zidovudine has been researched along with ganciclovir in 107 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 10 (9.35) | 18.7374 |
1990's | 52 (48.60) | 18.2507 |
2000's | 31 (28.97) | 29.6817 |
2010's | 13 (12.15) | 24.3611 |
2020's | 1 (0.93) | 2.80 |
Authors | Studies |
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Bennett, SM; Nguyen-Ba, N; Ogilvie, KK | 1 |
Clement, J; Erickson, J; Hayashi, S; Herrin, T; Kern, E; Norbeck, DW; Plattner, JJ; Rosenbrook, W; Sham, H; Swanson, R | 1 |
Drach, JC; Kern, ER; Krawczyk, SH; Kucera, LS; Nassiri, MR; Ptak, RG; Townsend, LB; Wotring, LL | 1 |
Andrei, G; Balzarini, J; Blache, Y; Chapat, JP; Chavignon, O; De Clercq, E; Debouzy, JC; Elhakmaoui, A; Essassi, EM; Gueiffier, A; Kerbal, A; Lhassani, M; Snoeck, R; Teulade, JC; Witvrouw, M | 1 |
Balzarini, J; De Clercq, E; Faraj, A; Fedorov, II; Gosselin, G; Gurskaya, GV; Imbach, JL; Jasko, MV; Kazmina, EM; Sommadossi, JP; Zavodnic, VE | 1 |
Breitenbach, JM; Cheng, YC; Drach, JC; Fan, BY; Kern, ER; Ksebati, MB; Lin, JS; Ptak, RG; Qiu, YL; Zemlicka, J | 1 |
Jeong, LS; Yoo, SJ | 1 |
Andrei, G; De Clercq, E; Dimas, K; Foscolos, GB; Fytas, G; Kolocouris, A; Kolocouris, N; Pannecouque, C; Snoeck, R; Stamatiou, G; Witvrouw, M; Zoidis, G | 1 |
Cha, SH; Endou, H; Khamdang, S; Kimura, H; Kobayashi, Y; Narikawa, S; Sekine, T; Takeda, M; Yamamoto, T | 1 |
Cheng, YC; Drach, JC; Gullen, E; Kern, ER; Matsumi, S; Mitsuya, H; Zemlicka, J; Zhou, S | 1 |
Balzarini, J; Barral, K; Camplo, M; De Clercq, E; Hider, RC; Neyts, J | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Cheng, YC; Drach, JC; Gullen, E; Kern, ER; Mitsuya, H; Tamiya, S; Zemlicka, J; Zhou, S | 1 |
Alvarez, K; Balzarini, J; Barral, K; Canard, B; Neyts, J; Priet, S; Sire, J | 1 |
Hong, JH; Kim, A | 1 |
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Kesel, AJ | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Çapan, G; Cihan-Üstündağ, G; Gürsoy, E; Naesens, L; Ulusoy-Güzeldemirci, N | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
Andrei, G; Buckheit, RW; De Jonghe, S; Groaz, E; Hartman, T; Herdewijn, P; Kalkeri, R; Luo, M; Ptak, RG; Schols, D; Snoeck, R | 1 |
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
Koziel, MJ; Walker, BD | 1 |
Skolnik, PR | 1 |
Foerster, M; Kastner, U; Neubert, R | 1 |
Morris, DJ | 2 |
Ruutu, P | 1 |
Hsiung, GD; Medina, DJ; Mellors, JW | 1 |
Cox, SW; Wahren, B | 1 |
Anderson, S; Beck, EJ; Coker, R; Coleman, D; Harris, JR; Main, J; Migdal, C; Peters, BS; Pinching, AJ | 1 |
Alton, NK; Baldwin, G; Glaspy, JA; Miles, SA; Mitsuyasu, RT; Moreno, J; Souza, L | 1 |
Causey, D | 1 |
Dieterich, DT; Rahmin, M | 1 |
Crumpacker, C; Finberg, RW; Heagy, W; Lopez, PA | 1 |
Baguley, WA; Nassiri, MR; Prichard, LE; Prichard, MN; Shipman, C | 1 |
Knight, DR; Shaw, DR; Sommadossi, JP; Waterman, AL | 1 |
Gil, A; Lavilla, P; López Dupla, JM; Pintado, V; Valencia, ME | 1 |
De Clercq, E | 1 |
Bozzette, S; Connor, JD; Dieterich, D; Hochster, H; Liebes, L; Pettinelli, C; Reichman, RC; Sonke, RL; Spector, SA; Valentine, F | 1 |
Marsh, R; Millar, AB; Miller, RF; Mindel, A; Patou, G; Semple, SJ | 1 |
Balzarini, J; Bron, D; De Clercq, E; Delforge, A; Lagneaux, L; Snoeck, R; Stryckmans, P; Van der Auwera, P | 1 |
Bryson, YJ | 1 |
Gor, D; Helbert, M; Janes, K; Jeffries, DJ; Kocsis, AE; Mitchell, D; Peddle, B; Pinching, AJ; Robinson, D; Stoneham, C | 1 |
