Page last updated: 2024-08-23

zidovudine and ganciclovir

zidovudine has been researched along with ganciclovir in 107 studies

Research

Studies (107)

TimeframeStudies, this research(%)All Research%
pre-199010 (9.35)18.7374
1990's52 (48.60)18.2507
2000's31 (28.97)29.6817
2010's13 (12.15)24.3611
2020's1 (0.93)2.80

Authors

AuthorsStudies
Bennett, SM; Nguyen-Ba, N; Ogilvie, KK1
Clement, J; Erickson, J; Hayashi, S; Herrin, T; Kern, E; Norbeck, DW; Plattner, JJ; Rosenbrook, W; Sham, H; Swanson, R1
Drach, JC; Kern, ER; Krawczyk, SH; Kucera, LS; Nassiri, MR; Ptak, RG; Townsend, LB; Wotring, LL1
Andrei, G; Balzarini, J; Blache, Y; Chapat, JP; Chavignon, O; De Clercq, E; Debouzy, JC; Elhakmaoui, A; Essassi, EM; Gueiffier, A; Kerbal, A; Lhassani, M; Snoeck, R; Teulade, JC; Witvrouw, M1
Balzarini, J; De Clercq, E; Faraj, A; Fedorov, II; Gosselin, G; Gurskaya, GV; Imbach, JL; Jasko, MV; Kazmina, EM; Sommadossi, JP; Zavodnic, VE1
Breitenbach, JM; Cheng, YC; Drach, JC; Fan, BY; Kern, ER; Ksebati, MB; Lin, JS; Ptak, RG; Qiu, YL; Zemlicka, J1
Jeong, LS; Yoo, SJ1
Andrei, G; De Clercq, E; Dimas, K; Foscolos, GB; Fytas, G; Kolocouris, A; Kolocouris, N; Pannecouque, C; Snoeck, R; Stamatiou, G; Witvrouw, M; Zoidis, G1
Cha, SH; Endou, H; Khamdang, S; Kimura, H; Kobayashi, Y; Narikawa, S; Sekine, T; Takeda, M; Yamamoto, T1
Cheng, YC; Drach, JC; Gullen, E; Kern, ER; Matsumi, S; Mitsuya, H; Zemlicka, J; Zhou, S1
Balzarini, J; Barral, K; Camplo, M; De Clercq, E; Hider, RC; Neyts, J1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Cheng, YC; Drach, JC; Gullen, E; Kern, ER; Mitsuya, H; Tamiya, S; Zemlicka, J; Zhou, S1
Alvarez, K; Balzarini, J; Barral, K; Canard, B; Neyts, J; Priet, S; Sire, J1
Hong, JH; Kim, A1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Kesel, AJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Çapan, G; Cihan-Üstündağ, G; Gürsoy, E; Naesens, L; Ulusoy-Güzeldemirci, N1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Andrei, G; Buckheit, RW; De Jonghe, S; Groaz, E; Hartman, T; Herdewijn, P; Kalkeri, R; Luo, M; Ptak, RG; Schols, D; Snoeck, R1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Koziel, MJ; Walker, BD1
Skolnik, PR1
Foerster, M; Kastner, U; Neubert, R1
Morris, DJ2
Ruutu, P1
Hsiung, GD; Medina, DJ; Mellors, JW1
Cox, SW; Wahren, B1
Anderson, S; Beck, EJ; Coker, R; Coleman, D; Harris, JR; Main, J; Migdal, C; Peters, BS; Pinching, AJ1
Alton, NK; Baldwin, G; Glaspy, JA; Miles, SA; Mitsuyasu, RT; Moreno, J; Souza, L1
Causey, D1
Dieterich, DT; Rahmin, M1
Crumpacker, C; Finberg, RW; Heagy, W; Lopez, PA1
Baguley, WA; Nassiri, MR; Prichard, LE; Prichard, MN; Shipman, C1
Knight, DR; Shaw, DR; Sommadossi, JP; Waterman, AL1
Gil, A; Lavilla, P; López Dupla, JM; Pintado, V; Valencia, ME1
De Clercq, E1
Bozzette, S; Connor, JD; Dieterich, D; Hochster, H; Liebes, L; Pettinelli, C; Reichman, RC; Sonke, RL; Spector, SA; Valentine, F1
Marsh, R; Millar, AB; Miller, RF; Mindel, A; Patou, G; Semple, SJ1
Balzarini, J; Bron, D; De Clercq, E; Delforge, A; Lagneaux, L; Snoeck, R; Stryckmans, P; Van der Auwera, P1
Bryson, YJ1
Gor, D; Helbert, M; Janes, K; Jeffries, DJ; Kocsis, AE; Mitchell, D; Peddle, B; Pinching, AJ; Robinson, D; Stoneham, C1
Jacobson, MA; O'Donnell, JJ1
Nightingale, SC1
Hartung, HP; Heininger, K; Toyka, KV1
Cantrill, H; Henry, K; Kish, MA1
Blum, MR; de Miranda, P; Gordon, SM; Jacobson, MA; Mills, J; Volberding, P1
Chevalier, A; Norol, F; Picard, C; Schaeffer, A; Sobel, A1
Carlisle, R; Sommadossi, JP1
Cockerill, FR; Hermans, PE1
Groopman, JE; Scadden, DT; Wang, A; Zsebo, KM1
Anderson, R; Davis, G; Drew, WL; Lalezari, J; Lang, W; Miner, RC1
Crumpacker, C; Freeman, W; Hardy, D; Heinemann, MH; Holland, G; Klystra, J; Polsky, B; Sharuk, G; Spector, S; van der Horst, C1
Prichard, MW; Shipman, C1
Chiu, S; Fraser-Smith, EB; Freitas, VR; Michelson, S; Schatzman, RC1
Albrecht, H; Dietrich, M; Garweg, J; Knospe, V; Olszowski, W; Plettenberg, A; Stellbrink, HJ; Stoehr, A; Weitner, L1
Baird, BF; Davey, RT; deSmet, MD; Falloon, J; Kovacs, JA; Masur, H; Mellow, S; Nussenblatt, RB; Palestine, AG; Polis, MA1
Anderson, KP; Azad, RF; Brown-Driver, V; Buckheit, RW1
Detels, RR; Hoover, DR; Peng, Y; Phair, JP; Rinaldo, CR; Saah, A; Semba, R1
Kalnina, LB; Kaplina, EN; Lavrukhina, LA; Nosik, DN; Nosik, NN; Vaĭnberg, IP1
Rowe, PM1
Griffy, KG1
Chiang, Y; Drake, RR; Govindarajan, R; Hume, SD; Krisa, S; McMasters, R; Munshi, NC; Rechtin, TM; Saylors, RL1
Casserella, S; Cimoch, PJ; Griffy, KG; Jung, D; Lavelle, J; Pollard, R; Tarnowski, TL; Wong, R1
Davis, JL; Friedberg, DN; Holland, GN; Levinson, RD; Lindley, JI; Terry, BT; Tufail, A; Vann, R1
Chaisson, RE; Keruly, JC; Moore, RD1
De Clercq, E; Holý, A; Meerbach, A; Neyts, J; Wutzler, P1
Bubl, R; Di Gallo, A; Engelcke, G; Rinaldi, D; Rohrer, T; Rudin, C1
Byrne, GE; Cabral, L; Cai, JP; Harrington, WJ; Hurley, J; Jayaweera, D; Landy, H; Raez, L; Scerpella, E; Sfakianakis, G1
Fingeroth, JD; Gustafson, EA; Schinazi, RF1
Bareta, J; Hidalgo, J; Rhee, W; Steidl, S; Wutoh, AK1
Berebbi, M; Kudelova, M; Macakova, K; Matis, J; Raslova, H; Rezuchova, I1
Horowitz, D; King, AG1
Blackstock, W; Feng, W; Israel, B; Kenney, SC; Westphal, EM1
Poscher, M1
Alcorn, J; McNamara, PJ1
Aboulafia, DM1
Di Perri, G; Maiello, A; Quario, M; Racca, D; Sinicco, A; Zeme, DA1
Aldamiz-Etxebarría, M; Andonegui Navarro, J1
Baldanti, F; Galloni, D; Gerna, G; Lilleri, D; Piccinini, G; Seminari, E1
Bartlett, MG; Brown, SD; White, CA1
Baiocchi, RA; Barth, RF; Bhatt, D; Caligiuri, MA; Eisenbeis, CF; Ferketich, A; Grecula, J; Gupta, N; Moeschberger, M; Nuovo, GJ; Peng, R; Porcu, P; Roychowdhury, S; Schmalbrock, P; Vourganti, S; Yang, W1
Choi, BG; Hong, JH; Kwak, EY; Park, Y1
Gupta, SK; Janowicz, DM; Johnson, RM1
Frick, M; Geiger, M; Gottinger, W; Haas, G; Huemer, HP; Irschick, EU; Konwalinka, G; Ritsch-Marte, M; Singer, W1
Caligiuri, MA1
Davis, DA; Haque, M; Reynolds, IP; Singer, KE; Yarchoan, R1
Aleman, K; Little, RF; Marshall, V; O'Mahony, D; Pittaluga, S; Polizzotto, MN; Steinberg, SM; Tosato, G; Uldrick, TS; Wang, V; Whitby, D; Wyvill, KM; Yarchoan, R1
Polizzotto, MN; Uldrick, TS; Yarchoan, R1
Lurain, K; Uldrick, TS; Yarchoan, R1

