zidovudine and thymidine
zidovudine has been researched along with thymidine in 374 studies
Research
Studies (374)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 222 (59.36) | 18.7374 |
| 1990's | 60 (16.04) | 18.2507 |
| 2000's | 64 (17.11) | 29.6817 |
| 2010's | 27 (7.22) | 24.3611 |
| 2020's | 1 (0.27) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E | 1 |
| Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H | 1 |
| Alvarez, R; Balzarini, J; Camarasa, MJ; De Clercq, E; Jimeno, ML; San-Félix, A; Velázquez, S | 1 |
| Knaus, EE; Kumar, R; Wang, L; Wiebe, LI | 1 |
| Busson, R; De Keukeleire, D; Dugué, L; Froeyen, M; Herdewijn, P; Heyerick, A; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Vanheusden, V | 1 |
| Herdewijn, P; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Van Rompaey, P; Vanheusden, V | 1 |
| Al-Madhoun, AS; Barth, RF; Byun, Y; Eriksson, S; Johnsamuel, J; Tjarks, W; Yan, J; Yang, W | 1 |
| Björck, L; Clausen, AR; Piskur, J; Sandrini, MP; Shannon, O | 1 |
| Li, Y; Liotta, DC; Liu, L; Lutz, S; Soni, PB; Zhang, X | 1 |
| Agrofoglio, LA; Coats, SJ; Deville-Bonne, D; Eriksson, S; Lin, J; McBrayer, TR; Roy, V; Schinazi, RF; Wang, L; You, L | 1 |
| Barr, P; Lewin, CS; Shepherd, AJ | 1 |
| Arnér, ES; Eriksson, S; Spasokoukotskaja, T | 1 |
| Baba, M; De Clercq, E; Debyser, Z; Desmyter, J; Pauwels, R | 1 |
| Carson, DA; Hostetler, KY; Richman, DD; Stuhmiller, LM; van den Bosch, H; van Wijk, GM | 1 |
| Albert, J; Cox, SW; Uhlén, M; Wahlberg, J; Wahren, B | 1 |
| Bakhmedova, AA; Iartseva, IV; Iurkevich, AM; Mel'nik, SIa; Volosiuk, TP; Zhukova, OS | 1 |
| Domin, BA; Hajian, G; Koszalka, GW; Mahony, WB; Porter, DJ; Zimmerman, TP | 1 |
| Taniki, T; Weber, G; Zhen, YS | 1 |
| Arnér, ES; Eriksson, S; Valentin, A | 1 |
| Mitra, AK; Park, GB | 1 |
| Ayisi, NK; Gupta, SV; Qualtiere, LF | 1 |
| Bull, CO; Landry, ML; Milstone, LM; Reuveni, H; Schwartz, PM | 1 |
| Kinkade, P; Leung, LK; Wu, JM | 1 |
| Chen, MS; Prisbe, EJ; Suttmann, RT; Wu, JC | 1 |
| Beabealash-villi, RS; Chidgeavadze, ZG; Yuzhakov, AA | 1 |
| Agarwal, RP; Mian, AM | 1 |
| Liu, PK; Norwood, TH | 1 |
| Amyes, SG; Lewin, CS | 1 |
| Hung, K; Patel, SS; Szebeni, J; Wahl, LM; Weinstein, JN | 1 |
| Ahmed, AE; Jacob, S; Loh, JP; Nokta, M; Pollard, RB; Samra, SK | 1 |
| Nagai, M; Nakamura, H; Olah, E; Prajda, N; Szekeres, T; Weber, G | 1 |
| Allen, RA; Amyes, SG; Lewin, CS | 1 |
| Eriksson, S; Törnevik, Y | 1 |
| Herbert, V; Herzlich, BC; Nawabi, I; Ranginwala, M | 1 |
| Ichikawa, S; Nagai, M; Natsumeda, Y; Weber, G | 1 |
| Betageri, GV; Corcoran, M; Hung, K; Patel, SS; Szebeni, J; Wahl, LM; Weinstein, JN | 1 |
| Barry, DW; Bolognesi, D; Broder, S; Furman, PA; Gallo, RC; Lehrman, SN; Mitsuya, H; St Clair, MH; Weinhold, KJ | 1 |
| Bean, B | 1 |
| De Clercq, E | 1 |
| Bolognesi, DP; Broder, S; Freeman, GA; Furman, PA; Fyfe, JA; Lehrman, SN; Mitsuya, H; Rideout, JL; St Clair, MH; Weinhold, K | 1 |
| Hirsch, MS; Schooley, RT; Vogt, M | 1 |
| Harada, S; Kobayashi, N; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N | 1 |
| Chou, TC; Coleman, LA; Crumpacker, C; Furman, PA; Fyfe, JA; Hartshorn, KL; Hirsch, MS; Schooley, RT; Vogt, MW | 1 |
| Broder, S; Chabner, BA; DeVita, VT; Fauci, AS; Kovacs, JA | 1 |
| Hirsch, MS; Kaplan, JC | 2 |
| Kuno, S; Ueno, R | 2 |
| Beveridge, A; Herzyk, P; Neidle, S | 1 |
| Furman, P; Fyfe, JA; Olsen, JC; Swanstrom, R | 1 |
| Pedersen, C | 1 |
| Berenbaum, MC | 1 |
| Lin, TS; Prusoff, WH; Schinazi, RF | 1 |
| Gillis, JM; Hammer, SM | 1 |
| Brian, EL; Pagano, JS; Smith, MS | 1 |
| Camerman, A; Camerman, N; Mastropaolo, D | 1 |
| Pomerantz, RJ; Schooley, RT | 1 |
| Bibilashvili, RSh; Kavsan, VM; Kraevskiĭ, AA; Rudenko, NK; Shneĭder, MA | 1 |
| Bryson, YJ | 1 |
| Broder, S; Kuno, S; Looney, DJ; Mitsuya, H; Ueno, R; Wong-Staal, F | 1 |
| Broder, S; Mitsuya, H; Webb, TR | 1 |
| Bird, AG; Matthes, J; Walker, LA; Watson, JG | 1 |
| Lietman, PS | 1 |
| Clumeck, N; Hermans, P | 1 |
| Krayevsky, AA; Kukhanova, MM; Kuzminova, EA; Pyrinova, GB; Salganik, RI | 1 |
| August, EM; Brankovan, V; Ghazzouli, I; Hitchcock, MJ; Lin, TS; Mansuri, MM; Prusoff, WH; Sommadossi, JP; Starrett, JE; Sterzycki, RZ | 1 |
| Balzarini, J; De Clercq, E; Herdewijn, P | 1 |
| Chin, CD; Keilbaugh, SA; Lin, TS; Prusoff, WH; Simpson, MV | 1 |
| Bajpai, PK; Barbaro, RM; Benghuzzi, HA | 1 |
| Balzarini, J; De Clercq, E; Desmyter, J; Goubau, P; Herdewijn, P; Pauwels, R; Vandeputte, M; Vanderhaeghe, H | 1 |
| Carson, DA; Kornbluth, RS; Richman, DD | 1 |
| Kaplan, JC; Sandström, EG | 1 |
| Miller, JL | 1 |
| Baba, M; Balzarini, J; Broder, S; de Clercq, E; Herdewijn, P; Johns, DG; Pauwels, R | 1 |
| Brady, RO; O'Neill, RR | 1 |
| Berg, G; Dalakas, M; Fischl, M; Grafman, J; Klecker, RW; McAtee, N; Perno, CF; Thomas, RV; Wichman, A; Yarchoan, R | 1 |
| Bovey, EH; Büchi, ER; Chave, JP; Erard, PA; Michel, AE | 1 |
| Biron, K; Lin, JC; Pagano, JS; Smith, MC; Zhang, ZX | 1 |
| Broder, S; Mitsuya, H | 1 |
| Bozzette, S; Fay, MT; Freeman, WR; Hardy, D; Wiley, CA | 1 |
| Broder, S; Yarchoan, R | 2 |
| Chou, TC; Coleman, LA; Durno, AG; Hirsch, MS; Kaplan, JC; Paradis, TJ; Schooley, RT; Vogt, MW | 1 |
| Balfour, HH; Henry, K; Thurn, JR | 1 |
| Pardridge, WM; Terasaki, T | 1 |
| D'Amico, DJ; Hirsch, MS; Kosloff, BR; Pinkston, P; Schooley, RT; Skolnik, PR | 1 |
| Barry, DW; Blum, RM; Durack, DT; Gelmann, E; Klecker, RW; Lehrman, SN; Lyerly, HK; Markham, PD; Weinhold, KJ; Yarchoan, R | 1 |
| Frame, PT; Hagler, DN | 1 |
| Berg, G; Brouwers, P; Brunetti, A; Fischl, MA; Grafman, J; Safai, B; Spitzer, AR; Thomas, RV; Wichman, A; Yarchoan, R | 1 |
| Carter, WA; Mitchell, WM; Montefiori, DC; Robinson, WE; Strayer, DR | 1 |
| Davtyan, DG; Vinters, HV | 1 |
| Ingeberg, S; Pedersen, C | 1 |
| Brewton, GW; Duvic, M; Rios, A | 1 |
| Bach, MC | 2 |
| Helbert, M; Mitchell, D; Pinching, AJ; Stoneham, C | 1 |
| Allain, JP; Dubinsky, R; Fischl, MA; Klecker, RW; McAtee, N; McNeely, MC; Perno, CF; Thomas, RV; Wills, RJ; Yarchoan, R | 1 |
| Braun-Falco, O; Fröschl, M; Hohenleutner, U; Holzmann, H; Ruzicka, T | 1 |
| Gama-Sosa, MA; Rosas, HD; Ruprecht, RM | 1 |
| Cload, P; Coutinho, RA; de Gans, J; de Wolf, F; Fiddian, AP; Goudsmit, J; Lange, JM; Schellekens, PT; van der Noordaa, J | 1 |
| Boucher, CA; Danner, SA; Goudsmit, J; Lange, JM; Reiss, P | 1 |
| Chave, JP; Decrey, H; Francioli, P; Glauser, MP; Meylan, PR | 1 |
| Delord, B; Faivre, R; Fleury, HJ; Morere, G | 1 |
| Forster, S; Helbert, M; Jeffries, D; Kocsis, A; Peddle, B; Pinching, AJ; Robinson, D | 1 |
| Ho, M; Lewis, JH; Ragni, MV; Tama, G | 1 |
| Steel, M | 1 |
| Loke, RH; Murray-Lyon, IM; Wade, JP | 1 |
| Collins, P; Evans, R; Hawkins, DA; Lawrence, A; Oliver, N; Shanson, DC; Youle, MM | 1 |
| Costello, C; Fuller, G; Gazzard, B; Hargreaves, M | 1 |
| de Gans, J; Portegies, P; Tiessens, G | 1 |
| Fletcher, T; Harris, JR; Helbert, M; Peddle, B; Pinching, AJ | 1 |
| Sandström, E | 1 |
| Weber, J | 1 |
| Allain, JP; Blum, MR; Lehrman, SN; Leuther, M; Maha, M; McAtee, N; Mitsuya, H; Surbone, A; Thomas, RV; Yarchoan, R | 1 |
| Chouc, PY; Disdier, P; Harle, JR; Weiller, PJ | 1 |
| Clements, ML; Cohn, S; Miotti, P; Nelson, KE; Polk, BF | 1 |
| Marwick, C; Riesenberg, DE | 1 |
| Marx, JL | 1 |
| Barnes, DM | 5 |
| Baba, M; De Clercq, E; Desmyter, J; Herdewijn, P; Pauwels, R; Vandeputte, M | 1 |
| Chen, MS; Kinney-Thomas, E; Lin, TS; Prusoff, WH; Schinazi, RF | 1 |
| Harada, S; Nakashima, H; Yamamoto, N | 1 |
| de Noronha, F; Johnston, K; Lehrman, SN; Roneker, C; Tavares, L | 1 |
| Cantrill, H; Henry, K; Kish, MA | 1 |
| Drucker, JL; King, DH | 1 |
| Offerhaus, L | 1 |
| Jaenisch, R; Ruprecht, RM; Sharpe, AH | 1 |
| Broder, S; Matsushita, S; Mitsuya, H; Reitz, MS | 1 |
| Hamamoto, Y; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N | 1 |
| Barry, DW; LaFon, SW; Lehrman, SN | 1 |
| Barry, DW; Furman, PA | 1 |
| Hirsch, MS | 2 |
| Ayers, KM | 1 |
| Andrews, J; Richman, DD | 1 |
| Koshland, DE | 1 |
| Kobayashi, N; Matsuda, A; Nakashima, H; Tochikura, T; Ueda, T; Yamamoto, N | 1 |
| Kaneko, Y; Kobayashi, N; Nakashima, H; Tochikura, TS; Yamamoto, N | 1 |
| Chafey, S; Gottlieb, MS; Wolfe, PR | 1 |
| Ikuta, K; Imai, H; Kato, S; Suehiro, S; Ueda, S; Yamamoto, N | 2 |
| Souhrada, L | 1 |
| Costello, C; Luckit, J; Mir, N | 1 |
| Despotes, JC; Emeson, EE; Falk, LA; Jackson, GG; Knigge, M; Mack, D; Paul, DA; Rubenis, M | 1 |
| Cload, P; Danner, SA; de Gans, J; de Wolf, F; Derix, MM; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Ongerboer de Visser, BW | 1 |
| Courouce, AM; Lefrere, JJ; Salmon, C | 1 |
| Berman, SM; Nakasato, S; Roberts, DE; Segal, GP; Wishnow, RM; Wyle, FA | 1 |
| Dalakas, MC; Elder, G; Sever, JL; Spitzer, R; Yarchoan, R | 1 |
| Fessas, P; Fourtounis, P; Karabinis, A; Kourtis, A; Mangakis, J; Vaiopoulos, G | 1 |
| Pickus, OB | 1 |
| Balfour, HH; Chinnock, BJ; de Miranda, P; Fletcher, CV; Henry, K; Quinn, RP | 1 |
| Goldman, B | 1 |
| Becker, P; Criner, GJ; Furth, P; Murray, RJ | 1 |
| Busch, K; Kessler, HA; Maxwell, S; Scheftner, WA | 1 |
| Dickmeiss, E; Permin, H | 1 |
| Ersbøll, J; Krebs, HJ; Mathiesen, L; Petersen, CS | 1 |
| Colarian, J | 1 |
| de Miranda, P; Kessler, HA; Lehrman, SN; Spear, JB | 1 |
| Glaser, V | 1 |
| Langen, P; Lehmann, C; Matthes, E; Rosenthal, HA; Scholz, D | 1 |
| Balzarini, J; De Clercq, E; Kinjo, J; Lesiak, K; Torrence, PF | 1 |
| Farrell, PL; Gold, JW; Heinemann, MH; Mamelok, A; Polsky, B; Roberts, CW | 1 |
| Frick, LW; Furman, PA; Krenitsky, TA; Nelson, DJ; St Clair, MH | 1 |
| Nightingale, SL | 1 |
| Klein, RS; Phelan, JA | 1 |
| Hedaya, MA; Sawchuk, RJ | 1 |
| Blum, MR; de Miranda, P; Good, SS; Liao, SH | 1 |
| Blanche, S; Burgard, M; Caniglia, M; Duhamel, G; Fischer, A; Griscelli, C; Rouzioux, C; Tardieu, M | 1 |
| Cesario, T; Packer, SJ; Williams, JH | 1 |
| Anokhin, KV; Belotserkovskaia, NA; Kraevskiĭ, AA | 1 |
| Gil Aguado, A; Lavilla, P; Pintado, V; Valencia, ME | 1 |
| Balis, FM; Brouwers, P; Eddy, J; Falloon, J; Jarosinski, P; Moss, H; Murphy, RF; Pizzo, PA; Rubin, M; Wolters, P | 1 |
| Ayela, P; Garnier, G; Thyss, A; Viens, P | 1 |
| Barbaro, DJ; Coldiron, BM; Orcutt, VL | 1 |
| Carlisle, R; Schinazi, RF; Sommadossi, JP; Zhou, Z | 1 |
| Durno, AG; Eckstein, F; Hartmann, H; Hirsch, MS; Hunsmann, G; Vogt, MW | 1 |
| Handlon, AL; Oppenheimer, NJ | 1 |
| Blum, MR; de Miranda, P; Gordon, SM; Jacobson, MA; Mills, J; Volberding, P | 1 |
| Dainiak, N; Goldman, L; Kreczko, S; Riordan, MA; Worthington, M | 1 |
| Basgoz, N; Blumenfeld, W; Owen, WF; Schmidt, DM | 1 |
| Azon-Masoliver, A; Castel, T; Gatell, J; Mallolas, J | 1 |
| Buchanan, RJ | 1 |
| Levitt, JA; Nightingale, SL; Norris, JA; Young, FE | 1 |
| Barinaga, M | 1 |
| Atkinson, H; Grant, I; Ostrow, D | 1 |
| Balfour, HH; Chinnock, B; Dunn, DL; Erice, A; Rhame, FS | 1 |
| Rada, B | 1 |
| Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Schooley, RT; Volberding, PA | 1 |
| Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Hirsch, MS; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Volberding, PA | 1 |
| Brook, I | 1 |
| Groopman, JE | 1 |
| Harrington, JA; Miller, WH; Spector, T | 1 |
| Harvengt, C | 1 |
| Broder, S | 1 |
| Marotta, RF; Perry, S | 1 |
| Feeney, GF; Frazer, I | 1 |
| Greene, JB; Hymes, KB; Karpatkin, S | 1 |
| Carleton, S; Fauci, AS; Gralnick, HR; Kirk, LE; Kovacs, JA; Lane, HC; Masur, H; Parker, RI; Walker, RE | 1 |
| Kennedy, CJ; Paradise, M; Wu, AW | 1 |
| Bessen, LJ; Greene, JB; Louie, E; Seitzman, P; Weinberg, H | 1 |
| Allain, JP; Chaisson, RE; Leuther, M; Volberding, PA | 1 |
| Marwick, C | 1 |
| Kolata, G | 2 |
| DeHovitz, JA | 1 |
| Blumberg, RS; Byington, R; Chou, TC; Hartshorn, KL; Hirsch, MS; Schooley, RT; Vogt, MW | 1 |
| Mahony, WB; Prus, KL; Zimmerman, TP | 1 |
| Weissman, JB | 1 |
| Chandrasekar, PH | 1 |
| Baba, M; De Clercq, E; Ito, M; Nakashima, H; Pauwels, R; Shigeta, S; Yamamoto, N | 1 |
| De Clercq, E; Gil-Fernández, C | 1 |
| Friedland, G; Macklin, R | 1 |
| Cohen, SS | 1 |
| Chattopadhyaya, J; Löfgren, B; Nordenfelt, E; Oberg, B | 1 |
| Forester, G | 1 |