Jacobson, MA; O'Donnell, JJ | 1 |
Nightingale, SC | 1 |
Hartung, HP; Heininger, K; Toyka, KV | 1 |
Cantrill, H; Henry, K; Kish, MA | 1 |
Blum, MR; de Miranda, P; Gordon, SM; Jacobson, MA; Mills, J; Volberding, P | 1 |
Chevalier, A; Norol, F; Picard, C; Schaeffer, A; Sobel, A | 1 |
Carlisle, R; Sommadossi, JP | 1 |
Cockerill, FR; Hermans, PE | 1 |
Groopman, JE; Scadden, DT; Wang, A; Zsebo, KM | 1 |
Anderson, R; Davis, G; Drew, WL; Lalezari, J; Lang, W; Miner, RC | 1 |
Crumpacker, C; Freeman, W; Hardy, D; Heinemann, MH; Holland, G; Klystra, J; Polsky, B; Sharuk, G; Spector, S; van der Horst, C | 1 |
Prichard, MW; Shipman, C | 1 |
Chiu, S; Fraser-Smith, EB; Freitas, VR; Michelson, S; Schatzman, RC | 1 |
Albrecht, H; Dietrich, M; Garweg, J; Knospe, V; Olszowski, W; Plettenberg, A; Stellbrink, HJ; Stoehr, A; Weitner, L | 1 |
Baird, BF; Davey, RT; deSmet, MD; Falloon, J; Kovacs, JA; Masur, H; Mellow, S; Nussenblatt, RB; Palestine, AG; Polis, MA | 1 |
Anderson, KP; Azad, RF; Brown-Driver, V; Buckheit, RW | 1 |
Detels, RR; Hoover, DR; Peng, Y; Phair, JP; Rinaldo, CR; Saah, A; Semba, R | 1 |
Kalnina, LB; Kaplina, EN; Lavrukhina, LA; Nosik, DN; Nosik, NN; Vaĭnberg, IP | 1 |
Rowe, PM | 1 |
Griffy, KG | 1 |
Chiang, Y; Drake, RR; Govindarajan, R; Hume, SD; Krisa, S; McMasters, R; Munshi, NC; Rechtin, TM; Saylors, RL | 1 |
Casserella, S; Cimoch, PJ; Griffy, KG; Jung, D; Lavelle, J; Pollard, R; Tarnowski, TL; Wong, R | 1 |
Davis, JL; Friedberg, DN; Holland, GN; Levinson, RD; Lindley, JI; Terry, BT; Tufail, A; Vann, R | 1 |
Chaisson, RE; Keruly, JC; Moore, RD | 1 |
De Clercq, E; Holý, A; Meerbach, A; Neyts, J; Wutzler, P | 1 |
Bubl, R; Di Gallo, A; Engelcke, G; Rinaldi, D; Rohrer, T; Rudin, C | 1 |
Byrne, GE; Cabral, L; Cai, JP; Harrington, WJ; Hurley, J; Jayaweera, D; Landy, H; Raez, L; Scerpella, E; Sfakianakis, G | 1 |
Fingeroth, JD; Gustafson, EA; Schinazi, RF | 1 |
Bareta, J; Hidalgo, J; Rhee, W; Steidl, S; Wutoh, AK | 1 |
Berebbi, M; Kudelova, M; Macakova, K; Matis, J; Raslova, H; Rezuchova, I | 1 |
Horowitz, D; King, AG | 1 |
Blackstock, W; Feng, W; Israel, B; Kenney, SC; Westphal, EM | 1 |
Poscher, M | 1 |
Alcorn, J; McNamara, PJ | 1 |
Aboulafia, DM | 1 |
Di Perri, G; Maiello, A; Quario, M; Racca, D; Sinicco, A; Zeme, DA | 1 |
Aldamiz-Etxebarría, M; Andonegui Navarro, J | 1 |
Baldanti, F; Galloni, D; Gerna, G; Lilleri, D; Piccinini, G; Seminari, E | 1 |
Bartlett, MG; Brown, SD; White, CA | 1 |
Baiocchi, RA; Barth, RF; Bhatt, D; Caligiuri, MA; Eisenbeis, CF; Ferketich, A; Grecula, J; Gupta, N; Moeschberger, M; Nuovo, GJ; Peng, R; Porcu, P; Roychowdhury, S; Schmalbrock, P; Vourganti, S; Yang, W | 1 |
Choi, BG; Hong, JH; Kwak, EY; Park, Y | 1 |
Gupta, SK; Janowicz, DM; Johnson, RM | 1 |
Frick, M; Geiger, M; Gottinger, W; Haas, G; Huemer, HP; Irschick, EU; Konwalinka, G; Ritsch-Marte, M; Singer, W | 1 |
Caligiuri, MA | 1 |
Davis, DA; Haque, M; Reynolds, IP; Singer, KE; Yarchoan, R | 1 |
Aleman, K; Little, RF; Marshall, V; O'Mahony, D; Pittaluga, S; Polizzotto, MN; Steinberg, SM; Tosato, G; Uldrick, TS; Wang, V; Whitby, D; Wyvill, KM; Yarchoan, R | 1 |
Polizzotto, MN; Uldrick, TS; Yarchoan, R | 1 |
Lurain, K; Uldrick, TS; Yarchoan, R | 1 |
15 review(s) available for zidovudine and ganciclovir
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Viruses, chemotherapy and immunity.
