Page last updated: 2024-08-23

zidovudine and methotrexate

zidovudine has been researched along with methotrexate in 58 studies

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.72)	18.7374
1990's	17 (29.31)	18.2507
2000's	19 (32.76)	29.6817
2010's	20 (34.48)	24.3611
2020's	1 (1.72)	2.80

Authors

Authors	Studies
Baraldi, PG; Bazzanini, R; Guarneri, M; La Colla, P; Manfredini, S; Marongiu, ME; Pani, A; Simoni, D; Tramontano, E	1
Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N	1
Topliss, JG; Yoshida, F	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Abe, T; Inui, K; Masuda, S; Saito, H; Takeuchi, A	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T	1
Jolivette, LJ; Ward, KW	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Taniki, T; Weber, G; Zhen, YS	1
Calabresi, P; Darnowski, JW; Goulette, FA; Renaud, CA; Tosi, P	1
Bennett, JM; Cohen, P; Kahn, J; Kaplan, L; Levine, AM; Metroka, C; Rarick, MU; Rodman, N; Walsh, C; Wernz, JC	1
Nagai, M; Nakamura, H; Olah, E; Prajda, N; Szekeres, T; Weber, G	1
Ichikawa, S; Nagai, M; Natsumeda, Y; Weber, G	1
Kashani-Sabet, M; Scanlon, KJ; Sowers, LC	1
Allegra, CJ; Grogan, L; Sotos, GA	1
Henson, E; McClarty, G; Wang, LL	1
Chandrasekaran, B; Duch, DS; Kute, TE	1
Lundberg, JH; Tefferi, A; Weitz, JJ; Witzig, TE	1
Arza, B; Barceló, MJ; Cadafalch, J; García-Die, F; Parellada, MM; Remacha, A	1
Ansari, R; Gonin, R; Loehrer, PJ; McClean, J; Miller, KD; Mortimer, J; Pletcher, W; Spiridonidis, CH; Weber, G	1
Chiodo, F; Coronado, O; Costigliola, P; Gherlinzoni, F; Gritti, F; Mazza, P; Mazzetti, M; Raise, E; Tosi, P; Tura, S; Visani, G	1
Chiodo, F; Coronado, O; Costigliola, P; Gherlinzoni, F; Gritti, F; Mazzetti, M; Tosi, P; Visani, G	1
Antony, AC; Gharehbaghi, K; Jayaram, HN; Li, QJ; Sun, XL; Xiao, X	1
Büchele, T; Dempke, W; Grothey, A; Schmoll, HJ	1
Alwayn, IP; Andrews, D; Awwad, M; Basker, M; Buhler, L; Cooper, DK; Harper, D; Lambrigts, D; Sachs, DH; Thall, A; Treter, S; White-Scharf, M	1
Ambudkar, SV; Nandigama, K; Sauna, ZE	1
Jena, GB; Pawar, AA; Ramarao, P; Tripathi, DN; Vikram, A	1
Grubb, B; Henderson, DB; Pandya, AG	1
Ahmad, T; Jena, GB; Khan, S; Parekh, CV; Shekh, K; Vikram, A; Yadav, L	1
Ashlock, B; Bayraktar, S; Bayraktar, UD; Cabral, L; Diaz, LA; Dittmer, DP; Pereira, D; Ramos, JC; Toomey, N	1
Davis, K; Fabian, E; Greenhaw, J; Groeters, S; Herold, M; Kamp, H; Looser, R; Marxfeld, H; Mattes, W; Mellert, W; Moeller, N; Montoya-Parra, G; Prokoudine, A; Strauss, V; van Ravenzwaay, B; Walk, T	1
Fukushima, T	1
Cook, LB; Phillips, AA	1

Reviews

5 review(s) available for zidovudine and methotrexate

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Cancer treatment reviews, 1994, Volume: 20, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine	1994
Where do we stand with 5-fluorouracil? Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chronotherapy; Colorectal Neoplasms; Dipyridamole; Drug Synergism; Fluorouracil; Humans; Interferons; Leucovorin; Levamisole; Methotrexate; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Trimetrexate; Zidovudine	1999
[Treatment of adult T-cell leukemia-lymphoma]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:10 Topics: Allografts; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Epirubicin; Etoposide; Hematopoietic Stem Cell Transplantation; Human T-lymphotropic virus 1; Humans; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Nitrosourea Compounds; Prednisolone; Prednisone; Prognosis; Salvage Therapy; Vincristine; Vindesine; Zidovudine	2014

Trials

2 trial(s) available for zidovudine and methotrexate

Article	Year
Low-dose chemotherapy with central nervous system prophylaxis and zidovudine maintenance in AIDS-related lymphoma. A prospective multi-institutional trial. JAMA, 1991, Jul-03, Volume: 266, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Diseases; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; HIV Seropositivity; Humans; Leucovorin; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Opportunistic Infections; Prospective Studies; Vincristine; Zidovudine	1991
A phase II study of weekly oral methotrexate and zidovudine (AZT) in advanced adenocarcinoma of the pancreas and hepatocellular carcinoma. Investigational new drugs, 1996, Volume: 14, Issue:2 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Pancreatic Neoplasms; Remission Induction; Zidovudine	1996

Article

Year

Low-dose chemotherapy with central nervous system prophylaxis and zidovudine maintenance in AIDS-related lymphoma. A prospective multi-institutional trial.

