zidovudine and prednisone
zidovudine has been researched along with prednisone in 42 studies
Research
Studies (42)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (35.71) | 18.2507 |
| 2000's | 19 (45.24) | 29.6817 |
| 2010's | 7 (16.67) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Lessell, S; Newman, NJ | 1 |
| Bender, AN; Farraye, J; Mendelson, SG; Simpson, DM; Wolfe, DE | 1 |
| Cheson, BD; Feigal, EG | 1 |
| Kania, RJ; McGarr, J; Molloy, PJ; Naum, SM; Van Thiel, DH | 1 |
| Friedel, SD; Friedman, RF; Ganiban, GJ; Liss, RA | 1 |
| Aucott, JN; Gogate, P; Graham, RC; Granieri, J; Smith, H; Wisnieski, JJ | 1 |
| Lundberg, JH; Tefferi, A; Weitz, JJ; Witzig, TE | 1 |
| Balk, AH; Claas, FH; Daane, CR; Heyse, P; Jutte, NH; Mochtar, B; Vaessen, LM; Weimar, W | 1 |
| Fornairon, S; Idatte, JM; Lesprit, P; Michaut, P; Modaï, J; Nochy, D | 1 |
| Albrecht, H; Greten, H; Stellbrink, HJ | 1 |
| Etoh, K; Matsuoka, M; Suzushima, H; Takatsuki, K; Tamiya, S | 1 |
| Arastéh, K; Herbst, H; Huhn, D; Knauf, W; Kronawitter, U; Mitrou, P; Nerl, C; Scheidegger, C; Schürmann, D; Trenn, G; Van Lunzen, J; Weiss, R | 1 |
| Cohen, P; Gayraud, M; Gherardi, R; Guillevin, L; Jarrousse, B; Leon, A; Lhote, F | 1 |
| Arazo, P; Manero, FJ; Sesma, J | 1 |
| Crukley, J; Demaerschalk, B; Hammond, R; Kaye, K; Stewart, S; Walsh, K | 1 |
| Besson, C; Brebion, A; Delaunay, C; Gonin, C; Hermine, O; Panelatti, G; Plumelle, Y | 1 |
| Bergallo, M; Bollero, C; Cavallo, R; Lembo, D; Leonardi, G; Merlino, C; Musso, T; Ponzi, AN; Re, D; Segoloni, GP | 1 |
| Abboud, M; Locatelli, F; Muwakkit, S; Razzouk, B; Wilimas, J | 1 |
| Almeida, FA; Chiba, AK; Colleoni, GW; Fernandes, MA; Michalany, NS; Petri, V; Pombo-de-Oliveira, MS; Sakamoto, FH; Teixeira, SP; Yamamoto, M | 1 |
| Barbosa, HS; Bittencourt, AL; Farre, L; Pimenta, A | 1 |
| Grossman, ME; Husain, S; MacGregor-Cortelli, B; Marneros, AG; Neylon, E; Nuovo, GJ; O'Connor, OA; Patterson, M; Silvers, DN; Zain, JM | 1 |
| Bittencourt, AL; Farré, L; Mota, K; Oliveira, RF | 1 |
| Grubb, B; Henderson, DB; Pandya, AG | 1 |
| Fukushima, T | 1 |
| Cook, LB; Phillips, AA | 1 |
Reviews
5 review(s) available for zidovudine and prednisone
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Ocular syphilis and neurosyphilis in a patient with human immunodeficiency virus infection.
Topics: Adult; Angiography; Drug Therapy, Combination; Eye Diseases; HIV Infections; Humans; Male; Neurosyphilis; Penicillins; Prednisone; Syphilis Serodiagnosis; Zidovudine | 1995 |
B19 virus infection in renal transplant recipients.
Topics: Anemia; Antibodies, Monoclonal; Antibodies, Viral; Antilymphocyte Serum; Basiliximab; Cyclosporine; Cytomegalovirus Infections; Diagnosis, Differential; Disease Susceptibility; DNA, Viral; Female; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Interleukin-1; Kidney Transplantation; Male; Mycophenolic Acid; Parvoviridae Infections; Parvovirus B19, Human; Phosphoproteins; Polymerase Chain Reaction; Postoperative Complications; Prednisone; Recombinant Fusion Proteins; Retrospective Studies; T-Lymphocytes; Tacrolimus; Viral Load; Viral Matrix Proteins; Viremia; Zidovudine | 2003 |
[Treatment of adult T-cell leukemia-lymphoma].
Topics: Allografts; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Epirubicin; Etoposide; Hematopoietic Stem Cell Transplantation; Human T-lymphotropic virus 1; Humans; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Nitrosourea Compounds; Prednisolone; Prednisone; Prognosis; Salvage Therapy; Vincristine; Vindesine; Zidovudine | 2014 |
Trials
2 trial(s) available for zidovudine and prednisone
| Article | Year |
|---|---|
Prophylactic therapy with OKT3 does not affect donor specific reactivity of peripheral blood lymphocytes from heart transplant recipients.