Topics: Acyclovir; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Infections; Drug Resistance, Microbial; Ganciclovir; Herpesviridae Infections; HIV Infections; HIV-1; Humans; Immunity, Cellular; Interferons; Major Histocompatibility Complex; Virus Diseases; Zidovudine | 1992 |
[Antiviral drugs].
Topics: Acyclovir; Antiviral Agents; Ganciclovir; Humans; Immunocompromised Host; Interferon-alpha; Virus Diseases; Zidovudine | 1991 |
Concomitant ganciclovir and zidovudine treatment for cytomegalovirus retinitis in patients with HIV infection: an approach to treatment.
Topics: Cytomegalovirus Infections; Drug Therapy, Combination; Eye Infections, Viral; Ganciclovir; HIV Infections; Humans; Opportunistic Infections; Retinitis; Zidovudine | 1991 |
[Drug surveillance for adverse reactions in patients with human immunodeficiency virus infection].
Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Antitubercular Agents; Drug-Related Side Effects and Adverse Reactions; Ganciclovir; HIV Infections; Humans; Opportunistic Infections; Pentamidine; Product Surveillance, Postmarketing; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine | 1990 |
New acquisitions in the chemotherapy of viral infections.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Chemical Phenomena; Chemistry; Cytomegalovirus Infections; Ganciclovir; Humans; Zidovudine | 1990 |
Promising new antiviral drugs.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Herpes Simplex; Herpes Zoster; Humans; Interferons; Phosphonoacetic Acid; Ribavirin; Thymidine; Zidovudine | 1988 |
Cotton-wool spots and cytomegalovirus retinitis in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Cytomegalovirus Infections; Diabetic Retinopathy; Diagnosis, Differential; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Pneumonia, Pneumocystis; Prognosis; Retinal Diseases; Retinitis; Zidovudine | 1989 |
[Neuromuscular manifestations of HIV-1 and HTLV-I infections].
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adrenal Cortex Hormones; Capsaicin; Carbamazepine; Demyelinating Diseases; Ganciclovir; HIV-1; HTLV-I Infections; Humans; Muscular Diseases; Neuritis; Neuromuscular Diseases; Peripheral Nervous System Diseases; Polyneuropathies; Zidovudine | 1988 |
Adverse effects and drug interactions of clinical importance with antiviral drugs.
Topics: Acyclovir; AIDS-Related Opportunistic Infections; Amantadine; Antiviral Agents; Didanosine; Drug Interactions; Foscarnet; Ganciclovir; Humans; Interferon-alpha; Ribavirin; Rimantadine; Vidarabine; Zalcitabine; Zidovudine | 1994 |
Increased survival of a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis who received sodium phosphonoformate (foscarnet).
Topics: Acquired Immunodeficiency Syndrome; Cohort Studies; Cytomegalovirus Infections; Didanosine; Drug Tolerance; Follow-Up Studies; Foscarnet; Ganciclovir; Humans; Infusions, Intravenous; Injections, Intravenous; Retinitis; Survival Rate; Time Factors; Zidovudine | 1993 |
Combined treatment with zidovudine, lamivudine, nelfinavir and ganciclovir in an infant with human immunodeficiency virus type 1 infection and cytomegalovirus encephalitis: case report and review of the literature.
Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Cytomegalovirus Infections; Diseases in Twins; Drug Therapy, Combination; Encephalitis, Viral; Female; Ganciclovir; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Lamivudine; Nelfinavir; Zidovudine | 1999 |
Recent advances in the treatment of transplant-related lymphoma.
Topics: Antiviral Agents; Burkitt Lymphoma; Female; Ganciclovir; Humans; Immunotherapy; Kidney Transplantation; Male; Pancreas Transplantation; Zidovudine | 2006 |
Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease.
Topics: Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Castleman Disease; Ganciclovir; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Rituximab; Valganciclovir; Zidovudine | 2012 |
Treatment of Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease.
