Page last updated: 2024-08-23

zidovudine and antipyrine

zidovudine has been researched along with antipyrine in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (42.11)18.2507
2000's8 (42.11)29.6817
2010's3 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Jolivette, LJ; Ward, KW1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Campillo, NE; Guerra, A; Páez, JA1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Brockmeyer, NH; Goos, M; Mertins, L; Spatz, D; Tillmann, I1
Henderson, GI; Johnson, RF; King, TS; Schenken, RS; Schenker, S1
Hamby, RL; Henderson, GI; Perez, AB; Schenken, RS; Schenker, S; Yang, Y1
al-Habet, S; Ravasco, RJ; Tuntland, T; Unadkat, JD1
Baughman, WL; Massarella, J; Nosbisch, C; Tuntland, T; Unadkat, JD1
Blaschke, T; Campbell, TB; Collier, A; Kahn, J; Kuritzkes, DR; Messari, F; Phair, J; Pottage, JC; Rosandich, ME; Schooley, RT; Stein, DS1
Barthel, B; Brockmeyer, NH; Goos, M; Mertins, L; Tillmann, I1
Nosbisch, C; Odinecs, A; Tuntland, T; Unadkat, JD1

Trials

1 trial(s) available for zidovudine and antipyrine

ArticleYear
Phase 1 study of combination therapy with L-697,661 and zidovudine. The ACTG 184 Protocol Team.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Aug-01, Volume: 12, Issue:4

    Topics: Adult; Antipyrine; Antiviral Agents; Base Sequence; Benzoxazoles; Cross-Over Studies; DNA Primers; DNA, Viral; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Genes, pol; Genotype; HIV Seropositivity; HIV-1; Humans; Male; Molecular Sequence Data; Pilot Projects; Pyridones; Reverse Transcriptase Inhibitors; Zidovudine

1996

Other Studies

18 other study(ies) available for zidovudine and antipyrine

ArticleYear
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Endogenous interferon plasma levels and antipyrine pharmacokinetics in patients with viral infections.
    International journal of clinical pharmacology, therapy, and toxicology, 1992, Volume: 30, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antipyrine; Female; Humans; Interferons; Male; Radioimmunoassay; Respiratory Tract Infections; Virus Diseases; Zidovudine

1992
Azidothymidine (zidovudine) transport by the human placenta.
    The American journal of the medical sciences, 1990, Volume: 299, Issue:1

    Topics: Antipyrine; Biological Transport; Female; Humans; Kinetics; Placenta; Pregnancy; Zidovudine

1990
Transfer of dideoxyinosine across the human isolated placenta.
    British journal of clinical pharmacology, 1994, Volume: 38, Issue:3

    Topics: Antipyrine; Biological Transport; Chromatography, High Pressure Liquid; Didanosine; Female; Glucose; Humans; Hydrogen-Ion Concentration; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Uric Acid; Zidovudine

1994
Efflux of zidovudine and 2',3'-dideoxyinosine out of the cerebrospinal fluid when administered alone and in combination to Macaca nemestrina.
    Pharmaceutical research, 1994, Volume: 11, Issue:2

    Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Didanosine; Drug Interactions; Female; Macaca nemestrina; Male; Zidovudine

1994
Mechanism and rate of placental transfer of zalcitabine (2',3'-dideoxycytidine) in Macaca nemestrina.
    American journal of obstetrics and gynecology, 1996, Volume: 174, Issue:3

    Topics: Amniotic Fluid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Antiviral Agents; Cattle; Cross-Over Studies; Drug Interactions; Female; Fetal Blood; Macaca nemestrina; Placenta; Pregnancy; Random Allocation; Zalcitabine; Zidovudine

1996
Pharmacokinetic interaction of fluconazole and zidovudine in HIV-positive patients.
    European journal of medical research, 1997, Sep-29, Volume: 2, Issue:9

    Topics: 17-Hydroxycorticosteroids; Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antifungal Agents; Antipyrine; Candidiasis, Oral; Drug Interactions; Drug Therapy, Combination; Fluconazole; Half-Life; Humans; Hydrocortisone; Male; Zidovudine

1997
In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:1

    Topics: Amniotic Fluid; Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Female; Fetal Blood; Macaca nemestrina; Maternal-Fetal Exchange; Metabolic Clearance Rate; Pregnancy; Zidovudine

1998