| Brynes, RK; Causey, D; Gill, PS; Levine, AM; Loureiro, C; Rarick, M | 1 |
| Armstrong, D; Campbell, SW; Gold, JW; Kleinberg, ML; Melamed, AJ; Muller, RJ | 1 |
| Zuger, A | 1 |
| Phillips, AJ; Spence, AA | 1 |
| Jablon, L | 1 |
| Andes, WA | 1 |
| Panwalker, AP | 1 |
| Mirsky, H | 1 |
| Camsonne, R; Hurrault de Ligny, B; Letellier, P | 1 |
| Beleslin, DB | 1 |
| Carlisle, R; Sommadossi, JP | 1 |
| Furth, PA; Kazakis, AM | 1 |
| Cohen, OJ; Lyerly, HK; Weinhold, KJ | 1 |
| Flanigan, T; Graham, R; Shapiro, E | 1 |
| Cockerill, FR; Hermans, PE | 1 |
| Richman, DD | 1 |
| Gallo, RC | 1 |
| Broder, S; Collins, JM; Jenkins, JF; Klecker, RW; Myers, CE; Thomas, R; Yarchoan, R | 1 |
| Uretsky, SD | 1 |
| Elwell, LP; Ferone, R; Freeman, GA; Fyfe, JA; Hill, JA; Knick, VB; Ray, PH; Richards, CA; Rideout, JL; Singer, SC | 1 |
| Dosne Pasqualini, C | 1 |
| Chen, MS; Prusoff, WH; Schinazi, RF; Shiau, GT | 1 |
| Henson, E; McClarty, G; Wang, LL | 1 |
| Honda, Y; Takahashi, Y; Tsuchiya, T | 1 |
| Andrews, CW; Aulabaugh, AE; Painter, GR | 1 |
| Back, DJ; Barry, MG; Veal, GJ; Wild, MJ | 1 |
| Lerner-Tung, MB; Medina, DJ; Mellors, JW; Nelson, CJ; Strair, RK; Tung, PP | 1 |
| Antonelli, G; Cianfriglia, M; Dianzani, F; Riva, E; Signoretti, C; Simeoni, E; Strosselli, S; Turriziani, O | 1 |
| Bajpai, PK; Nagy, EA | 1 |
| Bawdon, RE; Kaul, S; Sobhi, S | 1 |
| Auclair, C; Carteau, S; Goulaouic, H; Mouscadet, JF; Subra, F | 1 |
| Balzarini, J | 1 |
| Domin, BA; Mahony, WB; Zimmerman, TP | 1 |
| Breimer, DD; de Boer, AG; Jaehde, U; Langemeijer, MW; Masereeuw, R | 1 |
| Neitzel, H; Nündel, M; Riedel, E; Schultis, HK; von Baeyer, H | 1 |
| Cenacchi, A; Gamberi, B; Ottaviani, E; Tosi, P; Tura, S; Visani, G | 1 |
| Hu, M | 1 |
| Ellemunter, H; Gschwentner, M; Huemer, H; Laich, A; Nagl, UO; Pinggera, GM; Ritter, M; Schmarda, A; Susanna, A; Wöll, E | 1 |
| Freeman, GA; Rideout, JL; Shaver, SR; Short, SA | 1 |
| Antonelli, G; D'Offizi, G; Dianzani, F; Ferri, F; Narciso, P; Turriziani, O; Verri, A | 1 |
| Joseph, PE; Nusbaum, NJ | 1 |
| Baba, M; Hashimoto, KI; Okamoto, M; Shigeta, S; Tsunoda, R | 1 |
| Munch-Petersen, B | 1 |
| Back, DJ; Barry, MG; Hoggard, PG; Kewn, S; Khoo, SH | 1 |
| Segal, MB; Thomas, SA | 2 |
| Alekseeva, SG; Esipov, DS; Oskolkova, OV; Perepelov, AV; Shvets, VI; Zamiatina, AIu | 1 |
| Clement, JG; Pardridge, WM; Wu, D | 1 |
| Julias, JG; Pathak, VK | 1 |
| Knaus, EE; Parang, K; Wiebe, LI | 1 |
| Antony, AC; Gharehbaghi, K; Jayaram, HN; Li, QJ; Sun, XL; Xiao, X | 1 |
| Balzarini, J; Camarasa, MJ; Chamorro, C; De Clercq, E; Jimeno, ML; Tuñón, V; Velázquez, S | 1 |
| Bendayan, R; Hong, M; Schlichter, L | 1 |
| Galegov, GA; Kraevskiĭ, AA; Selimova, LM | 1 |
| Boretto, J; Canard, B; Deville-Bonne, D; Guerreiro, C; Janin, J; Meyer, P; Sarfati, S; Schneider, B; Véron, M | 1 |
| Kong, F; Ning, J | 1 |
| Agut, H; Angleraud, F; Bonmarchand, M; Brun-Vezinet, F; Calvez, V; Coutellier, A; Delaugerre, C; Descamps, D; Izopet, J; Katlama, C; Matheron, S; Mouroux, M; Valantin, MA; Yvon-Groussin, A | 1 |
| Knecht, W; Munch-Petersen, B; Piskur, J | 1 |
| Clark, R; Cohen, C; Cooley, T; Grosso, R; Gulick, R; Marlowe, SI; Mauney, J; Mulanovich, V; Santana, J; Schoellkopf, N; Squires, KE; Stevens, M; Tebas, P; Uffelman, K; Wright, D; Yangco, B | 1 |
| Bellos, N; Eron, JJ; Esinhart, J; Grosso, R; Jemsek, J; Murphy, RL; Parenti, DM; Peterson, D; Pottage, J; Rashbaum, BC; Schoellkopf, N; Sepulveda, G; Stevens, M; Swindells, S | 1 |
| Bower, M; Gazzard, BG; Mandalia, S; Matthews, GV; Moyle, GJ; Nelson, M | 1 |
| Aquaro, S; Balzarini, J; Bianchi, V; De Clercq, E; Knispel, T; Meier, C; Perno, CF; Rampazzo, C | 1 |
| D'Cruz, OJ; Uckun, FM; Venkatachalam, TK | 1 |
| Becker, SL; Fusco, GP; Fusco, JS; Graham, NM; Hansen, NI; Igboko, EF; Raffanti, SR; Slatko, GH | 1 |
| Becker, S; Fisher, R; Graham, N; Henry, K; Hernandez, J; Hirani, A; Liao, Q; Raffanti, S; Ross, L; Scarsella, A; St Clair, M | 1 |
| Barber, GN; Boise, LH; Cabral, L; Deyev, VV; Harrington, WJ; Liu, LH; Podack, ER; Scott, D; Toomey, NL; Wood, C | 1 |
| Congote, LF; DiFalco, MR | 1 |
| Ait-Khaled, M; Amphlett, G; Clotet, B; Katlama, C; Staszewski, S; Stone, C; Tisdale, M | 1 |
| Gajary, LC; Mansky, LM; Pearl, DK | 1 |
| Pendergrass, S; Qazi, S; Richman, D; Uckun, FM; Venkatachalam, TK | 1 |
| Bates, M; Hellmann, NS; Hughes, MD; Katzenstein, DA; Shafer, RW; Shulman, NS; Whitcomb, JM; Winters, MA; Zolopa, AR | 1 |
| Carr, A; Cooper, DA; Hoy, J; Hudson, J; Law, M; Martin, A; Smith, DE | 1 |
| Andrzejewska, M; Górska, A; Kamiński, J; Kazimierezuk, Z | 1 |
| Aboulker, JP; Brun-Vézinet, F; Descamps, D; Flandre, P; Izopet, J; Joly, V; Meiffrédy, V; Tamalet, C | 1 |
| Akbay, A; Aki-Sener, E; Oren, I; Temiz-Arpaci, O; Yalçin, I | 1 |
| Belin, MF; Ghersi-Egea, JF; Strazielle, N | 1 |
| Kidd, ME; Modica-Napolitano, JS; Nalbandian, A; Nalbandian, R; Nguyen, CC | 1 |
| Biour, M; Djouadi, F; Fromenty, B; Guimont, MC; Igoudjil, A; Lettéron, P; Maisonneuve, C; Note, R; Pessayre, D; Peytavin, G | 1 |
| Bölske, G; Carnrot, C; Eriksson, S; Wang, L; Wehelie, R | 1 |
| Calvez, V; Delaugerre, C; Katlama, C; Marcelin, AG; Simon, A; Viegas, P; Wirden, M | 1 |
| Ajana, F; Alcaraz, I; Bocket, L; Gerard, Y; Goffard, A; Mouton, Y; Viget, N; Wattré, P; Yazdanpanah, Y | 1 |
| Franco, S; Martínez, MA; Mas, A; Matamoros, T; Menéndez-Arias, L; Vázquez-Alvarez, BM | 1 |
| Konrad, M; Lavie, A | 1 |
| Goldschmidt, V; Marquet, R | 1 |
| Bates, M; Chappey, C; Clair, MS; Fisher, R; Lanier, ER; Parkin, N; Ross, L; Tisdale, M | 1 |
| Mak, IT; Nedelec, LF; Weglicki, WB | 1 |
| Bentley, AT; Gingerich, J; Hatch, M; McKee, EE; Susan-Resiga, D | 1 |
| Antonelli, G; Antonelli, L; Butera, O; Gianotti, N; Girardi, E; Iaiani, G; Lazzarin, A; Mazzi, R; Parisi, SG; Turriziani, O | 1 |
| Canard, B; Deval, J; Guerreiro, C; Matamoros, T; Menéndez-Arias, L; Mulard, L | 1 |
| Brooks, JL; Cook, PD; Fagan, P; Hurd, T; Prhavc, M; Rajwanshi, VK; Wang, G | 1 |
| Götte, M; Kuritzkes, DR; Liang, F; Miranda, LR | 1 |
| Borderi, M | 1 |
| Bentley, AT; Lynx, MD; McKee, EE | 1 |
| Alexander, L; Collins, JA; Margolis, A; Paintsil, E | 1 |
| Kiseleva, IaIu; Pliasunova, OA; Pokrovskaia, NV; Pokrovskiĭ, AG | 1 |
| Bacheler, L; Koontz, D; Mellors, JW; Parikh, UM | 1 |
| Lynx, MD; McKee, EE | 1 |
| Cases-González, CE; Franco, S; Martínez, MA; Menéndez-Arias, L | 1 |
| Averbuch, D; Einhorn, M; Engelhard, D; Gottesman, G; Gradstein, S; Grisaru-Soen, G; Grossman, Z; Kedem, E; Lanier, ER; Ofir, M; Schapiro, JM | 1 |
| Bentley, AT; LaClair, DD; Lynx, MD; McKee, EE; Susan-Resiga, D | 1 |
| Agarwal, HK; Parang, K | 1 |
| Dauer, B; Doerr, HW; Haberl, A; Hanke, N; Knecht, G; Locher, L; Moesch, M; Mueller, A; Staszewski, S; Stürmer, M | 1 |
| Clavel, F; Dam, E; Gerstoft, J; Joergensen, LB; Laursen, AL; Mathiesen, S; Roge, B | 1 |
| Bussmann, H; DeGruttola, V; Essex, M; Gaseitsiwe, S; Marlink, RG; Moyo, S; Musonda, R; Novitsky, V; Thomas, A; Van Widenfelt, E; Wester, CW | 1 |
| Kang, BK; Lynx, MD; McKee, EE | 1 |
| Côté, HC; Gadawski, I; Papp, E | 1 |
| Bonjoch, A; Clotet, B; Domingo, P; Galindo, MJ; Iribarren, J; Llibre, JM; Martinez-Picado, J; Negredo, E; Pérez-Alvarez, N; Schapiro, J | 1 |
| Chishu, T; Kang, YS; Kose, N; Nakashima, E; Nishimura, T; Sai, Y; Sato, K; Seki, Y; Terasaki, T | 1 |
| Bélec, L; Charpentier, C; Karmochkine, M; Laureillard, D; Piketty, C; Si-Mohamed, A; Sodqi, M; Weiss, L | 1 |
| Portilla, J | 1 |
| Baba, M; Cheng, YC; Tanaka, H; Wang, X | 1 |
| Delviks-Frankenberry, KA; Hase, S; Maldarelli, F; Nikolenko, GN; Pathak, VK; Takebe, Y | 1 |
| Martínez, MA; Matamoros, T; Menéndez-Arias, L; Nevot, M | 1 |
| Back, DJ; Bray, PG; Janneh, O; Owen, A; Pirmohamed, M | 1 |
| Amatore, C; Arbault, S; Jaouen, G; Koh, AC; Leong, WK; Top, S; Valleron, MA; Woo, CH | 1 |
| Borojerdi, JP; Braun, HM; Cooch, CC; Keller, E; McKee, E; Ming, J; Olivero, OA; Poirier, MC; Vazquez, IL; Yu, M | 1 |
| Chen, CM; Dornfeld, K; Johnson, M; Smith, BJ | 1 |
| Radzio, J; Sluis-Cremer, N; Tachedjian, G; Yap, SH | 1 |
| Alexander, V; Chandra, G; Choi, J; Choi, WJ; Chun, J; Jeon, JH; Jeong, LS; Kim, HO; Lee, HW; Tosh, DK | 1 |
| Eriksson, S; Sun, R; Wang, L | 1 |
| Adhikary, A; Khanduri, D; Pottiboyina, V; Rice, CT; Sevilla, MD | 1 |
| Laclair, DD; McKee, EE; Morris, GW | 1 |
| Curran, A; Ribera, E | 1 |
| Baumann, J; Delviks-Frankenberry, KA; Lengruber, RB; Nikolenko, GN; Pathak, VK; Santos, AF; Soares, MA | 1 |
| Menéndez-Arias, L | 1 |
| Fessel, WJ; Israelski, D; Kagan, R; Kaufman, D; Melikian, GL; Rhee, SY; Robbins, GK; Shafer, RW; Taylor, J; Towner, W; Troia-Cancio, PV; Zolopa, A | 1 |
| McCann, KA; McKee, EE; Williams, DW | 1 |
| Bauerfeind, R; Behrens, GM; Binz, A; Leverkus, M; Panayotova-Dimitrova, D; Stankov, MV; Vondran, FW | 1 |
| Chaiwarith, R; Kotarathitithum, W; Nuntachit, N; Praparattanapan, J; Sirisanthana, T; Supparatpinyo, K | 1 |
| Antinori, A; Bansi, L; Boumis, E; Callegaro, A; Ceccherini-Silberstein, F; Dunn, D; Fearnhill, E; Forbici, F; Francisci, D; Maggiolo, F; Mussini, C; Nicastri, E; Palamara, G; Perno, CF; Sabin, C; Santoro, MM; Zazzi, M; Zoncada, A | 1 |
| Chandrasekar, S; Idris, MM; Kavitha, M; Mahesh Kumar, J; Mainkar, PS; Meghah, V; Nagesh, N; Pal, B; Reddy, CR; Srinivas, G; Vinay Kumar, P | 1 |
| Alcolea Palafox, M; Álvarez-Ros, MC; El-Sayed, AA; Tamara Molina, A | 1 |
| Badia, R; Ballana, E; Clotet, B; Esté, JA; Martí, R; Pauls, E; Riveira-Muñoz, E; Ruiz, A; Terradas, G; Torres-Torronteras, J | 1 |
| Palafox, MA | 1 |
| Jin, Y; Li, M; Qi, S; Yao, W; Zhang, S; Zhao, J | 1 |
| Hsiung, CH; Kamath, VG; Lizenby, ZJ; McKee, EE | 1 |
| Ostermeier, M; Parhi, S; Shelat, NY | 1 |
| Dunn, DT; Gilks, C; Goodall, RL; Gupta, RK; Kaleebu, P; Kityo, C; Mugarura, L; Munderi, P; Nkurunziza, P; Pattery, T; Pillay, D | 1 |
| Hofer, A; Jiménez-González, A; Krakovka, S; Larsen, NB; Luján, HD; Luján, LA; Ranjbarian, F; Reggenti, A; Saura, A; Svärd, SG | 1 |
Reviews
25 review(s) available for zidovudine and thymidine
| Article | Year |
|---|---|
Chemotherapeutic approaches to the treatment of the acquired immune deficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adsorption; Antibodies, Viral; Antigens, Viral; Aurintricarboxylic Acid; Deltaretrovirus; Deoxycytidine; Foscarnet; Genes, Viral; Glycoproteins; Humans; Interferons; Male; Phosphonoacetic Acid; Retroviridae Infections; Reverse Transcriptase Inhibitors; Ribavirin; RNA, Viral; Suramin; Thymidine; Transcription, Genetic; Viral Proteins; Virus Replication; Zalcitabine; Zidovudine | 1986 |
Developmental therapeutics and the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Deoxyribonucleosides; HIV; Humans; Interferons; Interleukin-2; Opportunistic Infections; Pneumonia, Pneumocystis; Thymidine; Toxoplasmosis; Virus Replication; Zidovudine | 1987 |
Therapy of human immunodeficiency virus infections.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Foscarnet; Humans; Immunotherapy; Interferons; Oligodeoxyribonucleotides; Phosphonoacetic Acid; Ribavirin; Suramin; Thymidine; Zidovudine | 1987 |
Promising new antiviral drugs.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Herpes Simplex; Herpes Zoster; Humans; Interferons; Phosphonoacetic Acid; Ribavirin; Thymidine; Zidovudine | 1988 |
Antiviral drugs other than zidovudine and immunomodulating therapies in human immunodeficiency virus infection. An overview.
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Antiviral Agents; Humans; Immunotherapy; Interferons; Thymidine; Zidovudine | 1988 |
Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Forecasting; Foscarnet; Immunotherapy; Phosphonoacetic Acid; Rifabutin; Rifamycins; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine | 1987 |
Progress in the development of antiviral therapy for HTLV-III-associated diseases.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; HIV; Humans; Phosphonoacetic Acid; Ribavirin; Rifabutin; Rifamycins; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine | 1987 |
Antiviral drugs for AIDS. Current status and future prospects.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Humans; Interferon Type I; Phosphonoacetic Acid; Ribavirin; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine | 1986 |