Topics: Biopsy; Castleman Disease; Doxorubicin; Ganciclovir; Herpesvirus 8, Human; Humans; Interleukin-6; Lymph Nodes; Rituximab; Valganciclovir; Zidovudine | 2018 |
10 trial(s) available for zidovudine and ganciclovir
Article | Year |
---|---|
Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; CD4-Positive T-Lymphocytes; Cytomegalovirus Infections; Drug Therapy, Combination; Drug Tolerance; Foscarnet; Ganciclovir; Humans; Leukocyte Count; Phosphonoacetic Acid; Random Allocation; Retinitis; Zidovudine | 1992 |
Cytomegalovirus colitis in AIDS: presentation in 44 patients and a review of the literature.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cecum; Colitis; Colon; Cytomegalovirus Infections; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Fever; Ganciclovir; Humans; Male; Prospective Studies; Recurrence; Weight Loss; Zidovudine | 1991 |
Toxicity of combined ganciclovir and zidovudine for cytomegalovirus disease associated with AIDS. An AIDS Clinical Trials Group Study.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Anemia; Chemical and Drug Induced Liver Injury; Cytomegalovirus Infections; Drug Therapy, Combination; Female; Ganciclovir; Humans; Leukopenia; Male; Middle Aged; Multicenter Studies as Topic; Neutropenia; Prospective Studies; Time Factors; Vomiting; Zidovudine | 1990 |
From the Food and Drug Administration.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Anemia; Antiviral Agents; Clinical Trials as Topic; Cytomegalovirus Infections; Erythropoietin; Ganciclovir; Humans; Zidovudine | 1989 |
Failure of high-dose oral acyclovir to suppress CMV viruria or induce ganciclovir-resistant CMV in HIV antibody positive patients.
Topics: Acyclovir; Administration, Oral; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Drug Resistance, Microbial; Drug Therapy, Combination; Fibroblasts; Follow-Up Studies; Ganciclovir; HIV Seropositivity; Humans; Zidovudine | 1995 |
Combination of ganciclovir and granulocyte-macrophage colony-stimulating factor in the treatment of cytomegalovirus retinitis in AIDS patients. The ACTG 073 Team.
Topics: Adult; AIDS-Related Opportunistic Infections; Cytomegalovirus Retinitis; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Ganciclovir; Granulocyte-Macrophage Colony-Stimulating Factor; HIV Infections; Humans; Male; Neutropenia; Prognosis; Zidovudine | 1994 |
[Secondary prevention of cytomegalovirus retinitis with ganciclovir].
Topics: Adult; AIDS-Related Opportunistic Infections; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Ganciclovir; Humans; Male; Recurrence; Retinitis; Retrospective Studies; Zidovudine | 1993 |
Increased survival of a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis who received sodium phosphonoformate (foscarnet).
Topics: Acquired Immunodeficiency Syndrome; Cohort Studies; Cytomegalovirus Infections; Didanosine; Drug Tolerance; Follow-Up Studies; Foscarnet; Ganciclovir; Humans; Infusions, Intravenous; Injections, Intravenous; Retinitis; Survival Rate; Time Factors; Zidovudine | 1993 |
Pharmacokinetics of oral ganciclovir alone and in combination with zidovudine, didanosine, and probenecid in HIV-infected subjects.
Topics: Administration, Oral; Adult; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Didanosine; Drug Interactions; Female; Ganciclovir; Half-Life; HIV Infections; Humans; Male; Probenecid; Renal Agents; Zidovudine | 1998 |
High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy.
Topics: Adult; Anti-HIV Agents; Castleman Disease; Drug Therapy, Combination; Female; Ganciclovir; Herpesviridae Infections; Herpesvirus 8, Human; HIV Infections; Humans; Male; Middle Aged; Pilot Projects; Prodrugs; Protein Kinase Inhibitors; Protein Kinases; Survival Analysis; Valganciclovir; Viral Load; Viral Proteins; Virus Activation; Zidovudine | 2011 |
83 other study(ies) available for zidovudine and ganciclovir
Article | Year |
---|---|
Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogues.
Topics: Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidine Nucleosides; Pyrroles; Simplexvirus | 1990 |
Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Guanine; Herpesviridae; HIV; Humans; Mice; Microbial Sensitivity Tests | 1990 |
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
Topics: Antibiotics, Antineoplastic; Antiviral Agents; Arabinonucleosides; Cytomegalovirus; Herpesvirus 1, Human; HIV; Humans; KB Cells; Pyrimidine Nucleosides; Toyocamycin | 1995 |
Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; HeLa Cells; Humans; Nucleosides; Pyridines; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured; Vero Cells | 1996 |
Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.
Topics: Antiviral Agents; Crystallography, X-Ray; Dideoxynucleosides; HIV-1; HIV-2; Humans; Isomerism; Models, Chemical; Models, Molecular; Structure-Activity Relationship; Thymidine; Virus Replication | 1997 |
(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.
Topics: Adenosine; Animals; Anti-HIV Agents; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Cyclopropanes; Guanosine; Hepatitis B virus; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Mice; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Spectrophotometry, Infrared; Vero Cells; Virus Replication | 1998 |
Synthesis and antiviral activity of novel isodideoxy nucleosides with exocyclic methylene.
Topics: Acyclovir; Antiviral Agents; Cell Survival; Cytomegalovirus; Dideoxynucleosides; Drug Design; Ganciclovir; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Hydrocarbons; Indicators and Reagents; Methane; Microbial Sensitivity Tests; Structure-Activity Relationship; Xylose; Zidovudine | 1998 |
New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
Topics: Bacteria; Cell Division; Cell Line; Formazans; Humans; Hydrazones; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Tetrazolium Salts; Thiosemicarbazones; Tumor Cells, Cultured; Viruses | 2002 |
Human organic anion transporters and human organic cation transporters mediate renal antiviral transport.
