Compounds > zd 7288
Page last updated: 2024-09-03

zd 7288 and lidocaine

zd 7288 has been researched along with lidocaine in 7 studies

Compound Research Comparison

Studies
(zd 7288)		Trials
(zd 7288)		Recent Studies (post-2010)
(zd 7288)		Studies
(lidocaine)		Trials
(lidocaine)		Recent Studies (post-2010) (lidocaine)
382013726,0905,9045,591

Protein Interaction Comparison

ProteinTaxonomyzd 7288 (IC50)lidocaine (IC50)
Sodium channel protein type 4 subunit alphaHomo sapiens (human)2

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bischoff, U; Bräu, ME; Hempelmann, G; Olschewski, A; Vogel, W1
Beck, DR; Buvanendran, A; Kroin, JS; Topic, JE; Tuman, KJ; Watts, DE1
Akar, FG; Cho, HC; Jones, SP; Li, RA; Marbán, E; Tomaselli, GF; Tsang, SY; Xue, T1
Putrenko, I; Schwarz, SK1
Berrebi, AS; Felix, RA; Fridberger, A; Leijon, S; Magnusson, AK1
Eysel, UT; Imbrosci, B; Koesling, D; Mergia, E; Mittmann, T; Neitz, A; Petrasch-Parwez, E1
Dasgupta, D; Sikdar, SK1

Other Studies

7 other study(ies) available for zd 7288 and lidocaine

ArticleYear
Local anaesthetics block hyperpolarization-activated inward current in rat small dorsal root ganglion neurones.
    British journal of pharmacology, 2003, Volume: 139, Issue:7

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Electrophysiology; Ganglia, Spinal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Inhibitory Concentration 50; Ion Channels; Lidocaine; Mepivacaine; Neurons; Potassium Channels; Pyrimidines; Rats; Tetraethylammonium; Time Factors

2003
Clonidine prolongation of lidocaine analgesia after sciatic nerve block in rats Is mediated via the hyperpolarization-activated cation current, not by alpha-adrenoreceptors.
    Anesthesiology, 2004, Volume: 101, Issue:2

    Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Clonidine; Colforsin; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; In Vitro Techniques; Ion Channels; Lidocaine; Male; Nerve Block; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sciatic Nerve

2004
Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers.
    Circulation, 2005, Jan-04, Volume: 111, Issue:1

    Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cell Differentiation; Cell Fusion; Cells, Cultured; Defective Viruses; Electrophysiology; Female; Genes, Reporter; Genetic Vectors; Giant Cells; Green Fluorescent Proteins; Guinea Pigs; Heart; Heart Conduction System; Heart Ventricles; HIV-1; Humans; Isoproterenol; Lidocaine; Mice; Myocardial Contraction; Myocytes, Cardiac; Organ Culture Techniques; Pericardium; Pluripotent Stem Cells; Pyrimidines; Rats; Transduction, Genetic

2005
Lidocaine blocks the hyperpolarization-activated mixed cation current, I(h), in rat thalamocortical neurons.
    Anesthesiology, 2011, Volume: 115, Issue:4

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Cardiovascular Agents; Cerebral Cortex; Cesium; Cyclic Nucleotide-Gated Cation Channels; Data Interpretation, Statistical; Electrophysiological Phenomena; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Interneurons; Lidocaine; Membrane Potentials; Neural Pathways; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Pyrimidines; Rats; Rats, Wistar; Thalamus

2011
Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Aug-31, Volume: 31, Issue:35

    Topics: Acoustic Stimulation; Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Auditory Pathways; Biophysics; Calcium; Calcium Channel Blockers; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Female; Gene Expression Regulation, Developmental; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Lidocaine; Mibefradil; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nerve Net; Neural Inhibition; Neurons; Olivary Nucleus; Periodicity; Potassium Channels; Psychoacoustics; Pyrimidines; Reaction Time; Sound; Tetrodotoxin

2011
Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus.
    Cerebral cortex (New York, N.Y. : 1991), 2014, Volume: 24, Issue:7

    Topics: Anesthetics, Local; Animals; Animals, Newborn; CA1 Region, Hippocampal; Cyclic GMP; Electric Stimulation; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Mice; Mice, Knockout; Neurons; Nitric Oxide; Patch-Clamp Techniques; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Tetraethylammonium

2014
Calcium permeable AMPA receptor-dependent long lasting plasticity of intrinsic excitability in fast spiking interneurons of the dentate gyrus decreases inhibition in the granule cell layer.
    Hippocampus, 2015, Volume: 25, Issue:3

    Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Biophysics; Calcium; Dentate Gyrus; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; In Vitro Techniques; Interneurons; Lidocaine; Male; Models, Neurological; Nerve Net; Patch-Clamp Techniques; Pyrimidines; Rats; Receptors, AMPA; Time Factors

2015