Compounds > zeneca zd 6169
Page last updated: 2024-09-05

zeneca zd 6169 and cromakalim

zeneca zd 6169 has been researched along with cromakalim in 13 studies

Compound Research Comparison

Studies
(zeneca zd 6169)		Trials
(zeneca zd 6169)		Recent Studies (post-2010)
(zeneca zd 6169)		Studies
(cromakalim)		Trials
(cromakalim)		Recent Studies (post-2010) (cromakalim)
42031,3882079
42034403

Protein Interaction Comparison

ProteinTaxonomyzeneca zd 6169 (IC50)cromakalim (IC50)
ATP-binding cassette sub-family C member 9Homo sapiens (human)0.57
ATP-binding cassette sub-family C member 8Homo sapiens (human)0.57
ATP-sensitive inward rectifier potassium channel 11Homo sapiens (human)0.57
ATP-sensitive inward rectifier potassium channel 8Homo sapiens (human)0.57

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (46.15)18.2507
2000's7 (53.85)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Altenbach, RJ; Bai, H; Brioni, JD; Brune, ME; Buckner, SA; Carroll, WA; Cassidy, C; Chen, Y; Coghlan, MJ; Daza, AV; Drizin, I; Fey, TA; Fitzgerald, M; Gopalakrishnan, M; Gregg, RJ; Henry, RF; Holladay, MW; King, LL; Kort, ME; Kym, PR; Milicic, I; Sullivan, JP; Tang, R; Turner, SC; Whiteaker, KL; Yi, L; Zhang, H1
Altenbach, RJ; Brune, ME; Buckner, SA; Carroll, WA; Coghlan, MJ; Daza, AV; Fabiyi, A; Gopalakrishnan, M; Henry, RF; Khilevich, A; Kort, ME; Milicic, I; Scott, VE; Smith, JC; Whiteaker, KL1
Brown, FJ; Empfield, J; Li, JH; McConville, M; Ohnmacht, CJ; Potter-Lee, L; Russell, K; Stetz, SL; Trainor, DA; Trivedi, S1
Do, ML; Empfield, JR; Halterman, TJ; Howe, BB; Ohnmacht, CJ; Pettinger, SJ; Russell, K; Stow, RB; Trainor, DA; Yochim, CL1
Bertelsen, DL; Chun, A; Kau, S; Levin, RM; Murphy, J1
Bonev, A; Heppner, TJ; Kau, ST; Li, JH; Nelson, MT1
Jow, B; Numann, R1
Bonev, AD; Heppner, TJ; Herrera, GM; Nelson, MT; Petkov, GV1
Brading, AF; Ito, Y; Masaki, I; Sueishi, K; Takano, M; Teramoto, N; Yonemitsu, Y; Yunoki, T1
Brioni, JD; Brune, ME; Coghlan, MJ; Fabiyi, AC; Gopalakrishnan, M; Lynch, JJ1
Brune, ME; Buckner, SA; Coghlan, M; Daza, A; Fey, TA; Gopalakrishnan, M; Milicic, I1
Brown, FJ; Ceccarelli, C; Chun, AL; Empfield, JR; Forst, JM; Frank, CA; Gibson, KH; Grant, TL; Harris, RJ; Howe, BB; Hulsizer, JM; Kau, ST; Lewis, JJ; Lin, MM; Masek, BB; Mayhugh, DR; McLaren, FM; Neilson, KL; Ohnmacht, CJ; Russell, K; Shapiro, HS; Silverman, SM; Smith, RW; Trainor, DA; Warwick, PJ1
Brune, ME; Buckner, SA; Carroll, WA; Castle, NA; Coghlan, MJ; Daza, AV; Fabiyi, A; Gopalakrishnan, M; Milicic, I; Scott, VE; Sullivan, JP; Turner, SC; White, TK1

Other Studies

13 other study(ies) available for zeneca zd 6169 and cromakalim

ArticleYear
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)
    Journal of medicinal chemistry, 2004, Jun-03, Volume: 47, Issue:12

    Topics: Adenosine Triphosphate; Animals; Cyclic S-Oxides; Electric Stimulation; Guinea Pigs; Hemodynamics; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Quinolones; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder; Urodynamics