Topics: Acyclovir; Anti-HIV Agents; Antiviral Agents; Biological Transport; Cells, Cultured; Ganciclovir; Humans; Kidney; Kinetics; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; Renal Agents; Zidovudine | 2002 |
(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.
Topics: Adenosine Deaminase; Antiviral Agents; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 4, Human; Nucleosides; Virus Replication | 2004 |
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives.
Topics: Animals; Antiviral Agents; Cell Line; Cell Proliferation; Chlorocebus aethiops; Deferiprone; HeLa Cells; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; HIV-2; Humans; Ligands; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Pyridones; Structure-Activity Relationship; Vero Cells | 2006 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Topics: Adenine; Adenosine Deaminase; Antiviral Agents; Cyclopropanes; Cytomegalovirus; Cytopathogenic Effect, Viral; Guanine; Hepatitis B virus; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV-1; Humans; Purine Nucleosides; Stereoisomerism; Structure-Activity Relationship; Viral Plaque Assay | 2006 |
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Boranes; Boron Compounds; Chlorocebus aethiops; DNA Viruses; HIV-1; Humans; In Vitro Techniques; Nucleosides; Organophosphonates; Phosphates; RNA Viruses; Structure-Activity Relationship; Vero Cells; Virus Replication | 2006 |
Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides.
Topics: Antiviral Agents; Cells, Cultured; Cyclopropanes; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV; Humans; Hydrocarbons, Fluorinated; Microbial Sensitivity Tests; Molecular Structure; Nucleosides | 2007 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Broad-spectrum antiviral activity including human immunodeficiency and hepatitis C viruses mediated by a novel retinoid thiosemicarbazone derivative.
Topics: Anti-Bacterial Agents; Benzaldehydes; Cell Line, Tumor; Chromatography, Thin Layer; Cytomegalovirus; Hepacivirus; Herpesvirus 3, Human; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Retinoids; Stereoisomerism; Structure-Activity Relationship; Thiosemicarbazones | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones.
Topics: Animals; Antiviral Agents; Cats; Cells, Cultured; Chlorocebus aethiops; DNA Viruses; Dogs; Dose-Response Relationship, Drug; HeLa Cells; Humans; Indoles; Madin Darby Canine Kidney Cells; Microbial Sensitivity Tests; Molecular Structure; RNA Viruses; Semicarbazides; Structure-Activity Relationship; Thiazolidines; Vero Cells; Virus Replication | 2016 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Cell Line; Cytomegalovirus; Drug Resistance, Viral; Drug Stability; Esters; Hepatitis B virus; Herpesvirus 3, Human; Humans; Hydrogen-Ion Concentration; Microsomes, Liver; Nucleosides; Organophosphonates; Prodrugs; Stereoisomerism; Structure-Activity Relationship | 2017 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Treatment of CMV retinitis.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Drug Therapy, Combination; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Retinitis; Zidovudine | 1992 |
Effect of six virustatic nucleoside analogues on the development of fetal rat thymus in organ culture.
Topics: Animals; Antiviral Agents; Cell Differentiation; Cell Division; Cells, Cultured; Didanosine; Female; Flow Cytometry; Ganciclovir; Immunity, Cellular; Male; Nucleotides; Organ Culture Techniques; Pregnancy; Rats; Rats, Wistar; Thymus Gland; Vidarabine; Zalcitabine; Zidovudine | 1992 |
Treatment of CMV retinitis.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Viral; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Retinitis; Zidovudine | 1992 |
Ganciclovir antagonizes the anti-human immunodeficiency virus type 1 activity of zidovudine and didanosine in vitro.
Topics: Didanosine; Drug Interactions; Ganciclovir; HIV-1; Zidovudine | 1992 |
Treatment of CMV retinitis.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Synergism; Drug Therapy, Combination; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Zidovudine | 1992 |
Cytomegalovirus infection in AIDS. Patterns of disease, response to therapy and trends in survival.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Colitis; Cytomegalovirus Infections; Female; Foscarnet; Ganciclovir; Humans; London; Male; Neutropenia; Opportunistic Infections; Phosphonoacetic Acid; Prevalence; Recurrence; Retinitis; Retrospective Studies; Survival Rate; Thrombocytopenia; Zidovudine | 1991 |
Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Blood Cell Count; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Erythropoietin; Ganciclovir; Gene Products, gag; Granulocyte Colony-Stimulating Factor; Hemoglobins; HIV; HIV Core Protein p24; Humans; Injections, Subcutaneous; Neutropenia; Opportunistic Infections; Recombinant Proteins; Viral Core Proteins; Virus Replication; Zidovudine | 1991 |
Inhibition of immune functions by antiviral drugs.
Topics: Acyclovir; Antiviral Agents; Cell Cycle; Cells, Cultured; Concanavalin A; Didanosine; DNA; Ganciclovir; Humans; Immunity; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Proteins; Ribavirin; Zidovudine | 1991 |
Three-dimensional analysis of the synergistic cytotoxicity of ganciclovir and zidovudine.
