ziconotide and zopiclone

A 50-year-old female patient with chronic neuropathic pain in the distribution of the second branch of the trigeminal nerve was unsuccessfully treated over several years. Intrathecal therapy with ziconotide was administered at an initial dose of 0.33 microg/d, which was gradually increased by 0.7 microg/d. Subjective pain on the numeric rating scale was reduced from 9/10 to 3-4/10 at a dose of 6.3 microg/d. Long-term treatment was continued at a ziconotide concentration of 12.5 microg/mL and a daily dose of 3.9 microg/d by a SynchroMed Infusion System (Medtronic, Minneapolis, MN). Pain reduction was maintained in the follow-up observation period over 5 months.

Topics: Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Azabicyclo Compounds; Calcium Channel Blockers; Female; Humans; Hypnotics and Sedatives; Injections, Spinal; Long-Term Care; Middle Aged; omega-Conotoxins; Pain Measurement; Peripheral Nervous System Diseases; Piperazines; Trigeminal Neuralgia

Topics: Acamprosate; Adenine Nucleotides; Alcohol Deterrents; Amyloid; Analgesics, Non-Narcotic; Anti-HIV Agents; Antifungal Agents; Antineoplastic Agents; Aptamers, Nucleotide; Arabinonucleosides; Azabicyclo Compounds; Benzofurans; Clofarabine; Drug Approval; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Echinocandins; Exenatide; Fibroblast Growth Factor 7; Guanine; Humans; Hypoglycemic Agents; Islet Amyloid Polypeptide; Lipopeptides; Lipoproteins; Macular Degeneration; Micafungin; omega-Conotoxins; Patient Education as Topic; Peptides; Peptides, Cyclic; Piperazines; Pyrrolidines; Quinuclidines; Solifenacin Succinate; Stomatitis; Taurine; Tetrahydroisoquinolines; Urinary Incontinence; Venoms

Topics: Adenine Nucleotides; Adolescent; Adult; Aptamers, Nucleotide; Arabinonucleosides; Azabicyclo Compounds; Child; Child, Preschool; Clofarabine; Contraindications; Diethylcarbamazine; Dosage Forms; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Humans; Iloprost; Infant; Meglumine; Middle Aged; Oligonucleotides; omega-Conotoxins; Organometallic Compounds; Piperazines; Saquinavir; Trypan Blue