Spectrum of antiviral activity and mechanism of action of zidovudine. An overview.
Topics: Animals; Antiviral Agents; HIV; Humans; Retroviridae; Thymidine; Virus Replication; Zidovudine | 1988 |
Antiviral drug development for the treatment of human immunodeficiency virus infections. An overview.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Humans; Thymidine; United States; Virus Replication; Zidovudine | 1988 |
Preclinical toxicology of zidovudine. An overview.
Topics: Animals; Antiviral Agents; Drug Evaluation, Preclinical; Female; Male; Thymidine; Zidovudine | 1988 |
AIDS commentary. Azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Humans; Thymidine; Zidovudine | 1988 |
Assessment and management of the AIDS patient with neuropsychiatric disturbances.
Topics: Acquired Immunodeficiency Syndrome; Anxiety; Humans; Male; Neurocognitive Disorders; Social Support; Thymidine; Zidovudine | 1988 |
[Experimental chemotherapy of AIDS].
Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Antimony; Antiviral Agents; Humans; Oligopeptides; Peptide T; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine | 1988 |
Treatment of human immunodeficiency virus infections.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Therapy, Combination; HIV; Humans; Ribavirin; Thymidine; Zidovudine | 1987 |
AIDS-related Kaposi's sarcoma: therapeutic modalities.
Topics: Acquired Immunodeficiency Syndrome; Bone Marrow Transplantation; Combined Modality Therapy; Doxorubicin; Humans; Interferon Type I; Opportunistic Infections; Sarcoma, Kaposi; Thymidine; Vinblastine; Zidovudine | 1987 |
Strategies for the future chemotherapy of human immunodeficiency virus (HIV).
Topics: Acquired Immunodeficiency Syndrome; Drug Evaluation; HIV; Humans; Thymidine; Zidovudine | 1987 |
AIDS dementia: a review of the literature.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Brain; Counseling; Dementia; Humans; Nervous System Diseases; Neurocognitive Disorders; Social Support; Thymidine; Zidovudine | 1987 |
Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. A progress report.
Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Structure-Activity Relationship; Thymidine; Zidovudine | 1987 |
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.
Topics: Animals; Antiviral Agents; Dideoxyadenosine; Dideoxynucleosides; Humans; Lamivudine; Purines; Pyrimidines; Retroviridae; Spiro Compounds; Stavudine; Thymidine; Uridine; Zalcitabine; Zidovudine | 1994 |
Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase.
Topics: Anti-HIV Agents; Dideoxynucleotides; Humans; Nucleoside-Phosphate Kinase; Nucleotides; Phosphorylation; Prodrugs; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymine Nucleotides; Zidovudine | 2004 |
Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs).
Topics: Adenosine Triphosphate; DNA Primers; Drug Resistance, Multiple, Viral; Foscarnet; HIV; HIV Reverse Transcriptase; Humans; Point Mutation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 2004 |
[Use of thymidine-sparing regimens in first-line therapy and in switches from thymidine analogues].
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Stavudine; Thymidine; Treatment Outcome; Zidovudine | 2005 |
[Tenofovir as a strategy to avoid or limit adverse effects].
Topics: Adenine; Anemia; Anti-HIV Agents; Antimetabolites; Clinical Trials as Topic; DNA, Mitochondrial; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Glucose Metabolism Disorders; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Multicenter Studies as Topic; Organophosphonates; Prospective Studies; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zidovudine | 2008 |
From old to new nucleoside reverse transcriptase inhibitors: changes in body fat composition, metabolic parameters and mitochondrial toxicity after the switch from thymidine analogs to tenofovir or abacavir.
Topics: Adenine; Adipose Tissue; Body Composition; Dideoxynucleosides; Drug Substitution; Humans; Metabolism; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zidovudine | 2011 |
Trials
35 trial(s) available for zidovudine and thymidine
| Article | Year |
|---|---|
[Chemotherapy and immunoprophylaxis of HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Foscarnet; HIV; Humans; Phosphonoacetic Acid; Reverse Transcriptase Inhibitors; Ribavirin; Suramin; Thymidine; Viral Vaccines; Virus Replication; Zidovudine | 1986 |
Progress in antiviral drug and vaccine development assessed at international AIDS conference.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Evaluation; Drug Therapy, Combination; Humans; Ribavirin; Thymidine; Viral Vaccines; Zalcitabine; Zidovudine | 1987 |
Long-term administration of 3'-azido-2',3'-dideoxythymidine to patients with AIDS-related neurological disease.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Clinical Trials as Topic; Dementia; Humans; Male; Middle Aged; Paraplegia; Peripheral Nervous System Diseases; Thymidine; Time Factors; Zidovudine | 1988 |
AIDS. Treatment strategies and the Minnesota AIDS Clinical Trials Unit.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Humans; Opportunistic Infections; Thymidine; Zalcitabine; Zidovudine | 1988 |
Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Body Weight; Clinical Trials as Topic; Deltaretrovirus; Female; Humans; Infusions, Parenteral; Intestinal Absorption; Leukocyte Count; Lymphocytes; Male; Pneumonia, Pneumocystis; Sarcoma, Kaposi; T-Lymphocytes, Helper-Inducer; Thymidine; Virus Replication; Zidovudine | 1986 |
Zidovudine (AZT)
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine | 1987 |
Effect of zidovudine on serum human immunodeficiency virus antigen levels in symptom-free subjects.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antigens, Viral; Antiviral Agents; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; HIV; Homosexuality; Humans; Male; Random Allocation; Thymidine; Zidovudine | 1988 |
AIDS drug shows promise in preliminary clinical trial.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Deltaretrovirus; Humans; Thymidine; Virus Replication; Zidovudine | 1986 |
[Azidothymidine and HIV infection].
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Interactions; Humans; Thymidine; Zalcitabine; Zidovudine | 1987 |
Prophylactically administered Retrovir in health care workers potentially exposed to the human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Allied Health Personnel; Clinical Trials as Topic; Double-Blind Method; Humans; Occupational Diseases; Thymidine; Zidovudine | 1988 |
Antiviral drug development for the treatment of human immunodeficiency virus infections. An overview.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Humans; Thymidine; United States; Virus Replication; Zidovudine | 1988 |
Results of continued monitoring of participants in the placebo-controlled trial of zidovudine for serious human immunodeficiency virus infection.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; Follow-Up Studies; Humans; Opportunistic Infections; Placebos; Thymidine; Time Factors; Zidovudine | 1988 |
Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT).
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antigens, Viral; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; HIV; HIV Antigens; HIV Core Protein p24; Humans; Lymphocytes; Retroviridae Proteins; Thymidine; Zidovudine | 1988 |
AIDS commentary. Azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Humans; Thymidine; Zidovudine | 1988 |
The FDA's new procedures for the use of investigational drugs in treatment.
Topics: Acquired Immunodeficiency Syndrome; Catastrophic Illness; Clinical Protocols; Clinical Trials as Topic; Drug Information Services; Humans; Informed Consent; Orphan Drug Production; Pharmaceutical Preparations; Quality Control; Thymidine; United States; United States Food and Drug Administration; Zidovudine | 1988 |
Commercial venture to speed up AIDS drug tests in California.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Drug Industry; Humans; San Francisco; Thymidine; Zidovudine | 1988 |
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Opportunistic Infections; Pneumonia, Pneumocystis; Random Allocation; Sarcoma, Kaposi; Thymidine; Zidovudine | 1987 |
The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; AIDS-Related Complex; Anemia; Antiviral Agents; Blood Transfusion; Bone Marrow; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Count; Female; Hemoglobins; Humans; Leukocyte Count; Male; Neutropenia; Platelet Count; Random Allocation; Thymidine; Vitamin B 12; Zidovudine | 1987 |
Approval of zidovudine (AZT) for acquired immunodeficiency syndrome. A challenge to the medical and pharmaceutical communities.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Drug Utilization; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine | 1987 |
"On the shelf" AIDS drug in clinical trial.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Fusidic Acid; HIV; Humans; Thymidine; Virus Replication; Zidovudine | 1987 |
Zidovudine approved by FDA for treatment of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Clinical Trials as Topic; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine | 1987 |
Anemia and erythropoiesis in patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi sarcoma treated with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anemia; Antiviral Agents; Drug Evaluation; Erythrocyte Indices; Erythropoiesis; Hemoglobins; Humans; Male; Middle Aged; Prospective Studies; Random Allocation; Sarcoma, Kaposi; Thymidine; Zidovudine | 1988 |
Senate votes to expand anti-AIDS drug trials.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Government Agencies; Humans; National Institutes of Health (U.S.); Thymidine; United States; Zidovudine | 1986 |
Promising results halt trial of anti-AIDS drug.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Humans; Thymidine; Zidovudine | 1986 |
Azidothymidine for AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Bone Marrow Diseases; Clinical Trials as Topic; Humans; Kinetics; Thymidine; Zidovudine | 1986 |
Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Biological Availability; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Drug Evaluation; Half-Life; Humans; Infusions, Intravenous; Kinetics; Thymidine; Zidovudine | 1987 |
Report from the war zone.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Humans; New York City; Pharmacy Service, Hospital; Thymidine; Zidovudine | 1987 |
[Clinical trial with a new drug in acquired immunodeficiency syndrome].
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Double-Blind Method; Humans; Thymidine; Zidovudine | 1986 |
A comparison of stavudine plus lamivudine versus zidovudine plus lamivudine in combination with indinavir in antiretroviral naive individuals with HIV infection: selection of thymidine analog regimen therapy (START I).
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lamivudine; Male; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Zidovudine | 2000 |
A comparison of stavudine, didanosine and indinavir with zidovudine, lamivudine and indinavir for the initial treatment of HIV-1 infected individuals: selection of thymidine analog regimen therapy (START II).
Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Didanosine; Dideoxynucleosides; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lamivudine; Male; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Viral Load; Zidovudine | 2000 |
Zidovudine and stavudine sequencing in HIV treatment planning: findings from the CHORUS HIV cohort.
Topics: Adolescent; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Homosexuality; Humans; Logistic Models; Longitudinal Studies; Male; Middle Aged; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; White People; Zidovudine | 2001 |
Subtle decreases in stavudine phenotypic susceptibility predict poor virologic response to stavudine monotherapy in zidovudine-experienced patients.
