Page last updated: 2024-09-03

zd 7288 and gamma-aminobutyric acid

zd 7288 has been researched along with gamma-aminobutyric acid in 22 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Compound Research Comparison

Studies
(zd 7288)
Trials
(zd 7288)
Recent Studies (post-2010)
(zd 7288)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
382013740,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomyzd 7288 (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (9.09)18.2507
2000's14 (63.64)29.6817
2010's6 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lupica, CR; Svoboda, KR1
Carlen, PL; Perez Velazquez, JL; Skinner, FK; Tian, GF; Wu, CP; Zhang, L; Zhang, Y1
Aghajanian, GK; Jolas, T; Nestler, EJ1
Morris, NP; Robertson, B; Southan, AP; Stephens, GJ1
Bell, JA; Hoffman, AF; Lupica, CR; Watson, PL1
Egli, RE; Winder, DG1
Danik, M; Laplante, F; Manseau, F; Quirion, R; Sotty, F; Williams, S1
Chiu, K; Raastad, M; Soleng, AF1
Buhl, EH; Cunningham, MO; Davies, CH; Kopell, N; Whittington, MA1
Alreja, M; Datta, S; Wu, M; Xu, C1
Feuerstein, TJ; Freiman, TM; Surges, R1
Darcy, DP; Isaacson, JS; Murphy, GJ1
Bartfai, T; Behrens, M; Conti, B; Korn, H; Tabarean, IV1
Bolam, JP; Boyes, J; Shigemoto, R; Stanford, IM1
Israel, JM; Oliet, SH; Poulain, DA1
Chen, CC; Cheng, JK; Huang, YJ; Lin, CF; Lin, CS; Tsaur, ML1
Deng, PY; Lei, S; Xiao, Z1
Carloni, P; Cherubini, E; Giorgetti, A; Griguoli, M; Maul, A; Nguyen, C1
Robinson, HP; Tateno, T1
Al Otaibi, M; Djouhri, L; Sathish, J; Smith, T1
Chen, L; Mao, J; McCabe, MF; Mi, W; Shen, S; Sun, Y; Wang, S; Yang, J; Yang, L; You, Z; Zhang, S1
Fu, B; Huang, T; Liu, SJ; Wang, B; Wang, J; Weng, XC1

Other Studies

22 other study(ies) available for zd 7288 and gamma-aminobutyric acid

ArticleYear
Opioid inhibition of hippocampal interneurons via modulation of potassium and hyperpolarization-activated cation (Ih) currents.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Sep-15, Volume: 18, Issue:18

    Topics: Analgesics; Analgesics, Opioid; Animals; Baclofen; Barium; Cardiovascular Agents; Cations; Cell Size; Cells, Cultured; Cesium; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Interneurons; Male; Membrane Potentials; Potassium; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1998
Slow oscillations (
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Nov-15, Volume: 18, Issue:22

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Age Factors; Animals; Benzoates; Bicuculline; Cardiovascular Agents; Cesium; Chlorides; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junctions; Glycine; Hippocampus; Interneurons; Male; Membrane Potentials; Neural Pathways; Organ Culture Techniques; Patch-Clamp Techniques; Periodicity; Pyrimidines; Rats; Rats, Wistar; Receptors, GABA-A; Synapses; Temperature; Xanthines

1998
Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway.
    Neuroscience, 2000, Volume: 95, Issue:2

    Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cardiovascular Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Isoquinolines; Male; Membrane Potentials; Morphine; N-Methylaspartate; Neural Inhibition; Periaqueductal Gray; Phenylephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome; Sulfonamides; Sympathomimetics; Tetrazoles; Tetrodotoxin; Thionucleotides

2000
Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells.
    The Journal of physiology, 2000, Jul-01, Volume: 526 Pt 1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cardiovascular Agents; Cells, Cultured; Cerebellum; Cesium; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Interneurons; Ion Channels; Male; Membrane Potentials; Mice; Nerve Tissue Proteins; Neural Inhibition; Patch-Clamp Techniques; Potassium Channels; Presynaptic Terminals; Purkinje Cells; Pyrimidines; Receptors, AMPA

2000
Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons.
    Journal of neurophysiology, 2001, Volume: 86, Issue:1

    Topics: Animals; Cardiovascular Agents; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Ion Channel Gating; Male; Membrane Potentials; Organ Culture Techniques; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Synaptic Transmission

2001
Dorsal and ventral distribution of excitable and synaptic properties of neurons of the bed nucleus of the stria terminalis.
    Journal of neurophysiology, 2003, Volume: 90, Issue:1

    Topics: Action Potentials; Animals; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Potassium Channel Blockers; Potassium Channels; Pyrimidines; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Synaptic Transmission

2003
Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity.
    The Journal of physiology, 2003, Sep-15, Volume: 551, Issue:Pt 3

    Topics: Acetylcholine; Action Potentials; Animals; Cardiotonic Agents; Carrier Proteins; Choline O-Acetyltransferase; Electrophysiology; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamine; Hippocampus; Isoenzymes; Membrane Transport Proteins; Neurons; Periodicity; Phenotype; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Septal Nuclei; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Transport Proteins

2003
Unmyelinated axons in the rat hippocampus hyperpolarize and activate an H current when spike frequency exceeds 1 Hz.
    The Journal of physiology, 2003, Oct-15, Volume: 552, Issue:Pt 2

