letters, 2010, May-21, Volume: 12, Issue:10

    Topics: Anti-HIV Agents; Cell Line; Crystallography, X-Ray; DNA; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Organoselenium Compounds; Thymidine; Zidovudine

2010
Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity.
    Nucleosides, nucleotides & nucleic acids, 2010, Volume: 29, Issue:4-6

    Topics: Animals; Chromatography, Gel; Deoxycytidine; Dideoxynucleosides; Enzyme Activation; Humans; Mitochondria; Phosphorylation; Rats; Recombinant Proteins; Thymidine; Thymidine Kinase; Zidovudine

2010
Formation of aminyl radicals on electron attachment to AZT: abstraction from the sugar phosphate backbone versus one-electron oxidation of guanine.
    The journal of physical chemistry. B, 2010, Jul-22, Volume: 114, Issue:28

    Topics: Anti-HIV Agents; Electron Spin Resonance Spectroscopy; Electrons; Free Radicals; Guanine; Models, Theoretical; Oxidation-Reduction; Sugar Phosphates; Thymidine; Thymine; Zidovudine

2010
Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria.
    Antiviral therapy, 2010, Volume: 15, Issue:4

    Topics: Animals; Anti-HIV Agents; Deoxycytidine; Male; Mitochondria, Heart; Myocardium; Nucleosides; Perfusion; Phosphorylation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zalcitabine; Zidovudine

2010
Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations.
    The Journal of antimicrobial chemotherapy, 2011, Volume: 66, Issue:4

    Topics: Amino Acid Substitution; Anti-HIV Agents; Brazil; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Mutant Proteins; Mutation, Missense; Nevirapine; Protein Structure, Tertiary; Thymidine; Zidovudine

2011
A structural frame for understanding the role of thymidine analogue resistance mutations in resistance to zidovudine and other nucleoside analogues.
    Antiviral therapy, 2011, Volume: 16, Issue:7

    Topics: Anti-HIV Agents; Binding Sites; Catalytic Domain; DNA; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Nucleosides; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine

2011
Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:5

    Topics: Adenine; Algorithms; Anti-HIV Agents; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Genomics; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Least-Squares Analysis; Mutation; Nucleosides; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine; Zidovudine

2012
Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria.
    Journal of neurochemistry, 2012, Volume: 122, Issue:1

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Kinetics; Male; Mitochondria; Nucleotidases; Phosphorylation; Pyrimidine Nucleosides; Rats; Rats, Sprague-Dawley; Stavudine; Thymidine; Time Factors; Tritium; Zidovudine

2012
Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation.
    AIDS (London, England), 2012, Oct-23, Volume: 26, Issue:16

    Topics: Anti-HIV Agents; Autophagy; Blotting, Western; Cells, Cultured; DNA, Mitochondrial; Fatty Liver; Female; Flow Cytometry; Hep G2 Cells; HIV Infections; Humans; Lipid Metabolism; Male; Microscopy, Electron; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Stavudine; Thymidine; Zidovudine

2012
Resistance-associated mutations after initial antiretroviral treatment failure in a large cohort of patients infected with HIV-1 subtype CRF01_AE.
    Current HIV research, 2012, Volume: 10, Issue:8

    Topics: Adult; Aged; Anti-HIV Agents; Cohort Studies; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thailand; Thymidine; Treatment Failure; Zidovudine

2012
Drug-resistance development differs between HIV-1-infected patients failing first-line antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors with and without thymidine analogues.
    HIV medicine, 2013, Volume: 14, Issue:9

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Thymidine; Treatment Failure; Viral Load; Zidovudine

2013
Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Click Chemistry; DNA Fragmentation; DNA, Neoplasm; G-Quadruplexes; Humans; Ligands; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Skin Neoplasms; Thymidine; Triazoles; Tumor Burden; Zidovudine

2013
Conformational analysis of the anti-HIV Nikavir prodrug: comparisons with AZT and Thymidine, and establishment of structure-activity relationships/tendencies in other 6'-derivatives.
    Journal of biomolecular structure & dynamics, 2015, Volume: 33, Issue:4

    Topics: Anti-HIV Agents; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Organophosphonates; Prodrugs; Quantum Theory; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thermodynamics; Thymidine; Zidovudine

2015
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8

    Topics: CD4-Positive T-Lymphocytes; Gene Expression; HIV Reverse Transcriptase; HIV-2; Host-Pathogen Interactions; Humans; Jurkat Cells; Macrophages; Monomeric GTP-Binding Proteins; Primary Cell Culture; Reverse Transcriptase Inhibitors; SAM Domain and HD Domain-Containing Protein 1; Stavudine; Thymidine; Viral Regulatory and Accessory Proteins; Virus Replication; Zidovudine

2014
Structure and conformational analysis of the anti-HIV reverse transcriptase inhibitor AZT using MP2 and DFT methods. Differences with the natural nucleoside thymidine. Simulation of the 1st phosphorylation step with ATP.
    Physical chemistry chemical physics : PCCP, 2014, Dec-07, Volume: 16, Issue:45

    Topics: Adenosine Triphosphate; HIV Reverse Transcriptase; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Phosphorylation; Quantum Theory; Reverse Transcriptase Inhibitors; Thermodynamics; Thymidine; Water; Zidovudine

2014
Amphiphilic lipid derivatives of 3'-hydroxyurea-deoxythymidine: preparation, properties, molecular self-assembly, simulation and in vitro anticancer activity.
    Colloids and surfaces. B, Biointerfaces, 2014, Nov-01, Volume: 123

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxyurea; In Vitro Techniques; Nanostructures; Thymidine; Zidovudine

2014
Heart mitochondrial TTP synthesis and the compartmentalization of TMP.
    The Journal of biological chemistry, 2015, Jan-23, Volume: 290, Issue:4

    Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Creatine Kinase; Cytosol; Electron Transport; Female; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocardium; Oligomycins; Phosphocreatine; Phosphorylation; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine

2015
Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase.
    Protein engineering, design & selection : PEDS, 2017, Volume: 30, Issue:2

    Topics: Biomarkers, Tumor; Enzyme Activation; Gene Library; Phosphorylation; Prodrugs; Protein Domains; Recombinant Fusion Proteins; Simplexvirus; Thymidine; Thymidine Kinase; Zidovudine

2017
Rapid accumulation of HIV-1 thymidine analogue mutations and phenotypic impact following prolonged viral failure on zidovudine-based first-line ART in sub-Saharan Africa.
    The Journal of antimicrobial chemotherapy, 2017, 05-01, Volume: 72, Issue:5

    Topics: Adult; Africa South of the Sahara; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Mutation; Nevirapine; Polymerase Chain Reaction; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Thymidine; Treatment Failure; Viral Load; Zidovudine

2017
Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery.
    The Journal of biological chemistry, 2022, Volume: 298, Issue:6

    Topics: Animals; DNA Replication; Drug Discovery; Gerbillinae; Giardia lamblia; Giardiasis; Metronidazole; Protozoan Proteins; Thymidine; Thymidine Kinase; Zidovudine

2022