Reviews

15 review(s) available for zidovudine and ganciclovir

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Viruses, chemotherapy and immunity.
    Parasitology, 1992, Volume: 105 Suppl

    Topics: Acyclovir; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Infections; Drug Resistance, Microbial; Ganciclovir; Herpesviridae Infections; HIV Infections; HIV-1; Humans; Immunity, Cellular; Interferons; Major Histocompatibility Complex; Virus Diseases; Zidovudine

1992
[Antiviral drugs].
    Duodecim; laaketieteellinen aikakauskirja, 1991, Volume: 107, Issue:10

    Topics: Acyclovir; Antiviral Agents; Ganciclovir; Humans; Immunocompromised Host; Interferon-alpha; Virus Diseases; Zidovudine

1991
Concomitant ganciclovir and zidovudine treatment for cytomegalovirus retinitis in patients with HIV infection: an approach to treatment.
    Journal of acquired immune deficiency syndromes, 1991, Volume: 4 Suppl 1

    Topics: Cytomegalovirus Infections; Drug Therapy, Combination; Eye Infections, Viral; Ganciclovir; HIV Infections; Humans; Opportunistic Infections; Retinitis; Zidovudine

1991
[Drug surveillance for adverse reactions in patients with human immunodeficiency virus infection].
    Anales de medicina interna (Madrid, Spain : 1984), 1990, Volume: 7, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Antitubercular Agents; Drug-Related Side Effects and Adverse Reactions; Ganciclovir; HIV Infections; Humans; Opportunistic Infections; Pentamidine; Product Surveillance, Postmarketing; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine

