Compounds > zd 7288
Page last updated: 2024-09-03

zd 7288 and mibefradil

zd 7288 has been researched along with mibefradil in 3 studies

Compound Research Comparison

Studies
(zd 7288)		Trials
(zd 7288)		Recent Studies (post-2010)
(zd 7288)		Studies
(mibefradil)		Trials
(mibefradil)		Recent Studies (post-2010) (mibefradil)
382013766769143

Protein Interaction Comparison

ProteinTaxonomyzd 7288 (IC50)mibefradil (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.156
Voltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)1.0476
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.333
Voltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)0.4122
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.5
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
ATP-dependent translocase ABCB1Homo sapiens (human)1.58
Cytochrome P450 3A4Homo sapiens (human)0.2575
Cytochrome P450 2D6Homo sapiens (human)0.063
Cytochrome P450 2C9 Homo sapiens (human)2.14
Sodium channel protein type 4 subunit alphaRattus norvegicus (Norway rat)0.5
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.34
ATP-dependent translocase ABCB1Mus musculus (house mouse)7.4
Sodium channel protein type 1 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 4 subunit alphaHomo sapiens (human)0.98
Cytochrome P450 2J2Homo sapiens (human)2.14
Voltage-dependent L-type calcium channel subunit beta-3Rattus norvegicus (Norway rat)1
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)0.878
Sodium channel protein type 7 subunit alphaHomo sapiens (human)0.98
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.333
Voltage-dependent N-type calcium channel subunit alpha-1BRattus norvegicus (Norway rat)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4543
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.333
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.2795
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 9 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 2 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 3 subunit alphaHomo sapiens (human)0.98
Voltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)0.4187
Sodium channel protein type 11 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 8 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 10 subunit alphaHomo sapiens (human)0.98

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berrebi, AS; Felix, RA; Fridberger, A; Leijon, S; Magnusson, AK1
Forsythe, ID; Hennig, MH; Kopp-Scheinpflug, C; Robinson, SW; Tempel, BL; Tozer, AJ1
Carr, TL; Khurana, T; Meeker, G; Pirtle, TJ1

Other Studies

3 other study(ies) available for zd 7288 and mibefradil

ArticleYear
Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Aug-31, Volume: 31, Issue:35

    Topics: Acoustic Stimulation; Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Auditory Pathways; Biophysics; Calcium; Calcium Channel Blockers; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Female; Gene Expression Regulation, Developmental; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Lidocaine; Mibefradil; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nerve Net; Neural Inhibition; Neurons; Olivary Nucleus; Periodicity; Potassium Channels; Psychoacoustics; Pyrimidines; Reaction Time; Sound; Tetrodotoxin

2011
The sound of silence: ionic mechanisms encoding sound termination.
    Neuron, 2011, Sep-08, Volume: 71, Issue:5

    Topics: Acoustic Stimulation; Action Potentials; Animals; Animals, Newborn; Auditory Pathways; Biophysics; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Chlorides; Computer Simulation; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Functional Laterality; Furosemide; Gene Expression Regulation; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channel Gating; K Cl- Cotransporters; Mibefradil; Mice; Mice, Inbred CBA; Mice, Knockout; Models, Neurological; Neurons; Olivary Nucleus; Patch-Clamp Techniques; Potassium Channels; Psychoacoustics; Pyrimidines; Reaction Time; Sodium Potassium Chloride Symporter Inhibitors; Stilbamidines; Symporters; Synaptic Potentials

2011
ZD7288 and mibefradil inhibit the myogenic heartbeat in Daphnia magna indicating its dependency on HCN and T-type calcium ion channels.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2018, Volume: 222

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cardiotonic Agents; Cyclic Nucleotide-Gated Cation Channels; Daphnia; Dose-Response Relationship, Drug; Heart Rate; Mibefradil; Pyrimidines

2018