Topics: Cell Division; Cell Survival; Drug Evaluation, Preclinical; Drug Synergism; Ganciclovir; Humans; KB Cells; Tumor Cells, Cultured; Zidovudine | 1991 |
3'-Azido-3'-deoxythymidine inhibition of human lymphocyte cytolytic function in vitro.
Topics: Acyclovir; Cell Survival; Cells, Cultured; Cytotoxicity Tests, Immunologic; Ganciclovir; Humans; Interleukin-2; Phenotype; Recombinant Proteins; T-Lymphocytes, Cytotoxic; Zidovudine | 1991 |
Treatment of cytomegalovirus retinitis with zidovudine and ganciclovir in patients with AIDS: outcome and toxicity.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cytomegalovirus Infections; Drug Therapy, Combination; Ganciclovir; Humans; Male; Middle Aged; Opportunistic Infections; Retinitis; Zidovudine | 1990 |
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro.
Topics: Adenine; Adult; Antiviral Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cidofovir; Cytomegalovirus; Cytosine; Foscarnet; Ganciclovir; Granulocytes; Hematopoietic Stem Cells; HIV; Humans; Macrophages; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Zidovudine | 1990 |
Drugs for viral infections.
Topics: Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Humans; Interferon Type I; Recombinant Proteins; Virus Diseases; Zidovudine | 1990 |
Clinical experience with zidovudine for patients with acquired immune deficiency syndrome and acquired immune deficiency syndrome-related complex.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; AIDS-Related Complex; Bone Marrow; Brain Diseases; Dapsone; Ganciclovir; HIV Antigens; HIV Core Protein p24; Humans; Meningoencephalitis; Muscular Diseases; Neuropsychological Tests; Opportunistic Infections; Respiratory Function Tests; Retroviridae Proteins; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Zidovudine | 1989 |
Intravitreous ganciclovir for patients receiving zidovudine.
Topics: Acyclovir; Adult; Antiviral Agents; Cytomegalovirus Infections; Ganciclovir; Humans; Injections; Male; Retinitis; Thymidine; Vitreous Body; Zidovudine | 1987 |
Prolonged pancytopenia due to combined ganciclovir and zidovudine therapy.
Topics: Acyclovir; Antiviral Agents; Drug Therapy, Combination; Ganciclovir; Humans; Male; Middle Aged; Pancytopenia; Thymidine; Zidovudine | 1988 |
[Plasma exchange in polyradiculoneuritis in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Ganciclovir; HIV Seropositivity; Humans; Male; Middle Aged; Plasma Exchange; Polyradiculoneuropathy; Zidovudine | 1988 |
Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro.
Topics: Acyclovir; Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Ganciclovir; Hematopoietic Stem Cells; Humans; Thymidine; Zidovudine | 1987 |
Antiviral agents.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Herpes Simplex; Humans; Idoxuridine; Influenza A virus; Influenza, Human; Ribavirin; Rimantadine; Thymidine; Vidarabine; Viruses; Zidovudine | 1987 |
In vitro effects of stem-cell factor or interleukin-3 on myelosuppression associated with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Bone Marrow Diseases; Cell Division; Colony-Forming Units Assay; Erythroid Precursor Cells; Ganciclovir; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Interferon alpha-2; Interferon-alpha; Interleukin-3; Macrophages; Recombinant Proteins; Stem Cell Factor; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Zidovudine | 1994 |
Efficacy of ganciclovir in combination with zidovudine against cytomegalovirus in vitro and in vivo. Freitas, V.R., Fraser-Smith, E.B., Chiu, S., Michelson, S. and Schatzman, R.C. (1993) Antiviral Res. 21, 301-315.
Topics: Cytomegalovirus; Cytomegalovirus Infections; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Ganciclovir; Humans; Zidovudine | 1994 |
Efficacy of ganciclovir in combination with zidovudine against cytomegalovirus in vitro and in vivo.
Topics: Animals; Cytomegalovirus; Cytomegalovirus Infections; Dose-Response Relationship, Drug; Drug Combinations; Female; Ganciclovir; Herpesviridae Infections; Humans; Mice; Muromegalovirus; Regression Analysis; Zidovudine | 1993 |
Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs.
Topics: Antiviral Agents; Base Sequence; Cell Line; Cytomegalovirus; Drug Interactions; Foscarnet; Ganciclovir; HIV-1; Humans; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; RNA, Viral; Thionucleotides; Virus Replication; Zalcitabine; Zidovudine | 1995 |
Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cohort Studies; Cytomegalovirus Retinitis; Foscarnet; Ganciclovir; HIV Infections; HIV-1; Humans; Immune Tolerance; Incidence; Male; Pneumonia, Pneumocystis; Prevalence; Survival Rate; Zidovudine | 1996 |
[Action of drugs based on native DNA against RNA and DNA containing viruses].
Topics: Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Ganciclovir; HIV; Humans; Interferon Inducers; Mice; RNA, Double-Stranded; RNA, Fungal; Simplexvirus; Zidovudine | 1995 |
Two candidates for a live AIDS vaccine emerge.