1990
New acquisitions in the chemotherapy of viral infections.
    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1990, Volume: 52, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Chemical Phenomena; Chemistry; Cytomegalovirus Infections; Ganciclovir; Humans; Zidovudine

1990
Promising new antiviral drugs.
    Journal of the American Academy of Dermatology, 1988, Volume: 18, Issue:1 Pt 2

    Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Herpes Simplex; Herpes Zoster; Humans; Interferons; Phosphonoacetic Acid; Ribavirin; Thymidine; Zidovudine

1988
Cotton-wool spots and cytomegalovirus retinitis in AIDS.
    International ophthalmology clinics, 1989,Summer, Volume: 29, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Cytomegalovirus Infections; Diabetic Retinopathy; Diagnosis, Differential; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Pneumonia, Pneumocystis; Prognosis; Retinal Diseases; Retinitis; Zidovudine

1989
[Neuromuscular manifestations of HIV-1 and HTLV-I infections].
    Deutsche medizinische Wochenschrift (1946), 1988, Dec-16, Volume: 113, Issue:50

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adrenal Cortex Hormones; Capsaicin; Carbamazepine; Demyelinating Diseases; Ganciclovir; HIV-1; HTLV-I Infections; Humans; Muscular Diseases; Neuritis; Neuromuscular Diseases; Peripheral Nervous System Diseases; Polyneuropathies; Zidovudine

1988
Adverse effects and drug interactions of clinical importance with antiviral drugs.
    Drug safety, 1994, Volume: 10, Issue:4

    Topics: Acyclovir; AIDS-Related Opportunistic Infections; Amantadine; Antiviral Agents; Didanosine; Drug Interactions; Foscarnet; Ganciclovir; Humans; Interferon-alpha; Ribavirin; Rimantadine; Vidarabine; Zalcitabine; Zidovudine

1994
Increased survival of a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis who received sodium phosphonoformate (foscarnet).
    The American journal of medicine, 1993, Volume: 94, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Cohort Studies; Cytomegalovirus Infections; Didanosine; Drug Tolerance; Follow-Up Studies; Foscarnet; Ganciclovir; Humans; Infusions, Intravenous; Injections, Intravenous; Retinitis; Survival Rate; Time Factors; Zidovudine

1993
Combined treatment with zidovudine, lamivudine, nelfinavir and ganciclovir in an infant with human immunodeficiency virus type 1 infection and cytomegalovirus encephalitis: case report and review of the literature.
    The Pediatric infectious disease journal, 1999, Volume: 18, Issue:4

    Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Cytomegalovirus Infections; Diseases in Twins; Drug Therapy, Combination; Encephalitis, Viral; Female; Ganciclovir; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Lamivudine; Nelfinavir; Zidovudine

1999
Recent advances in the treatment of transplant-related lymphoma.
    Clinical advances in hematology & oncology : H&O, 2006, Volume: 4, Issue:1

    Topics: Antiviral Agents; Burkitt Lymphoma; Female; Ganciclovir; Humans; Immunotherapy; Kidney Transplantation; Male; Pancreas Transplantation; Zidovudine

2006
Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease.
    Current opinion in oncology, 2012, Volume: 24, Issue:5

    Topics: Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Castleman Disease; Ganciclovir; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Rituximab; Valganciclovir; Zidovudine

2012
Treatment of Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease.
    Hematology/oncology clinics of North America, 2018, Volume: 32, Issue:1

    Topics: Biopsy; Castleman Disease; Doxorubicin; Ganciclovir; Herpesvirus 8, Human; Humans; Interleukin-6; Lymph Nodes; Rituximab; Valganciclovir; Zidovudine

2018

Trials

10 trial(s) available for zidovudine and ganciclovir

ArticleYear
Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis.
    The New England journal of medicine, 1992, 01-23, Volume: 326, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; CD4-Positive T-Lymphocytes; Cytomegalovirus Infections; Drug Therapy, Combination; Drug Tolerance; Foscarnet; Ganciclovir; Humans; Leukocyte Count; Phosphonoacetic Acid; Random Allocation; Retinitis; Zidovudine

1992
Cytomegalovirus colitis in AIDS: presentation in 44 patients and a review of the literature.
    Journal of acquired immune deficiency syndromes, 1991, Volume: 4 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Cecum; Colitis; Colon; Cytomegalovirus Infections; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Fever; Ganciclovir; Humans; Male; Prospective Studies; Recurrence; Weight Loss; Zidovudine

1991
Toxicity of combined ganciclovir and zidovudine for cytomegalovirus disease associated with AIDS. An AIDS Clinical Trials Group Study.
    Annals of internal medicine, 1990, Jul-15, Volume: 113, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Anemia; Chemical and Drug Induced Liver Injury; Cytomegalovirus Infections; Drug Therapy, Combination; Female; Ganciclovir; Humans; Leukopenia; Male; Middle Aged; Multicenter Studies as Topic; Neutropenia; Prospective Studies; Time Factors; Vomiting; Zidovudine

1990
From the Food and Drug Administration.
    JAMA, 1989, Aug-11, Volume: 262, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Anemia; Antiviral Agents; Clinical Trials as Topic; Cytomegalovirus Infections; Erythropoietin; Ganciclovir; Humans; Zidovudine

1989
Failure of high-dose oral acyclovir to suppress CMV viruria or induce ganciclovir-resistant CMV in HIV antibody positive patients.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Mar-01, Volume: 8, Issue:3

    Topics: Acyclovir; Administration, Oral; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Drug Resistance, Microbial; Drug Therapy, Combination; Fibroblasts; Follow-Up Studies; Ganciclovir; HIV Seropositivity; Humans; Zidovudine

