zeneca zd 6169 has been researched along with glyburide in 9 studies
| Studies (zeneca zd 6169) | Trials (zeneca zd 6169) | Recent Studies (post-2010) (zeneca zd 6169) | Studies (glyburide) | Trials (glyburide) | Recent Studies (post-2010) (glyburide) |
|---|---|---|---|---|---|
| 42 | 0 | 3 | 6,554 | 620 | 1,344 |
| Protein | Taxonomy | zeneca zd 6169 (IC50) | glyburide (IC50) |
|---|---|---|---|
| ATP-binding cassette sub-family C member 9 | Homo sapiens (human) | 0.22 | |
| Bile salt export pump | Rattus norvegicus (Norway rat) | 5.7 | |
| Bile salt export pump | Homo sapiens (human) | 5.5333 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 1.602 | |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | 0.0043 | |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | 0.1121 | |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | 10 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 1.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Do, ML; Empfield, JR; Halterman, TJ; Howe, BB; Ohnmacht, CJ; Pettinger, SJ; Russell, K; Stow, RB; Trainor, DA; Yochim, CL | 1 |
| Bonev, A; Heppner, TJ; Kau, ST; Li, JH; Nelson, MT | 1 |
| de Groat, WC; Yu, Y | 1 |
| Jow, B; Numann, R | 1 |
| Bonev, AD; Heppner, TJ; Herrera, GM; Nelson, MT; Petkov, GV | 1 |
| Brading, AF; Ito, Y; Masaki, I; Sueishi, K; Takano, M; Teramoto, N; Yonemitsu, Y; Yunoki, T | 1 |
| Ikawa, S; Ito, Y; Naito, S; Seki, N; Takano, N; Tanaka, K; Teramoto, N; Yunoki, T | 1 |
| de Groat, WC; Fraser, MO; Yu, Y | 1 |
9 other study(ies) available for zeneca zd 6169 and glyburide
| Article | Year |
|---|---|
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
ZENECA ZD6169: a novel KATP channel opener with in vivo selectivity for urinary bladder.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Male; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Urinary Bladder | 1995 |
Zeneca ZD6169 activates ATP-sensitive K+ channels in the urinary bladder of the guinea pig.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Enzyme Activation; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Muscle, Smooth; Potassium Channels; Protein Kinase C; Pyrroles; Urinary Bladder | 1996 |
Effects of ZD6169, a K(ATP) channel opener, on the micturition reflex in the rat.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Capsaicin; Female; Glyburide; Hypoglycemic Agents; Mechanoreceptors; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pressure; Rats; Rats, Wistar; Reflex; Urinary Bladder; Urination; Urodynamics | 1999 |
The effects of ZD6169 on the ATP-dependent K(+) current (I(K)(ATP)) in isolated cat ventricular myocytes.
Topics: Action Potentials; Amides; Animals; Antihypertensive Agents; ATP-Binding Cassette Transporters; Benzophenones; Cats; Cell Separation; Cromakalim; Glyburide; Heart Ventricles; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Myocardium; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying | 1999 |
Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Amides; Animals; Benzophenones; Cromakalim; Glyburide; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Urinary Bladder | 2001 |
Dual action of ZD6169, a novel K(+) channel opener, on ATP-sensitive K(+) channels in pig urethral myocytes.
Topics: Adenosine Triphosphate; Amides; Animals; Anti-Arrhythmia Agents; Benzophenones; Cells, Cultured; COS Cells; Cromakalim; Electric Conductivity; Female; Glyburide; Hypoglycemic Agents; Imidazoles; Ion Channel Gating; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Swine; Time Factors; Urethra; Vasodilator Agents | 2001 |
The involvement of L-type Ca(2+) channels in the relaxant effects of the ATP-sensitive K(+) channel opener ZD6169 on pig urethral smooth muscle.
Topics: Adenosine Triphosphate; Amides; Animals; Barium; Benzophenones; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gene Expression; Glyburide; In Vitro Techniques; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Nifedipine; Potassium Channels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Urethra | 2001 |
Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves.
Topics: Acetic Acid; Amides; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Benzophenones; Blood Proteins; Capsaicin; Drug Interactions; Electric Stimulation; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Female; Glyburide; Membrane Proteins; Neurons, Afferent; Potassium Channels; Rats; Rats, Wistar; Stimulation, Chemical; Urethra; Urinary Bladder | 2004 |