Page last updated: 2024-08-23

zidovudine and thymidine 5'-triphosphate

zidovudine has been researched along with thymidine 5'-triphosphate in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (15.56)	18.7374
1990's	17 (37.78)	18.2507
2000's	15 (33.33)	29.6817
2010's	6 (13.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Amblard, F; Bassit, L; Bondada, L; Coats, SJ; Detorio, M; Grier, J; Hernandez-Santiago, BI; Koontz, D; Mellors, JW; Rapp, KL; Schinazi, RF; Sluis-Cremer, N	1
Ambrose, Z; Boyer, PL; Hughes, SH; Julias, JG; Liao, C; Marquez, VE; Meier, C; Vu, BC; Warnecke, S	1
Baba, M; Cheng, YC; Dutschman, GE; Grill, SP; Hamasaki, T; Paintsil, E; Tanaka, H; Wang, CJ; Wang, J; Yang, G	1
Ilina, T; Myshakina, NS; Parniak, MA; Sirivolu, VR; Vernekar, SK; Wang, Z	1
Barr, PJ; Bathurst, IC; Kenyon, GL; Ma, QF	1
Berk, L; Heijtink, RA; Schalm, SW	1
Eckstein, F; Grosse, F; Heidenreich, O; Kruhøffer, M	1
Miller, WH; Reardon, JE	1
Buckheit, RW; Germany, JM; Parker, WB; Ross, LJ; Secrist, JA; Shaddix, SC; Shannon, WM; Vince, R; White, EL	1
Bolognesi, DP; Broder, S; Freeman, GA; Furman, PA; Fyfe, JA; Lehrman, SN; Mitsuya, H; Rideout, JL; St Clair, MH; Weinhold, K	1
Bazin, H; Chattopadhyaya, J; Eriksson, B; Oberg, B; Vrang, L	1
Furman, P; Fyfe, JA; Olsen, JC; Swanstrom, R	1
Datema, R; Johansson, NG; Oberg, B; Stening, G; Tao, PZ	1
Frick, LW; Nelson, DJ	1
Bhalla, K; Birkhofer, M; Cole, J; Graham, G; Grant, S; Li, GR; MacLaughlin, W; Volsky, DJ	1
Harrington, JA; Miller, WH; Spector, T	1
Beck, RA; Cloos, L; Eger, K; Munch-Petersen, B; Tyrsted, G	1
Clayton, DA; Eriksson, S; Xu, B	1
Cloos, L; Hofbauer, R; Mortensen, BT; Munch-Petersen, B; Tyrsted, G; Völker, C	1
Erlichman, C; Mitrovski, B; Pressacco, J	1
Lewis, W; Meyer, RR; Simpson, JF	1
Furman, PA; Haire, SE; Martin, JL; Painter, GR; Ray, PH; Wilson, JE; Wright, LL	1
Bianchi, LC; Bianchi, V; Borella, S; Calderazzo, F; D'Agaro, P; Giacca, M; Rampazzo, C; Reichard, P	1
Arzumanov, AA; Dyatkina, NB; Krayevsky, AA; Semizarov, DG; Victorova, LS	1
Cox, S; Palmer, S	1
Back, DJ; Hart, CA; Hoggard, PG; Phiboonbanakit, D; Sales, SD; Sim, SM	1
Amacker, M; Faraj, A; Gosselin, G; Hübscher, U; Imbach, JL; Maga, G; Mathé, C; Sommadossi, JP; Spadari, S	1
Gao, WY; Johns, DG; Mitsuya, H; Tanaka, M	1
Maga, G; Pregnolato, M; Salvetti, R; Spadari, S; Ubiali, D	1
Agou, F; Biondi, R; Deville-Bonne, D; Guerreiro, C; Sarfati, R; Schneider, B; Veron, M	1
Ehresmann, B; Ehresmann, C; Lanchy, JM; Le Grice, SF; Marquet, R; Rigourd, M	1
Knecht, W; Munch-Petersen, B; Piskur, J	1
Arissawa, M; Felcman, J; Herrera, JO	1
Bölske, G; Carnrot, C; Eriksson, S; Wang, L; Wehelie, R	1
Carnrot, C; Eklund, H; Eriksson, S; Kosinska, U; Mikkelsen, NE; Munch-Petersen, B; Wang, L; Welin, M; Zhu, C	1
Guo, D; Jamburuthugoda, VK; Kim, B; Wedekind, JE	1
Hanes, JW; Johnson, KA	1
Eklund, H; Mikkelsen, NE; Munch-Petersen, B	1
Iams, TA; McKee, EE; Morris, GW; Slepchenko, KG	1
Saada, A	1
Chen, CM; Dornfeld, K; Johnson, M; Smith, BJ	1
Eriksson, S; Sun, R; Wang, L	1
Larsen, NB; Munch-Petersen, B; Piškur, J	1
Hsiung, CH; Kamath, VG; Lizenby, ZJ; McKee, EE	1
Johnson, KA; Li, A; Ziehr, JL	1

Trials

1 trial(s) available for zidovudine and thymidine 5'-triphosphate

Article	Year
Zidovudine inhibits hepatitis B virus replication. Antiviral research, 1992, Volume: 19, Issue:2 Topics: Administration, Oral; Hepatitis B; Hepatitis B virus; Humans; Netherlands; Nucleic Acid Synthesis Inhibitors; Thymine Nucleotides; Virus Replication; Zidovudine	1992

Other Studies

44 other study(ies) available for zidovudine and thymidine 5'-triphosphate

Article	Year
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9 Topics: Anti-HIV Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Molecular Structure; Reverse Transcriptase Inhibitors	2009
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription. Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17 Topics: Anti-HIV Agents; Base Sequence; Cell Line, Tumor; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Molecular Conformation; Pyrimidine Nucleosides; Reverse Transcriptase Inhibitors; Thymidine; Virus Replication	2009
