Page last updated: 2024-09-05

zeneca zd 6169 and nifedipine

zeneca zd 6169 has been researched along with nifedipine in 4 studies

Compound Research Comparison

Studies
(zeneca zd 6169)
Trials
(zeneca zd 6169)
Recent Studies (post-2010)
(zeneca zd 6169)
Studies
(nifedipine)
Trials
(nifedipine)
Recent Studies (post-2010) (nifedipine)
420316,0242,4961,505

Protein Interaction Comparison

ProteinTaxonomyzeneca zd 6169 (IC50)nifedipine (IC50)
perilipin-5Homo sapiens (human)7.133
perilipin-1Homo sapiens (human)9.619
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)8.376
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.0429
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.035
Cytochrome P450 1A2Homo sapiens (human)0.3
Cytochrome P450 3A4Homo sapiens (human)10
Adenosine receptor A3Homo sapiens (human)7.214
Cytochrome P450 2C9 Homo sapiens (human)3.06
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)10
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)7.214
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.0385
Potassium voltage-gated channel subfamily A member 5Homo sapiens (human)6.1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Rattus norvegicus (Norway rat)1.12
Adenosine receptor A1Homo sapiens (human)7.701
3-oxo-5-alpha-steroid 4-dehydrogenase 2Rattus norvegicus (Norway rat)1.12
C-C chemokine receptor type 2Homo sapiens (human)2.191
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)7.214
Cytochrome P450 2J2Homo sapiens (human)3.06
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.4733
Voltage-dependent L-type calcium channel subunit alpha-1CMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.035
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.0394
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.02
Potassium channel subfamily K member 2 Bos taurus (cattle)8.2
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)1.5
Voltage-dependent L-type calcium channel subunit alpha-1DMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1FMus musculus (house mouse)1.2

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Ikawa, S; Ito, Y; Naito, S; Seki, N; Takano, N; Tanaka, K; Teramoto, N; Yunoki, T1
Brioni, JD; Brune, ME; Carroll, WA; Coghlan, MJ; Fey, TA; Gopalakrishnan, M; Sullivan, JP; Williams, M1
Calzadilla, SV; Cox, BF; Fryer, RM; Gopalakrishnan, M; Hu, Y; Lin, CT; Marsh, KC; Preusser, LC; Reinhart, GA; Xu, H1

Other Studies

4 other study(ies) available for zeneca zd 6169 and nifedipine

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
The involvement of L-type Ca(2+) channels in the relaxant effects of the ATP-sensitive K(+) channel opener ZD6169 on pig urethral smooth muscle.
    British journal of pharmacology, 2001, Volume: 134, Issue:7

    Topics: Adenosine Triphosphate; Amides; Animals; Barium; Benzophenones; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gene Expression; Glyburide; In Vitro Techniques; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Nifedipine; Potassium Channels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Urethra

2001
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. II. in vivo characterization.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1

    Topics: Amides; Animals; ATP-Binding Cassette Transporters; Benzophenones; Cyclic S-Oxides; Cyclobutanes; Ion Channel Gating; KATP Channels; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitriles; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinolones; Swine; Urinary Bladder

2002
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine.
    Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:2

    Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Blood Pressure; Cyclic S-Oxides; Cyclobutanes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Heart Rate; Hypotension; Infusions, Intravenous; Ion Channel Gating; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitriles; Pharmaceutical Vehicles; Polyethylene Glycols; Potassium Channels; Quinolones; Tachycardia; Urinary Bladder; Urinary Incontinence; Vascular Resistance

2004