Compounds > zd 7288
Page last updated: 2024-09-03

zd 7288 and 1-methyl-3-isobutylxanthine

zd 7288 has been researched along with 1-methyl-3-isobutylxanthine in 4 studies

Compound Research Comparison

Studies
(zd 7288)		Trials
(zd 7288)		Recent Studies (post-2010)
(zd 7288)		Studies
(1-methyl-3-isobutylxanthine)		Trials
(1-methyl-3-isobutylxanthine)		Recent Studies (post-2010) (1-methyl-3-isobutylxanthine)
38201375,1485279

Protein Interaction Comparison

ProteinTaxonomyzd 7288 (IC50)1-methyl-3-isobutylxanthine (IC50)
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)8.1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)31
Chain A, Phosphodiesterase 9AHomo sapiens (human)500
Chain A, Class I phosphodiesterase PDEB1Leishmania major580
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)698
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)40
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Phosphodiesterase Bos taurus (cattle)9.9
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)4
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)3.1667
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)9.9
Adenosine receptor A1Rattus norvegicus (Norway rat)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)9.9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.242
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)3.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)0.1
Phosphodiesterase Rattus norvegicus (Norway rat)0.1

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Inoue, R; Ito, Y; Tanaka, M; Yanagida, H1
Abrahamczik, C; Budde, T; Caputi, L; Kanyshkova, T; Munsch, T; Pape, HC; Staak, R1
Genlain, M; Godaux, E; Ris, L1
Belluzzi, O; Borin, M; Fogli Iseppe, A; Gambardella, C; Pignatelli, A1

Other Studies

4 other study(ies) available for zd 7288 and 1-methyl-3-isobutylxanthine

ArticleYear
Temperature-sensitive gating of cation current in guinea pig ileal muscle activated by hyperpolarization.
    American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Animals; Cardiotonic Agents; Cations; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; Ion Channel Gating; Ion Channels; Male; Membrane Potentials; Muscle, Smooth; Norepinephrine; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pyrimidines; Sympathomimetics; Temperature; Tetraethylammonium

2000
Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Oct-26, Volume: 25, Issue:43

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adenine; Animals; Blotting, Northern; Cerebral Cortex; Cesium; Chlorides; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Electroencephalography; Enzyme Inhibitors; Epilepsy, Absence; Female; Gene Expression Regulation; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Microinjections; Neurons; Patch-Clamp Techniques; Potassium Channels; Protein Isoforms; Pyrimidines; Rats; Rats, Mutant Strains; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thalamus

2005
Involvement of hyperpolarization-activated cation channels in synaptic modulation.
    Neuroreport, 2007, Aug-06, Volume: 18, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Neural Pathways; Neurons; Phosphodiesterase Inhibitors; Potassium; Potassium Channel Blockers; Potassium Channels; Presynaptic Terminals; Pyrimidines; Rats; Rats, Wistar; Synaptic Membranes; Synaptic Transmission

2007
The h-current in periglomerular dopaminergic neurons of the mouse olfactory bulb.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Benzazepines; Colforsin; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Dopamine; Dopaminergic Neurons; Green Fluorescent Proteins; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ivabradine; Kinetics; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Norepinephrine; Olfactory Bulb; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Rats; Tyrosine 3-Monooxygenase

2013