Topics: Adult; Anti-HIV Agents; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Phenotype; Predictive Value of Tests; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Time Factors; Treatment Outcome; Viral Load; Zidovudine | 2002 |
Thymidine analogue withdrawal for lipoatrophic patients on protease-sparing therapy improves lipoatrophy but compromises antiviral control: the PIILR extension study.
Topics: Anti-HIV Agents; HIV-Associated Lipodystrophy Syndrome; Humans; Male; Middle Aged; Stavudine; Substance Withdrawal Syndrome; Thymidine; Zidovudine | 2002 |
Predictive factors and selection of thymidine analogue mutations by nucleoside reverse transcriptase inhibitors according to initial regimen received.
Topics: Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Predictive Value of Tests; Reverse Transcriptase Inhibitors; Selection, Genetic; Thymidine; Zalcitabine; Zidovudine | 2003 |
Thymidine analogue mutations in antiretroviral-naive HIV-1 patients on triple therapy including either zidovudine or stavudine.
Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Resistance, Multiple, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Stavudine; Thymidine; Viral Load; Zidovudine | 2004 |
Other Studies
316 other study(ies) available for zidovudine and thymidine
| Article | Year |
|---|---|
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Kinetics; Molecular Structure; Phosphorylation; Pyrimidine Nucleosides; Rabbits; Stavudine; T-Lymphocytes; Thymidine Kinase; Thymus Gland; Zidovudine | 1990 |
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication | 1987 |
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.
Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Polymers; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine; Uridine; Zidovudine | 1995 |
Synthesis, in vitro biological stability, and anti-HIV activity of 5-halo-6-alkoxy(or azido)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs to 3'-azido-3'-deoxythymidine (AZT).
Topics: Animals; Antiviral Agents; Blood-Brain Barrier; Brain; Bromides; Chlorides; Cysteine; Glutathione; HIV-1; Iodides; Mice; Molecular Structure; Prodrugs; Rats; Stereoisomerism; Structure-Activity Relationship; Zidovudine | 1994 |
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Topics: Antitubercular Agents; Azides; Enzyme Inhibitors; Humans; Kinetics; Models, Molecular; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Nucleosides; Nucleotides; Structure-Activity Relationship; Thymidine Monophosphate | 2003 |
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Topics: Antitubercular Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Structure-Activity Relationship; Thymidine; Thymine Nucleotides | 2003 |
Synthesis and biological evaluation of neutral and zwitterionic 3-carboranyl thymidine analogues for boron neutron capture therapy.
Topics: Animals; Binding Sites; Biological Availability; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Humans; Ions; Mice; Mice, Nude; Phosphorylation; Solubility; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase; Tissue Distribution; Xenograft Model Antitumor Assays | 2005 |
Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria.
Topics: Animals; Anti-Bacterial Agents; Deoxycytidine; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Sequence Data; Nucleosides; Phosphotransferases (Alcohol Group Acceptor); Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes | 2007 |
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
Topics: Animals; Drosophila melanogaster; Fluorescent Dyes; Nucleosides; Phosphotransferases (Alcohol Group Acceptor) | 2010 |
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.
Topics: Amino Acid Sequence; Anti-Infective Agents; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Molecular Sequence Data; Molecular Structure; Sequence Alignment; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase; Triazoles; Ureaplasma; Zidovudine | 2010 |
The effect of thymidine on the antibacterial and antiviral activity of zidovudine.
Topics: Deoxyadenosines; Escherichia coli; HIV-1; Salmonella typhimurium; SOS Response, Genetics; Thymidine; Zidovudine | 1992 |
Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.
Topics: Arabinonucleosides; Cladribine; Deoxycytidine; Deoxycytidine Kinase; Humans; Isoenzymes; Kinetics; Leukemia; Leukocytes; Mitochondria; Organ Specificity; Phosphorylation; Radioisotope Dilution Technique; Reference Values; Substrate Specificity; Thymidine; Thymidine Kinase; Tritium; Tumor Cells, Cultured; Zidovudine | 1992 |
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.
Topics: Antiviral Agents; Benzodiazepines; Dideoxynucleotides; HIV-1; Imidazoles; Kinetics; Molecular Structure; Recombinant Proteins; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Templates, Genetic; Thymidine; Thymine Nucleotides; Uracil; Zidovudine | 1992 |
Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine.
Topics: Antiviral Agents; Cell Line; HIV-1; Humans; Phospholipids; Prodrugs; T-Lymphocytes; Thymidine; Thymine Nucleotides; Viral Plaque Assay; Virus Replication; Zidovudine | 1992 |
Loss of synergistic response to combinations containing AZT in AZT-resistant HIV-1.
Topics: Antiviral Agents; Cells, Cultured; Didanosine; Drug Resistance, Microbial; Drug Synergism; HIV-1; Humans; Thymidine; Zidovudine | 1992 |
[Synthesis and cytotoxic properties of anomeric 5-substituted 3'-azido-2',3'-dideoxyuridines].
Topics: Antiviral Agents; Cell Line; Cell Survival; Chromatography, Thin Layer; DNA; Glycosylation; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thymidine; Zidovudine | 1992 |
Membrane permeation characteristics of 5'-modified thymidine analogs.
Topics: Antiviral Agents; Biological Transport; Dilazep; Dipyridamole; Erythrocyte Membrane; Erythrocytes; Humans; Kinetics; Nucleosides; Purines; Pyrimidines; Radioisotope Dilution Technique; Thymidine; Tritium; Zidovudine | 1992 |
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; DNA Replication; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Methotrexate; Pancreatic Neoplasms; Thymidine; Tumor Stem Cell Assay; Zidovudine | 1992 |
Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; Humans; Isoenzymes; Lymphocytes; Macrophages; Phosphorylation; Phytohemagglutinins; Substrate Specificity; Thymidine; Thymidine Kinase; Zidovudine | 1992 |
Mechanism and site dependency of intestinal mucosal transport and metabolism of thymidine analogues.
Topics: Animals; Chromatography, High Pressure Liquid; Colon; Intestinal Absorption; Intestinal Mucosa; Male; Perfusion; Rats; Rats, Inbred Strains; Thymidine; Zidovudine | 1992 |
Modified tetrazolium-based colorimetric method for determining the activities of anti-HIV compounds.
Topics: Antiviral Agents; Cell Line; Colorimetry; Didanosine; Foscarnet; HIV-1; Humans; Phosphonoacetic Acid; Tetrazolium Salts; Thymidine; Zalcitabine; Zidovudine | 1991 |
Antiviral activity of 5-iodo-2'-deoxyuridine and related drugs in human keratinocytes infected in vitro with herpes simplex virus type 1.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Drug Interactions; Guinea Pigs; Herpes Simplex; Humans; Idoxuridine; Keratinocytes; Simplexvirus; Thymidine; Thymidine Phosphorylase; Thymine; Zidovudine | 1991 |
Biochemical changes in ethanol-treated HL-60 cells.
Topics: Acquired Immunodeficiency Syndrome; Alcoholism; Biological Transport, Active; DNA; Ethanol; Humans; Interferons; Models, Biological; Receptors, Immunologic; Receptors, Interferon; Thymidine; Tumor Cells, Cultured; Zidovudine | 1990 |
Metabolism of 4'-azidothymidine. A compound with potent and selective activity against the human immunodeficiency virus.
Topics: Cell Line; DNA; HIV; Humans; Kinetics; Phosphorylation; Substrate Specificity; T-Lymphocytes; Thymidine; Thymidine Kinase; Thymidine Phosphorylase; Virus Replication; Zidovudine | 1992 |
A new method of synthesis of 3'-mercapto-3'-deoxythymidine.
Topics: Antiviral Agents; Cell Line; HIV; Humans; T-Lymphocytes; Thymidine; Zidovudine | 1991 |
Thymidine and zidovudine metabolism in chronically zidovudine-exposed cells in vitro.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleotides; Humans; Phosphorylation; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Time Factors; Zidovudine | 1991 |
Mutants from V79 fibroblasts exhibiting hypersensitivity to aphidicolin and 3'-azido-3'-deoxythymidine.
Topics: Animals; Aphidicolin; Cell Division; Cell Line; Cell Survival; Cricetinae; Cricetulus; Deoxyribonucleotides; Dideoxynucleotides; Diterpenes; DNA Replication; DNA-Directed DNA Polymerase; Mutation; Temperature; Thymidine; Thymine Nucleotides; Zidovudine | 1991 |
The role of the SOS response in bacteria exposed to zidovudine or trimethoprim.
Topics: beta-Galactosidase; Cell Survival; DNA Repair; Dose-Response Relationship, Drug; Escherichia coli; SOS Response, Genetics; Thymidine; Trimethoprim; Zidovudine | 1991 |
Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells.
Topics: Bone Marrow; Bone Marrow Cells; Dose-Response Relationship, Drug; Humans; Leukocytes, Mononuclear; Macrophages; Phosphorylation; Thymidine; Thymidine Kinase; Tritium; Uridine; Zidovudine | 1991 |
Comparative disposition and whole-body autoradiographic distribution of [2-14C]azidothymidine and [2-14C]thymidine in mice.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Male; Mice; Thymidine; Tissue Distribution; Zidovudine | 1991 |
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
Topics: Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Methotrexate; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine | 1991 |
Mechanisms of zidovudine resistance in bacteria.
Topics: DNA, Bacterial; Drug Resistance, Microbial; Edetic Acid; Enterobacteriaceae; Escherichia coli; Phosphorylation; Pseudomonas aeruginosa; Salmonella typhimurium; Staphylococcus; Staphylococcus aureus; Staphylococcus epidermidis; Thymidine; Thymidine Kinase; Zidovudine | 1990 |
2',3'-Dideoxycytidine toxicity in cultured human CEM T lymphoblasts: effects of combination with 3'-azido-3'-deoxythymidine and thymidine.
Topics: Cell Division; Cell Line; Cell Survival; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Interactions; Humans; Phosphorylation; T-Lymphocytes; Thymidine; Zalcitabine; Zidovudine | 1990 |
Synergy of inhibition of DNA synthesis in human bone marrow by azidothymidine plus deficiency of folate and/or vitamin B12?
Topics: Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Humans; Pyrimidines; Tetrahydrofolates; Thymidine; Vitamin B 12 Deficiency; Zidovudine | 1990 |
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics; Liver Neoplasms, Experimental; Methotrexate; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine | 1990 |
Effect of dipyridamole on transport and phosphorylation of thymidine and 3'-azido-3'-deoxythymidine in human monocyte/macrophages.
Topics: Biological Transport; Cells, Cultured; Dipyridamole; Humans; Macrophages; Monocytes; Phosphorylation; Thymidine; Zidovudine | 1990 |
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Deltaretrovirus; Gene Products, gag; Humans; Retroviridae Proteins; RNA-Directed DNA Polymerase; Thymidine; Transcription, Genetic; Zidovudine | 1985 |
Antiviral therapy. New drugs and their uses.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Chickenpox; Common Cold; Cytomegalovirus Infections; Herpes Simplex; Herpes Zoster; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Influenza, Human; Interferons; Ribavirin; Rimantadine; Thymidine; Vidarabine; Virus Diseases; Zidovudine | 1986 |
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.
Topics: Antiviral Agents; Cell Survival; HIV; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Reverse Transcriptase Inhibitors; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Virus Replication; Zidovudine | 1986 |
Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitro.
Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; HIV; HIV Antigens; Humans; Reverse Transcriptase Inhibitors; Thymidine; Viral Plaque Assay; Virus Replication; Zidovudine | 1986 |
Ribavirin antagonizes the effect of azidothymidine on HIV replication.
Topics: Cell Line; HIV; Humans; Lymphocytes; Monocytes; Phosphorylation; Phytohemagglutinins; Ribavirin; Ribonucleosides; RNA-Directed DNA Polymerase; Thymidine; Virus Replication; Zidovudine | 1987 |
Antiviral therapy.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cytomegalovirus; DNA, Viral; Drug Resistance, Microbial; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV; Humans; Interferons; Nucleosides; Reverse Transcriptase Inhibitors; Ribavirin; RNA, Messenger; RNA, Viral; Simplexvirus; Thymidine; Virus Diseases; Virus Physiological Phenomena; Virus Replication; Zidovudine | 1987 |
Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine.
Topics: Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Thymidine; Zidovudine | 1987 |
Conformational properties of 3'-azido-3'deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase.
Topics: Antiviral Agents; HIV; Models, Molecular; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 1987 |
3'-Azido-3'-deoxythymidine inhibits the replication of avian leukosis virus.
Topics: Animals; Antiviral Agents; Avian Leukosis Virus; Chick Embryo; DNA, Viral; Phosphorylation; Reverse Transcriptase Inhibitors; Thymidine; Thymine Nucleotides; Virus Replication; Zidovudine | 1987 |
[We can perhaps hold AIDS in check but we cannot cure it].
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Antiviral Agents; Humans; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 1987 |
Anti-HIV synergy between dextran sulphate and zidovudine.
Topics: Dextran Sulfate; Dextrans; Drug Synergism; HIV; Thymidine; Zidovudine | 1987 |
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.
Topics: Antiviral Agents; Deoxycytidine; HIV; Humans; Monocytes; Retroviridae Proteins; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Virus Replication; Zidovudine | 1987 |
Anti-HIV synergism between dextran sulphate and zidovudine.
Topics: Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Thymidine; Zidovudine | 1987 |
Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.
Topics: Antiviral Agents; Cell Line; Drug Synergism; Fluorescent Antibody Technique; HIV; Humans; Interleukin-3; Recombinant Proteins; RNA-Directed DNA Polymerase; Thymidine; Virus Replication; Zidovudine | 1987 |
Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine.
Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; DNA, Viral; Drug Resistance, Microbial; HIV; Humans; RNA-Directed DNA Polymerase; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine | 1987 |
Azidothymidine: crystal structure and possible functional role of the azido group.
Topics: Crystallography; Models, Molecular; RNA-Directed DNA Polymerase; Stereoisomerism; Structure-Activity Relationship; Thymidine; Zidovudine | 1987 |
[Inhibition of the avian leukosis-sarcoma complex with 3'-azido-3'-deoxythymidine (AzT); a model for screening and evaluation of chemotherapeutic agents against retrovirus infections].
Topics: Alpharetrovirus; Animals; Antiviral Agents; Avian Leukosis; Chick Embryo; Chickens; Drug Evaluation, Preclinical; Mice; Retroviridae Infections; Reverse Transcriptase Inhibitors; Thymidine; Virus Replication; Zidovudine | 1987 |
Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.
Topics: Antigens, Differentiation, T-Lymphocyte; Cell Line; Dextran Sulfate; Dextrans; Dideoxynucleosides; DNA, Viral; Fluorescent Antibody Technique; HIV; HIV Envelope Protein gp120; Immunologic Techniques; Retroviridae Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Suramin; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Fusion Proteins; Virion; Zidovudine | 1988 |
1-(2,3-Anhydro-beta-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus.
Topics: Ancitabine; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; HIV; Magnetic Resonance Spectroscopy; Mass Spectrometry; Thymidine; Uracil; Zidovudine | 1988 |
AIDS encephalopathy with response to treatment.
Topics: Antiviral Agents; Brain Diseases; Child, Preschool; gamma-Globulins; HIV Seropositivity; Humans; Male; Opportunistic Infections; Thymidine; Zidovudine | 1988 |
Antiviral chemotherapy.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Herpes Simplex; Herpes Zoster; Humans; Interferons; Thymidine; Zidovudine | 1988 |
Inhibition of reverse transcription in rat liver intracisternal A-particles by thymidine derivatives.