1995
Combination of ganciclovir and granulocyte-macrophage colony-stimulating factor in the treatment of cytomegalovirus retinitis in AIDS patients. The ACTG 073 Team.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1994, Volume: 13 Suppl 2

    Topics: Adult; AIDS-Related Opportunistic Infections; Cytomegalovirus Retinitis; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Ganciclovir; Granulocyte-Macrophage Colony-Stimulating Factor; HIV Infections; Humans; Male; Neutropenia; Prognosis; Zidovudine

1994
[Secondary prevention of cytomegalovirus retinitis with ganciclovir].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1993, Volume: 90, Issue:3

    Topics: Adult; AIDS-Related Opportunistic Infections; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Ganciclovir; Humans; Male; Recurrence; Retinitis; Retrospective Studies; Zidovudine

1993
Increased survival of a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis who received sodium phosphonoformate (foscarnet).
    The American journal of medicine, 1993, Volume: 94, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Cohort Studies; Cytomegalovirus Infections; Didanosine; Drug Tolerance; Follow-Up Studies; Foscarnet; Ganciclovir; Humans; Infusions, Intravenous; Injections, Intravenous; Retinitis; Survival Rate; Time Factors; Zidovudine

1993
Pharmacokinetics of oral ganciclovir alone and in combination with zidovudine, didanosine, and probenecid in HIV-infected subjects.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1998, Mar-01, Volume: 17, Issue:3

    Topics: Administration, Oral; Adult; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Didanosine; Drug Interactions; Female; Ganciclovir; Half-Life; HIV Infections; Humans; Male; Probenecid; Renal Agents; Zidovudine

1998
High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy.
    Blood, 2011, Jun-30, Volume: 117, Issue:26

    Topics: Adult; Anti-HIV Agents; Castleman Disease; Drug Therapy, Combination; Female; Ganciclovir; Herpesviridae Infections; Herpesvirus 8, Human; HIV Infections; Humans; Male; Middle Aged; Pilot Projects; Prodrugs; Protein Kinase Inhibitors; Protein Kinases; Survival Analysis; Valganciclovir; Viral Load; Viral Proteins; Virus Activation; Zidovudine

2011

Other Studies

83 other study(ies) available for zidovudine and ganciclovir

ArticleYear
Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogues.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidine Nucleosides; Pyrroles; Simplexvirus

1990
Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Guanine; Herpesviridae; HIV; Humans; Mice; Microbial Sensitivity Tests

1990
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
    Journal of medicinal chemistry, 1995, Sep-29, Volume: 38, Issue:20

    Topics: Antibiotics, Antineoplastic; Antiviral Agents; Arabinonucleosides; Cytomegalovirus; Herpesvirus 1, Human; HIV; Humans; KB Cells; Pyrimidine Nucleosides; Toyocamycin

1995
Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
    Journal of medicinal chemistry, 1996, Jul-05, Volume: 39, Issue:14

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; HeLa Cells; Humans; Nucleosides; Pyridines; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured; Vero Cells

1996
Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
    Journal of medicinal chemistry, 1997, Feb-14, Volume: 40, Issue:4

    Topics: Antiviral Agents; Crystallography, X-Ray; Dideoxynucleosides; HIV-1; HIV-2; Humans; Isomerism; Models, Chemical; Models, Molecular; Structure-Activity Relationship; Thymidine; Virus Replication

1997
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
    Journal of medicinal chemistry, 1998, Jan-01, Volume: 41, Issue:1

    Topics: Adenosine; Animals; Anti-HIV Agents; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Cyclopropanes; Guanosine; Hepatitis B virus; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Mice; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Spectrophotometry, Infrared; Vero Cells; Virus Replication

1998
Synthesis and antiviral activity of novel isodideoxy nucleosides with exocyclic methylene.
    Bioorganic & medicinal chemistry letters, 1998, Apr-07, Volume: 8, Issue:7

    Topics: Acyclovir; Antiviral Agents; Cell Survival; Cytomegalovirus; Dideoxynucleosides; Drug Design; Ganciclovir; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Hydrocarbons; Indicators and Reagents; Methane; Microbial Sensitivity Tests; Structure-Activity Relationship; Xylose; Zidovudine

1998
New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
    Bioorganic & medicinal chemistry letters, 2002, Mar-11, Volume: 12, Issue:5

    Topics: Bacteria; Cell Division; Cell Line; Formazans; Humans; Hydrazones; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Tetrazolium Salts; Thiosemicarbazones; Tumor Cells, Cultured; Viruses

2002
Human organic anion transporters and human organic cation transporters mediate renal antiviral transport.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:3

    Topics: Acyclovir; Anti-HIV Agents; Antiviral Agents; Biological Transport; Cells, Cultured; Ganciclovir; Humans; Kidney; Kinetics; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; Renal Agents; Zidovudine

2002
(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.
    Journal of medicinal chemistry, 2004, Dec-30, Volume: 47, Issue:27

    Topics: Adenosine Deaminase; Antiviral Agents; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 4, Human; Nucleosides; Virus Replication

2004
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives.
    Journal of medicinal chemistry, 2006, Jan-12, Volume: 49, Issue:1

    Topics: Animals; Antiviral Agents; Cell Line; Cell Proliferation; Chlorocebus aethiops; Deferiprone; HeLa Cells; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; HIV-2; Humans; Ligands; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Pyridones; Structure-Activity Relationship; Vero Cells

2006
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
    Journal of medicinal chemistry, 2006, Oct-05, Volume: 49, Issue:20

    Topics: Adenine; Adenosine Deaminase; Antiviral Agents; Cyclopropanes; Cytomegalovirus; Cytopathogenic Effect, Viral; Guanine; Hepatitis B virus; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV-1; Humans; Purine Nucleosides; Stereoisomerism; Structure-Activity Relationship; Viral Plaque Assay