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11 Topics: Anti-HIV Agents; Computer Simulation; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Reverse Transcriptase Inhibitors; Stavudine	2009
Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus. Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21 Topics: Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; HIV; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Zidovudine	2013
New thymidine triphosphate analogue inhibitors of human immunodeficiency virus-1 reverse transcriptase. Journal of medicinal chemistry, 1992, May-29, Volume: 35, Issue:11 Topics: Binding, Competitive; Dideoxynucleotides; HIV-1; Molecular Structure; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine Nucleotides; Zidovudine	1992
Inhibition of human immunodeficiency virus 1 reverse transcriptase by 3'-azidothymidine triphosphate. European journal of biochemistry, 1990, Sep-24, Volume: 192, Issue:3 Topics: Binding Sites; Catalysis; HIV-1; Kinetics; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Substrate Specificity; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine	1990
Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate. The Journal of biological chemistry, 1990, Nov-25, Volume: 265, Issue:33 Topics: Antiviral Agents; Base Sequence; Dideoxynucleotides; DNA, Viral; HIV-1; Kinetics; Molecular Sequence Data; Plasmids; Protein Binding; Recombinant Proteins; Restriction Mapping; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Templates, Genetic; Thymine Nucleotides; Tritium; Zidovudine	1990
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RN The Journal of biological chemistry, 1991, Jan-25, Volume: 266, Issue:3 Topics: Antiviral Agents; Base Sequence; Deoxyguanine Nucleotides; Dideoxynucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; HIV-1; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Reverse Transcriptase Inhibitors; RNA; Templates, Genetic; Thymine Nucleotides; Zidovudine	1991
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:21 Topics: Antiviral Agents; Cell Survival; HIV; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Reverse Transcriptase Inhibitors; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Virus Replication; Zidovudine	1986
Different patterns of inhibition of avian myeloblastosis virus reverse transcriptase activity by 3'-azido-3'-deoxythymidine 5'-triphosphate and its threo isomer. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:4 Topics: Avian Leukosis Virus; Avian Myeloblastosis Virus; Binding, Competitive; Dideoxynucleotides; Isomerism; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Viral Proteins; Zidovudine	1987
3'-Azido-3'-deoxythymidine inhibits the replication of avian leukosis virus. Journal of virology, 1987, Volume: 61, Issue:9 Topics: Animals; Antiviral Agents; Avian Leukosis Virus; Chick Embryo; DNA, Viral; Phosphorylation; Reverse Transcriptase Inhibitors; Thymidine; Thymine Nucleotides; Virus Replication; Zidovudine	1987
Inhibition of HIV-1 reverse transcriptase by 5'-triphosphates of 5-substituted uridine analogs. Antiviral research, 1989, Volume: 12, Issue:5-6 Topics: Antiviral Agents; DNA Polymerase II; DNA, Viral; Drug Design; HIV-1; Kinetics; Reverse Transcriptase Inhibitors; Templates, Genetic; Thymine Nucleotides; Uridine Triphosphate; Zidovudine	1989
Effects of 3'-azido-3'-deoxythymidine on the deoxynucleoside triphosphate pools of cultured human cells. Advances in experimental medicine and biology, 1989, Volume: 253B Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Dose-Response Relationship, Drug; Humans; Nucleoside-Phosphate Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1989
2'-Deoxycytidine protects normal human bone marrow progenitor cells in vitro against the cytotoxicity of 3'-azido-3'-deoxythymidine with preservation of antiretroviral activity. Blood, 1989, Nov-01, Volume: 74, Issue:6 Topics: Bone Marrow; CD4-Positive T-Lymphocytes; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Deoxycytidine; Deoxycytosine Nucleotides; Hematopoiesis; HIV; Humans; Phosphorylation; Thymine Nucleotides; Zidovudine	1989