JAMA, 1991, Jul-03, Volume: 266, Issue:1

Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Diseases; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; HIV Seropositivity; Humans; Leucovorin; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Opportunistic Infections; Prospective Studies; Vincristine; Zidovudine

1991

A phase II study of weekly oral methotrexate and zidovudine (AZT) in advanced adenocarcinoma of the pancreas and hepatocellular carcinoma.

Investigational new drugs, 1996, Volume: 14, Issue:2

Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Pancreatic Neoplasms; Remission Induction; Zidovudine

1996

Other Studies

51 other study(ies) available for zidovudine and methotrexate

Article	Year
Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides. Journal of medicinal chemistry, 1992, Mar-06, Volume: 35, Issue:5 Topics: Animals; Antineoplastic Agents; Antiviral Agents; B-Lymphocytes; Cell Division; Cyclization; Enterovirus; Glycosylation; HIV-1; Humans; Leukemia L1210; Mice; Molecular Structure; Nucleosides; Organosilicon Compounds; Pyrazoles; Silicon; Structure-Activity Relationship; T-Lymphocytes; Tumor Cells, Cultured; Vero Cells	1992
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19 Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1 Topics: Animals; Carrier Proteins; Cattle; Cell Line; Cells, Cultured; Folic Acid Antagonists; Kidney; Kinetics; Membrane Proteins; Methotrexate; Multidrug Resistance-Associated Proteins; Oocytes; Organ Specificity; Organic Anion Transporters; Substrate Specificity; Transfection; Xenopus laevis	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3 Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger	2004
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20 Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells. Oncology research, 1992, Volume: 4, Issue:2 Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; DNA Replication; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Methotrexate; Pancreatic Neoplasms; Thymidine; Tumor Stem Cell Assay; Zidovudine	1992
Azidothymidine-induced cytotoxicity and incorporation into DNA in the human colon tumor cell line HCT-8 is enhanced by methotrexate in vitro and in vivo. Cancer research, 1992, Aug-01, Volume: 52, Issue:15 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Line; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Thymidylate Synthase; Transplantation, Heterologous; Zidovudine	1992
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells. Cancer communications, 1991, Volume: 3, Issue:4 Topics: Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Methotrexate; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine	1991
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells. Cancer communications, 1990, Volume: 2, Issue:4 Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics; Liver Neoplasms, Experimental; Methotrexate; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine	1990
Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine. Cancer communications, 1989, Volume: 1, Issue:4 Topics: Cell Line; Cisplatin; Colonic Neoplasms; DNA Polymerase I; DNA Polymerase II; DNA Repair; DNA Replication; Drug Resistance; Etoposide; Floxuridine; Fluorouracil; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Zidovudine	1989
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis. Molecular microbiology, 1994, Volume: 14, Issue:2 Topics: Adenosine Triphosphate; Animals; Chlamydia trachomatis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; Guanosine Triphosphate; L Cells; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; RNA, Bacterial; Sulfisoxazole; Thymidine; Trimethoprim; Uracil; Zidovudine	1994
Synchronization of cells in the S phase of the cell cycle by 3'-azido-3'-deoxythymidine: implications for cell cytotoxicity. Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:6 Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Division; Cell Survival; Colonic Neoplasms; Computer Simulation; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Fluorouracil; Humans; Leukemia; Melanoma; Methotrexate; Pancreatic Neoplasms; S Phase; Tumor Cells, Cultured; Zidovudine	1995
Treatment of refractory T-cell chronic lymphocytic leukemia with purine nucleoside analogues. Leukemia & lymphoma, 1994, Volume: 14, Issue:1-2 Topics: 2-Chloroadenosine; Anemia; Antineoplastic Combined Chemotherapy Protocols; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclophosphamide; Deoxyadenosines; Fatal Outcome; Female; Humans; Immunophenotyping; Leukemia, Prolymphocytic; Leukemia, Prolymphocytic, T-Cell; Male; Methotrexate; Middle Aged; Neoplastic Stem Cells; Prednisone; Salvage Therapy; Vidarabine; Vincristine; Zidovudine	1994
The deoxyuridine suppression test in HIV-1 positive patients: the role of azydothymidine (AZT). European journal of haematology, 1996, Volume: 56, Issue:4 Topics: Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyuridine; Folic Acid; HIV Infections; HIV-1; Humans; Intestinal Absorption; Methotrexate; Vitamin B 12; Vitamin B 12 Deficiency; Zidovudine	1996