2006
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
    Journal of medicinal chemistry, 2006, Dec-28, Volume: 49, Issue:26

    Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Boranes; Boron Compounds; Chlorocebus aethiops; DNA Viruses; HIV-1; Humans; In Vitro Techniques; Nucleosides; Organophosphonates; Phosphates; RNA Viruses; Structure-Activity Relationship; Vero Cells; Virus Replication

2006
Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:4

    Topics: Antiviral Agents; Cells, Cultured; Cyclopropanes; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV; Humans; Hydrocarbons, Fluorinated; Microbial Sensitivity Tests; Molecular Structure; Nucleosides

2007
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
    Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2

    Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Broad-spectrum antiviral activity including human immunodeficiency and hepatitis C viruses mediated by a novel retinoid thiosemicarbazone derivative.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:5

    Topics: Anti-Bacterial Agents; Benzaldehydes; Cell Line, Tumor; Chromatography, Thin Layer; Cytomegalovirus; Hepacivirus; Herpesvirus 3, Human; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Retinoids; Stereoisomerism; Structure-Activity Relationship; Thiosemicarbazones

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones.
    Bioorganic & medicinal chemistry, 2016, Jan-15, Volume: 24, Issue:2

    Topics: Animals; Antiviral Agents; Cats; Cells, Cultured; Chlorocebus aethiops; DNA Viruses; Dogs; Dose-Response Relationship, Drug; HeLa Cells; Humans; Indoles; Madin Darby Canine Kidney Cells; Microbial Sensitivity Tests; Molecular Structure; RNA Viruses; Semicarbazides; Structure-Activity Relationship; Thiazolidines; Vero Cells; Virus Replication

2016
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
    Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14

    Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Cell Line; Cytomegalovirus; Drug Resistance, Viral; Drug Stability; Esters; Hepatitis B virus; Herpesvirus 3, Human; Humans; Hydrogen-Ion Concentration; Microsomes, Liver; Nucleosides; Organophosphonates; Prodrugs; Stereoisomerism; Structure-Activity Relationship

2017
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Treatment of CMV retinitis.
    The New England journal of medicine, 1992, Jun-18, Volume: 326, Issue:25

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Drug Therapy, Combination; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Retinitis; Zidovudine

1992
Effect of six virustatic nucleoside analogues on the development of fetal rat thymus in organ culture.
    Archives of toxicology, 1992, Volume: 66, Issue:10

    Topics: Animals; Antiviral Agents; Cell Differentiation; Cell Division; Cells, Cultured; Didanosine; Female; Flow Cytometry; Ganciclovir; Immunity, Cellular; Male; Nucleotides; Organ Culture Techniques; Pregnancy; Rats; Rats, Wistar; Thymus Gland; Vidarabine; Zalcitabine; Zidovudine

1992
Treatment of CMV retinitis.
    Lancet (London, England), 1992, Jan-25, Volume: 339, Issue:8787

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Viral; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Retinitis; Zidovudine

1992
Ganciclovir antagonizes the anti-human immunodeficiency virus type 1 activity of zidovudine and didanosine in vitro.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:5

    Topics: Didanosine; Drug Interactions; Ganciclovir; HIV-1; Zidovudine

1992
Treatment of CMV retinitis.
    The New England journal of medicine, 1992, Jun-18, Volume: 326, Issue:25

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Synergism; Drug Therapy, Combination; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Zidovudine

1992
Cytomegalovirus infection in AIDS. Patterns of disease, response to therapy and trends in survival.
    The Journal of infection, 1991, Volume: 23, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Colitis; Cytomegalovirus Infections; Female; Foscarnet; Ganciclovir; Humans; London; Male; Neutropenia; Opportunistic Infections; Phosphonoacetic Acid; Prevalence; Recurrence; Retinitis; Retrospective Studies; Survival Rate; Thrombocytopenia; Zidovudine

1991
Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine.
    Blood, 1991, May-15, Volume: 77, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Blood Cell Count; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Erythropoietin; Ganciclovir; Gene Products, gag; Granulocyte Colony-Stimulating Factor; Hemoglobins; HIV; HIV Core Protein p24; Humans; Injections, Subcutaneous; Neutropenia; Opportunistic Infections; Recombinant Proteins; Viral Core Proteins; Virus Replication; Zidovudine

1991
Inhibition of immune functions by antiviral drugs.
    The Journal of clinical investigation, 1991, Volume: 87, Issue:6

    Topics: Acyclovir; Antiviral Agents; Cell Cycle; Cells, Cultured; Concanavalin A; Didanosine; DNA; Ganciclovir; Humans; Immunity; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Proteins; Ribavirin; Zidovudine

1991
Three-dimensional analysis of the synergistic cytotoxicity of ganciclovir and zidovudine.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:6

    Topics: Cell Division; Cell Survival; Drug Evaluation, Preclinical; Drug Synergism; Ganciclovir; Humans; KB Cells; Tumor Cells, Cultured; Zidovudine

1991
3'-Azido-3'-deoxythymidine inhibition of human lymphocyte cytolytic function in vitro.
    Biochemical pharmacology, 1991, Jan-15, Volume: 41, Issue:2

    Topics: Acyclovir; Cell Survival; Cells, Cultured; Cytotoxicity Tests, Immunologic; Ganciclovir; Humans; Interleukin-2; Phenotype; Recombinant Proteins; T-Lymphocytes, Cytotoxic; Zidovudine

