Page last updated: 2024-08-23

zidovudine and nsc 614846

zidovudine has been researched along with nsc 614846 in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's14 (77.78)18.2507
2000's1 (5.56)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hua, M; Vince, R1
Bennett, M; Chu, CK; Jin, Y; Rapp, KL; Schinazi, RF; Wang, J1
Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA1
Cameron, JM; Figueiredo, HT; Mo, CL; Orr, DC; Penn, CR1
Cameron, JM; Coates, JA; Inggall, HJ; Pearson, BA; Penn, CR; Storer, R; Williamson, C1
Carter, SG; Kurtzberg, J1
Carter, SG; Kessler, JA; Rankin, CD1
Macy, LJ; McCaleb, G; Parker, WB; Secrist, JA; Shaddix, SC; Shannon, WM; Vince, R; White, EL1
Brownell, J; Daluge, S; Hua, M; Kiser, R; Lavelle, GC; Lee, FC; Qualls, J; Shannon, WM; Vince, R; Weislow, OS1
Parker, WB; Ross, LJ; Shannon, WM; White, EL1
Bennett, LL; Bowdon, BJ; Parker, WB; Rose, LM; Shaddix, SC; Shannon, WM; Vince, R1
Carter, SG; Kessler, JA; Kurtzberg, J; Pagano, JS; Rankin, CD; Smith, MS1
Alberdi, E; Martinez-Irujo, JJ; Santiago, E; Villahermosa, ML1
Akimov, SS; Bolsheva, NL; Chernov, DN; Krayevsky, AA; Yegorov, YE; Zelenin, AV1
Akhmalisheva, AK; Akimov, SS; Chernov, DN; Semenova, IV; Shinkarev, DB; Smirnova, YB; Yegorov, YE; Yegorova, IN; Zelenin, AV1
Kato, K; Miyasaka, T; Suzuki, H; Tanaka, H1
Mickle, T; Nair, V1
Betancor, G; Garriga, C; Martínez, MA; Martinez-Picado, J; Menéndez-Arias, L; Nevot, M; Puertas, MC1

Other Studies

18 other study(ies) available for zidovudine and nsc 614846

ArticleYear
Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Animals; Antiviral Agents; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Dideoxyadenosine; Dideoxynucleosides; HIV; Leukemia P388; Molecular Structure; Purine Nucleosides; Structure-Activity Relationship; Tumor Cells, Cultured; Virus Replication; Zidovudine

1990
Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.
    Journal of medicinal chemistry, 2005, Jun-02, Volume: 48, Issue:11

    Topics: Adenine; Anti-HIV Agents; Cells, Cultured; Cyclopentanes; Dideoxynucleosides; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Hydrogen Bonding; Lamivudine; Leukocytes, Mononuclear; Models, Molecular; Molecular Conformation; Mutation; Stereoisomerism; Structure-Activity Relationship

2005
In vitro toxicity of 3'-azido-3'-deoxythymidine, carbovir and 2',3'-didehydro-2',3'-dideoxythymidine to human and murine haematopoietic progenitor cells.
    British journal of haematology, 1992, Volume: 80, Issue:4

    Topics: Animals; Antiviral Agents; Bone Marrow Cells; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Dideoxynucleosides; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Mice; Mice, Inbred Strains; Stavudine; Zidovudine

1992
DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine triphosphate.
    The Journal of biological chemistry, 1992, Feb-25, Volume: 267, Issue:6

    Topics: Antiviral Agents; Base Sequence; Dideoxynucleosides; DNA, Viral; Escherichia coli; HIV Reverse Transcriptase; HIV-1; Kinetics; Molecular Sequence Data; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Transcription, Genetic; Zidovudine

1992
Carbovir: the (-) enantiomer is a potent and selective antiviral agent against human immunodeficiency virus in vitro.
    Antiviral research, 1991, Volume: 15, Issue:2

    Topics: CD4-Positive T-Lymphocytes; Cell Line; Cell Survival; Dideoxynucleosides; Giant Cells; HIV; Humans; Viral Core Proteins; Virus Replication; Zalcitabine; Zidovudine

