zd 7288 has been researched along with cardiovascular agents in 71 studies
| Studies (zd 7288) | Trials (zd 7288) | Recent Studies (post-2010) (zd 7288) | Studies (cardiovascular agents) | Trials (cardiovascular agents) | Recent Studies (post-2010) (cardiovascular agents) |
|---|---|---|---|---|---|
| 382 | 0 | 137 | 17,645 | 1,480 | 6,891 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (16.90) | 18.2507 |
| 2000's | 35 (49.30) | 29.6817 |
| 2010's | 24 (33.80) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BoSmith, RE; Briggs, I; Heapy, CG | 1 |
| BoSmith, RE; Briggs, I; Sturgess, NC | 1 |
| Johnson, IR; Rouse, W | 1 |
| Johnson, IR; Rouse, W; Stafford, PJ | 1 |
| Constanti, A; Harris, NC | 1 |
| Maccaferri, G; McBain, CJ | 1 |
| Choate, JK; Paterson, DJ; Sears, CE | 2 |
| Lupica, CR; Svoboda, KR | 1 |
| Cope, DW; Crunelli, V; Hughes, SW | 1 |
| Carlen, PL; Perez Velazquez, JL; Skinner, FK; Tian, GF; Wu, CP; Zhang, L; Zhang, Y | 1 |
| Casadei, B; Hogan, N; Paterson, DJ | 1 |
| Aghajanian, GK; Jolas, T; Nestler, EJ | 1 |
| Placantonakis, DG; Schwarz, C; Welsh, JP | 1 |
| Alonso, A; Dickson, CT; Fransén, E; Hasselmo, ME; Magistretti, J; Shalinsky, MH | 1 |
| Stuart, GJ; Williams, SR | 1 |
| Morris, NP; Robertson, B; Southan, AP; Stephens, GJ | 1 |
| Rothberg, BS; Shin, KS; Yellen, G | 1 |
| Bretton, C; Clergue, F; Dalle, C; Jirounek, P; Schneider, M | 1 |
| Dresse, A; Massotte, L; Renette, MF; Seutin, V | 1 |
| Di Pasquale, E; Hilaire, G; Monteau, R; Ptak, K; Tell, F | 1 |
| Giniatullin, RA; Svyatova, NV; Zefirov, TL; Ziyatdinova, NI | 1 |
| Bell, JA; Hoffman, AF; Lupica, CR; Watson, PL | 1 |
| Magee, JC | 1 |
| Chabbert, C; Chambard, JM; Desmadryl, G; Sans, A; Valmier, J | 1 |
| Ball, RW; Beaumont, V; Froemke, RC; Zhong, N; Zucker, RS | 1 |
| Deng, CX; Duttaroy, A; Fisahn, A; Gan, JW; McBain, CJ; Wess, J; Yamada, M | 1 |
| Greenwood, IA; Prestwich, SA | 1 |
| Zefirov, TL; Ziyatdinova, NI | 1 |
| Gainullin, AA; Zefirov, AL; Zefirov, TL; Ziyatdinova, NI | 1 |
| Sitdikov, FG; Zefirov, AL; Zefirov, TL; Ziiatdinova, NI | 1 |
| Agmon, A; Wells, JE | 1 |
| Biel, M; Feil, R; Feil, S; Herrmann, S; Hofmann, F; Löster, J; Ludwig, A; Stieber, J | 1 |
| Barnes, C; Biedermann, J; Garcia-Rill, E; Good, C; Kobayashi, T; Skinner, RD | 1 |
| Han, JS; Sun, Q; Tu, HY; Wan, Y; Xing, GG | 1 |
| Baruscotti, M; Bucchi, A; Difrancesco, D | 1 |
| Chang, L; Chaplan, SR; Lee, DH; Sorkin, LS | 1 |
| Brager, DH; Chen, X; Chitwood, RA; Fan, Y; Fricker, D; Johnston, D; Lu, HC | 1 |
| Ao, H; Brown, SM; Chang, L; Chaplan, SR; Dubin, AE; Higuera, ES; Lee, DH; Luo, L | 1 |
| Deng, P; Xu, ZC; Zhang, Y | 1 |