1991
Treatment of cytomegalovirus retinitis with zidovudine and ganciclovir in patients with AIDS: outcome and toxicity.
    Genitourinary medicine, 1990, Volume: 66, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Cytomegalovirus Infections; Drug Therapy, Combination; Ganciclovir; Humans; Male; Middle Aged; Opportunistic Infections; Retinitis; Zidovudine

1990
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1990, Volume: 9, Issue:8

    Topics: Adenine; Adult; Antiviral Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cidofovir; Cytomegalovirus; Cytosine; Foscarnet; Ganciclovir; Granulocytes; Hematopoietic Stem Cells; HIV; Humans; Macrophages; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Zidovudine

1990
Drugs for viral infections.
    The Medical letter on drugs and therapeutics, 1990, Aug-10, Volume: 32, Issue:824

    Topics: Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Humans; Interferon Type I; Recombinant Proteins; Virus Diseases; Zidovudine

1990
Clinical experience with zidovudine for patients with acquired immune deficiency syndrome and acquired immune deficiency syndrome-related complex.
    The Journal of infection, 1989, Volume: 18 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; AIDS-Related Complex; Bone Marrow; Brain Diseases; Dapsone; Ganciclovir; HIV Antigens; HIV Core Protein p24; Humans; Meningoencephalitis; Muscular Diseases; Neuropsychological Tests; Opportunistic Infections; Respiratory Function Tests; Retroviridae Proteins; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Zidovudine

1989
Intravitreous ganciclovir for patients receiving zidovudine.
    JAMA, 1987, Jun-12, Volume: 257, Issue:22

    Topics: Acyclovir; Adult; Antiviral Agents; Cytomegalovirus Infections; Ganciclovir; Humans; Injections; Male; Retinitis; Thymidine; Vitreous Body; Zidovudine

1987
Prolonged pancytopenia due to combined ganciclovir and zidovudine therapy.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:2

    Topics: Acyclovir; Antiviral Agents; Drug Therapy, Combination; Ganciclovir; Humans; Male; Middle Aged; Pancytopenia; Thymidine; Zidovudine

1988
[Plasma exchange in polyradiculoneuritis in AIDS].
    Annales de medecine interne, 1988, Volume: 139 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Ganciclovir; HIV Seropositivity; Humans; Male; Middle Aged; Plasma Exchange; Polyradiculoneuropathy; Zidovudine

1988
Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:3

    Topics: Acyclovir; Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Ganciclovir; Hematopoietic Stem Cells; Humans; Thymidine; Zidovudine

1987
Antiviral agents.
    Mayo Clinic proceedings, 1987, Volume: 62, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Herpes Simplex; Humans; Idoxuridine; Influenza A virus; Influenza, Human; Ribavirin; Rimantadine; Thymidine; Vidarabine; Viruses; Zidovudine

1987
In vitro effects of stem-cell factor or interleukin-3 on myelosuppression associated with AIDS.
    AIDS (London, England), 1994, Volume: 8, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Bone Marrow Diseases; Cell Division; Colony-Forming Units Assay; Erythroid Precursor Cells; Ganciclovir; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Interferon alpha-2; Interferon-alpha; Interleukin-3; Macrophages; Recombinant Proteins; Stem Cell Factor; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Zidovudine

1994
Efficacy of ganciclovir in combination with zidovudine against cytomegalovirus in vitro and in vivo. Freitas, V.R., Fraser-Smith, E.B., Chiu, S., Michelson, S. and Schatzman, R.C. (1993) Antiviral Res. 21, 301-315.
    Antiviral research, 1994, Volume: 24, Issue:4

    Topics: Cytomegalovirus; Cytomegalovirus Infections; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Ganciclovir; Humans; Zidovudine

1994
Efficacy of ganciclovir in combination with zidovudine against cytomegalovirus in vitro and in vivo.
    Antiviral research, 1993, Volume: 21, Issue:4

    Topics: Animals; Cytomegalovirus; Cytomegalovirus Infections; Dose-Response Relationship, Drug; Drug Combinations; Female; Ganciclovir; Herpesviridae Infections; Humans; Mice; Muromegalovirus; Regression Analysis; Zidovudine

1993
Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs.
    Antiviral research, 1995, Volume: 28, Issue:2

    Topics: Antiviral Agents; Base Sequence; Cell Line; Cytomegalovirus; Drug Interactions; Foscarnet; Ganciclovir; HIV-1; Humans; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; RNA, Viral; Thionucleotides; Virus Replication; Zalcitabine; Zidovudine

1995
Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:7

    Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cohort Studies; Cytomegalovirus Retinitis; Foscarnet; Ganciclovir; HIV Infections; HIV-1; Humans; Immune Tolerance; Incidence; Male; Pneumonia, Pneumocystis; Prevalence; Survival Rate; Zidovudine

1996
[Action of drugs based on native DNA against RNA and DNA containing viruses].
    Klinicheskaia meditsina, 1995, Volume: 73, Issue:6

    Topics: Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Ganciclovir; HIV; Humans; Interferon Inducers; Mice; RNA, Double-Stranded; RNA, Fungal; Simplexvirus; Zidovudine

1995
Two candidates for a live AIDS vaccine emerge.
    Lancet (London, England), 1996, Sep-14, Volume: 348, Issue:9029

    Topics: Acquired Immunodeficiency Syndrome; AIDS Vaccines; Animals; Ganciclovir; HIV-1; Humans; Macaca mulatta; Mice; Vaccines, Attenuated; Zidovudine

1996
Pharmacokinetics of oral ganciclovir capsules in HIV-infected persons.
    AIDS (London, England), 1996, Volume: 10 Suppl 4