Topics: Animals; Dideoxynucleotides; DNA; Genes, Intracisternal A-Particle; Microsomes, Liver; Proto-Oncogenes; Rats; Rats, Inbred Strains; Retroviridae; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Templates, Genetic; Thymidine; Thymine Nucleotides; Zidovudine | 1989 |
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
Topics: Antiviral Agents; Bone Marrow; Dideoxynucleosides; HIV; Stavudine; Thymidine; Zidovudine | 1989 |
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Deoxycytidine; Deoxyribonucleotides; Dideoxynucleosides; Dose-Response Relationship, Drug; HIV; Humans; Mice; Phosphorylation; Sarcoma Viruses, Murine; Solubility; Stavudine; Thymidine; Zidovudine | 1989 |
Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication.
Topics: Animals; Dideoxynucleosides; DNA Replication; HIV-1; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains; Thymidine; Virus Replication; Zidovudine | 1989 |
Sustained delivery of 3H-thymidine by means of ceramic capsules in rats.
Topics: Animals; Capsules; Ceramics; Delayed-Action Preparations; Drug Implants; Male; Rats; Rats, Inbred Strains; Thymidine; Zidovudine | 1989 |
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.
Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Deoxycytidine; Flow Cytometry; Fluorescent Antibody Technique; HIV; Humans; Thymidine; Zalcitabine; Zidovudine | 1987 |
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.
Topics: Adenosine Kinase; Cell Line; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dideoxyadenosine; HIV; Humans; Macrophages; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Uridine Kinase; Virus Replication; Zalcitabine; Zidovudine | 1987 |
The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.
Topics: Animals; Antiviral Agents; Cell Line; Deoxycytidine; HIV; Humans; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Retroviridae; Thymidine; Zalcitabine; Zidovudine | 1988 |
Therapy for neurological involvement in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Blood-Brain Barrier; Central Nervous System Diseases; Deoxycytidine; Humans; Immunotherapy; Molecular Biology; Retroviridae; Thymidine; Zalcitabine; Zidovudine | 1988 |
Can AZT treatment in AIDS patients aggravate pre-existing CMV retinitis?
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cytomegalovirus Infections; Humans; Male; Retinitis; Thymidine; Zidovudine | 1988 |
Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus.
Topics: Cell Line; Cytomegalovirus; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV; Simplexvirus; Thymidine; Virus Replication; Zidovudine | 1988 |
Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro.
Topics: Cytopathogenic Effect, Viral; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; HIV; In Vitro Techniques; Nucleosides; Retroviridae; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Proteins; Virus Replication; Zalcitabine; Zidovudine | 1988 |
Atypical retinitis in patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Cytomegalovirus Infections; Fluorescein Angiography; Fundus Oculi; Humans; Male; Retinitis; Ribavirin; Thymidine; Zidovudine | 1988 |
Synergistic interaction of 2',3'-dideoxycytidine and recombinant interferon-alpha-A on replication of human immunodeficiency virus type 1.
Topics: Antiviral Agents; Cell Line; Deoxycytidine; Drug Synergism; HIV; Humans; Interferon Type I; Leukocytes; Recombinant Proteins; Thymidine; Virus Replication; Zalcitabine; Zidovudine | 1988 |
Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier.
Topics: Animals; Antiviral Agents; Blood-Brain Barrier; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; Liver; Male; Rats; Rats, Inbred Strains; Thymidine; Zalcitabine; Zidovudine | 1988 |
Resolution of cytomegalovirus retinitis with zidovudine therapy. Case report.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cytomegalovirus Infections; Fundus Oculi; Humans; Male; Retinitis; Thymidine; Zidovudine | 1988 |
Azidothymidine neurotoxicity.
Topics: Acquired Immunodeficiency Syndrome; Adult; Epilepsies, Partial; Humans; Male; Opportunistic Infections; Thymidine; Zidovudine | 1986 |
Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Humans; Male; Middle Aged; Nervous System Diseases; Thymidine; Zidovudine | 1987 |
Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus.
Topics: Antiviral Agents; Cell Line; HIV; Humans; Poly I-C; Poly U; Polyribonucleotides; Thymidine; Virus Replication; Zidovudine | 1987 |
Wernicke's encephalopathy in AIDS patient treated with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Thymidine; Wernicke Encephalopathy; Zidovudine | 1987 |
Serum thymidine kinase in AIDS patients treated with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Humans; Thymidine; Thymidine Kinase; Zidovudine | 1987 |
Remission of AIDS-associated psoriasis with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Humans; Male; Psoriasis; Thymidine; Zidovudine | 1987 |
Zidovudine for lymphocytic interstitial pneumonia associated with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Humans; Male; Middle Aged; Pulmonary Fibrosis; Thymidine; Zidovudine | 1987 |
Zidovudine for lymphocytic interstitial pneumonitis in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Pulmonary Fibrosis; Thymidine; Zidovudine | 1987 |
Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Deoxycytidine; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; HIV; Humans; Male; Middle Aged; Thymidine; Zalcitabine; Zidovudine | 1988 |
Treatment of HIV-induced retinoid-resistant psoriasis with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Drug Resistance; Etretinate; Homosexuality; Humans; Male; Psoriasis; Thymidine; Zidovudine | 1987 |
Combination therapy after retroviral inoculation.
Topics: Animals; Antiviral Agents; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Interferon Type I; Mice; Mice, Inbred BALB C; Recombinant Proteins; Retroviridae Infections; Thymidine; Zidovudine | 1988 |
Resumption of HIV antigen production during continuous zidovudine treatment.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Antiviral Agents; HIV; Humans; Thymidine; Zidovudine | 1988 |
Post-exposure prophylaxis against HIV infection in health care workers.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Female; Humans; Laboratory Infection; Thymidine; Zidovudine | 1988 |
Isolation of HIV from mononuclear cells of patients receiving zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antiviral Agents; HIV; Humans; Leukocytes, Mononuclear; Thymidine; Zidovudine | 1988 |
Necrotising myopathy and zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Muscular Diseases; Necrosis; Thymidine; Zidovudine | 1988 |
Update on AIDS--new video cassette.
Topics: Acquired Immunodeficiency Syndrome; Congresses as Topic; Drug Therapy; Humans; Immunotherapy; Thymidine; Videotape Recording; Zidovudine | 1988 |
Acute meningo-encephalitis on dose reduction of zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Complex; Antiviral Agents; Follow-Up Studies; HIV; Homosexuality; Humans; Male; Meningoencephalitis; Middle Aged; Neutropenia; Thrombocytopenia; Thymidine; Virus Replication; Zidovudine | 1988 |
Increased frequency of haemarthroses in haemophilic patient treated with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Hemarthrosis; Hemophilia A; Humans; Male; Middle Aged; Thymidine; Zidovudine | 1988 |
IVth international AIDS conference.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Child; Congresses as Topic; Female; Health Education; HIV; HIV Antibodies; Humans; Male; Sweden; Thymidine; Zidovudine | 1988 |
Myelopathy after stopping zidovudine.
Topics: Humans; Male; Middle Aged; Spinal Cord Diseases; Substance Withdrawal Syndrome; Thymidine; Zidovudine | 1988 |
Acyclovir-resistant herpes in AIDS treated with foscarnet.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Drug Resistance, Microbial; Female; Foscarnet; Herpes Genitalis; Humans; Organophosphorus Compounds; Phosphonoacetic Acid; Simplexvirus; Thymidine; Zidovudine | 1988 |
Zidovudine overdose.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Thymidine; Zidovudine | 1988 |
Acute meningoencephalitis on dose reduction of zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; HIV; Humans; Meningoencephalitis; Thymidine; Virus Replication; Zidovudine | 1988 |
Zidovudine-associated myopathy.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Muscular Diseases; Thymidine; Zidovudine | 1988 |
AIDS: the virus, antivirals and vaccines.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Genes, Viral; HIV; Humans; Phosphonoacetic Acid; Suramin; Thymidine; Tungsten; Tungsten Compounds; Viral Vaccines; Virus Replication; Zidovudine | 1987 |
Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; AIDS-Related Complex; Antiviral Agents; Drug Interactions; Drug Therapy, Combination; Hematologic Diseases; Humans; Male; Middle Aged; Nervous System Diseases; Pilot Projects; T-Lymphocytes, Helper-Inducer; Thymidine; Zidovudine | 1988 |
[Dysautonomic orthostatic hypotension in human immunodeficiency virus infection. Remission in azidovudine therapy].
Topics: Acquired Immunodeficiency Syndrome; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Humans; Hypotension, Orthostatic; Male; Thymidine; Zidovudine | 1988 |
The influence of human immunodeficiency virus (HIV) infection on antibody responses to influenza vaccines.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antibodies, Viral; Antiviral Agents; Hemagglutination Inhibition Tests; HIV Core Protein p24; HIV Seropositivity; Humans; Influenza A virus; Influenza B virus; Influenza Vaccines; Leukocyte Count; Male; Prospective Studies; Retroviridae Proteins; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Core Proteins; Zidovudine | 1988 |
Anti-AIDS agents show varying early results in vitro and in vivo.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Deltaretrovirus; Humans; Ribavirin; Suramin; Thymidine; Tungsten; Tungsten Compounds; Zidovudine | 1985 |
In search of the best drugs against AIDS.
Topics: Acquired Immunodeficiency Syndrome; Deltaretrovirus; Humans; Ribavirin; Suramin; Thymidine; Zidovudine | 1986 |
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Structure-Activity Relationship; Thymidine; Virus Replication; Zidovudine | 1987 |
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
Topics: Antiviral Agents; Deoxycytidine; Fluorescence; HIV; Humans; In Vitro Techniques; Monocytes; Thymidine; Zalcitabine; Zidovudine | 1987 |
Substances affecting the infection and replication of human immunodeficiency virus (HIV).
Topics: Cell Line; Cytopathogenic Effect, Viral; Deltaretrovirus; Dinoprostone; HIV; Humans; Interferon-gamma; Prostaglandins E; Tetradecanoylphorbol Acetate; Thymidine; Tretinoin; Virus Replication; Zidovudine | 1986 |
3'-Azido-3'-deoxythymidine in feline leukemia virus-infected cats: a model for therapy and prophylaxis of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Viral; Antineoplastic Agents; Antiviral Agents; Cats; Leukemia Virus, Feline; Leukemia, Experimental; Thymidine; Zidovudine | 1987 |
Intravitreous ganciclovir for patients receiving zidovudine.
Topics: Acyclovir; Adult; Antiviral Agents; Cytomegalovirus Infections; Ganciclovir; Humans; Injections; Male; Retinitis; Thymidine; Vitreous Body; Zidovudine | 1987 |
Management of viral infections in AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cytomegalovirus Infections; Herpes Simplex; Herpes Zoster; Herpesvirus 4, Human; Humans; Leukoplakia, Oral; Opportunistic Infections; Thymidine; Tumor Virus Infections; Virus Diseases; Zidovudine | 1987 |
Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy.
Topics: Animals; Animals, Newborn; Antiviral Agents; Central Nervous System Diseases; Female; Fetal Diseases; Gestational Age; Maternal-Fetal Exchange; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Retroviridae; Thymidine; Tumor Virus Infections; Virulence; Zidovudine | 1987 |
Pharmacological inhibition of in vitro infectivity of human T lymphotropic virus type I.
Topics: Deltaretrovirus; Deoxycytidine; DNA, Viral; Humans; Lymphocyte Activation; T-Lymphocytes, Helper-Inducer; Tetanus Toxoid; Thymidine; Virus Replication; Zalcitabine; Zidovudine | 1987 |
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.
Topics: Antigens, Viral; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Thymidine; Viral Plaque Assay; Virus Replication; Zalcitabine; Zidovudine | 1987 |
Brain damage by AIDS under active study.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Cell Line; Cell Transformation, Viral; Encephalitis; Glioma; Histocytochemistry; Humans; Macrophages; Membrane Proteins; Microscopy, Electron; Neuroglia; T-Lymphocytes; Thymidine; Viral Proteins; Zidovudine | 1987 |
TPA and PDQ.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Quality Control; Thymidine; Tissue Plasminogen Activator; United States; United States Food and Drug Administration; Zidovudine | 1987 |
Effect of 3'-azido-2',3'-dideoxythymidine (AZT) and neutralizing antibody on human immunodeficiency virus (HIV)-induced cytopathic effects: implication of giant cell formation for the spread of virus in vivo.
Topics: Antibodies, Viral; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Antiviral Agents; Cell Fusion; Cytopathogenic Effect, Viral; HIV; Neutralization Tests; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine | 1987 |
Suppression of human immunodeficiency virus replication by 3'-azido-3'-deoxythymidine in various human hematopoietic cell lines in vitro: augmentation of the effect by lentinan.
Topics: Cell Line; Drug Synergism; Hematopoietic Stem Cells; HIV; Humans; Lentinan; Polysaccharides; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine | 1987 |
Response of AIDS-related thrombocytopenia to intravenous and oral azidothymidine (3'-azido-3'-deoxythymidine).
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Humans; Injections, Intravenous; Leukocyte Count; Platelet Count; T-Lymphocytes; Thrombocytopenia; Thymidine; Zidovudine | 1987 |
Amplification of human immuno-deficiency virus production from a virus-producing cell line in culture at high cell density.
Topics: Cell Line; Culture Media; Electrophoresis, Polyacrylamide Gel; HIV; Humans; Membrane Proteins; Thymidine; Viral Proteins; Virion; Virology; Virus Replication; Zidovudine | 1987 |
Suppression by neurotropin of production of human immuno-deficiency virus by the virus-producing MOLT-4 cell line.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Surface; Antigens, Viral; Cell Line; HIV; Humans; Polysaccharides; Thymidine; Virion; Virus Replication; Zidovudine | 1987 |
AIDS, cardiovascular drugs approved in 1987.
Topics: Drug and Narcotic Control; Humans; Thymidine; Tissue Plasminogen Activator; United States; United States Food and Drug Administration; Zidovudine | 1987 |
The blood transfusion service and zidovudine treatment for AIDS.
Topics: Acquired Immunodeficiency Syndrome; Anemia; Antiviral Agents; Blood Transfusion; Humans; Thymidine; Zidovudine | 1987 |
Decline of HIV antigen levels in cerebrospinal fluid during treatment with low-dose zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Central Nervous System Diseases; HIV; HIV Antigens; Humans; Male; Thymidine; Time Factors; Virus Replication; Zidovudine | 1988 |
HIV antigenemia and zidovudine.
Topics: Antigens, Viral; Antiviral Agents; HIV; HIV Antigens; Humans; Thymidine; Zidovudine | 1988 |
Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Agranulocytosis; Humans; Leukocyte Count; Lithium; Lithium Carbonate; Male; Middle Aged; Neutropenia; Neutrophils; Thymidine; Zidovudine | 1988 |
Treatment of human immunodeficiency virus-related polyneuropathy with 3'-azido-2',3'-dideoxythymidine.
Topics: Acquired Immunodeficiency Syndrome; Aged; Female; Humans; Leg; Nervous System Diseases; Neural Conduction; Paralysis; Sural Nerve; Thymidine; Zidovudine | 1988 |
Nail pigmentation and azidothymidine.
Topics: Antiviral Agents; Humans; Male; Middle Aged; Nails; Pigmentation; Thymidine; Zidovudine | 1988 |
Overdose of zidovudine.