Topics: Acquired Immunodeficiency Syndrome; AIDS Vaccines; Animals; Ganciclovir; HIV-1; Humans; Macaca mulatta; Mice; Vaccines, Attenuated; Zidovudine | 1996 |
Pharmacokinetics of oral ganciclovir capsules in HIV-infected persons.
Topics: Anti-HIV Agents; Antiviral Agents; Area Under Curve; Biological Availability; Clinical Trials as Topic; Didanosine; Drug Interactions; Drug Therapy, Combination; Ganciclovir; HIV Infections; Humans; Zidovudine | 1996 |
Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.
Topics: Acyclovir; Cell Line; Dose-Response Relationship, Drug; Ganciclovir; Genetic Therapy; Growth Inhibitors; Herpesvirus 1, Human; HIV-1; Humans; Hydroxyurea; Nucleosides; Stavudine; Substrate Specificity; T-Lymphocytes; Thymidine Kinase; Zalcitabine; Zidovudine | 1997 |
Chronic multifocal retinal infiltrates in patients infected with human immunodeficiency virus.
Topics: Acyclovir; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chronic Disease; Fundus Oculi; Ganciclovir; HIV Infections; Humans; Male; Middle Aged; Retinal Diseases; Syndrome; Uveitis; Visual Acuity; Zidovudine | 1998 |
Anemia and survival in HIV infection.
Topics: Adult; Anemia; Anti-HIV Agents; Anti-Infective Agents; Blood Transfusion; Erythropoietin; Female; Ganciclovir; Hemoglobins; HIV Infections; Humans; Incidence; Longitudinal Studies; Male; Prognosis; Proportional Hazards Models; Risk Factors; Survival Analysis; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine | 1998 |
Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication.
Topics: Acyclovir; Antiviral Agents; Cell Line; DNA Replication; DNA, Viral; Ganciclovir; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Molecular Structure; Nucleic Acid Hybridization; Nucleosides; Nucleotides; Organophosphonates; Purines; Virus Replication; Zidovudine | 1998 |
Treatment of AIDS-related primary central nervous system lymphoma with zidovudine, ganciclovir, and interleukin 2.
Topics: Adolescent; Adult; Anti-HIV Agents; Apoptosis; Brain Neoplasms; Drug Therapy, Combination; Female; Ganciclovir; Humans; Interleukin-2; Lymphoma, AIDS-Related; Male; Treatment Outcome; Tumor Cells, Cultured; Zidovudine | 1999 |
Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.
Topics: Antiviral Agents; Cell Line; Deoxyribonucleosides; Diphosphates; Ganciclovir; Herpesvirus 1, Human; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Nucleoside-Phosphate Kinase; Open Reading Frames; Phosphorylation; Recombinant Fusion Proteins; Substrate Specificity; Thymidine Kinase; Tritium; Zidovudine | 2000 |
Survival differences associated with treatment of cytomegalovirus retinitis in Maryland patients with AIDS, 1987-1994.
Topics: Adult; Age Factors; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Cytomegalovirus Retinitis; Drug Therapy, Combination; Female; Foscarnet; Ganciclovir; Humans; Male; Maryland; Retrospective Studies; Risk Factors; Sex Factors; Zidovudine | 1999 |
Drug combination treats brain cancer.
Topics: Anti-HIV Agents; Brain Neoplasms; CD4 Lymphocyte Count; Drug Therapy, Combination; Epstein-Barr Virus Infections; Ganciclovir; HIV Infections; Humans; Interleukin-2; Lymphoma, AIDS-Related; Radiotherapy, Adjuvant; Treatment Outcome; Zidovudine | 1999 |
The bystander effect mediated by the new murine gammaherpesvirus 72--thymidine kinase/5'-fluoro-2'-deoxyuridine (MHV72-TK/5-FUdR) system in vitro.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Death; Cell Survival; Coculture Techniques; Dose-Response Relationship, Drug; Floxuridine; Gammaherpesvirinae; Ganciclovir; Herpesvirus 1, Human; Mice; Nucleosides; Prodrugs; Rats; Reverse Transcriptase Polymerase Chain Reaction; Thymidine Kinase; Transfection; Tumor Cells, Cultured; Zidovudine | 2000 |
Colorimetric determination of inhibition of hematopoietic progenitor cells in soft agar.
Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Antiviral Agents; Colony-Forming Units Assay; Colony-Stimulating Factors; Colorimetry; Coloring Agents; Cytarabine; Cytokines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluorouracil; Ganciclovir; Growth Inhibitors; Hematopoietic Stem Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Tetrazolium Salts; Thiazoles; Zidovudine | 2000 |
Activation of lytic Epstein-Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: a potential method for treating EBV-positive malignancies.
Topics: Animals; Antiviral Agents; B-Lymphocytes; Biotransformation; Burkitt Lymphoma; Butyrates; Cell Death; Cell Line, Transformed; Epstein-Barr Virus Infections; Ganciclovir; Herpesvirus 4, Human; Humans; Lymphocytes; Mice; Mice, SCID; Neoplasms, Experimental; Stomach Neoplasms; Tumor Virus Infections; Virus Activation; Xenograft Model Antitumor Assays; Zidovudine | 2000 |
Combination treatment and single drugs: interview with Margaret Poscher, M.D. Interview by John S. James.