    Topics: Anti-HIV Agents; Antiviral Agents; Area Under Curve; Biological Availability; Clinical Trials as Topic; Didanosine; Drug Interactions; Drug Therapy, Combination; Ganciclovir; HIV Infections; Humans; Zidovudine

1996
Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.
    Antiviral research, 1997, Volume: 35, Issue:3

    Topics: Acyclovir; Cell Line; Dose-Response Relationship, Drug; Ganciclovir; Genetic Therapy; Growth Inhibitors; Herpesvirus 1, Human; HIV-1; Humans; Hydroxyurea; Nucleosides; Stavudine; Substrate Specificity; T-Lymphocytes; Thymidine Kinase; Zalcitabine; Zidovudine

1997
Chronic multifocal retinal infiltrates in patients infected with human immunodeficiency virus.
    American journal of ophthalmology, 1998, Volume: 125, Issue:3

    Topics: Acyclovir; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chronic Disease; Fundus Oculi; Ganciclovir; HIV Infections; Humans; Male; Middle Aged; Retinal Diseases; Syndrome; Uveitis; Visual Acuity; Zidovudine

1998
Anemia and survival in HIV infection.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1998, Sep-01, Volume: 19, Issue:1

    Topics: Adult; Anemia; Anti-HIV Agents; Anti-Infective Agents; Blood Transfusion; Erythropoietin; Female; Ganciclovir; Hemoglobins; HIV Infections; Humans; Incidence; Longitudinal Studies; Male; Prognosis; Proportional Hazards Models; Risk Factors; Survival Analysis; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine

1998
Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication.
    Antiviral chemistry & chemotherapy, 1998, Volume: 9, Issue:3

    Topics: Acyclovir; Antiviral Agents; Cell Line; DNA Replication; DNA, Viral; Ganciclovir; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Molecular Structure; Nucleic Acid Hybridization; Nucleosides; Nucleotides; Organophosphonates; Purines; Virus Replication; Zidovudine

1998
Treatment of AIDS-related primary central nervous system lymphoma with zidovudine, ganciclovir, and interleukin 2.
    AIDS research and human retroviruses, 1999, May-20, Volume: 15, Issue:8

    Topics: Adolescent; Adult; Anti-HIV Agents; Apoptosis; Brain Neoplasms; Drug Therapy, Combination; Female; Ganciclovir; Humans; Interleukin-2; Lymphoma, AIDS-Related; Male; Treatment Outcome; Tumor Cells, Cultured; Zidovudine

1999
Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.
    Journal of virology, 2000, Volume: 74, Issue:2

    Topics: Antiviral Agents; Cell Line; Deoxyribonucleosides; Diphosphates; Ganciclovir; Herpesvirus 1, Human; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Nucleoside-Phosphate Kinase; Open Reading Frames; Phosphorylation; Recombinant Fusion Proteins; Substrate Specificity; Thymidine Kinase; Tritium; Zidovudine

2000
Survival differences associated with treatment of cytomegalovirus retinitis in Maryland patients with AIDS, 1987-1994.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Jul-01, Volume: 56, Issue:13

    Topics: Adult; Age Factors; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Cytomegalovirus Retinitis; Drug Therapy, Combination; Female; Foscarnet; Ganciclovir; Humans; Male; Maryland; Retrospective Studies; Risk Factors; Sex Factors; Zidovudine

1999
Drug combination treats brain cancer.
    AIDS patient care and STDs, 1999, Volume: 13, Issue:12

    Topics: Anti-HIV Agents; Brain Neoplasms; CD4 Lymphocyte Count; Drug Therapy, Combination; Epstein-Barr Virus Infections; Ganciclovir; HIV Infections; Humans; Interleukin-2; Lymphoma, AIDS-Related; Radiotherapy, Adjuvant; Treatment Outcome; Zidovudine

1999
The bystander effect mediated by the new murine gammaherpesvirus 72--thymidine kinase/5'-fluoro-2'-deoxyuridine (MHV72-TK/5-FUdR) system in vitro.
    Antiviral chemistry & chemotherapy, 2000, Volume: 11, Issue:4

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Death; Cell Survival; Coculture Techniques; Dose-Response Relationship, Drug; Floxuridine; Gammaherpesvirinae; Ganciclovir; Herpesvirus 1, Human; Mice; Nucleosides; Prodrugs; Rats; Reverse Transcriptase Polymerase Chain Reaction; Thymidine Kinase; Transfection; Tumor Cells, Cultured; Zidovudine

2000
Colorimetric determination of inhibition of hematopoietic progenitor cells in soft agar.
    Journal of immunological methods, 2000, Oct-20, Volume: 244, Issue:1-2

    Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Antiviral Agents; Colony-Forming Units Assay; Colony-Stimulating Factors; Colorimetry; Coloring Agents; Cytarabine; Cytokines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluorouracil; Ganciclovir; Growth Inhibitors; Hematopoietic Stem Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Tetrazolium Salts; Thiazoles; Zidovudine

2000
Activation of lytic Epstein-Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: a potential method for treating EBV-positive malignancies.
    Cancer research, 2000, Oct-15, Volume: 60, Issue:20

    Topics: Animals; Antiviral Agents; B-Lymphocytes; Biotransformation; Burkitt Lymphoma; Butyrates; Cell Death; Cell Line, Transformed; Epstein-Barr Virus Infections; Ganciclovir; Herpesvirus 4, Human; Humans; Lymphocytes; Mice; Mice, SCID; Neoplasms, Experimental; Stomach Neoplasms; Tumor Virus Infections; Virus Activation; Xenograft Model Antitumor Assays; Zidovudine