    Topics: Action Potentials; Animals; Axons; Cesium; Electric Stimulation; Electrophysiology; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hydrogen; In Vitro Techniques; Ion Channels; Male; Myelin Sheath; Nerve Fibers; Neural Conduction; Pyrimidines; Rats; Receptors, Presynaptic; Synapses

2003
Gamma oscillations induced by kainate receptor activation in the entorhinal cortex in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Oct-29, Volume: 23, Issue:30

    Topics: Action Potentials; Animals; Biological Clocks; Electroencephalography; Entorhinal Cortex; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Interneurons; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Theta Rhythm

2003
Hippocampal theta rhythm is reduced by suppression of the H-current in septohippocampal GABAergic neurons.
    The European journal of neuroscience, 2004, Volume: 19, Issue:8

    Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Neurons; Pyrimidines; Rats; Rats, Sprague-Dawley; Septum of Brain; Synaptic Transmission; Theta Rhythm

2004
Input resistance is voltage dependent due to activation of Ih channels in rat CA1 pyramidal cells.
    Journal of neuroscience research, 2004, May-15, Volume: 76, Issue:4

    Topics: 4-Aminopyridine; Acetates; Amines; Animals; Animals, Newborn; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Radiation; Electric Impedance; Electric Stimulation; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channel Gating; Ion Channels; Membrane Potentials; Nickel; Patch-Clamp Techniques; Potassium Channel Blockers; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar; Tetrodotoxin

2004
Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit.
    Nature neuroscience, 2005, Volume: 8, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Bicuculline; Cadmium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Chelating Agents; Dendrites; Diagnostic Imaging; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Neural Conduction; Neural Inhibition; Neural Networks, Computer; Neurons; Nickel; Nimodipine; Olfactory Bulb; Patch-Clamp Techniques; Phosphinic Acids; Potassium; Propanolamines; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors; Valine

2005
Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture.
    Neuroscience, 2005, Volume: 135, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Calcium Channel Blockers; Cells, Cultured; Electric Impedance; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamus, Anterior; Immunohistochemistry; Isoenzymes; Membrane Potentials; Mice; Microtubule-Associated Proteins; Muscimol; Neural Inhibition; Neurons; Nimodipine; Patch-Clamp Techniques; Pyrimidines; Receptors, AMPA; Sodium; Sodium Channel Blockers; Temperature; Tetrodotoxin; Valine

2005
Functional presynaptic HCN channels in the rat globus pallidus.
    The European journal of neuroscience, 2007, Volume: 25, Issue:7

    Topics: Animals; Cyclic Nucleotide-Gated Cation Channels; gamma-Aminobutyric Acid; Globus Pallidus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; Ion Channels; Male; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Potassium Channels; Presynaptic Terminals; Pyrimidines; Rats; Rats, Sprague-Dawley

2007
Oxytocin-induced postinhibitory rebound firing facilitates bursting activity in oxytocin neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Jan-09, Volume: 28, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Neural Inhibition; Neurons; Nickel; Ornipressin; Oxytocin; Picrotoxin; Pyrimidines; Rats; Rats, Wistar; Time Factors; Up-Regulation

2008
Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test.
    European journal of anaesthesiology, 2009, Volume: 26, Issue:10

    Topics: Amines; Analgesics; Animals; Cardiotonic Agents; Cyclic Nucleotide-Gated Cation Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Injections, Spinal; Male; Pain; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley

2009
Distinct modes of modulation of GABAergic transmission by Group I metabotropic glutamate receptors in rat entorhinal cortex.
    Hippocampus, 2010, Volume: 20, Issue:8

    Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Benzoates; Cardiotonic Agents; Cyclopropanes; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phenylacetates; Potassium Channel Blockers; Pyrimidines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptic Transmission; Tetraethylammonium

2010
Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Aug-11, Volume: 30, Issue:32

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Analysis of Variance; Animals; Biological Clocks; Cardiovascular Agents; Colforsin; Cyclic Nucleotide-Gated Cation Channels; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Interneurons; Male; Mecamylamine; Mice; Mice, Transgenic; Models, Biological; Models, Molecular; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Somatostatin

2010
The mechanism of ethanol action on midbrain dopaminergic neuron firing: a dynamic-clamp study of the role of I(h) and GABAergic synaptic integration.
    Journal of neurophysiology, 2011, Volume: 106, Issue:4

    Topics: Action Potentials; Animals; Cyclic Nucleotide-Gated Cation Channels; Dopamine; Dopaminergic Neurons; Ethanol; GABAergic Neurons; gamma-Aminobutyric Acid; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Interneurons; Membrane Potentials; Models, Neurological; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase; Ventral Tegmental Area

2011
Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats.
    Neuroscience, 2015, Jun-04, Volume: 295

    Topics: Amines; Animals; Axotomy; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lectins; Neuralgia; Pain Threshold; Pyrimidines; Radiculopathy; Rats; Rats, Wistar; Reaction Time; Spinal Nerves

2015
Neuropeptide S modulates the amygdaloidal HCN activities (Ih) in rats: Implication in chronic pain.
    Neuropharmacology, 2016, Volume: 105

    Topics: Amygdala; Animals; Chronic Pain; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Interneurons; Male; MAP Kinase Signaling System; Neuropeptides; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Tachykinins

2016
[Effects of HCN2 in the development of peripheral neuropathic pain in rats].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2017, Apr-08, Volume: 33, Issue:4

    Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Neuralgia; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Nerves

2017