Page last updated: 2024-09-03

zd 7288 and 2-amino-5-phosphonovalerate

zd 7288 has been researched along with 2-amino-5-phosphonovalerate in 19 studies

Compound Research Comparison

Studies
(zd 7288)
Trials
(zd 7288)
Recent Studies (post-2010)
(zd 7288)
Studies
(2-amino-5-phosphonovalerate)
Trials
(2-amino-5-phosphonovalerate)
Recent Studies (post-2010) (2-amino-5-phosphonovalerate)
38201374,3931539

Protein Interaction Comparison

ProteinTaxonomyzd 7288 (IC50)2-amino-5-phosphonovalerate (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.29

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's9 (47.37)29.6817
2010's8 (42.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cope, DW; Crunelli, V; Hughes, SW1
Carlen, PL; Perez Velazquez, JL; Skinner, FK; Tian, GF; Wu, CP; Zhang, L; Zhang, Y1
Ross, ST; Soltesz, I1
Andreasen, M; Fernandez, N; Nedergaard, S1
Bajorat, R; Bräuer, AU; Deisz, RA; Kole, MH; Nitsch, R; Pahnke, J; Rolfs, A; Strauss, U1
Anderson, AE; Johnston, D; Leung, V; Lin, X; Shah, MM1
Darcy, DP; Isaacson, JS; Murphy, GJ1
Bie, B; Pan, ZZ; Peng, Y; Zhang, Y1
Bartfai, T; Behrens, M; Conti, B; Korn, H; Tabarean, IV1
Brager, DH; Chen, X; Chitwood, RA; Fan, Y; Fricker, D; Johnston, D; Lu, HC1
Brown, JT; Cobb, SR; Davies, CH; Farmer, C; Gill, CH; Lappin, SC; McNaughton, NC; Randall, A; Shivji, N1
Bayliss, DA; Chen, X; Kapur, J; Schwartz, LC; Shu, S; Sun, C1
Chapman, CA; Sparks, DW3
Kunz, PA; Philpot, BD; Roberts, AC1
Bean, BP; Yamada-Hanff, J1
Chen, L; Chen, XY; Deng, WS; Han, XH; Hao, XM; Liu, HX; Liu, ZR; Sun, FJ; Wang, H; Xie, JX; Xu, R; Xue, Y; Yung, WH1
Arts, M; Ben-Shaul, Y; Drose, DR; Gorin, M; Hanganu-Opatz, IL; Kahan, A; Mathar, R; O'Connor, S; Spehr, M; Tsitoura, C; Watznauer, K1

Other Studies

19 other study(ies) available for zd 7288 and 2-amino-5-phosphonovalerate

ArticleYear
Dynamic clamp study of Ih modulation of burst firing and delta oscillations in thalamocortical neurons in vitro.
    Neuroscience, 1998, Volume: 87, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Cardiovascular Agents; Cats; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Geniculate Bodies; In Vitro Techniques; Male; Neurons; Organophosphorus Compounds; Patch-Clamp Techniques; Periodicity; Pyrimidines; Rats; Rats, Wistar; Sleep; Thalamus; Wakefulness

1998
Slow oscillations (
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Nov-15, Volume: 18, Issue:22

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Age Factors; Animals; Benzoates; Bicuculline; Cardiovascular Agents; Cesium; Chlorides; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junctions; Glycine; Hippocampus; Interneurons; Male; Membrane Potentials; Neural Pathways; Organ Culture Techniques; Patch-Clamp Techniques; Periodicity; Pyrimidines; Rats; Rats, Wistar; Receptors, GABA-A; Synapses; Temperature; Xanthines

1998
Selective depolarization of interneurons in the early posttraumatic dentate gyrus: involvement of the Na(+)/K(+)-ATPase.
    Journal of neurophysiology, 2000, Volume: 83, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Benzoates; Bicuculline; Brain Injuries; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; In Vitro Techniques; Interneurons; Membrane Potentials; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Strophanthidin; Tetrodotoxin; Wounds, Nonpenetrating

2000
Influence of the hyperpolarization-activated cation current, I(h), on the electrotonic properties of the distal apical dendrites of hippocampal CA1 pyramidal neurones.
    Brain research, 2002, Mar-15, Volume: 930, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Barium Compounds; Cesium; Chlorides; Dendrites; Electromagnetic Fields; Electrophysiology; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channels; Male; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar

2002
An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.
    The European journal of neuroscience, 2004, Volume: 19, Issue:11

    Topics: 2-Amino-5-phosphonovalerate; Animals; Blotting, Western; Brain; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Interactions; Electric Impedance; Epilepsy, Absence; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Ion Channel Gating; Ion Channels; Male; Membrane Potentials; Neocortex; Nerve Tissue Proteins; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Inbred Strains; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity

2004
Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons.
    Neuron, 2004, Oct-28, Volume: 44, Issue:3

    Topics: Analysis of Variance; Animals; Bicuculline; Blotting, Western; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Electroencephalography; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; In Vitro Techniques; Ion Channels; Kainic Acid; Male; Membrane Potentials; Muscle Proteins; Neuronal Plasticity; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Seizures; Valine

2004
Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit.
    Nature neuroscience, 2005, Volume: 8, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Bicuculline; Cadmium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Chelating Agents; Dendrites; Diagnostic Imaging; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Neural Conduction; Neural Inhibition; Neural Networks, Computer; Neurons; Nickel; Nimodipine; Olfactory Bulb; Patch-Clamp Techniques; Phosphinic Acids; Potassium; Propanolamines; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors; Valine