Effector studies of 3'-azidothymidine nucleotides with human ribonucleotide reductase. Biochemical pharmacology, 1987, Nov-01, Volume: 36, Issue:21 Topics: Antiviral Agents; Cytidine Diphosphate; Guanosine Diphosphate; Humans; Kinetics; Nucleotides; Oxidation-Reduction; Ribonucleotide Reductases; Thymidine; Thymine Nucleotides; Zidovudine	1987
Different affinity of the two forms of human cytosolic thymidine kinase towards pyrimidine analogs. Biochimica et biophysica acta, 1995, Jul-19, Volume: 1250, Issue:2 Topics: Adenosine Triphosphate; Cytosol; G1 Phase; Humans; Isoenzymes; Kinetics; Thymidine Kinase; Thymine Nucleotides; Zidovudine	1995
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase. The Journal of biological chemistry, 1995, Aug-11, Volume: 270, Issue:32 Topics: Antiviral Agents; Base Sequence; Deoxyribonucleotides; Dideoxynucleotides; DNA-Directed DNA Polymerase; HIV; Mitochondria; Molecular Sequence Data; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity; Thymine Nucleotides; Zidovudine	1995
Altered substrate and inhibitor specificity of purified human adult thymidine kinases (TK2) from leukemic cells. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Adult; Cell Line; Floxuridine; Humans; Isoenzymes; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Reference Values; Substrate Specificity; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine	1994
Cytotoxic and biochemical implications of combining AZT and AG-331. Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:5 Topics: Antimetabolites, Antineoplastic; Cell Division; DNA Damage; DNA-Directed DNA Polymerase; DNA, Single-Stranded; Drug Interactions; Drug Synergism; Humans; Image Processing, Computer-Assisted; Indoles; Substrate Specificity; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Zidovudine	1995
Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine. Circulation research, 1994, Volume: 74, Issue:2 Topics: Animals; Cattle; Dideoxynucleotides; DNA Polymerase III; Kinetics; Mitochondria, Heart; Phosphorylation; Thymine Nucleotides; Zidovudine	1994
Recombinant human immunodeficiency virus type 1 reverse transcriptase is heterogeneous. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Jan-01, Volume: 11, Issue:1 Topics: Antiviral Agents; Chromatography, Affinity; Chromatography, Gel; Dideoxynucleotides; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Escherichia coli; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Protein Conformation; Protein Denaturation; Recombinant Fusion Proteins; RNA-Directed DNA Polymerase; Spectrometry, Fluorescence; Thymine Nucleotides; Urea; Zidovudine	1996
Synergistic antiviral action of ribonucleotide reductase inhibitors and 3'-azido-3'-deoxythymidine on HIV type 1 infection in vitro. AIDS research and human retroviruses, 1996, May-20, Volume: 12, Issue:8 Topics: Antiviral Agents; Cell Cycle; Cytidine; Drug Synergism; Enzyme Inhibitors; HIV Core Protein p24; HIV-1; Humans; Hydroxyurea; Leukocytes, Mononuclear; Phosphorylation; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Thymine Nucleotides; Tumor Cells, Cultured; Virus Replication; Zidovudine	1996
Gamma-phosphate-substituted 2'-deoxynucleoside 5'-triphosphates as substrates for DNA polymerases. The Journal of biological chemistry, 1996, Oct-04, Volume: 271, Issue:40 Topics: Animals; Antiviral Agents; Dideoxynucleotides; DNA-Directed DNA Polymerase; Drug Stability; Humans; Phosphates; Substrate Specificity; Thymine Nucleotides; Zidovudine	1996
Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:2 Topics: Anti-HIV Agents; Cell Line; Deoxycytosine Nucleotides; Drug Synergism; Hydroxyurea; Lamivudine; Phosphorylation; Thymine Nucleotides; Zidovudine	1997
Effect of ribavirin on zidovudine efficacy and toxicity in vitro: a concentration-dependent interaction. AIDS research and human retroviruses, 1998, Dec-20, Volume: 14, Issue:18 Topics: Anti-HIV Agents; Antiviral Agents; Cell Line; Drug Synergism; Humans; Reverse Transcriptase Inhibitors; Ribavirin; Thymine Nucleotides; Zidovudine	1998
