zd 7288 has been researched along with clonidine in 9 studies
| Studies (zd 7288) | Trials (zd 7288) | Recent Studies (post-2010) (zd 7288) | Studies (clonidine) | Trials (clonidine) | Recent Studies (post-2010) (clonidine) |
|---|---|---|---|---|---|
| 382 | 0 | 137 | 13,692 | 2,044 | 1,394 |
| Protein | Taxonomy | zd 7288 (IC50) | clonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.101 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0115 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.002 | |
| Nischarin | Rattus norvegicus (Norway rat) | 0.3662 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BoSmith, RE; Briggs, I; Heapy, CG | 1 |
| BoSmith, RE; Briggs, I; Sturgess, NC | 1 |
| Bretton, C; Clergue, F; Dalle, C; Jirounek, P; Schneider, M | 1 |
| Camm, AJ; Yusuf, S | 1 |
| Beck, DR; Buvanendran, A; Kroin, JS; Topic, JE; Tuman, KJ; Watts, DE | 1 |
| Baruscotti, M; Bucchi, A; Difrancesco, D | 1 |
| Bay, KD; Garcia-Rill, E; Good, CH; Mamiya, K; Skinner, RD | 1 |
| Andrews, GD; Carr, DB; Glen, WB; Lavin, A | 1 |
| Guo, LJ; Li, CJ; Li, HG; Lv, Q; Xu, XL; Zhou, M | 1 |
2 review(s) available for zd 7288 and clonidine
| Article | Year |
|---|---|
Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Benzazepines; Calcium Channel Blockers; Clonidine; Diagnosis, Differential; Humans; Isoindoles; Ivabradine; Phthalimides; Pyrimidines; Sinoatrial Node; Tachycardia, Sinus; Vasodilator Agents; Verapamil | 2003 |
Physiology and pharmacology of the cardiac pacemaker ("funny") current.
Topics: Amino Acid Sequence; Animals; Benzazepines; Cardiovascular Agents; Clonidine; Cyclic Nucleotide-Gated Cation Channels; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Ivabradine; Nerve Tissue Proteins; Potassium Channels; Pyrimidines; Sinoatrial Node; Structure-Activity Relationship | 2005 |
7 other study(ies) available for zd 7288 and clonidine
| Article | Year |
|---|---|
Effects of Zeneca ZD7288 in comparison with alinidine and UL-FS 49 on guinea pig sinoatrial node and ventricular action potentials.
Topics: Action Potentials; Animals; Benzazepines; Cardiovascular Agents; Clonidine; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Microelectrodes; Myocardial Contraction; Papillary Muscles; Pyrimidines; Sinoatrial Node | 1994 |
Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzazepines; Cardiovascular Agents; Clonidine; Electrophysiology; Guinea Pigs; In Vitro Techniques; Ion Channels; Membrane Potentials; Pyrimidines; Sinoatrial Node | 1993 |
Inhibition of the I(h) current in isolated peripheral nerve: a novel mode of peripheral antinociception?
Topics: Action Potentials; Adrenergic alpha-Agonists; Analgesics; Animals; Barium; Cardiovascular Agents; Clonidine; Electric Stimulation; Female; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Nerve Fibers; Nerve Fibers, Myelinated; Peripheral Nerves; Pyrimidines; Rabbits; Sucrose; Vagus Nerve | 2001 |
Clonidine prolongation of lidocaine analgesia after sciatic nerve block in rats Is mediated via the hyperpolarization-activated cation current, not by alpha-adrenoreceptors.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Clonidine; Colforsin; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; In Vitro Techniques; Ion Channels; Lidocaine; Male; Nerve Block; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sciatic Nerve | 2004 |
Alpha-2 adrenergic regulation of pedunculopontine nucleus neurons during development.
Topics: Acetylcholine; Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Biotin; Clonidine; Electric Stimulation; Female; In Vitro Techniques; Male; NADP; Neurons; Pedunculopontine Tegmental Nucleus; Pregnancy; Pyrimidines; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Yohimbine | 2006 |
alpha2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents.
Topics: Adenylyl Cyclases; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Cesium; Clonidine; Cyclic Nucleotide-Gated Cation Channels; Excitatory Postsynaptic Potentials; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Male; Membrane Potentials; Neuronal Plasticity; Patch-Clamp Techniques; Potassium Channels; Prefrontal Cortex; Protein Kinase C; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Synapses; Synaptic Transmission; Time Factors; Type C Phospholipases | 2007 |
Clonidine suppresses the induction of long-term potentiation by inhibiting HCN channels at the Schaffer collateral-CA1 synapse in anesthetized adult rats.
Topics: Aging; Anesthesia; Animals; Blood Pressure; CA1 Region, Hippocampal; Cells, Cultured; Clonidine; Glutamates; Heart Rate; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Injections, Intraperitoneal; Injections, Intraventricular; Long-Term Potentiation; Male; Neurons; Pyrimidines; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Yohimbine | 2013 |