2005
cAMP-mediated mechanisms for pain sensitization during opioid withdrawal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Apr-13, Volume: 25, Issue:15

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Colforsin; Cyclic AMP; Dose-Response Relationship, Radiation; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Imines; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Oxidoreductases; Pain; Pain Measurement; Patch-Clamp Techniques; Pyrimidines; Raphe Nuclei; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides

2005
Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture.
    Neuroscience, 2005, Volume: 135, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Calcium Channel Blockers; Cells, Cultured; Electric Impedance; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamus, Anterior; Immunohistochemistry; Isoenzymes; Membrane Potentials; Mice; Microtubule-Associated Proteins; Muscimol; Neural Inhibition; Neurons; Nimodipine; Patch-Clamp Techniques; Pyrimidines; Receptors, AMPA; Sodium; Sodium Channel Blockers; Temperature; Tetrodotoxin; Valine

2005
Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h).
    Nature neuroscience, 2005, Volume: 8, Issue:11

    Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium Channel Blockers; Cardiovascular Agents; Cyclic Nucleotide-Gated Cation Channels; Diagnostic Imaging; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Long-Term Potentiation; Male; Membrane Potentials; Neurons; omega-Conotoxins; Organophosphates; Patch-Clamp Techniques; Potassium Channels; Potassium Chloride; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Statistics, Nonparametric; Tetrodotoxin; Time Factors

2005
Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices.
    Synapse (New York, N.Y.), 2006, Volume: 59, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Animals, Newborn; Bicuculline; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Ion Channels; Male; Neural Inhibition; Patch-Clamp Techniques; Pyrimidines; Rats; Time Factors

2006
Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Feb-17, Volume: 30, Issue:7

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anti-Anxiety Agents; Bicuculline; Cerebral Cortex; Cyclic Nucleotide-Gated Cation Channels; Desoxycorticosterone; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Agents; Homeostasis; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Patch-Clamp Techniques; Potassium Channels; Protein Subunits; Pyramidal Cells; Pyridazines; Pyrimidines; Receptors, GABA-A; Sodium Channel Blockers; Synapses; Tetrodotoxin; Up-Regulation; Valine

2010
Cholinergic receptor activation induces a relative facilitation of synaptic responses in the entorhinal cortex during theta- and gamma-frequency stimulation of parasubicular inputs.
    Neuroscience, 2013, Jan-29, Volume: 230

    Topics: Acetylcholine; Animals; Anthracenes; Brain Waves; Carbachol; Cholinergic Agents; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Neural Pathways; Phosphinic Acids; Propanolamines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, Cholinergic; Synapses; Valine

2013
Presynaptic NMDA receptor mechanisms for enhancing spontaneous neurotransmitter release.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, May-01, Volume: 33, Issue:18

    Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Presynaptic Terminals; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Sodium Chloride; Synapses; Tetrodotoxin

2013
Persistent sodium current drives conditional pacemaking in CA1 pyramidal neurons under muscarinic stimulation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Sep-18, Volume: 33, Issue:38

    Topics: Acetylcholine; Action Potentials; Animals; Animals, Newborn; Biological Clocks; CA1 Region, Hippocampal; Cholinergic Agents; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; In Vitro Techniques; Male; Mice; Muscarine; Nickel; Patch-Clamp Techniques; Phosphinic Acids; Picrotoxin; Propanolamines; Pyramidal Cells; Pyrimidines; Quinoxalines; Sodium Channel Blockers; Sodium Channels; Valine

2013
Contribution of Ih to the relative facilitation of synaptic responses induced by carbachol in the entorhinal cortex during repetitive stimulation of the parasubiculum.
    Neuroscience, 2014, Oct-10, Volume: 278

    Topics: Acetylcholine; Action Potentials; Animals; Carbachol; Cholinergic Agonists; Electric Stimulation; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Neural Pathways; Potassium Channels; Pyrimidines; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Valine

2014
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate firing of globus pallidus neurons in vivo.
    Molecular and cellular neurosciences, 2015, Volume: 68

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Cardiotonic Agents; Cesium; Chlorides; Excitatory Amino Acid Antagonists; Globus Pallidus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Mice; Mice, Inbred C57BL; Neurons; Posture; Pyrimidines; Rats; Rats, Wistar; Subthalamic Nucleus; Valine; Wakefulness

2015
Interdependent Conductances Drive Infraslow Intrinsic Rhythmogenesis in a Subset of Accessory Olfactory Bulb Projection Neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Mar-16, Volume: 36, Issue:11

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Cardiovascular Agents; Excitatory Amino Acid Antagonists; Group II Phospholipases A2; In Vitro Techniques; Mice; Mice, Inbred C57BL; Models, Neurological; Neurons; Olfactory Bulb; Olfactory Pathways; omega-Agatoxin IVA; Periodicity; Pyrimidines; Spider Venoms; Valine

2016
Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.
    Journal of neurophysiology, 2016, 08-01, Volume: 116, Issue:2

    Topics: Afferent Pathways; Analysis of Variance; Animals; Bicuculline; Cardiovascular Agents; Electric Stimulation; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Hippocampus; Male; Patch-Clamp Techniques; Phosphinic Acids; Pyrimidines; Rats; Rats, Long-Evans; Synapses; Time Factors; Valine

2016