| Gibina, AE; Sergejeva, AM; Zefirov, AL; Zefirov, TL; Ziyatdinova, NI | 1 |
| Destexhe, A; Sanchez-Vives, MV; Winograd, M | 1 |
| Colino, A; Halliwell, JV; Sánchez-Alonso, JL | 1 |
| Deng, P; Fan, Y; Lu, HC; Schulz, PE; Wang, YC; Xu, ZC | 1 |
| Brown, JT; Randall, AD | 1 |
| Bal, R; Baydas, G | 1 |
| Bolter, CP; Turner, MJ | 1 |
| Das, P; Fadool, DA; Kaczmarek, LK; Lu, S | 1 |
| Ibáñez-Sandoval, O; Koós, T; Shah, F; Tecuapetla, F; Tepper, JM; Unal, B | 1 |
| Carloni, P; Cherubini, E; Giorgetti, A; Griguoli, M; Maul, A; Nguyen, C | 1 |
| Chu, Z; Moenter, SM; Takagi, H | 1 |
| Putrenko, I; Schwarz, SK | 1 |
| Kolaj, M; Renaud, LP; Rønnekleiv, OK; Zhang, L | 1 |
| Hu, SJ; Li, HM; Song, XJ; Song, Y; Xie, RG; Xing, JL; Yue, ZF | 1 |
| Káli, S; Zemankovics, R | 1 |
| Belmonte, C; González, O; Madrid, R; Orio, P; Parra, A; Viana, F | 1 |
| Karakossian, MH; Maiz, J; Otis, TS; Pakaprot, N; Robleto, K; Thompson, RF | 1 |
| Horner, RL; Montandon, G | 1 |
| Blacklaws, J; Borowska, J; Goulding, M; Jones, CT; Zhang, H; Zhang, Y | 1 |
| Nevian, T; Santello, M | 1 |
| Chen, L; Gao, GD; Ge, SN; Jia, D; Wang, JL; Yan, ZQ; Yang, C; Zhang, JR; Zhu, JL | 1 |
| Bolter, CP; Han, SY | 1 |
| Arts, M; Ben-Shaul, Y; Drose, DR; Gorin, M; Hanganu-Opatz, IL; Kahan, A; Mathar, R; O'Connor, S; Spehr, M; Tsitoura, C; Watznauer, K | 1 |
| Chapman, CA; Sparks, DW | 1 |
| Halladay, LR; Holmes, AJ; Knoll, AT; Levitt, P | 1 |
| Cao, DN; Li, J; Song, R; Wu, N; Zhang, SZ | 1 |
| Bossi, E; Cinquetti, R; Marcozzi, C; Moriondo, A; Negrini, D; Reguzzoni, M; Solari, E | 1 |
| Balfanz, S; Baumann, A; Budde, T; Chaudhary, R; Chetkovich, DM; Datunashvili, M; Heuermann, RJ; Lüttjohann, A; Meuth, P; Narayanan, V; Pape, HC; van Luijtelaar, G; Zobeiri, M | 1 |
| Heinbockel, T; Jones, M; Xue, Y; Ying, M; Zhan, X; Zou, L | 1 |
| Altman, MT; Arnsten, AFT; Crimins, JL; Mazer, JA; Paspalas, CD; Wang, M; Yang, ST | 1 |
| Dong, X; Fang, Z; He, F; Hu, X; Li, L; Liu, Q; Yang, Z; Yi, S | 1 |
1 review(s) available for zd 7288 and cardiovascular agents
| Article | Year |
|---|---|
Physiology and pharmacology of the cardiac pacemaker ("funny") current.
Topics: Amino Acid Sequence; Animals; Benzazepines; Cardiovascular Agents; Clonidine; Cyclic Nucleotide-Gated Cation Channels; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Ivabradine; Nerve Tissue Proteins; Potassium Channels; Pyrimidines; Sinoatrial Node; Structure-Activity Relationship | 2005 |
70 other study(ies) available for zd 7288 and cardiovascular agents
| Article | Year |
|---|---|
Effects of Zeneca ZD7288 in comparison with alinidine and UL-FS 49 on guinea pig sinoatrial node and ventricular action potentials.