2004
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
    Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23

    Topics: Adenosine Triphosphate; Animals; Aza Compounds; Cell Line; Crystallography, X-Ray; Dihydropyridines; Electric Stimulation; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Ion Channel Gating; Mice; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels, Inwardly Rectifying; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder

2006
K-channel opening activity of ZD6169 and its analogs: effect on 86Rb efflux and 3H-P1075 binding in bladder smooth muscle.
    Pharmacology, 1995, Volume: 50, Issue:6

    Topics: Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Kinetics; Muscle, Smooth; Potassium Channels; Pyridines; Pyrroles; Rubidium; Urinary Bladder; Vasodilator Agents

1995
ZENECA ZD6169: a novel KATP channel opener with in vivo selectivity for urinary bladder.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2

    Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Male; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Urinary Bladder

1995
Comparative effects of intravesical versus extravesical administration of ZD6169 and cromakalim on the response of the in vitro rat whole bladder to field stimulation.
    Pharmacology, 1996, Volume: 52, Issue:6

    Topics: Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder

1996
Zeneca ZD6169 activates ATP-sensitive K+ channels in the urinary bladder of the guinea pig.
    Pharmacology, 1996, Volume: 53, Issue:3

    Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Enzyme Activation; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Muscle, Smooth; Potassium Channels; Protein Kinase C; Pyrroles; Urinary Bladder

1996
The effects of ZD6169 on the ATP-dependent K(+) current (I(K)(ATP)) in isolated cat ventricular myocytes.
    European journal of pharmacology, 1999, Oct-27, Volume: 383, Issue:2

    Topics: Action Potentials; Amides; Animals; Antihypertensive Agents; ATP-Binding Cassette Transporters; Benzophenones; Cats; Cell Separation; Cromakalim; Glyburide; Heart Ventricles; Hypoglycemic Agents; In Vitro Techniques; KATP Channels; Myocardium; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying

1999
Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:5

    Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Amides; Animals; Benzophenones; Cromakalim; Glyburide; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Urinary Bladder

2001
Dual action of ZD6169, a novel K(+) channel opener, on ATP-sensitive K(+) channels in pig urethral myocytes.
    British journal of pharmacology, 2001, Volume: 133, Issue:1

    Topics: Adenosine Triphosphate; Amides; Animals; Anti-Arrhythmia Agents; Benzophenones; Cells, Cultured; COS Cells; Cromakalim; Electric Conductivity; Female; Glyburide; Hypoglycemic Agents; Imidazoles; Ion Channel Gating; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Swine; Time Factors; Urethra; Vasodilator Agents

2001
In vivo evaluation of the potency and bladder-vascular selectivity of the ATP-sensitive potassium channel openers (-)-cromakalim, ZD6169 and WAY-133537 in rats.
    BJU international, 2003, Volume: 91, Issue:3

    Topics: Amides; Animals; Benzophenones; Calcium Channels; Cromakalim; Cyclobutanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Male; Muscarinic Antagonists; Muscle Contraction; Nitriles; Rats; Rats, Sprague-Dawley; Reflex, Abnormal; Urinary Bladder; Urinary Bladder Neck Obstruction; Urinary Bladder, Neurogenic; Vasodilator Agents

2003
Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.
    European journal of pharmacology, 2006, Feb-17, Volume: 532, Issue:1-2

    Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Carbachol; Cholinergic Agonists; Cromakalim; Cyclic S-Oxides; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Histamine; Hypertrophy; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyridines; Quinolones; Serotonin; Serotonin Agents; Swine; Urinary Bladder; Urinary Bladder Neck Obstruction; Vasodilator Agents

2006
N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.
    Journal of medicinal chemistry, 1996, Nov-08, Volume: 39, Issue:23

    Topics: Amides; Animals; Cricetinae; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Rats; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence

1996
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
    Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10

    Topics: Amides; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Cell Line; Fluorescent Dyes; Humans; Hypertrophy; Male; Membrane Potentials; Muscle Contraction; Naphthalenes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Receptors; Swine; Transfection; Urinary Bladder

2003