Topics: Blood Transfusion; Cell Division; Cyclosporine; Cytotoxicity, Immunologic; Drug Therapy, Combination; Endocardium; Graft Enhancement, Immunologic; Graft Rejection; Heart Transplantation; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Muromonab-CD3; Prednisone; Tissue Donors; Treatment Outcome; Zidovudine | 1994 |
HIV-related non-Hodgkin's lymphoma: CHOP induction therapy and interferon-alpha-2b/zidovudine maintenance therapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Humans; Interferon alpha-2; Interferon-alpha; Lymphoma, AIDS-Related; Male; Pilot Projects; Prednisone; Prospective Studies; Recombinant Proteins; Risk Factors; Survival Rate; Treatment Outcome; Vincristine; Zidovudine | 1998 |
Other Studies
35 other study(ies) available for zidovudine and prednisone
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Bilateral optic neuropathies with remission in two HIV-positive men.
Topics: Adult; HIV Infections; HIV Seropositivity; Humans; Male; Optic Nerve Diseases; Prednisone; Prognosis; Remission Induction; Zidovudine | 1992 |
Human immunodeficiency virus wasting syndrome may represent a treatable myopathy.
Topics: Acquired Immunodeficiency Syndrome; Adult; HIV Infections; HIV Seropositivity; Humans; Middle Aged; Muscular Diseases; Prednisone; Time Factors; Weight Loss; Zidovudine | 1990 |
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Antiprotozoal Agents; Antiviral Agents; Atovaquone; Candidiasis, Oral; Clindamycin; Clotrimazole; Cryptosporidiosis; Cytomegalovirus Infections; Dapsone; Didanosine; Drug Combinations; Drug Therapy, Combination; Fluconazole; Flucytosine; Folic Acid Antagonists; Foscarnet; Glucuronates; Herpes Simplex; Herpes Zoster; Humans; Isoniazid; Itraconazole; Ketoconazole; Lamivudine; Mycobacterium avium-intracellulare Infection; Naphthoquinones; Nystatin; Pentamidine; Pneumocystis Infections; Pneumonia, Pneumocystis; Prednisone; Primaquine; Reverse Transcriptase Inhibitors; Stavudine; Syphilis; Toxoplasmosis; Trimetrexate; Tuberculosis; Zalcitabine; Zidovudine | 1995 |
Clinical trials referral resource. AIDS-related non-Hodgkin's lymphomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Erythropoietin; Etoposide; Granulocyte Colony-Stimulating Factor; Humans; Interleukin-3; Lymphoma, AIDS-Related; Lymphoma, Non-Hodgkin; Prednisone; Vincristine; Zidovudine | 1993 |
Use of thalidomide in treatment and maintenance of idiopathic esophageal ulcers in HIV+ individuals.
Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Female; HIV Seropositivity; HIV-1; Humans; Prednisone; Thalidomide; Ulcer; Zidovudine | 1995 |
Sarcoid myopathy in a patient with human immunodeficiency virus infection.
Topics: Adult; CD4 Antigens; HIV Infections; Homosexuality, Male; Humans; Male; Muscular Diseases; Prednisone; Sarcoidosis; Zidovudine | 1995 |
Treatment of refractory T-cell chronic lymphocytic leukemia with purine nucleoside analogues.
Topics: 2-Chloroadenosine; Anemia; Antineoplastic Combined Chemotherapy Protocols; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclophosphamide; Deoxyadenosines; Fatal Outcome; Female; Humans; Immunophenotyping; Leukemia, Prolymphocytic; Leukemia, Prolymphocytic, T-Cell; Male; Methotrexate; Middle Aged; Neoplastic Stem Cells; Prednisone; Salvage Therapy; Vidarabine; Vincristine; Zidovudine | 1994 |
Renal involvement in the diffuse infiltrative CD8 lymphocytosis syndrome.
Topics: Adult; Anti-HIV Agents; CD8-Positive T-Lymphocytes; HIV Infections; Humans; Kidney Diseases; Lymphocytosis; Male; Prednisone; Zalcitabine; Zidovudine | 1997 |
Resolution of HIV-associated cystic benign lymphoepithelial lesion of the parotid gland in a patient undergoing chemotherapy for non-Hodgkin's lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Cyclophosphamide; Cysts; Didanosine; Doxorubicin; Fatal Outcome; HIV Infections; Humans; Hyperplasia; Lymphoma, Non-Hodgkin; Male; Middle Aged; Parotid Diseases; Prednisone; Vincristine; Zidovudine | 1996 |
Hundreds enrolled in canadian HIV trials.
Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Canada; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; HIV Protease Inhibitors; Humans; Isoquinolines; Nelfinavir; Prednisone; Randomized Controlled Trials as Topic; Ritonavir; Sulfonic Acids; Vincristine; Zidovudine | 1997 |
Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells.
Topics: Adult; Aged; Alleles; Antibodies, Monoclonal; Antineoplastic Agents; Antiviral Agents; Apoptosis; Cyclophosphamide; DNA Mutational Analysis; DNA, Neoplasm; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Exons; fas Receptor; Fatal Outcome; Gene Expression Regulation, Leukemic; Human T-lymphotropic virus 1; Humans; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Male; Neoplasm Proteins; Neoplastic Stem Cells; Neutrophils; Polymerase Chain Reaction; Prednisone; RNA, Messenger; RNA, Neoplasm; Sequence Deletion; T-Lymphocytes; Vincristine; Zidovudine | 1998 |
Successful treatment of HIV-related vasculitis with peripheral neuropathy with short-term steroids followed by the association of zidovudine and plasmapheresis.
Topics: Adult; AIDS-Related Opportunistic Infections; Combined Modality Therapy; HIV Seropositivity; Humans; Male; Peripheral Nervous System Diseases; Plasmapheresis; Prednisone; Prospective Studies; Vasculitis; Zidovudine | 1993 |
[Bilateral hip necrosis, corticoids, and human immunodeficiency virus protease inhibitors].
Topics: Aged; Antiretroviral Therapy, Highly Active; Dexamethasone; Didanosine; Femur Head Necrosis; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Male; Prednisone; Zidovudine | 2001 |
AZT myopathy and HIV-1 polymyositis: one disease or two?
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Anti-Inflammatory Agents; Biopsy; Electromyography; HIV-1; Humans; Male; Middle Aged; Mitochondria, Muscle; Mitochondrial Myopathies; Muscle, Skeletal; Polymyositis; Prednisone; Zidovudine | 2002 |
Treatment of adult T-cell leukemia-lymphoma by CHOP followed by therapy with antinucleosides, alpha interferon and oral etoposide.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Prednisone; Retrospective Studies; Survival Analysis; Treatment Outcome; Vincristine; Zalcitabine; Zidovudine | 2002 |
Report of a child with vitiligo and Evans syndrome.
Topics: Anemia, Hemolytic, Autoimmune; Antibodies, Anticardiolipin; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Autoimmune Diseases; Child, Preschool; Cyclosporine; Eczema; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Infections; Male; Milk Hypersensitivity; Prednisone; Rituximab; Salmonella Infections; Syndrome; Thrombocytopenia; Vitiligo; Zidovudine | 2003 |
Cutaneous T-cell lymphoma with HTLV-I infection: clinical overlap with adult T-cell leukemia/lymphoma.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brazil; Cyclophosphamide; DNA, Viral; Doxorubicin; Endemic Diseases; Humans; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Male; Neoplasm Recurrence, Local; Polymerase Chain Reaction; Prednisone; Vincristine; Zidovudine | 2006 |
A case of adult T-cell leukemia/lymphoma (ATL) with a survival of more than 13 years.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Cyclophosphamide; Doxorubicin; Human T-lymphotropic virus 1; Humans; Interferons; Leukemia-Lymphoma, Adult T-Cell; Lymphocytosis; Male; Prednisone; Treatment Outcome; Vincristine; Zidovudine | 2008 |
Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions.
Topics: Adult; Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biopsy; Cyclophosphamide; Diagnosis, Differential; Disease Progression; Doxorubicin; Drug Eruptions; Epidermis; Etoposide; Exanthema; Folic Acid Antagonists; Humans; Interferon alpha-2; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Male; Prednisone; Recombinant Proteins; Vincristine; Zidovudine | 2009 |
A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Diabetes Mellitus; Diagnosis, Differential; Doxorubicin; Eczema, Dyshidrotic; HTLV-I Infections; Human T-lymphotropic virus 1; Humans; Immunohistochemistry; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Male; Mycosis Fungoides; Polymerase Chain Reaction; Prednisone; Skin Neoplasms; Vincristine; Zidovudine | 2009 |
Adult T-cell lymphoma/leukemia presenting as pagetoid reticulosis of the palms and soles.
Topics: Adult; Antigens, CD; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Diagnosis, Differential; Diagnostic Errors; Doxorubicin; Etoposide; Fatal Outcome; Foot; Hand; Humans; Interferons; Jamaica; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Pagetoid Reticulosis; Prednisone; Skin Neoplasms; Vincristine; Zidovudine | 2011 |
How I treat adult T-cell leukemia/lymphoma.
Topics: Aged; Allografts; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Dexamethasone; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Human T-lymphotropic virus 1; Humans; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Prednisone; Raltegravir Potassium; Recurrence; Remission Induction; Therapies, Investigational; Vincristine; Virus Activation; Zidovudine | 2021 |