Topics: Action Potentials; Animals; Benzazepines; Cardiovascular Agents; Clonidine; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Microelectrodes; Myocardial Contraction; Papillary Muscles; Pyrimidines; Sinoatrial Node | 1994 |
Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzazepines; Cardiovascular Agents; Clonidine; Electrophysiology; Guinea Pigs; In Vitro Techniques; Ion Channels; Membrane Potentials; Pyrimidines; Sinoatrial Node | 1993 |
Haemodynamic actions of a novel sino-atrial node function modulator, ZENECA ZD7288, in the anaesthetized dog: a comparison with zatebradine, atenolol and nitrendipine.
Topics: Animals; Atenolol; Benzazepines; Cardiotonic Agents; Cardiovascular Agents; Dogs; Heart Rate; Hemodynamics; Nitrendipine; Pyrimidines; Sinoatrial Node | 1994 |
The haemodynamic actions of ZENECA ZD7288, a novel sino-atrial node function modulator, in the exercising beagle: a comparison with zatebradine and propranolol.
Topics: Animals; Benzazepines; Cardiotonic Agents; Cardiovascular Agents; Dogs; Heart Rate; Hemodynamics; Physical Conditioning, Animal; Propranolol; Pyrimidines; Sinoatrial Node | 1994 |
Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro.
Topics: Animals; Cardiovascular Agents; Cesium; Electrophysiology; Guinea Pigs; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pyrimidines; Substantia Nigra | 1995 |
The hyperpolarization-activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens-alveus interneurones.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Cardiovascular Agents; Cesium; Electrophysiology; Hippocampus; Isoproterenol; Neurons; Norepinephrine; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Sprague-Dawley | 1996 |
Inhibition of nitric oxide synthase slows heart rate recovery from cholinergic activation.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Arginine; Calcium Channel Blockers; Cardiovascular Agents; Cesium; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Male; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Pyrimidines; Vagus Nerve | 1998 |
Opioid inhibition of hippocampal interneurons via modulation of potassium and hyperpolarization-activated cation (Ih) currents.
Topics: Analgesics; Analgesics, Opioid; Animals; Baclofen; Barium; Cardiovascular Agents; Cations; Cell Size; Cells, Cultured; Cesium; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Interneurons; Male; Membrane Potentials; Potassium; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
Dynamic clamp study of Ih modulation of burst firing and delta oscillations in thalamocortical neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Cardiovascular Agents; Cats; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Geniculate Bodies; In Vitro Techniques; Male; Neurons; Organophosphorus Compounds; Patch-Clamp Techniques; Periodicity; Pyrimidines; Rats; Rats, Wistar; Sleep; Thalamus; Wakefulness | 1998 |
Slow oscillations (
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Age Factors; Animals; Benzoates; Bicuculline; Cardiovascular Agents; Cesium; Chlorides; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junctions; Glycine; Hippocampus; Interneurons; Male; Membrane Potentials; Neural Pathways; Organ Culture Techniques; Patch-Clamp Techniques; Periodicity; Pyrimidines; Rats; Rats, Wistar; Receptors, GABA-A; Synapses; Temperature; Xanthines | 1998 |
NO-cGMP pathway accentuates the decrease in heart rate caused by cardiac vagal nerve stimulation.
Topics: Animals; Blood Pressure; Carbachol; Cardiovascular Agents; Cyclic GMP; Electric Stimulation; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitroprusside; Pyrimidines; Rabbits; Vagus Nerve; Vasodilator Agents | 1999 |
Nitric oxide donors can increase heart rate independent of autonomic activation.
Topics: Adrenergic beta-Antagonists; Animals; Autonomic Nervous System; Baroreflex; Cardiovascular Agents; Heart Rate; In Vitro Techniques; Male; Molsidomine; Nitric Oxide Donors; Nitroprusside; Propranolol; Pyrimidines; Rabbits; Sympathectomy; Vagotomy; Vasodilator Agents | 1999 |
Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cardiovascular Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Isoquinolines; Male; Membrane Potentials; Morphine; N-Methylaspartate; Neural Inhibition; Periaqueductal Gray; Phenylephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome; Sulfonamides; Sympathomimetics; Tetrazoles; Tetrodotoxin; Thionucleotides | 2000 |
Serotonin suppresses subthreshold and suprathreshold oscillatory activity of rat inferior olivary neurones in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Amphetamines; Animals; Cardiovascular Agents; Electric Impedance; Electrophysiology; Ketanserin; Methysergide; Neurons; Olivary Nucleus; Periodicity; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2000 |
Properties and role of I(h) in the pacing of subthreshold oscillations in entorhinal cortex layer II neurons.