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. Nucleic acids research, 1999, Feb-15, Volume: 27, Issue:4 Topics: Anti-HIV Agents; Carbohydrates; Catalysis; Deoxycytosine Nucleotides; Deoxyribonucleosides; Dideoxynucleosides; Dideoxynucleotides; DNA; Drug Resistance, Microbial; HIV Reverse Transcriptase; Humans; Hydroxyl Radical; Isoleucine; Kinetics; Nevirapine; Recombinant Fusion Proteins; Reverse Transcriptase Inhibitors; Ribose; Templates, Genetic; Thymine Nucleotides; Tyrosine; Zidovudine	1999
Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine. Molecular pharmacology, 1999, Volume: 55, Issue:3 Topics: Anti-HIV Agents; Antimetabolites; Drug Interactions; Drug Resistance, Microbial; Drug Resistance, Multiple; Floxuridine; Fluorouracil; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidylate Synthase; Thymine Nucleotides; Virus Replication; Zidovudine	1999
Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:5 Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Binding, Competitive; Catalytic Domain; Cyclopropanes; Dideoxynucleotides; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Oxazines; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	2000
The mechanism of phosphorylation of anti-HIV D4T by nucleoside diphosphate kinase. Molecular pharmacology, 2000, Volume: 57, Issue:5 Topics: Adenosine Triphosphate; Anti-HIV Agents; Dideoxynucleotides; HIV Reverse Transcriptase; Humans; Kinetics; Nucleoside-Diphosphate Kinase; Phosphorylation; Stavudine; Thymine Nucleotides; Zidovudine	2000
Inhibition of the initiation of HIV-1 reverse transcription by 3'-azido-3'-deoxythymidine. Comparison with elongation. The Journal of biological chemistry, 2000, Sep-01, Volume: 275, Issue:35 Topics: Base Sequence; Dideoxynucleotides; Diphosphates; DNA Primers; HIV Reverse Transcriptase; HIV-1; Humans; Hydrolysis; Kinetics; Lymphocytes; Peptide Chain Elongation, Translational; Thymine Nucleotides; Transcription, Genetic; Zidovudine	2000
Identification of residues involved in the specificity and regulation of the highly efficient multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster. Journal of molecular biology, 2000, Aug-25, Volume: 301, Issue:4 Topics: Animals; Cytarabine; Dideoxyadenosine; Directed Molecular Evolution; Drosophila melanogaster; Enzyme Activation; Feedback; Inhibitory Concentration 50; Kinetics; Mutation; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Substrate Specificity; Thymidine; Thymine Nucleotides; Zalcitabine; Zidovudine	2000
Theoretical investigation of the triphosphate forms of azidothymidine and thymidine. Journal of biochemistry and molecular biology, 2003, May-31, Volume: 36, Issue:3 Topics: Dideoxynucleotides; Models, Theoretical; Stereoisomerism; Thymine Nucleotides; Zidovudine	2003
Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth. Molecular microbiology, 2003, Volume: 50, Issue:3 Topics: Amino Acid Sequence; Cell Division; Cloning, Molecular; Deoxyuridine; Escherichia coli; Feedback, Physiological; Molecular Sequence Data; Molecular Weight; Mycoplasma pneumoniae; Nucleosides; Phosphates; Pyrimidine Nucleosides; Recombinant Proteins; Sequence Homology, Amino Acid; Stavudine; Substrate Specificity; Tetrahydrouridine; Thymidine; Thymidine Kinase; Thymine Nucleotides; Ureaplasma urealyticum; Zidovudine	2003
Structures of thymidine kinase 1 of human and mycoplasmic origin. Proceedings of the National Academy of Sciences of the United States of America, 2004, Dec-28, Volume: 101, Issue:52 Topics: Amino Acid Sequence; Antimetabolites; Binding Sites; Crystallization; Deoxyribonucleosides; Evolution, Molecular; Humans; Hydrogen Bonding; Ions; Models, Molecular; Molecular Sequence Data; Mycoplasma; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Thymidine Kinase; Thymine Nucleotides; Ureaplasma urealyticum; Zidovudine; Zinc	2004
