Page last updated: 2024-08-23

zidovudine and floxuridine

zidovudine has been researched along with floxuridine in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.17)18.7374
1990's7 (29.17)18.2507
2000's7 (29.17)29.6817
2010's9 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Björck, L; Clausen, AR; Piskur, J; Sandrini, MP; Shannon, O1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Celewicz, L; Gajecka, M; Klich, K; Kubicka, MM; Przybylski, P; Pyta, K; Ruszkowski, P1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Celewicz, L; Kleczewska, N; Liberska, J; Ruszkowski, P; Singh, A; Trznadel, R1
Ashida, N; Baba, M; Ikeda, T; Machida, H; Sakata, S; Shigeta, S1
Kashani-Sabet, M; Scanlon, KJ; Sowers, LC1
Cloos, L; Hofbauer, R; Mortensen, BT; Munch-Petersen, B; Tyrsted, G; Völker, C1
Canupp, D; Leonard, S; Nyce, J; Schulz, S; Wong, S1
Medina, DJ; Sathya, B; Strair, RK; Tung, PP1
Abul-Hajj, YJ; Akanni, AO; Ballato, G; Chang, S; Larson, RS; McIntee, EJ; Wagner, CR1
Gao, WY; Johns, DG; Mitsuya, H; Tanaka, M1
Medina, DJ; Strair, RK; Tung, PP1
Berebbi, M; Kudelova, M; Macakova, K; Matis, J; Raslova, H; Rezuchova, I1
Akiyama, S; Baba, M; Furukawa, T; Gotanda, T; Haraguchi, M; Hongye, Z; Nakagawa, M; Sumizawa, T; Tachiwada, T; Tsuneyoshi, K1
Eklund, H; Mikkelsen, NE; Munch-Petersen, B1
Chen, CM; Dornfeld, K; Johnson, M; Smith, BJ1
Clifford, M; Czaplewski, L; Dowson, CG; Garner, RC; Hind, CK; Jackson, T; Sutton, JM1

Reviews

1 review(s) available for zidovudine and floxuridine

ArticleYear
Use of floxuridine to modulate the antiviral activity of zidovudine.
    AIDS research and human retroviruses, 1996, Jul-20, Volume: 12, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cell Line; Cell Survival; Drug Therapy, Combination; Floxuridine; Humans; Zidovudine

1996

Other Studies

23 other study(ies) available for zidovudine and floxuridine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Deoxycytidine; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Sequence Data; Nucleosides; Phosphotransferases (Alcohol Group Acceptor); Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes

2007
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Synthesis, Antibacterial, and Anticancer Evaluation of Novel Spiramycin-Like Conjugates Containing C(5) Triazole Arm.
    Journal of medicinal chemistry, 2016, 09-08, Volume: 59, Issue:17

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cycloaddition Reaction; Drug Screening Assays, Antitumor; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Models, Molecular; Solubility; Spiramycin; Structure-Activity Relationship; Thermodynamics; Triazoles

2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Synthesis and in vitro anticancer activity of new gemcitabine-nucleoside analogue dimers containing methyltriazole or ester-methyltriazole linker.
    Bioorganic & medicinal chemistry letters, 2019, 09-15, Volume: 29, Issue:18

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Deoxycytidine; Dimerization; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esters; Gemcitabine; Humans; Molecular Structure; Nucleosides; Structure-Activity Relationship; Triazoles

2019
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:1

    Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cytarabine; Drug Combinations; Floxuridine; Fluorouracil; Herpesvirus 3, Human; HIV-1; Humans; Zidovudine

1992
Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine.
    Cancer communications, 1989, Volume: 1, Issue:4

    Topics: Cell Line; Cisplatin; Colonic Neoplasms; DNA Polymerase I; DNA Polymerase II; DNA Repair; DNA Replication; Drug Resistance; Etoposide; Floxuridine; Fluorouracil; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Zidovudine

1989
Altered substrate and inhibitor specificity of purified human adult thymidine kinases (TK2) from leukemic cells.
    Advances in experimental medicine and biology, 1994, Volume: 370