Topics: Animals; Barium; Biological Clocks; Buffers; Cardiovascular Agents; Cesium; Dose-Response Relationship, Drug; Electric Stimulation; Entorhinal Cortex; In Vitro Techniques; Ion Transport; Male; Membrane Potentials; Memory; Models, Neurological; Neurons; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Long-Evans; Tetrodotoxin; Time Factors | 2000 |
Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons.
Topics: Animals; Axons; Cardiovascular Agents; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Electric Stimulation; Excitatory Postsynaptic Potentials; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Membrane Potentials; Neocortex; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin | 2000 |
Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cardiovascular Agents; Cells, Cultured; Cerebellum; Cesium; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Interneurons; Ion Channels; Male; Membrane Potentials; Mice; Nerve Tissue Proteins; Neural Inhibition; Patch-Clamp Techniques; Potassium Channels; Presynaptic Terminals; Purkinje Cells; Pyrimidines; Receptors, AMPA | 2000 |
Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate.
Topics: Amino Acid Sequence; Cardiovascular Agents; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channel Gating; Ion Channels; Kidney; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Patch-Clamp Techniques; Potassium Channels; Protein Structure, Tertiary; Pyrimidines | 2001 |
Inhibition of the I(h) current in isolated peripheral nerve: a novel mode of peripheral antinociception?
Topics: Action Potentials; Adrenergic alpha-Agonists; Analgesics; Animals; Barium; Cardiovascular Agents; Clonidine; Electric Stimulation; Female; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Nerve Fibers; Nerve Fibers, Myelinated; Peripheral Nerves; Pyrimidines; Rabbits; Sucrose; Vagus Nerve | 2001 |
Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biological Clocks; Calcium; Calcium Channels; Cardiovascular Agents; Cations; Cesium; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Antagonists; Male; Mesencephalon; Neurons; Organ Culture Techniques; Organophosphorus Compounds; Pyrimidines; Rats; Rats, Wistar; Sulpiride | 2001 |
Perinatal changes of I(h) in phrenic motoneurons.
Topics: Animals; Animals, Newborn; Cardiovascular Agents; Cesium; Fetus; Membrane Potentials; Motor Neurons; Patch-Clamp Techniques; Phrenic Nerve; Pyrimidines; Rats; Rats, Sprague-Dawley; Respiratory Center; Respiratory Mechanics; Respiratory Muscles | 2001 |
Blockade of hyperpolarizing currents produces a dose-dependent effect on heart rate.
Topics: Animals; Cardiovascular Agents; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Injections, Intravenous; Membrane Potentials; Pyrimidines; Rats | 2001 |
Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons.
Topics: Animals; Cardiovascular Agents; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Ion Channel Gating; Male; Membrane Potentials; Organ Culture Techniques; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2001 |
Dendritic mechanisms of phase precession in hippocampal CA1 pyramidal neurons.
Topics: Action Potentials; Animals; Cardiovascular Agents; Dendrites; Hippocampus; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Theta Rhythm | 2001 |
Hyperpolarization-activated (Ih) current in mouse vestibular primary neurons.
Topics: Animals; Cardiovascular Agents; Cell Separation; Cesium; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Membrane Potentials; Mice; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrimidines; Sodium; Vestibule, Labyrinth | 2001 |
Temporal synaptic tagging by I(h) activation and actin: involvement in long-term facilitation and cAMP-induced synaptic enhancement.
Topics: Actins; Animals; Astacoidea; Benzazepines; Biomarkers; Calcium Signaling; Cardiovascular Agents; Cyclic AMP; Cytoskeleton; Electric Stimulation; Ion Channels; Long-Term Potentiation; Membrane Potentials; Motor Neurons; Nervous System Physiological Phenomena; Neuromuscular Junction; Pyrimidines; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission | 2002 |
Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents.
Topics: Animals; Biological Clocks; Cardiovascular Agents; Cation Transport Proteins; Cyclic AMP-Dependent Protein Kinases; Hippocampus; Immunohistochemistry; Indoles; Interneurons; Ion Channels; Membrane Potentials; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; Nerve Net; Potassium Channel Blockers; Pyramidal Cells; Pyridines; Pyrimidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Synaptic Transmission | 2002 |
Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells.