Topics: Adult; Humans; Male; Thymidine; Zidovudine | 1988 |
AZT helpful in HIV infection.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine | 1988 |
Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Chromatography, High Pressure Liquid; Humans; Male; Radioimmunoassay; Semen; Thymidine; Zidovudine | 1988 |
Health of Toronto's street kids disturbing, study reveals.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Behavior; Antiviral Agents; Attitude to Health; Chlamydia Infections; Female; Humans; Ill-Housed Persons; Male; Ontario; Pregnancy; Pregnancy in Adolescence; Thymidine; Zidovudine | 1988 |
Recovery from cryptococcemia and the adult respiratory distress syndrome in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amphotericin B; Antiviral Agents; Cryptococcosis; Humans; Intubation, Intratracheal; Male; Radiography; Respiratory Distress Syndrome; Thymidine; Zidovudine | 1988 |
Manic syndrome associated with zidovudine treatment.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Bipolar Disorder; Cognition Disorders; Humans; Male; Thymidine; Zidovudine | 1988 |
[HIV infection and AIDS. Paris, 25-29 January 1988].
Topics: Acquired Immunodeficiency Syndrome; Antibody Formation; HIV; Humans; Thymidine; Zidovudine | 1988 |
[Zidovudin (Retrovir). A new antiviral agents against human immunodeficiency viruses (HIV)].
Topics: Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Thymidine; Zidovudine | 1988 |
Clostridium difficile colitis following antiviral therapy in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Enterocolitis, Pseudomembranous; Humans; Male; Middle Aged; Thymidine; Zidovudine | 1988 |
Zidovudine overdosage.
Topics: Adult; Antiviral Agents; Ataxia; Humans; Male; Nystagmus, Pathologic; Suicide, Attempted; Thymidine; Zidovudine | 1988 |
The effect of zidovudine on antigen levels in HIV infection.
Topics: Acyclovir; Antigens, Viral; Antiviral Agents; Drug Therapy, Combination; HIV; HIV Antigens; HIV Seropositivity; Humans; Male; Thymidine; Zidovudine | 1988 |
Prophylactic Retrovir study for health care workers.
Topics: Acquired Immunodeficiency Syndrome; Health Occupations; Humans; Thymidine; Zidovudine | 1988 |
Update on AIDS--new video cassette.
Topics: Acquired Immunodeficiency Syndrome; Forecasting; Humans; Research; Thymidine; Videotape Recording; Zidovudine | 1988 |
Phosphorylation, anti-HIV activity and cytotoxicity of 3'-fluorothymidine.
Topics: Animals; Antiviral Agents; Cell Division; Cell Line; Cell Survival; Cytidine Diphosphate; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Mice; Phosphorylation; Rats; Thymidine; Virus Replication; Zidovudine | 1988 |
AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system.
Topics: Acquired Immunodeficiency Syndrome; Animals; Brain; Cell Line; Chemical Phenomena; Chemistry; Dementia; Dihydropyridines; HIV; Humans; Male; Mice; Moloney murine sarcoma virus; Pharmaceutical Preparations; Prodrugs; Rats; Rats, Inbred Strains; Thymidine; Virus Replication; Zidovudine | 1988 |
Response of human immunodeficiency virus-associated uveitis to zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Humans; Male; Thymidine; Uveitis; Visual Acuity; Zidovudine | 1988 |
Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells.
Topics: Antiviral Agents; Cell Line; Deoxyribonucleotides; Humans; Kinetics; Leukemia; Thymidine; Zidovudine | 1988 |
From the Food and Drug Administration. Update on zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine | 1988 |
Resolution of oral hairy leukoplakia during treatment with azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Homosexuality; Humans; Leukoplakia, Oral; Male; Thymidine; Tongue Neoplasms; Zidovudine | 1988 |
A sensitive liquid-chromatographic method for determination of 3'-azido-3'-deoxythymidine (AZT) in plasma and urine.
Topics: Chromatography, High Pressure Liquid; Humans; Reference Values; Thymidine; Zidovudine | 1988 |
Study to examine use of retrovir.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Evaluation; Humans; Occupational Diseases; Thymidine; Zidovudine | 1988 |
Pharmacokinetics and bioavailability of zidovudine in humans.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antiviral Agents; Biological Availability; Drug Evaluation; Humans; Thymidine; Zidovudine | 1988 |
Zidovudine therapy in children with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Male; Thymidine; Zidovudine | 1988 |
Mycobacterium avium complex infection presenting as endobronchial lesions in immunosuppressed patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Bronchial Diseases; Bronchoscopy; Female; Humans; Male; Middle Aged; Mycobacterium avium; Mycobacterium Infections; Opportunistic Infections; Radiography; Thymidine; Zidovudine | 1988 |
[Disordered long-term memory in mice as affected by azidothymidine].
Topics: Animals; Antiviral Agents; Avoidance Learning; Dose-Response Relationship, Drug; Male; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Reaction Time; Thymidine; Time Factors; Zidovudine | 1988 |
[Severe anemia after administration of zidovudine].
Topics: Acquired Immunodeficiency Syndrome; Adult; Anemia; Humans; Male; Thymidine; Zidovudine | 1988 |
Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection.
Topics: Acquired Immunodeficiency Syndrome; Brain; Brain Diseases; Child; Child, Preschool; Follow-Up Studies; Glucose; Humans; Infant; Infusions, Intravenous; Intelligence Tests; Opportunistic Infections; Thymidine; Tomography, X-Ray Computed; Zidovudine | 1988 |
AIDS update--a roundup of news and trends.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine | 1988 |
Thrombocytopenia, the acquired immunodeficiency syndrome (AIDS), and zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Thrombocytopenia; Thymidine; Zidovudine | 1988 |
Resolution of resistant chronic herpetic lesions with zidovudine in a patient with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Chronic Disease; Herpes Simplex; Humans; Male; Opportunistic Infections; Thymidine; Zidovudine | 1988 |
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.
Topics: Antiviral Agents; Cytidine; HIV; Humans; In Vitro Techniques; Macrophages; Stem Cells; Thymidine; Uridine; Virus Replication; Zidovudine | 1988 |
Enhanced in vitro inhibition of HIV-1 replication by 3'-fluoro-3'-deoxythymidine compared to several other nucleoside analogs.
Topics: Cell Line; Dideoxynucleosides; HIV-1; In Vitro Techniques; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Structure-Activity Relationship; Thymidine; Virus Replication; Zidovudine | 1988 |
Thiol reduction of 3'-azidothymidine to 3'-aminothymidine: kinetics and biomedical implications.
Topics: Chromatography, High Pressure Liquid; Dideoxynucleosides; Dithiothreitol; Kinetics; Oxidation-Reduction; Sulfhydryl Compounds; Thymidine; Zidovudine | 1988 |
Treatment of pneumocystis pneumonia in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Humans; Pneumonia, Pneumocystis; Thymidine; Zidovudine | 1988 |
Prolonged pancytopenia due to combined ganciclovir and zidovudine therapy.
Topics: Acyclovir; Antiviral Agents; Drug Therapy, Combination; Ganciclovir; Humans; Male; Middle Aged; Pancytopenia; Thymidine; Zidovudine | 1988 |
3'-Azido-3'-deoxythymidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells.
Topics: Antiviral Agents; Cell Division; Colony-Forming Units Assay; Depression, Chemical; Hematopoiesis; Hematopoietic Stem Cells; Humans; Interleukin-3; Thymidine; Zidovudine | 1988 |
Granulomatous pulmonary lesions in patients with the acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Antiviral Agents; Granuloma; Humans; Male; Pentamidine; Pneumonia, Pneumocystis; Thymidine; Zidovudine | 1988 |
Zidovudine-induced nail pigmentation.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Nail Diseases; Opportunistic Infections; Pigmentation Disorders; Pneumonia, Pneumocystis; Thymidine; Zidovudine | 1988 |
State Medicaid coverage of AZT and AIDS-related policies.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Hospices; Humans; Insurance Benefits; Insurance, Health, Reimbursement; Medicaid; Thymidine; United States; Zidovudine | 1988 |
Neutropenia in an HIV-1-infected renal transplant recipient treated with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Agranulocytosis; Antiviral Agents; Humans; Kidney Transplantation; Male; Neutropenia; Thymidine; Zidovudine | 1988 |
Effector studies of 3'-azidothymidine nucleotides with human ribonucleotide reductase.
Topics: Antiviral Agents; Cytidine Diphosphate; Guanosine Diphosphate; Humans; Kinetics; Nucleotides; Oxidation-Reduction; Ribonucleotide Reductases; Thymidine; Thymine Nucleotides; Zidovudine | 1987 |
Drugs recently released in Belgium. Carboplatin, cefmenoxime, zidovudine.
Topics: Antineoplastic Agents; Antiviral Agents; Carboplatin; Cefmenoxime; Cefotaxime; Humans; Organoplatinum Compounds; Thymidine; Zidovudine | 1987 |
Azidothymidine in the treatment of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Humans; Male; Thymidine; Zidovudine | 1988 |
AIDS-associated psoriasis responds to azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Psoriasis; Thymidine; Zidovudine | 1988 |
The effect of azidothymidine on HIV-related thrombocytopenia.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Platelet Count; Thrombocytopenia; Thymidine; Zidovudine | 1988 |
AIDS drug patent.
Topics: Acquired Immunodeficiency Syndrome; Humans; Patents as Topic; Thymidine; United States; Zidovudine | 1988 |
Factitious false-positive test for HIV.
Topics: Adult; Factitious Disorders; False Positive Reactions; HIV Seropositivity; Humans; Male; Thymidine; Zidovudine | 1988 |
Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Humans; Myositis; Thymidine; Zidovudine | 1988 |
AIDS drug assistance program.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Medical Assistance; New York; Thymidine; Zidovudine | 1988 |
Significant changes in HIV antigen level in the serum of patients treated with azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Antiviral Agents; HIV; HIV Antigens; Humans; Thymidine; Zidovudine | 1986 |
Possible drug interaction during therapy with azidothymidine and acyclovir for AIDS.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Drug Interactions; Herpes Simplex; Humans; Male; Sleep Stages; Thymidine; Zidovudine | 1987 |
AZT (zidovudine) just a step away from FDA approval for AIDS therapy.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine | 1987 |
Imminent marketing of AZT raises problems.
Topics: Acquired Immunodeficiency Syndrome; Humans; Thymidine; Zidovudine | 1987 |
FDA approves AZT.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Humans; Thymidine; United States; United States Food and Drug Administration; Zidovudine | 1987 |
Azidothymidine and human immunodeficiency virus infection.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine | 1987 |
Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.
Topics: Antiviral Agents; Drug Synergism; HIV; Humans; Interferon Type I; Recombinant Proteins; Thymidine; Virus Replication; Zidovudine | 1987 |
3'-azido-3'-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion.
Topics: Antiviral Agents; Biological Transport; Cell Membrane Permeability; Diffusion; Erythrocytes; Humans; Kinetics; Lymphocytes; Thymidine; Zidovudine | 1987 |
Availability of AZT for treatment of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Humans; Thymidine; United States; Zidovudine | 1987 |
"Cure" of chronic cryptosporidiosis during treatment with azidothymidine in a patient with the acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Chronic Disease; Cryptosporidiosis; Diarrhea; Humans; Male; Opportunistic Infections; Thymidine; Zidovudine | 1987 |
Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)].
Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Drug Interactions; Glycyrrhetinic Acid; Glycyrrhizic Acid; HIV; Humans; Thymidine; Zidovudine | 1987 |
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro.
Topics: Adenine; African Swine Fever Virus; Amides; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Iridoviridae; Organophosphonates; Organophosphorus Compounds; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tubercidin; Vero Cells; Virus Replication; Zidovudine | 1987 |
AIDS research: the ethics of clinical trials.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Beneficence; Clinical Trials as Topic; Control Groups; Ethical Analysis; Ethics, Professional; Human Experimentation; Humans; Patient Advocacy; Patient Selection; Personal Autonomy; Research; Research Subjects; Risk Assessment; Social Justice; Thymidine; Zidovudine | 1986 |
Antiretroviral therapy for AIDS.
Topics: Acquired Immunodeficiency Syndrome; DNA, Viral; Humans; Thymidine; Zidovudine | 1987 |
Inhibition of hepatitis B virus DNA polymerase by 3'-azido-3'-deoxythymidine triphosphate but not by its threo analog.
Topics: Antiviral Agents; Carrier State; Dideoxynucleotides; Hepatitis B; Hepatitis B virus; Humans; Nucleic Acid Synthesis Inhibitors; Thymidine; Thymine Nucleotides; Zidovudine | 1987 |
Profound cytopenia secondary to azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Pancytopenia; Thymidine; Zidovudine | 1987 |
Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Bone Marrow Diseases; Humans; Male; Middle Aged; Pancytopenia; Random Allocation; Thymidine; Zidovudine | 1987 |
Possible zidovudine-induced hepatotoxicity.
Topics: Adult; Antiviral Agents; Humans; Liver; Liver Function Tests; Male; Thymidine; Zidovudine | 1987 |
Promoting Retrovir.
Topics: Acquired Immunodeficiency Syndrome; Advertising; Drug Industry; Humans; Thymidine; United States; Zidovudine | 1987 |
Zidovudine and the anaesthetist.
Topics: Acquired Immunodeficiency Syndrome; Anesthesiology; Anesthetics; Antiviral Agents; Drug Interactions; Humans; Thymidine; Zidovudine | 1987 |
Azidothymidine (AZT).
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; HIV; Humans; Thymidine; Zidovudine | 1987 |
AZT in hemophilia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Blood Platelets; Hemophilia A; Humans; Male; Thymidine; Zidovudine | 1987 |
Update on AZT for AIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Drug Interactions; Hematologic Diseases; Humans; Thymidine; Zidovudine | 1987 |
Nail pigmentation in the acquired immunodeficiency syndrome (AIDS)
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Humans; Male; Nail Diseases; Pigmentation Disorders; Thymidine; Zidovudine | 1987 |
A pinch of will is better than a pound of perhaps.
Topics: Acquired Immunodeficiency Syndrome; Adult; Attitude to Health; Humans; Male; Social Support; Thymidine; Zidovudine | 1987 |
A little more to improve safety and efficiency of AZT in AIDS therapy.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Thymidine; Zidovudine | 1987 |
[AIDS and antiretroviral agents: specificity of azidothymidine].
Topics: Acquired Immunodeficiency Syndrome; Humans; Thymidine; Zidovudine | 1987 |
Zidovudine for AIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Humans; Thymidine; Zidovudine | 1987 |
Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro.
Topics: Acyclovir; Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Ganciclovir; Hematopoietic Stem Cells; Humans; Thymidine; Zidovudine | 1987 |
Nail pigmentation changes associated with azidothymidine (zidovudine).
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Black People; Female; Humans; Male; Nail Diseases; Pigmentation Disorders; Pneumonia, Pneumocystis; Thymidine; Zidovudine | 1987 |
Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.
Topics: Antigen-Presenting Cells; Antiviral Agents; Cell Line; Cell Survival; HIV; Humans; Lymphocyte Activation; Models, Biological; Radioimmunoassay; T-Lymphocytes; Tetanus Toxoid; Thymidine; Zidovudine | 1987 |
Prophylaxis against Pneumocystis carinii pneumonia in patients receiving azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Middle Aged; Pneumonia, Pneumocystis; Thymidine; Zidovudine | 1987 |
Antiviral agents.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Herpes Simplex; Humans; Idoxuridine; Influenza A virus; Influenza, Human; Ribavirin; Rimantadine; Thymidine; Vidarabine; Viruses; Zidovudine | 1987 |
Dideoxynucleosides are less inhibitory in vitro against human immunodeficiency virus type 2 (HIV-2) than against HIV-1.
Topics: Antiviral Agents; Cell Line; Drug Resistance, Microbial; HIV; Humans; T-Lymphocytes; Thymidine; Virus Replication; Zidovudine | 1987 |
The AIDS virus.
Topics: Acquired Immunodeficiency Syndrome; Animals; Chlorocebus aethiops; Genes, Viral; History, 20th Century; HIV; Humans; Lymphocytes; Thymidine; Viral Envelope Proteins; Viral Vaccines; Zidovudine | 1987 |
Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U).