Topics: Acyclovir; Administration, Oral; Antiviral Agents; CD4 Lymphocyte Count; Didanosine; Drug Administration Schedule; Drug Resistance, Microbial; Drug Therapy, Combination; Ganciclovir; HIV Infections; Humans; Lamivudine; Stavudine; Zalcitabine; Zidovudine | 1995 |
New combination for brain cancer.
Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Clinical Trials as Topic; Ganciclovir; Humans; Interleukin-2; Lymphoma; Treatment Outcome; Zidovudine | 1999 |
Acyclovir, ganciclovir, and zidovudine transfer into rat milk.
Topics: Acyclovir; Animals; Anti-HIV Agents; Antiviral Agents; Chromatography, High Pressure Liquid; Female; Ganciclovir; Infusions, Intravenous; Lactation; Milk; Rats; Rats, Sprague-Dawley; Zidovudine | 2002 |
Interleukin-2, ganciclovir, and high-dose zidovudine for the treatment of AIDS-associated primary central nervous system lymphoma.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Antineoplastic Agents; Central Nervous System Neoplasms; Drug Therapy, Combination; Ganciclovir; Humans; Interleukin-2; Lymphoma, AIDS-Related; Male; Treatment Refusal; Zidovudine | 2002 |
A case of flare syndrome.
Topics: Acute Disease; Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; Cidofovir; Cytomegalovirus Retinitis; Cytosine; Drug Therapy, Combination; Ganciclovir; HIV Infections; Humans; Indinavir; Lamivudine; Male; Organophosphonates; Organophosphorus Compounds; Zidovudine | 2001 |
[Cytomegalovirus retinitis after highly active antiretroviral therapy: a case report].
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; Cytomegalovirus Retinitis; Didanosine; Ganciclovir; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Male; Retinal Hemorrhage; Reverse Transcriptase Inhibitors; Risk; Saquinavir; Stavudine; Substance Abuse, Intravenous; Zidovudine | 2002 |
Multiple relapses of human cytomegalovirus retinitis during HAART in an AIDS patient with reconstitution of CD4+ T cell count in the absence of HCMV-specific CD4+ T cell response.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cytomegalovirus Retinitis; Didanosine; Follow-Up Studies; Ganciclovir; HIV Protease Inhibitors; Humans; Lamivudine; Lymphocyte Activation; Male; Nevirapine; Recurrence; Reverse Transcriptase Inhibitors; Stavudine; Zidovudine | 2003 |
Pharmacokinetics of intravenous acyclovir, zidovudine, and acyclovir-zidovudine in pregnant rats.
Topics: Acyclovir; Amniotic Fluid; Animals; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Combinations; Female; Ganciclovir; Injections, Intravenous; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Zidovudine | 2003 |
Experimental treatment of Epstein-Barr virus-associated primary central nervous system lymphoma.
Topics: Animals; Antiviral Agents; Brain Neoplasms; Combined Modality Therapy; Epstein-Barr Virus Infections; Ganciclovir; Herpesvirus 4, Human; Humans; Kidney Transplantation; Lymphoma, B-Cell; Male; Middle Aged; Rats; RNA, Messenger; Thymidine Kinase; Up-Regulation; Xenograft Model Antitumor Assays; Zidovudine | 2003 |
Synthesis and antiviral activity of novel C-methyl branched cyclopropyl nucleosides.
Topics: Adenine; Antiviral Agents; Crystallography, X-Ray; Cyclization; Cyclopropanes; Cytomegalovirus; Cytotoxicity Tests, Immunologic; Ganciclovir; Herpesvirus 1, Human; HIV-1; Korea; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Purine Nucleosides; Purines; Ribavirin; Zidovudine | 2003 |
Successful treatment of CMV ventriculitis immune reconstitution syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; CD4 Antigens; Cerebral Ventricles; Cytomegalovirus Infections; Female; Ganciclovir; Humans; Injections, Intravenous; Magnetic Resonance Imaging; Pneumocystis carinii; Pneumocystis Infections; Pneumonia, Bacterial; Zidovudine | 2005 |
Phagocytosis of human retinal pigment epithelial cells: evidence of a diurnal rhythm, involvement of the cytoskeleton and interference of antiviral drugs.
Topics: Actins; Acyclovir; Antiviral Agents; Cells, Cultured; Circadian Rhythm; Cytoskeletal Proteins; Cytoskeleton; Europium; Fluorescent Dyes; Ganciclovir; Humans; Microspheres; Phagocytosis; Pigment Epithelium of Eye; Zidovudine | 2006 |
Hypoxia enhances the phosphorylation and cytotoxicity of ganciclovir and zidovudine in Kaposi's sarcoma-associated herpesvirus infected cells.
Topics: Antiviral Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Synergism; Ganciclovir; Herpesviridae; Humans; Hypoxia; Mass Spectrometry; Phosphorylation; Sarcoma, Kaposi; Tumor Cells, Cultured; Zidovudine | 2007 |