Topics: Animals; Bucladesine; Cardiovascular Agents; Cations; Cesium; Cyclic Nucleotide-Gated Cation Channels; Gene Expression; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Membrane Potentials; Muscle Proteins; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Portal Vein; Potassium; Potassium Channels; Pyrimidines; Rabbits; Sodium | 2002 |
Parasympathetic nervous system modulates effects of hyperpolarization-activated channel blockade.
Topics: Animals; Bradycardia; Cardiovascular Agents; Cyclic Nucleotide-Gated Cation Channels; Electrocardiography; Heart; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Parasympathetic Nervous System; Potassium Channels; Pyrimidines; Rats; Stroke Volume; Vagotomy; Vagus Nerve | 2002 |
Blockade of hyperpolarization-activated channels modifies the effect of beta-adrenoceptor stimulation.
Topics: Animals; Bradycardia; Cardiovascular Agents; Electrophysiology; Heart; Isoproterenol; Pyrimidines; Rats; Receptors, Adrenergic, beta; Time Factors; Vagotomy; Vagus Nerve | 2002 |
[Autonomic control of cardiac function involves modulation of hyperpolarization activated channels in vitro].
Topics: Animals; Autonomic Nervous System; Bradycardia; Cardiovascular Agents; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Electric Conductivity; Electric Stimulation; Electrocardiography; Heart; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Potassium Channels; Pyrimidines; Rats; Vagotomy; Vagus Nerve | 2003 |
The role of the hyperpolarization-activated cationic current I(h) in the timing of interictal bursts in the neonatal hippocampus.
Topics: Animals; Animals, Newborn; Biological Clocks; Cardiovascular Agents; Cations; Colforsin; Computer Simulation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Mice; Models, Neurological; Periodicity; Potassium Channel Blockers; Pyrimidines; Receptors, GABA-A; Seizures; Synaptic Transmission | 2003 |
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart.
Topics: Action Potentials; Animals; Blotting, Western; Cardiovascular Agents; Cations; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Electrophysiology; Gene Deletion; Heart Rate; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; In Situ Hybridization; Ion Channels; Lac Operon; Membrane Potentials; Mice; Mice, Transgenic; Muscle Proteins; Myocardium; Pacemaker, Artificial; Potassium Channels; Protein Isoforms; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sinoatrial Node; Time Factors | 2003 |
Developmental changes in pedunculopontine nucleus (PPN) neurons.
Topics: Action Potentials; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Avidin; Cardiovascular Agents; Cell Count; Cell Size; Female; Fluoresceins; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; NADP; Neurons; Pregnancy; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tegmentum Mesencephali; Tetrodotoxin; Xanthenes | 2004 |
Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Male; Neural Inhibition; Neuralgia; Neurons; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated rats.
Topics: Animals; Axotomy; Cardiovascular Agents; Cations; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Ion Channels; Ligation; Male; Nerve Fibers, Myelinated; Neuralgia; Neurons, Afferent; Pain Threshold; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Pyrimidines; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Spinal Nerves | 2005 |
Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h).
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium Channel Blockers; Cardiovascular Agents; Cyclic Nucleotide-Gated Cation Channels; Diagnostic Imaging; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Long-Term Potentiation; Male; Membrane Potentials; Neurons; omega-Conotoxins; Organophosphates; Patch-Clamp Techniques; Potassium Channels; Potassium Chloride; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Statistics, Nonparametric; Tetrodotoxin; Time Factors | 2005 |
Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat.
Topics: Acute Disease; Animals; Cardiovascular Agents; Chronic Disease; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Mechanoreceptors; Merkel Cells; Nociceptors; Pain; Peripheral Nerves; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Skin | 2007 |
Inhibition of Ih in striatal cholinergic interneurons early after transient forebrain ischemia.
Topics: Animals; Calcium; Cardiovascular Agents; Cholinergic Fibers; Corpus Striatum; Cyclic AMP; Interneurons; Ischemic Attack, Transient; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A1; Stroke | 2008 |
Age-related peculiarities of contractile activity of rat myocardium during blockade of hyperpolarization-activated currents.