Topics: Antiviral Agents; DNA Replication; DNA, Bacterial; Drug Resistance, Microbial; Enterobacteriaceae; Escherichia coli; HIV; Kinetics; Microbial Sensitivity Tests; Mutation; Thymidine; Thymidine Kinase; Vibrio; Zidovudine | 1987 |
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Deoxyribonucleosides; Female; Kinetics; Leukemia L1210; Mice; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus; Structure-Activity Relationship; Thymidine; Zidovudine | 1980 |
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
Topics: Adenosine Triphosphate; Animals; Chlamydia trachomatis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; Guanosine Triphosphate; L Cells; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; RNA, Bacterial; Sulfisoxazole; Thymidine; Trimethoprim; Uracil; Zidovudine | 1994 |
Synthesis of (3'R)-3'-deoxy-3'-C-nitromethylthymidine.
Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; HIV-1; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Thymidine; Zidovudine | 1995 |
A comparison of the conformations of the 5'-triphosphates of zidovudine (AZT) and thymidine bound to HIV-1 reverse transcriptase.
Topics: HIV Reverse Transcriptase; HIV-1; Magnetic Resonance Spectroscopy; Molecular Structure; Protein Binding; Recombinant Proteins; RNA-Directed DNA Polymerase; Thymidine; Zidovudine | 1993 |
Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells.
Topics: Analysis of Variance; B-Lymphocytes; Cell Line; Cells, Cultured; Didanosine; Drug Interactions; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Phosphorylation; Phytohemagglutinins; Thymidine; Zalcitabine; Zidovudine | 1994 |
Sanctuary growth of human immunodeficiency virus in the presence of 3'-azido-3'-deoxythymidine.
Topics: Cell Line; Dose-Response Relationship, Drug; Drug Resistance; HIV-1; Humans; In Vitro Techniques; Phosphorylation; Thymidine; Virus Replication; Zidovudine | 1995 |
Zidovudine induces the expression of cellular resistance affecting its antiviral activity.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; DNA, Viral; Drug Resistance, Microbial; HIV-1; Humans; Thymidine; Thymidine Kinase; Zidovudine | 1994 |
Development of a ceramic matrix system for continuous delivery of azidothymidine.
Topics: Calcium Phosphates; Ceramics; Drug Implants; Thymidine; Zidovudine | 1994 |
The ex vivo transfer of the anti-HIV nucleoside compound d4T in the human placenta.
Topics: Diffusion; Dipyridamole; Female; Fetal Blood; Gestational Age; Humans; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Stavudine; Thymidine; Zidovudine | 1994 |
Potentiation of 2',3'-dideoxycytidine (ddC) by hydroxyurea and thymidine on the Moloney murine leukemia virus (MoMLV) early replicative steps.
Topics: 3T3 Cells; Animals; Drug Synergism; Hydroxyurea; Mice; Moloney murine leukemia virus; Thymidine; Transcription, Genetic; Virus Replication; Zalcitabine; Zidovudine | 1994 |
Inhibition of thymidine transport by 3'-azido-3'-deoxythymidine and its metabolites.
Topics: Biological Transport; Dideoxynucleosides; Erythrocytes; Humans; Thymidine; Zidovudine | 1993 |
In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors.
Topics: Analysis of Variance; Animals; Azides; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Central Nervous System; Deoxyglucose; Diffusion; Endothelium, Vascular; Injections, Intravenous; Injections, Intraventricular; Male; Probenecid; Rats; Rats, Wistar; Sodium Azide; Thymidine; Zidovudine | 1994 |
Covalent coupling of nucleosides to low density lipoprotein (LDL) generates macrophage specific (drug)-carriers.
Topics: Animals; Apolipoproteins B; Autoradiography; Biological Transport; Cells, Cultured; Drug Carriers; Endocytosis; Humans; Lipoproteins, LDL; Lysine; Macrophages; Mice; Thymidine; Zidovudine | 1993 |
Synergistic cytotoxicity of AZT plus alpha and gamma interferon in chronic myeloid leukemia cell line K562.
Topics: Cell Division; Cell Line; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Humans; Interferon alpha-2; Interferon-alpha; Interferon-gamma; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Recombinant Proteins; Thymidine; Tumor Cells, Cultured; Zidovudine | 1993 |
Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model system.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Drug Interactions; Epithelium; Humans; Intestinal Mucosa; Intestines; Nucleosides; Thymidine; Zidovudine | 1993 |
Antiviral drugs from the nucleoside analog family block volume-activated chloride channels.
Topics: 3T3 Cells; Acyclovir; Animals; Antiviral Agents; Cell Size; Chloride Channels; Humans; Mice; Patch-Clamp Techniques; Thymidine; Tumor Cells, Cultured; Uridine; Zidovudine | 1995 |
2-amino-9-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)-6-substituted-9H-purines: synthesis and anti-HIV activity.
Topics: Antiviral Agents; Cell Line, Transformed; Cytopathogenic Effect, Viral; Dideoxynucleosides; Guanosine; HIV-1; Humans; Lactobacillus; Pentosyltransferases; Purines; Structure-Activity Relationship; T-Lymphocytes; Thymidine; Zidovudine | 1995 |
Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase.
Topics: Cell Line; HIV Infections; HIV-1; Humans; Kinetics; Leukocytes, Mononuclear; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Time Factors; Tritium; Zidovudine | 1996 |
AZT incorporation into mitochondria: study in a human myeloid cell line.
Topics: Antimetabolites; HL-60 Cells; Humans; Mitochondria; Scintillation Counting; Thymidine; Zidovudine | 1996 |
Stavudine selectively induces apoptosis in HIV type 1-infected cells.
Topics: Anti-HIV Agents; Apoptosis; Cell Line; Didanosine; DNA Fragmentation; Down-Regulation; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reverse Transcriptase Inhibitors; Stavudine; T-Lymphocytes; Thymidine; Zalcitabine; Zidovudine | 1997 |
Thymidine in the micromolar range promotes rejoining of UVC-induced DNA strand breaks and prevents azidothymidine from inhibiting the rejoining in quiescent human lymphocytes.
Topics: Adult; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; DNA Damage; DNA Repair; Humans; Lymphocytes; Methyl Methanesulfonate; Middle Aged; Reproducibility of Results; Thymidine; Ultraviolet Rays; Zidovudine | 1997 |
Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro.
Topics: Anti-HIV Agents; Cells, Cultured; Drug Interactions; Humans; Leukemia, Monocytic, Acute; Leukocytes, Mononuclear; Phosphorylation; Phytohemagglutinins; Stavudine; Stimulation, Chemical; Thymidine; Zidovudine | 1997 |
The passage of azidodeoxythymidine into and within the central nervous system: does it follow the parent compound, thymidine?
Topics: Animals; Central Nervous System; Guinea Pigs; Thymidine; Zidovudine | 1997 |
[Synthesis of phosphoceramide azidothymidine and phosphoceramide didehydrodeoxythymidine].
Topics: Anti-HIV Agents; Ceramides; Dideoxynucleotides; Esterification; Magnetic Resonance Spectroscopy; Prodrugs; Thymidine; Zidovudine | 1997 |
Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat.
Topics: Animals; Anti-HIV Agents; Blood-Brain Barrier; Drug Evaluation, Preclinical; Lamivudine; Male; Rats; Rats, Sprague-Dawley; Thymidine; Zidovudine | 1998 |
Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate.
Topics: Cell Line; Deoxyribonucleotides; Genetic Vectors; Hydroxyurea; Mutation; Retroviridae; Thymidine; Zidovudine | 1998 |
The transport of the anti-HIV drug, 2',3'-didehydro-3'-deoxythymidine (D4T), across the blood-brain and blood-cerebrospinal fluid barriers.
Topics: Analysis of Variance; Animals; Anti-HIV Agents; Biological Transport; Blood-Brain Barrier; Brain; Guinea Pigs; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine | 1998 |
Pharmacokinetics and tissue distribution of (+/-)-3'-azido-2',3'-dideoxy-5'-O-(2-bromomyristoyl)thymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine (AZT) in mice.
Topics: Animals; Anti-HIV Agents; Area Under Curve; Brain; Chromatography, High Pressure Liquid; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred BALB C; Myristic Acids; Prodrugs; Thymidine; Tissue Distribution; Zidovudine | 1998 |
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.
Topics: Antimetabolites, Antineoplastic; Carrier Proteins; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Gene Transfer Techniques; Humans; Methotrexate; Receptors, Cell Surface; Thymidine; Thymidine Kinase; Uterine Cervical Neoplasms; Zidovudine | 1999 |
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region.
Topics: Anti-HIV Agents; Cell Line; Dimerization; HIV-1; HIV-2; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Fast Atom Bombardment; Spiro Compounds; Stavudine; Thymidine; Uridine; Zidovudine | 1999 |
A Na(+)-dependent nucleoside transporter in microglia.
Topics: Adenosine; Animals; Carrier Proteins; Cell Size; Cells, Cultured; Cytidine; Dideoxynucleosides; Dose-Response Relationship, Drug; Guanosine; Membrane Proteins; Microglia; Nucleic Acid Probes; Nucleoside Transport Proteins; Rats; Rats, Wistar; Sodium; Thymidine; Time Factors; Uridine; Zidovudine | 2000 |
[Combination of phosphazide and crixivan inhibit replication of HIV-1 strains that are resistant to azidothymidine].
Topics: Anti-HIV Agents; Azides; Cell Line; Drug Resistance, Microbial; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Microbial Sensitivity Tests; Organophosphonates; Reverse Transcriptase Inhibitors; Thymidine; Virus Replication; Zidovudine | 1999 |
Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase.
Topics: Anti-HIV Agents; Boron Compounds; Crystallography, X-Ray; DNA Repair; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Models, Molecular; Molecular Conformation; Nucleoside-Diphosphate Kinase; Protein Binding; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Thymidine; Transcription, Genetic; Zidovudine | 2000 |
A facile synthesis of 1-(5'-O-acetyl-3'-O-benzyl-beta-D-xylofuranosyl)thymidine: a potentially viable intermediate for the preparation of the anti-AIDS drugs, AZT and D4T.
Topics: Anti-HIV Agents; Stavudine; Thymidine; Zidovudine | 2000 |
[Conditions of "thymidine analog mutations" (TAMs) in naive patients treated with different combinations of d4T].
Topics: Anti-HIV Agents; Drug Resistance; Humans; Lamivudine; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine | 2000 |
Identification of residues involved in the specificity and regulation of the highly efficient multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster.
Topics: Animals; Cytarabine; Dideoxyadenosine; Directed Molecular Evolution; Drosophila melanogaster; Enzyme Activation; Feedback; Inhibitory Concentration 50; Kinetics; Mutation; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Substrate Specificity; Thymidine; Thymine Nucleotides; Zalcitabine; Zidovudine | 2000 |
Absence of association between individual thymidine analogues or nonnucleoside analogues and lipid abnormalities in HIV-1-infected persons on initial therapy.
Topics: Adult; Alkynes; Anti-HIV Agents; Arteriosclerosis; Benzoxazines; Cholesterol; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lipids; Male; Nevirapine; Oxazines; Risk Factors; Stavudine; Thymidine; Triglycerides; Zidovudine | 2000 |
Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP.
Topics: 5'-Nucleotidase; Anti-HIV Agents; Culture Media; Dideoxynucleotides; Half-Life; Humans; Hydrogen-Ion Concentration; Leukocytes, Mononuclear; Macrophages; Monocytes; Stavudine; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Time Factors; Tritium; Tumor Cells, Cultured; Zidovudine | 2000 |
Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm.
Topics: Cervix Uteri; Chromatography, High Pressure Liquid; Dideoxynucleotides; Epithelial Cells; Female; Flow Cytometry; Genitalia, Female; Humans; Male; Nucleotides; Phosphorylation; Sperm Motility; Spermatozoa; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Vagina; Zidovudine | 2001 |
Thymidine analog and multinucleoside resistance mutations are associated with decreased phenotypic susceptibility to stavudine in HIV type 1 isolated from zidovudine-naive patients experiencing viremia on stavudine-containing regimens.
Topics: Anti-HIV Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; HIV Infections; HIV Protease; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Viremia; Zidovudine | 2001 |
Induction of a TRAIL-mediated suicide program by interferon alpha in primary effusion lymphoma.
Topics: Antimetabolites, Antineoplastic; Antiviral Agents; Apoptosis; Apoptosis Regulatory Proteins; Arabidopsis Proteins; bcl-X Protein; Biopolymers; Cysteine Endopeptidases; Drug Synergism; Enzyme Activation; Epstein-Barr Virus Infections; Etoposide; Fatty Acid Desaturases; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Herpesviridae Infections; Herpesvirus 4, Human; Herpesvirus 8, Human; HIV Infections; Humans; Immunocompromised Host; Immunologic Factors; Interferon-alpha; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Membrane Glycoproteins; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Thymidine; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tumor Virus Infections; Zidovudine | 2001 |
Antagonism between interleukin 3 and erythropoietin in mice with azidothymidine-induced anemia and in bone marrow endothelial cells.
Topics: Anemia; Animals; Antimetabolites; Bone Marrow Cells; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium; Erythropoietin; HL-60 Cells; Humans; Insulin-Like Growth Factor II; Interleukin-3; Jurkat Cells; Liver; Mice; Recombinant Fusion Proteins; Thymidine; Zidovudine | 2002 |
M184V is associated with a low incidence of thymidine analogue mutations and low phenotypic resistance to zidovudine and stavudine.
Topics: Drug Resistance, Microbial; Genotype; HIV Infections; HIV-1; Humans; Mutation; Phenotype; Retrospective Studies; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Viral Load; Zidovudine | 2002 |
Combination of drugs and drug-resistant reverse transcriptase results in a multiplicative increase of human immunodeficiency virus type 1 mutant frequencies.
Topics: Animals; Anti-HIV Agents; COS Cells; Dose-Response Relationship, Drug; Drug Resistance, Viral; Genetic Vectors; HeLa Cells; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Lamivudine; Mutation; Reverse Transcriptase Inhibitors; Thymidine; Virus Replication; Zidovudine | 2002 |
Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations.
Topics: Anti-HIV Agents; Dideoxynucleotides; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nucleosides; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Thymidine; Thymidine Monophosphate; Zidovudine | 2002 |
Microwave-assisted synthesis of O'-adamantylated uracil-derived nucleosides.
Topics: Adamantane; Deoxyuridine; Hot Temperature; HSP70 Heat-Shock Proteins; Microwaves; Molecular Chaperones; Nucleosides; Saccharomyces cerevisiae Proteins; Thymidine; Uracil; Zidovudine | 2003 |
Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives.
Topics: Benzimidazoles; Benzoxazoles; Dideoxynucleotides; HIV Reverse Transcriptase; Indicators and Reagents; Magnetic Resonance Spectroscopy; Pyridines; Reverse Transcriptase Inhibitors; Spectrophotometry, Infrared; Thiazoles; Thymidine; Thymine Nucleotides; Zidovudine | 2003 |
Choroid plexus controls brain availability of anti-HIV nucleoside analogs via pharmacologically inhibitable organic anion transporters.
Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biological Availability; Blood-Brain Barrier; Choroid Plexus; Epithelial Cells; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Thymidine; Viral Load; Zidovudine | 2003 |
The selective in vitro cytotoxicity of carcinoma cells by AZT is enhanced by concurrent treatment with delocalized lipophilic cations.
Topics: Adenosine Triphosphate; Carcinoma; Cations; Cell Survival; Colony-Forming Units Assay; Humans; Male; Pyridines; Thiazoles; Thymidine; Tumor Cells, Cultured; Zidovudine | 2003 |
Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments.