3'-Azido 3'-deoxythymidine + methotrexate as a novel antineoplastic combination in the treatment of human immunodeficiency virus-related non-Hodgkin's lymphomas. Blood, 1997, Jan-15, Volume: 89, Issue:2 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Lymphoma, AIDS-Related; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Zidovudine	1997
AZT plus methotrexate in HIV-related non-Hodgkin's lymphomas. Leukemia & lymphoma, 1998, Volume: 30, Issue:1-2 Topics: Adult; Anti-HIV Agents; Antimetabolites, Antineoplastic; Drug Therapy, Combination; Female; Humans; Lymphoma, AIDS-Related; Male; Methotrexate; Middle Aged; Zidovudine	1998
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity. Cancer research, 1999, Feb-15, Volume: 59, Issue:4 Topics: Antimetabolites, Antineoplastic; Carrier Proteins; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Gene Transfer Techniques; Humans; Methotrexate; Receptors, Cell Surface; Thymidine; Thymidine Kinase; Uterine Cervical Neoplasms; Zidovudine	1999
Effect of B cell/plasma cell depletion or suppression on anti-Gal antibody in the baboon. Transplantation proceedings, 2000, Volume: 32, Issue:5 Topics: Animals; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Adhesion Molecules; Cladribine; Galactosides; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Lectins; Lymphocyte Depletion; Methotrexate; Papio; Plasma Cells; Sialic Acid Binding Ig-like Lectin 2; Thymus Gland; Whole-Body Irradiation; Zidovudine	2000
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state. The Journal of biological chemistry, 2004, Nov-19, Volume: 279, Issue:47 Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beryllium; Biological Transport; Catalysis; Cations; Cell Line; Cell Membrane; Chelating Agents; Cobalt; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Edetic Acid; Fluorides; Humans; Hydrolysis; Insecta; Kinetics; Magnesium; Manganese; Methotrexate; Models, Biological; Multidrug Resistance-Associated Proteins; Nucleotides; Organophosphonates; Protein Binding; Substrate Specificity; Vanadates; Zidovudine	2004
Pre-bled-young-rats in genotoxicity testing: a model for peripheral blood micronucleus assay. Regulatory toxicology and pharmacology : RTP, 2008, Volume: 52, Issue:2 Topics: Animals; Area Under Curve; Diethylnitrosamine; Disease Models, Animal; Hemorrhage; Male; Methotrexate; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Quercetin; Rats; Rats, Sprague-Dawley; Reticulocytes; Streptozocin; Time Factors; Zidovudine	2008
Adult T-cell lymphoma/leukemia presenting as pagetoid reticulosis of the palms and soles. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:5 Topics: Adult; Antigens, CD; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Diagnosis, Differential; Diagnostic Errors; Doxorubicin; Etoposide; Fatal Outcome; Foot; Hand; Humans; Interferons; Jamaica; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Pagetoid Reticulosis; Prednisone; Skin Neoplasms; Vincristine; Zidovudine	2011
Pretreatment with valproic acid, a histone deacetylase inhibitor, enhances the sensitivity of the peripheral blood micronucleus assay in rodents. Mutation research, 2013, Feb-18, Volume: 751, Issue:1 Topics: Animals; Cyclophosphamide; Erythrocytes; Histone Deacetylase Inhibitors; Male; Methotrexate; Mice; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley; Reticulocytes; Sensitivity and Specificity; Valproic Acid; Zidovudine	2013
Zidovudine-based lytic-inducing chemotherapy for Epstein-Barr virus-related lymphomas. Leukemia & lymphoma, 2014, Volume: 55, Issue:4 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Cell Line, Tumor; Combined Modality Therapy; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Staging; Remission Induction; Retrospective Studies; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Treatment Outcome; Zidovudine	2014
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. Toxicology letters, 2014, Nov-04, Volume: 230, Issue:3 Topics: Animals; Atropine; Captopril; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Flutamide; Lamivudine; Liver; Male; Mannitol; Metabolomics; Methotrexate; Neomycin; Oxidative Stress; Phenytoin; Piperazines; Propylthiouracil; Rats; Rats, Wistar; Streptomycin; Triazoles; Valproic Acid; Vancomycin; Zidovudine	2014
How I treat adult T-cell leukemia/lymphoma. Blood, 2021, 01-28, Volume: 137, Issue:4 Topics: Aged; Allografts; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Dexamethasone; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Human T-lymphotropic virus 1; Humans; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Prednisone; Raltegravir Potassium; Recurrence; Remission Induction; Therapies, Investigational; Vincristine; Virus Activation; Zidovudine	2021