Topics: Aging; Animals; Cardiovascular Agents; Cyclic Nucleotide-Gated Cation Channels; Heart Ventricles; Myocardial Contraction; Myocardium; Pyrimidines; Rats | 2007 |
Hyperpolarization-activated graded persistent activity in the prefrontal cortex.
Topics: Animals; Biophysics; Calcium; Cardiovascular Agents; Electrophysiology; Female; Ferrets; Guinea Pigs; Male; Membrane Potentials; Neurons; Prefrontal Cortex; Pyrimidines; Rats; Time Factors | 2008 |
ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, T-Type; Cardiovascular Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Hippocampus; In Vitro Techniques; Membrane Potentials; Nickel; Nifedipine; Patch-Clamp Techniques; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin | 2008 |
Transient cerebral ischemia increases CA1 pyramidal neuron excitability.
Topics: Animals; Cardiovascular Agents; Cell Death; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Lamotrigine; Male; Membrane Potentials; Patch-Clamp Techniques; Pyramidal Cells; Pyrimidines; Rats; Statistics, Nonparametric; Triazines | 2008 |
Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons.
Topics: Action Potentials; Animals; Anthracenes; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Carbamates; Cardiovascular Agents; Chelating Agents; Egtazic Acid; Hippocampus; In Vitro Techniques; KCNQ Potassium Channels; Male; Membrane Potentials; Neuronal Plasticity; Patch-Clamp Techniques; Phenylenediamines; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar | 2009 |
Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cardiovascular Agents; Cats; Cochlear Nucleus; Dendrites; Elapid Venoms; Evoked Potentials; Ion Channels; Mice; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Pyrimidines; Sodium Channel Blockers; Stellate Ganglion; Tetrodotoxin | 2009 |
Tertiapin-Q removes a large and rapidly acting component of vagal slowing of the guinea-pig cardiac pacemaker.
Topics: Action Potentials; Analysis of Variance; Animals; Barium Compounds; Bee Venoms; Cardiovascular Agents; Chlorides; Electric Stimulation; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Pacemaker, Artificial; Potassium Channel Blockers; Pyrimidines; Vagus Nerve | 2009 |
The slack sodium-activated potassium channel provides a major outward current in olfactory neurons of Kv1.3-/- super-smeller mice.
Topics: Animals; Animals, Newborn; Biophysics; Cardiovascular Agents; Cells, Cultured; Electric Stimulation; Gene Expression Regulation; In Vitro Techniques; Kv1.3 Potassium Channel; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Sodium-Activated; Pyrimidines; RNA Interference; Sodium Channel Blockers; Tetrodotoxin; Transfection | 2010 |
Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analysis of Variance; Animals; Anti-Inflammatory Agents; Bicuculline; Calcium Channel Blockers; Cardiovascular Agents; Cell Count; Colchicine; Corpus Striatum; Electric Stimulation; Excitatory Amino Acid Antagonists; Flufenamic Acid; GABA Antagonists; Green Fluorescent Proteins; In Vitro Techniques; Lysine; Mice; Mice, Transgenic; Neural Pathways; Neurons; Nimodipine; Patch-Clamp Techniques; Pyrimidines; Synapses; Synaptic Transmission; Time Factors; Tubulin Modulators; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2010 |
Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Analysis of Variance; Animals; Biological Clocks; Cardiovascular Agents; Colforsin; Cyclic Nucleotide-Gated Cation Channels; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Interneurons; Male; Mecamylamine; Mice; Mice, Transgenic; Models, Biological; Models, Molecular; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Somatostatin | 2010 |
Hyperpolarization-activated currents in gonadotropin-releasing hormone (GnRH) neurons contribute to intrinsic excitability and are regulated by gonadal steroid feedback.