Topics: Aminoisobutyric Acids; Animals; Blotting, Northern; Cholesterol; DNA; Fatty Acids; Immunoblotting; Ketone Bodies; Lactic Acid; Lipid Metabolism; Liver; Male; Metabolism; Mice; Mitochondria; Oxidation-Reduction; Phospholipids; Pyruvic Acid; Reverse Transcriptase Inhibitors; Thymidine; Triglycerides; Zidovudine | 2003 |
Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth.
Topics: Amino Acid Sequence; Cell Division; Cloning, Molecular; Deoxyuridine; Escherichia coli; Feedback, Physiological; Molecular Sequence Data; Molecular Weight; Mycoplasma pneumoniae; Nucleosides; Phosphates; Pyrimidine Nucleosides; Recombinant Proteins; Sequence Homology, Amino Acid; Stavudine; Substrate Specificity; Tetrahydrouridine; Thymidine; Thymidine Kinase; Thymine Nucleotides; Ureaplasma urealyticum; Zidovudine | 2003 |
Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure.
Topics: Anti-HIV Agents; Base Sequence; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Treatment Failure; Viral Load; Zidovudine | 2004 |
Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNA prim
Topics: Adenosine Triphosphate; Amino Acid Sequence; Base Sequence; Codon; DNA; DNA Primers; Drug Resistance, Viral; Gene Deletion; HIV Reverse Transcriptase; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Phenotype; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Sequence Homology, Amino Acid; Stavudine; Thymidine; Time Factors; Tyrosine; Zidovudine | 2004 |
Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.
Topics: Adenine; Algorithms; Anti-HIV Agents; Databases, Genetic; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV; HIV Infections; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zalcitabine; Zidovudine | 2004 |
Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT.
Topics: Animals; Aorta; Cattle; Cell Survival; Cells, Cultured; Dideoxynucleotides; Endothelial Cells; Endothelium, Vascular; Free Radicals; Glutathione; In Vitro Techniques; Intracellular Membranes; Lipid Peroxidation; Magnesium; Microsomes, Liver; Molsidomine; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides; Zidovudine | 2004 |
Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity.
Topics: Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biological Transport; Chromatography, High Pressure Liquid; Dideoxynucleotides; DNA, Mitochondrial; In Vitro Techniques; Mitochondria, Heart; Phosphorylation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine | 2004 |
Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine Kinase; Female; HIV; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Middle Aged; RNA, Viral; Thymidine; Thymidine Kinase; Zidovudine | 2005 |
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues.
Topics: Adenosine Triphosphate; Boron Compounds; Dideoxynucleotides; Drug Resistance, Multiple, Viral; HIV-1; Humans; Kinetics; Mutation; Phosphorylation; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine | 2005 |
Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors.
Topics: Dideoxynucleotides; HIV Reverse Transcriptase; Molecular Mimicry; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymidine; Thymine Nucleotides; Zidovudine | 2005 |
The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.
Topics: Adenosine Triphosphate; Anti-HIV Agents; Base Sequence; Didanosine; DNA Primers; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 2005 |
3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity.
Topics: Animals; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Kinetics; Liver Diseases; Mitochondria, Liver; Phosphorylation; Rats; Rats, Sprague-Dawley; Thymidine; Zidovudine | 2006 |
The contribution of HIV fitness to the evolution pattern of reverse transcriptase inhibitor resistance.
Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; Evolution, Molecular; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Nevirapine; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 2006 |
[In vitro selection and phenotyping of HIV-1 mutants resistant to azidothymidine and didanosine].
Topics: Didanosine; Drug Resistance, Viral; HIV-1; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine | 2005 |
The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Arginine; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Lysine; Organophosphonates; Phenotype; Point Mutation; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine; Zalcitabine; Zidovudine | 2006 |
3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.
Topics: Animals; Chromatography, High Pressure Liquid; Mitochondria, Heart; Mitochondria, Liver; Phosphorylation; Rats; Thymidine; Zidovudine | 2006 |
Mutational patterns associated with the 69 insertion complex in multi-drug-resistant HIV-1 reverse transcriptase that confer increased excision activity and high-level resistance to zidovudine.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Anti-HIV Agents; Base Sequence; Drug Resistance, Multiple, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutagenesis, Insertional; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Thymidine; Zidovudine | 2007 |
Diminished selection for thymidine-analog mutations associated with the presence of M184V in Ethiopian children infected with HIV subtype C receiving lamivudine-containing therapy.
Topics: Anti-HIV Agents; Child; Child, Preschool; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Inhibitory Concentration 50; Lamivudine; Male; Microbial Sensitivity Tests; Mutation; Phenotype; Reverse Transcriptase Inhibitors; Selection, Genetic; Thymidine; Virus Replication; Zidovudine | 2006 |
Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart.
Topics: Animals; Heart; Mitochondria, Heart; Perfusion; Phosphorylation; Rats; Rats, Sprague-Dawley; Thymidine; Zidovudine | 2007 |
Application of solid-phase chemistry for the synthesis of 3'-fluoro-3'-deoxythymidine.
Topics: Anti-HIV Agents; Chemistry, Pharmaceutical; Dideoxynucleosides; Drug Design; Models, Chemical; Molecular Structure; Polymers; Thymidine; Trifluoroacetic Acid; Zidovudine | 2007 |
Evolution of resistance mutations during low-level viral replication in HIV-1-infected patients treated with zidovudine/lamivudine/abacavir as a first-line regimen.
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Dideoxynucleosides; DNA, Viral; Drug Combinations; Drug Monitoring; Drug Resistance, Viral; Follow-Up Studies; Genotype; Germany; HIV Infections; HIV-1; Humans; Lamivudine; Methionine; Mutation; Reverse Transcriptase Inhibitors; Thymidine; Time Factors; Treatment Failure; Valine; Viral Load; Virus Replication; Zidovudine | 2007 |
Long-term foscarnet therapy remodels thymidine analogue mutations and alters resistance to zidovudine and lamivudine in HIV-1.
Topics: Amino Acid Substitution; Anti-HIV Agents; Drug Resistance, Multiple, Viral; Evolution, Molecular; Foscarnet; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Point Mutation; Reverse Transcriptase Inhibitors; Species Specificity; Thymidine; Time Factors; Zidovudine | 2007 |
The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in southern Africa.
Topics: Africa, Southern; Antiretroviral Therapy, Highly Active; Didanosine; Drug Resistance, Multiple, Viral; Evolution, Molecular; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymidine; Treatment Failure; Zidovudine | 2007 |
Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines.
Topics: Animals; Anti-HIV Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Humans; Phosphorylation; Rats; Thymidine; U937 Cells; Zidovudine | 2008 |
Longitudinal effects of thymidine analogues on mtDNA, mtRNA and multidrug resistance (MDR-1) induction in cultured cells.
Topics: Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA, Mitochondrial; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; K562 Cells; RNA; RNA, Mitochondrial; Stavudine; Thymidine; Time Factors; Zidovudine | 2008 |
Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Thymidine; Viral Load; Zidovudine | 2008 |
Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1.
Topics: Animals; Cell Line; Dehydroepiandrosterone Sulfate; Drug Interactions; Models, Theoretical; Rats; Reverse Transcriptase Inhibitors; Thymidine; Trophoblasts; Zidovudine | 2008 |
Foscarnet salvage therapy efficacy is associated with the presence of thymidine-associated mutations (TAMs) in HIV-infected patients.
Topics: Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Foscarnet; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Mutation; Reverse Transcriptase Inhibitors; Salvage Therapy; Stavudine; Thymidine; Treatment Outcome; Zidovudine | 2008 |
Retention of metabolites of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel anti-human immunodeficiency virus type 1 thymidine analog, in cells.
Topics: Anti-HIV Agents; Biological Transport; Cell Line; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dipyridamole; Humans; Multidrug Resistance-Associated Proteins; Phosphodiesterase Inhibitors; Phosphorylation; Stavudine; Thymidine; Zidovudine | 2009 |
Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine.
Topics: Anti-HIV Agents; Cell Line; DNA Repair; Drug Resistance, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Point Mutation; Ribonuclease H; RNA, Viral; Thymidine; Viral Proteins; Zidovudine | 2009 |
Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.
Topics: Acyclovir; Adenosine Triphosphate; Anti-HIV Agents; DNA Mutational Analysis; DNA Primers; Drug Resistance, Multiple; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Stavudine; Thymidine; Valine; Zidovudine | 2009 |
The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytosol; HIV Protease Inhibitors; Hydrogen-Ion Concentration; Mice; Multidrug Resistance-Associated Proteins; Nigericin; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 2010 |
Pro-oxidant properties of AZT and other thymidine analogues in macrophages: implication of the azido moiety in oxidative stress.
Topics: Animals; Anti-HIV Agents; Azides; Cell Line, Tumor; Coordination Complexes; Humans; Macrophages; Mice; Osmium; Oxidants; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Thymidine; Zidovudine | 2010 |
Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells.
Topics: Anti-HIV Agents; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA; DNA Adducts; Down-Regulation; Drug Resistance, Neoplasm; Humans; Micronuclei, Chromosome-Defective; Micronucleus Tests; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Zidovudine | 2010 |
Azidothymidine enhances fluorodeoxyuridine-mediated radiosensitization.
Topics: Antimetabolites; Cell Cycle; Cell Line, Tumor; Cell Survival; Colony-Forming Units Assay; Deoxyuracil Nucleotides; DNA Breaks, Single-Stranded; DNA Damage; DNA Mismatch Repair; Drug Synergism; Flow Cytometry; Floxuridine; Humans; MutS Homolog 2 Protein; Poisson Distribution; Radiation Tolerance; Thymidine; Thymine Nucleotides; Zidovudine | 2010 |
N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations.
Topics: Drug Resistance, Multiple, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Phenotype; Reverse Transcriptase Inhibitors; Thymidine; Viral Load; Zidovudine | 2010 |
A new DNA building block, 4'-selenothymidine: synthesis and modification to 4'-seleno-AZT as a potential anti-HIV agent.
Topics: Anti-HIV Agents; Cell Line; Crystallography, X-Ray; DNA; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Organoselenium Compounds; Thymidine; Zidovudine | 2010 |
Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity.
Topics: Animals; Chromatography, Gel; Deoxycytidine; Dideoxynucleosides; Enzyme Activation; Humans; Mitochondria; Phosphorylation; Rats; Recombinant Proteins; Thymidine; Thymidine Kinase; Zidovudine | 2010 |
Formation of aminyl radicals on electron attachment to AZT: abstraction from the sugar phosphate backbone versus one-electron oxidation of guanine.
Topics: Anti-HIV Agents; Electron Spin Resonance Spectroscopy; Electrons; Free Radicals; Guanine; Models, Theoretical; Oxidation-Reduction; Sugar Phosphates; Thymidine; Thymine; Zidovudine | 2010 |
Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria.
Topics: Animals; Anti-HIV Agents; Deoxycytidine; Male; Mitochondria, Heart; Myocardium; Nucleosides; Perfusion; Phosphorylation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zalcitabine; Zidovudine | 2010 |
Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations.
Topics: Amino Acid Substitution; Anti-HIV Agents; Brazil; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Mutant Proteins; Mutation, Missense; Nevirapine; Protein Structure, Tertiary; Thymidine; Zidovudine | 2011 |
A structural frame for understanding the role of thymidine analogue resistance mutations in resistance to zidovudine and other nucleoside analogues.
Topics: Anti-HIV Agents; Binding Sites; Catalytic Domain; DNA; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Nucleosides; Reverse Transcriptase Inhibitors; Thymidine; Zidovudine | 2011 |
Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility.
Topics: Adenine; Algorithms; Anti-HIV Agents; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Genomics; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Least-Squares Analysis; Mutation; Nucleosides; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine; Zidovudine | 2012 |
Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Kinetics; Male; Mitochondria; Nucleotidases; Phosphorylation; Pyrimidine Nucleosides; Rats; Rats, Sprague-Dawley; Stavudine; Thymidine; Time Factors; Tritium; Zidovudine | 2012 |
Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation.
Topics: Anti-HIV Agents; Autophagy; Blotting, Western; Cells, Cultured; DNA, Mitochondrial; Fatty Liver; Female; Flow Cytometry; Hep G2 Cells; HIV Infections; Humans; Lipid Metabolism; Male; Microscopy, Electron; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Stavudine; Thymidine; Zidovudine | 2012 |
Resistance-associated mutations after initial antiretroviral treatment failure in a large cohort of patients infected with HIV-1 subtype CRF01_AE.
Topics: Adult; Aged; Anti-HIV Agents; Cohort Studies; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thailand; Thymidine; Treatment Failure; Zidovudine | 2012 |
Drug-resistance development differs between HIV-1-infected patients failing first-line antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors with and without thymidine analogues.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Thymidine; Treatment Failure; Viral Load; Zidovudine | 2013 |
Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Click Chemistry; DNA Fragmentation; DNA, Neoplasm; G-Quadruplexes; Humans; Ligands; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Skin Neoplasms; Thymidine; Triazoles; Tumor Burden; Zidovudine | 2013 |
Conformational analysis of the anti-HIV Nikavir prodrug: comparisons with AZT and Thymidine, and establishment of structure-activity relationships/tendencies in other 6'-derivatives.
Topics: Anti-HIV Agents; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Organophosphonates; Prodrugs; Quantum Theory; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thermodynamics; Thymidine; Zidovudine | 2015 |
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
Topics: CD4-Positive T-Lymphocytes; Gene Expression; HIV Reverse Transcriptase; HIV-2; Host-Pathogen Interactions; Humans; Jurkat Cells; Macrophages; Monomeric GTP-Binding Proteins; Primary Cell Culture; Reverse Transcriptase Inhibitors; SAM Domain and HD Domain-Containing Protein 1; Stavudine; Thymidine; Viral Regulatory and Accessory Proteins; Virus Replication; Zidovudine | 2014 |
Structure and conformational analysis of the anti-HIV reverse transcriptase inhibitor AZT using MP2 and DFT methods. Differences with the natural nucleoside thymidine. Simulation of the 1st phosphorylation step with ATP.
Topics: Adenosine Triphosphate; HIV Reverse Transcriptase; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Phosphorylation; Quantum Theory; Reverse Transcriptase Inhibitors; Thermodynamics; Thymidine; Water; Zidovudine | 2014 |
Amphiphilic lipid derivatives of 3'-hydroxyurea-deoxythymidine: preparation, properties, molecular self-assembly, simulation and in vitro anticancer activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxyurea; In Vitro Techniques; Nanostructures; Thymidine; Zidovudine | 2014 |
Heart mitochondrial TTP synthesis and the compartmentalization of TMP.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Creatine Kinase; Cytosol; Electron Transport; Female; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocardium; Oligomycins; Phosphocreatine; Phosphorylation; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine | 2015 |
Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase.
Topics: Biomarkers, Tumor; Enzyme Activation; Gene Library; Phosphorylation; Prodrugs; Protein Domains; Recombinant Fusion Proteins; Simplexvirus; Thymidine; Thymidine Kinase; Zidovudine | 2017 |
Rapid accumulation of HIV-1 thymidine analogue mutations and phenotypic impact following prolonged viral failure on zidovudine-based first-line ART in sub-Saharan Africa.
Topics: Adult; Africa South of the Sahara; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Mutation; Nevirapine; Polymerase Chain Reaction; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Thymidine; Treatment Failure; Viral Load; Zidovudine | 2017 |
Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery.
Topics: Animals; DNA Replication; Drug Discovery; Gerbillinae; Giardia lamblia; Giardiasis; Metronidazole; Protozoan Proteins; Thymidine; Thymidine Kinase; Zidovudine | 2022 |