    Topics: Adult; Cell Line; Floxuridine; Humans; Isoenzymes; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Reference Values; Substrate Specificity; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Zidovudine

1994
Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Apr-01, Volume: 90, Issue:7

    Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; DNA; DNA Replication; Drug Resistance; Floxuridine; Gene Expression Regulation, Enzymologic; Genome; Kinetics; Methylation; Nucleotides; Thymidine Kinase; Zidovudine

1993
Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors.
    Cancer research, 1997, Jun-15, Volume: 57, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Female; Floxuridine; Humans; Leukemia, T-Cell; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; RNA-Directed DNA Polymerase; Tumor Cells, Cultured; Zidovudine

1997
Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine.
    Molecular pharmacology, 1999, Volume: 55, Issue:3

    Topics: Anti-HIV Agents; Antimetabolites; Drug Interactions; Drug Resistance, Microbial; Drug Resistance, Multiple; Floxuridine; Fluorouracil; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidylate Synthase; Thymine Nucleotides; Virus Replication; Zidovudine

1999
Use of recombinant viruses to assess the pattern of early human immunodeficiency virus breakthrough infection in the presence of stavudine.
    The Journal of general virology, 1999, Volume: 80 ( Pt 9)

    Topics: Animals; Anti-HIV Agents; COS Cells; Defective Viruses; Floxuridine; HeLa Cells; HIV; Humans; Jurkat Cells; Leukemia Virus, Murine; Recombination, Genetic; Stavudine; Zidovudine

1999
The bystander effect mediated by the new murine gammaherpesvirus 72--thymidine kinase/5'-fluoro-2'-deoxyuridine (MHV72-TK/5-FUdR) system in vitro.
    Antiviral chemistry & chemotherapy, 2000, Volume: 11, Issue:4

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Death; Cell Survival; Coculture Techniques; Dose-Response Relationship, Drug; Floxuridine; Gammaherpesvirinae; Ganciclovir; Herpesvirus 1, Human; Mice; Nucleosides; Prodrugs; Rats; Reverse Transcriptase Polymerase Chain Reaction; Thymidine Kinase; Transfection; Tumor Cells, Cultured; Zidovudine

2000
Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity.
    Cancer letters, 2006, Dec-08, Volume: 244, Issue:2

    Topics: Antimetabolites; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Transfection; U937 Cells; Zidovudine

2006
Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
    The FEBS journal, 2008, Volume: 275, Issue:9

    Topics: Adenosine Diphosphate; Animals; Antimetabolites; Bromodeoxyuridine; Cytarabine; Cytidine Triphosphate; Drosophila melanogaster; Drosophila Proteins; Feedback; Floxuridine; Guanosine Triphosphate; Hydrogen Bonding; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship; Thymine Nucleotides; X-Ray Diffraction; Zalcitabine; Zidovudine

2008
Azidothymidine enhances fluorodeoxyuridine-mediated radiosensitization.
    International journal of radiation oncology, biology, physics, 2010, Mar-01, Volume: 76, Issue:3

    Topics: Antimetabolites; Cell Cycle; Cell Line, Tumor; Cell Survival; Colony-Forming Units Assay; Deoxyuracil Nucleotides; DNA Breaks, Single-Stranded; DNA Damage; DNA Mismatch Repair; Drug Synergism; Flow Cytometry; Floxuridine; Humans; MutS Homolog 2 Protein; Poisson Distribution; Radiation Tolerance; Thymidine; Thymine Nucleotides; Zidovudine

2010
Evaluation of a Library of FDA-Approved Drugs for Their Ability To Potentiate Antibiotics against Multidrug-Resistant Gram-Negative Pathogens.
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:8

    Topics: Anti-Bacterial Agents; Didanosine; Drug Resistance, Multiple, Bacterial; Ethanolamines; Floxuridine; Gram-Negative Bacteria; Microbial Sensitivity Tests; Mitoxantrone; Zidovudine

2019