Topics: Action Potentials; Animals; Cardiovascular Agents; Cell Polarity; Estradiol; Excitatory Amino Acid Antagonists; Feedback, Physiological; GABA Antagonists; Gonadotropin-Releasing Hormone; Hypothalamus; Male; Membrane Potentials; Mice; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Pyrimidines | 2010 |
Lidocaine blocks the hyperpolarization-activated mixed cation current, I(h), in rat thalamocortical neurons.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Cardiovascular Agents; Cerebral Cortex; Cesium; Cyclic Nucleotide-Gated Cation Channels; Data Interpretation, Statistical; Electrophysiological Phenomena; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Interneurons; Lidocaine; Membrane Potentials; Neural Pathways; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Pyrimidines; Rats; Rats, Wistar; Thalamus | 2011 |
Midline thalamic paraventricular nucleus neurons display diurnal variation in resting membrane potentials, conductances, and firing patterns in vitro.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Cardiovascular Agents; Caveolin 3; Chi-Square Distribution; Circadian Rhythm; Electric Stimulation; Female; In Vitro Techniques; Male; Midline Thalamic Nuclei; Neural Conduction; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Rats; Rats, Wistar; RNA, Messenger; Sodium Channel Blockers; Tetrodotoxin | 2012 |
Evoked bursting in injured Aβ dorsal root ganglion neurons: a mechanism underlying tactile allodynia.
Topics: Action Potentials; Animals; Biophysical Phenomena; Biophysics; Cardiovascular Agents; Chi-Square Distribution; Disease Models, Animal; Double-Blind Method; Elapid Venoms; Electric Stimulation; Female; Fourier Analysis; Ganglia, Spinal; Hyperalgesia; Male; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sodium Channel Blockers; Spinal Cord Compression; Tetrodotoxin; Time Factors | 2012 |
The effect of dendritic voltage-gated conductances on the neuronal impedance: a quantitative model.
Topics: Animals; Animals, Newborn; Biophysical Phenomena; Biophysics; CA1 Region, Hippocampal; Cardiovascular Agents; Dendrites; Electric Stimulation; Fourier Analysis; In Vitro Techniques; Membrane Potentials; Models, Neurological; Neural Conduction; Neurons; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Wistar; Reproducibility of Results | 2012 |
Role of Ih in the firing pattern of mammalian cold thermoreceptor endings.
Topics: Action Potentials; Animals; Benzazepines; Cardiovascular Agents; Cold Temperature; Cornea; Cyclic Nucleotide-Gated Cation Channels; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Ivabradine; Mice; Models, Neurological; Nerve Endings; Optic Nerve; Potassium Channels; Pyrimidines; Thermoreceptors | 2012 |
Prolonging the postcomplex spike pause speeds eyeblink conditioning.
Topics: Analysis of Variance; Animals; Benzimidazoles; Blinking; Calcium Channel Agonists; Cardiovascular Agents; Cerebellar Nuclei; Cerebellum; Conditioning, Eyelid; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Learning; Mice; Nerve Fibers; Picrotoxin; Purkinje Cells; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors | 2012 |
State-dependent contribution of the hyperpolarization-activated Na+/K+ and persistent Na+ currents to respiratory rhythmogenesis in vivo.
Topics: Analysis of Variance; Animals; Cardiovascular Agents; Electroencephalography; Excitatory Amino Acid Antagonists; Functional Laterality; In Vitro Techniques; Male; Membrane Potentials; Microdialysis; Motor Activity; Muscles; Neurons; Patch-Clamp Techniques; Periodicity; Pyrimidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Respiratory Center; Respiratory Mechanics; Riluzole; Sleep; Sodium Channels; Sodium-Potassium-Chloride Symporters; Veratridine; Wakefulness | 2013 |
Functional subpopulations of V3 interneurons in the mature mouse spinal cord.
Topics: Action Potentials; Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Benzimidazoles; Cardiovascular Agents; Cluster Analysis; Cyclopropanes; Electric Stimulation; In Vitro Techniques; Interneurons; Mice; Mice, Transgenic; Motor Activity; Naphthalenes; Nickel; Patch-Clamp Techniques; Proto-Oncogene Proteins c-fos; Pyrimidines; Repressor Proteins; RNA, Untranslated; Spinal Cord; Statistics, Nonparametric | 2013 |
Dysfunction of cortical dendritic integration in neuropathic pain reversed by serotoninergic neuromodulation.
Topics: Animals; Cardiovascular Agents; Cerebral Cortex; Dendrites; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lysine; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Neuralgia; Neurons; Pain Measurement; Potassium Channels; Pyrimidines; Receptors, Serotonin; Serotonin; Serotonin Agents; Time Factors | 2015 |
Decreased HCN2 expression in STN contributes to abnormal high-voltage spindles in the cortex and globus pallidus of freely moving rats.