2000
Combination treatment and single drugs: interview with Margaret Poscher, M.D. Interview by John S. James.
    AIDS treatment news, 1995, Jul-07, Issue:no 226

    Topics: Acyclovir; Administration, Oral; Antiviral Agents; CD4 Lymphocyte Count; Didanosine; Drug Administration Schedule; Drug Resistance, Microbial; Drug Therapy, Combination; Ganciclovir; HIV Infections; Humans; Lamivudine; Stavudine; Zalcitabine; Zidovudine

1995
New combination for brain cancer.
    TreatmentUpdate, 1999, Aug-01, Volume: 11, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials as Topic; Ganciclovir; Humans; Interleukin-2; Lymphoma; Treatment Outcome; Zidovudine

1999
Acyclovir, ganciclovir, and zidovudine transfer into rat milk.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:6

    Topics: Acyclovir; Animals; Anti-HIV Agents; Antiviral Agents; Chromatography, High Pressure Liquid; Female; Ganciclovir; Infusions, Intravenous; Lactation; Milk; Rats; Rats, Sprague-Dawley; Zidovudine

2002
Interleukin-2, ganciclovir, and high-dose zidovudine for the treatment of AIDS-associated primary central nervous system lymphoma.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, Jun-15, Volume: 34, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Antineoplastic Agents; Central Nervous System Neoplasms; Drug Therapy, Combination; Ganciclovir; Humans; Interleukin-2; Lymphoma, AIDS-Related; Male; Treatment Refusal; Zidovudine

2002
A case of flare syndrome.
    Le infezioni in medicina, 2001, Volume: 9, Issue:3

    Topics: Acute Disease; Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; Cidofovir; Cytomegalovirus Retinitis; Cytosine; Drug Therapy, Combination; Ganciclovir; HIV Infections; Humans; Indinavir; Lamivudine; Male; Organophosphonates; Organophosphorus Compounds; Zidovudine

2001
[Cytomegalovirus retinitis after highly active antiretroviral therapy: a case report].
    Archivos de la Sociedad Espanola de Oftalmologia, 2002, Volume: 77, Issue:9

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; Cytomegalovirus Retinitis; Didanosine; Ganciclovir; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Male; Retinal Hemorrhage; Reverse Transcriptase Inhibitors; Risk; Saquinavir; Stavudine; Substance Abuse, Intravenous; Zidovudine

2002
Multiple relapses of human cytomegalovirus retinitis during HAART in an AIDS patient with reconstitution of CD4+ T cell count in the absence of HCMV-specific CD4+ T cell response.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2003, Volume: 26, Issue:1

    Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cytomegalovirus Retinitis; Didanosine; Follow-Up Studies; Ganciclovir; HIV Protease Inhibitors; Humans; Lamivudine; Lymphocyte Activation; Male; Nevirapine; Recurrence; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine

2003
Pharmacokinetics of intravenous acyclovir, zidovudine, and acyclovir-zidovudine in pregnant rats.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:3

    Topics: Acyclovir; Amniotic Fluid; Animals; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Combinations; Female; Ganciclovir; Injections, Intravenous; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Zidovudine

2003
Experimental treatment of Epstein-Barr virus-associated primary central nervous system lymphoma.
    Cancer research, 2003, Mar-01, Volume: 63, Issue:5

    Topics: Animals; Antiviral Agents; Brain Neoplasms; Combined Modality Therapy; Epstein-Barr Virus Infections; Ganciclovir; Herpesvirus 4, Human; Humans; Kidney Transplantation; Lymphoma, B-Cell; Male; Middle Aged; Rats; RNA, Messenger; Thymidine Kinase; Up-Regulation; Xenograft Model Antitumor Assays; Zidovudine

2003
Synthesis and antiviral activity of novel C-methyl branched cyclopropyl nucleosides.
    Archives of pharmacal research, 2003, Volume: 26, Issue:9

    Topics: Adenine; Antiviral Agents; Crystallography, X-Ray; Cyclization; Cyclopropanes; Cytomegalovirus; Cytotoxicity Tests, Immunologic; Ganciclovir; Herpesvirus 1, Human; HIV-1; Korea; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Purine Nucleosides; Purines; Ribavirin; Zidovudine

2003
Successful treatment of CMV ventriculitis immune reconstitution syndrome.
    Journal of neurology, neurosurgery, and psychiatry, 2005, Volume: 76, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; CD4 Antigens; Cerebral Ventricles; Cytomegalovirus Infections; Female; Ganciclovir; Humans; Injections, Intravenous; Magnetic Resonance Imaging; Pneumocystis carinii; Pneumocystis Infections; Pneumonia, Bacterial; Zidovudine

2005
Phagocytosis of human retinal pigment epithelial cells: evidence of a diurnal rhythm, involvement of the cytoskeleton and interference of antiviral drugs.
    Ophthalmic research, 2006, Volume: 38, Issue:3

    Topics: Actins; Acyclovir; Antiviral Agents; Cells, Cultured; Circadian Rhythm; Cytoskeletal Proteins; Cytoskeleton; Europium; Fluorescent Dyes; Ganciclovir; Humans; Microspheres; Phagocytosis; Pigment Epithelium of Eye; Zidovudine

2006
Hypoxia enhances the phosphorylation and cytotoxicity of ganciclovir and zidovudine in Kaposi's sarcoma-associated herpesvirus infected cells.
    Cancer research, 2007, Jul-15, Volume: 67, Issue:14

    Topics: Antiviral Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Synergism; Ganciclovir; Herpesviridae; Humans; Hypoxia; Mass Spectrometry; Phosphorylation; Sarcoma, Kaposi; Tumor Cells, Cultured; Zidovudine

2007