Kinetic evidence for interaction of human immunodeficiency virus type 1 reverse transcriptase with the 3'-OH of the incoming dTTP substrate. Biochemistry, 2005, Aug-09, Volume: 44, Issue:31 Topics: Acyclovir; Amino Acid Substitution; Asparagine; Dideoxynucleotides; Glutamine; HIV Reverse Transcriptase; Hydroxyl Radical; Isoleucine; Kinetics; Models, Molecular; Protein Binding; Substrate Specificity; Thymine Nucleotides; Valine; Zidovudine	2005
A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase. Nucleic acids research, 2007, Volume: 35, Issue:20 Topics: Diphosphates; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Humans; Kinetics; Mitochondria; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine	2007
Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase. The FEBS journal, 2008, Volume: 275, Issue:9 Topics: Adenosine Diphosphate; Animals; Antimetabolites; Bromodeoxyuridine; Cytarabine; Cytidine Triphosphate; Drosophila melanogaster; Drosophila Proteins; Feedback; Floxuridine; Guanosine Triphosphate; Hydrogen Bonding; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship; Thymine Nucleotides; X-Ray Diffraction; Zalcitabine; Zidovudine	2008
Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity. The Biochemical journal, 2009, Aug-27, Volume: 422, Issue:3 Topics: Animals; Chromatography, High Pressure Liquid; Cytidine; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Heart; In Vitro Techniques; Male; Perfusion; Phosphorylation; Pyrimidine Nucleotides; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate; Zidovudine	2009
Fishing in the (deoxyribonucleotide) pool. The Biochemical journal, 2009, Aug-27, Volume: 422, Issue:3 Topics: Animals; Antimetabolites; Cytidine; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Heart; Humans; Mitochondria; Mitochondrial Diseases; Models, Biological; Phosphorylation; Pyrimidine Nucleotides; Rats; Thymine Nucleotides; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate; Zidovudine	2009
Azidothymidine enhances fluorodeoxyuridine-mediated radiosensitization. International journal of radiation oncology, biology, physics, 2010, Mar-01, Volume: 76, Issue:3 Topics: Antimetabolites; Cell Cycle; Cell Line, Tumor; Cell Survival; Colony-Forming Units Assay; Deoxyuracil Nucleotides; DNA Breaks, Single-Stranded; DNA Damage; DNA Mismatch Repair; Drug Synergism; Flow Cytometry; Floxuridine; Humans; MutS Homolog 2 Protein; Poisson Distribution; Radiation Tolerance; Thymidine; Thymine Nucleotides; Zidovudine	2010
The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:6 Topics: Animals; Antiviral Agents; Dideoxynucleosides; Female; Kinetics; Mitochondria; Phosphorylation; Rats; Rats, Sprague-Dawley; Thymidine Kinase; Thymine Nucleotides; Zidovudine	2011
Tomato thymidine kinase is subject to inefficient TTP feedback regulation. Nucleosides, nucleotides & nucleic acids, 2014, Volume: 33, Issue:4-6 Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Feedback, Physiological; Humans; Phosphorylation; Solanum lycopersicum; Thymidine Kinase; Thymine Nucleotides; Zidovudine	2014
Heart mitochondrial TTP synthesis and the compartmentalization of TMP. The Journal of biological chemistry, 2015, Jan-23, Volume: 290, Issue:4 Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Creatine Kinase; Cytosol; Electron Transport; Female; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocardium; Oligomycins; Phosphocreatine; Phosphorylation; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Zidovudine	2015
A new general method for simultaneous fitting of temperature and concentration dependence of reaction rates yields kinetic and thermodynamic parameters for HIV reverse transcriptase specificity. The Journal of biological chemistry, 2017, 04-21, Volume: 292, Issue:16 Topics: Computer Simulation; Coumarins; DNA; Dose-Response Relationship, Drug; HIV Infections; HIV Reverse Transcriptase; Ions; Kinetics; Magnesium; Molecular Dynamics Simulation; Mutation; Nucleotides; Protein Conformation; Reverse Transcriptase Inhibitors; Software; Substrate Specificity; Temperature; Thermodynamics; Thymine Nucleotides; Zidovudine	2017