Topics: Animals; Antiparkinson Agents; Cardiovascular Agents; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Antagonists; Globus Pallidus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Indoles; Kynurenic Acid; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Subthalamic Nucleus; Wakefulness | 2015 |
Effects of tertiapin-Q and ZD7288 on changes in sinoatrial pacemaker rhythm during vagal stimulation.
Topics: Acetylcholine; Animals; Arrhythmias, Cardiac; Bee Venoms; Biological Clocks; Cardiovascular Agents; Cations; Disease Models, Animal; Guinea Pigs; Heart Rate; Parasympathetic Nervous System; Potassium; Potassium Channel Blockers; Pyrimidines; Sinoatrial Node; Vagus Nerve; Vagus Nerve Stimulation | 2015 |
Interdependent Conductances Drive Infraslow Intrinsic Rhythmogenesis in a Subset of Accessory Olfactory Bulb Projection Neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Cardiovascular Agents; Excitatory Amino Acid Antagonists; Group II Phospholipases A2; In Vitro Techniques; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Olfactory Bulb; Olfactory Pathways; omega-Agatoxin IVA; Periodicity; Pyrimidines; Spider Venoms; Valine | 2016 |
Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.
Topics: Afferent Pathways; Analysis of Variance; Animals; Bicuculline; Cardiovascular Agents; Electric Stimulation; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Hippocampus; Male; Patch-Clamp Techniques; Phosphinic Acids; Pyrimidines; Rats; Rats, Long-Evans; Synapses; Time Factors; Valine | 2016 |
Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning.
Topics: Analysis of Variance; Animals; Cardiovascular Agents; Cerebral Cortex; Chromosome Mapping; Chromosomes, Human, Pair 13; Conditioning, Classical; Fear; Freezing Reaction, Cataleptic; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Mice; Mice, Inbred Strains; Phenotype; Potassium Channels; Pyrimidines; Quantitative Trait Loci | 2016 |
Nucleus accumbens hyperpolarization-activated cyclic nucleotide-gated channels modulate methamphetamine self-administration in rats.
Topics: Animals; Behavior, Animal; Cardiovascular Agents; Central Nervous System Stimulants; Dopamine; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Methamphetamine; Microdialysis; Nucleus Accumbens; Pyrimidines; Rats; Rats, Sprague-Dawley; Self Administration | 2016 |
Hyperpolarization-activated cyclic nucleotide-gated channels in peripheral diaphragmatic lymphatics.
Topics: Animals; Benzazepines; Cardiovascular Agents; Cesium; Chlorides; Diaphragm; Female; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; Ivabradine; Lymphatic Vessels; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium Channels; Pyrimidines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Vasoconstriction | 2016 |
Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels.
Topics: Action Potentials; Adenine; Adenylyl Cyclase Inhibitors; Animals; Cardiovascular Agents; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Female; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Neurological; Neural Pathways; Peroxins; Pyrimidines; Sodium Channel Blockers; Tetrodotoxin; Thalamus; Thionucleotides | 2018 |
The Effects of Quinine on Neurophysiological Properties of Dopaminergic Neurons.
Topics: Action Potentials; Analgesics, Non-Narcotic; Animals; Autistic Disorder; Biotin; Cardiovascular Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Piperidines; Pluripotent Stem Cells; Potassium Channel Blockers; Pyrimidines; Quinine; Sodium Channel Blockers; Substantia Nigra; Tetrodotoxin; Tyrosine 3-Monooxygenase | 2018 |
Core Differences in Synaptic Signaling Between Primary Visual and Dorsolateral Prefrontal Cortex.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cardiovascular Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Dendritic Spines; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Macaca mulatta; Membrane Potentials; Microscopy, Immunoelectron; Nerve Net; Neurons; Photic Stimulation; Prefrontal Cortex; Pyrimidines; Signal Transduction; Synapses; Visual Cortex | 2018 |
The role of HCN channels in peristaltic dysfunction in human ureteral tuberculosis.
Topics: Cardiovascular Agents; Female; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Middle Aged; Mucous Membrane; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Peristalsis; Potassium Channels; Pyrimidines; Tissue Culture Techniques; Tuberculosis, Urogenital; Ureter; Ureteral Diseases | 2018 |