1991
Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.
    Experimental hematology, 1990, Volume: 18, Issue:10

    Topics: Bone Marrow Cells; Cell Division; Colony-Forming Units Assay; Dideoxynucleosides; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Granulocytes; Hematopoietic Stem Cells; Humans; Macrophages; Megakaryocytes; Zidovudine

1990
Activities of (-)-carbovir and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.
    Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:6

    Topics: Antiviral Agents; Cell Line; Cell Survival; Dideoxynucleosides; HIV; Humans; Virus Replication; Zidovudine

1990
Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases.
    Biochemical and biophysical research communications, 1989, Jun-15, Volume: 161, Issue:2

    Topics: Deoxyguanine Nucleotides; Dideoxynucleosides; Dideoxynucleotides; DNA Primase; HIV; Humans; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; RNA Nucleotidyltransferases; Thymine Nucleotides; Zidovudine

1989
Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro.
    Biochemical and biophysical research communications, 1988, Oct-31, Volume: 156, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Molecular Structure; Structure-Activity Relationship; Virus Replication; Zalcitabine; Zidovudine

1988
Lack of synergy in the inhibition of HIV-1 reverse transcriptase by combinations of the 5'-triphosphates of various anti-HIV nucleoside analogs.
    Antiviral research, 1993, Volume: 22, Issue:4

    Topics: Antiviral Agents; Base Sequence; Deoxyadenine Nucleotides; Dideoxynucleosides; Dideoxynucleotides; DNA-Directed DNA Polymerase; DNA, Viral; Drug Synergism; HIV Reverse Transcriptase; Molecular Sequence Data; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine

1993
Metabolism of carbovir, a potent inhibitor of human immunodeficiency virus type 1, and its effects on cellular metabolism.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:5

    Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; DNA; Drug Synergism; Half-Life; HIV-1; Humans; Mycophenolic Acid; RNA; Zidovudine

1993
Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:1

    Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; Drug Synergism; HIV-1; Humans; Viral Plaque Assay; Virus Replication; Zidovudine

1993
A checkerboard method to evaluate interactions between drugs.
    Biochemical pharmacology, 1996, Mar-08, Volume: 51, Issue:5

    Topics: Alcohol Dehydrogenase; Animals; Data Interpretation, Statistical; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; HIV-1; Horses; Humans; Zidovudine

1996
Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts.
    FEBS letters, 1996, Jul-01, Volume: 389, Issue:2

    Topics: 3T3 Cells; Animals; Antiviral Agents; Base Sequence; Cell Division; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Cellular Senescence; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Resistance; Fibroblasts; Mice; Mice, Inbred CBA; Mitosis; Molecular Sequence Data; Polyploidy; Reverse Transcriptase Inhibitors; Simian virus 40; Telomerase; Zidovudine

1996
Blockade of telomerase function by nucleoside analogs.
    Biochemistry. Biokhimiia, 1997, Volume: 62, Issue:11

    Topics: Animals; Cell Division; Cell Line; Cell Line, Transformed; Cells, Cultured; Cellular Senescence; Clone Cells; Dideoxynucleosides; Fetus; Fibroblasts; Humans; Kinetics; Mice; Mice, Inbred CBA; Rats; Telomerase; Zidovudine

1997
Asymmetric synthesis of 4'-alpha-alkylcarbovir derivatives.
    Nucleic acids symposium series, 1997, Issue:37

    Topics: Alkylation; Anti-HIV Agents; Dideoxynucleosides; HIV; Indicators and Reagents; Molecular Structure; Zidovudine

1997
Correlation of anti-HIV activity with structure: use of electrostatic potential and conformational analysis.
    Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

    Topics: Adenine; Anti-HIV Agents; Computer Simulation; Deoxyribonucleotides; Dideoxynucleosides; Hydrogen Bonding; Isomerism; Models, Chemical; Models, Molecular; Static Electricity; Structure-Activity Relationship; Zidovudine

1999
Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11

    Topics: Cell Line; Cells, Cultured; Dideoxynucleosides; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; Humans; Polymorphism, Genetic; Reverse Transcriptase Inhibitors; Stavudine; Virus Replication; Zidovudine

2010