zardaverine has been researched along with rolipram in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbosa, J; Barrish, JC; Brown, B; Dodd, JH; Donaldson, K; Guo, J; Huynh, T; Kiener, PA; Leftheris, K; Pitts, WJ; Poss, MA; Roberge, JY; Starling, GC; Vaccaro, W; Watson, A | 1 |
| Artis, DR; Bollag, G; Card, GL; England, BP; Fong, D; Gillette, S; Ibrahim, PN; Kim, SH; Lee, B; Luu, C; Milburn, MV; Powell, B; Schlessinger, J; Suzuki, Y; Tabrizizad, M; Zhang, KY | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Jabaris, SS; Kodimuthali, A; Pal, M | 1 |
| Barlow, DJ; Ehrman, TM; Hylands, PJ | 1 |
| Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H | 1 |
| Barreiro, EJ; Bourguignon, JJ; Cardozo, SV; Fraga, CA; Justiniano, H; Kümmerle, AE; Lopes, AB; Lugnier, C; Martins, MA; Romeiro, NC; Schmitt, M; Villa, P | 1 |
| de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R | 1 |
| Bielska, M; Bruno, O; Bull, JA; Fossa, P; Giordanetto, F; Guariento, S; Iwanowa, X; Karawajczyk, A; Marchini, G | 1 |
| Gaal, L; Illes, P; Schudt, C | 1 |
| Dent, G; Magnussen, H; Nakashima, M; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Hatzelmann, A; Schudt, C; Tenor, H | 1 |
| Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Barnes, PJ; Dent, G; Evans, PM; Giembycz, MA; Rabe, KF | 1 |
| Bochnowicz, S; Hay, DW; Kotzer, CJ; Luttmann, MA; Osborn, RR; Torphy, TJ; Underwood, DC | 1 |
| Schade, FU; Schudt, C | 1 |
| Fischer, W; Schudt, C; Wendel, A | 1 |
| Banner, KH; Bertin, B; Moodley, I; Page, CP | 1 |
| Cheng, JB; Cohen, VL; Jayasinghe-Beck, R; Turner, CR; Watson, JW; Wright, KF | 1 |
| Enke, B; Ghofrani, HA; Grimminger, F; Schermuly, RT; Schudt, C; Seeger, W; Walmrath, D; Weissmann, N | 1 |
| Cunningham, FM; Lees, P; Page, CP; Rickards, KJ | 1 |
| Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N | 1 |
1 review(s) available for zardaverine and rolipram
| Article | Year |
|---|---|
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive | 2008 |
21 other study(ies) available for zardaverine and rolipram
| Article | Year |
|---|---|
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Binding Sites; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 7; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ligands; Purines; Structure-Activity Relationship; T-Lymphocytes | 2004 |
Structural basis for the activity of drugs that inhibit phosphodiesterases.
Topics: Binding Sites; Crystallography, X-Ray; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Tertiary | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.
Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship | 2010 |
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi | 2012 |
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Topics: Administration, Oral; Animals; Drug Design; Female; Humans; Hydrazones; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Models, Molecular; Molecular Conformation; Phosphodiesterase 4 Inhibitors; Pneumonia | 2012 |
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship | 2016 |
Design and synthesis of 4,5,6,7-tetrahydro-1H-1,2-diazepin-7-one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors.
Topics: Azepines; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Drug Design; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Molecular Structure; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2017 |
Effects of phosphodiesterase inhibition on the excitability of hippocampal pyramidal neurons in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Neurons; Phosphodiesterase Inhibitors; Pyramidal Tracts; Pyridazines; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram | 1991 |
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Antihypertensive Agents; Carbachol; Colforsin; Cytosol; Dinoprost; Dose-Response Relationship, Drug; Female; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Pyridazines; Pyrrolidinones; Rolipram | 1994 |
Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Benzamides; Blood Proteins; Cell Separation; Complement C5a; Cyclic Nucleotide Phosphodiesterases, Type 4; Electromagnetic Fields; Eosinophil Granule Proteins; Eosinophil-Derived Neurotoxin; Eosinophils; Humans; Inflammation Mediators; Luminescent Measurements; Naphthyridines; Neurotoxins; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridines; Pyrrolidinones; Ribonuclease, Pancreatic; Ribonucleases; Rolipram; Theophylline | 1995 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol.
Topics: Adolescent; Adult; Aged; Albuterol; Cyclic AMP; Drug Synergism; Eosinophils; Female; Humans; Male; Middle Aged; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyrrolidinones; Respiratory Burst; Rolipram | 1994 |
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.
Topics: Animals; Antigens; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Drug Synergism; Eosinophils; Guanidines; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Isoenzymes; Leukotriene D4; Male; Phosphodiesterase Inhibitors; Plethysmography, Whole Body; Pulmonary Eosinophilia; Pyridazines; Pyrrolidinones; Rolipram; Trachea | 1994 |
The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiovascular Agents; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Epoprostenol; Isoenzymes; Lipopolysaccharides; Macrophages; Male; Mice; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Pyridazines; Pyrrolidinones; Rolipram; SRS-A; Tumor Necrosis Factor-alpha | 1993 |
Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Galactosamine; Hepatitis; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Phosphodiesterase Inhibitors; Pyridazines; Pyrrolidinones; Rolipram; Shock, Septic; Tumor Necrosis Factor-alpha | 1993 |
Effect of isoenzyme selective phosphodiesterase inhibitors on the proliferation of murine thymus and spleen cells.
Topics: Animals; Cell Division; Female; Guanidines; Lymphocyte Activation; Mice; Phosphodiesterase Inhibitors; Pyridazines; Pyrrolidinones; Rolipram; Spleen; Thymus Gland | 1996 |
Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Animals; Bronchodilator Agents; Catecholamines; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Propranolol; Pyridazines; Pyrimidinones; Pyrrolidinones; Rolipram; Trachea | 1997 |
Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Inhalation; Aerosols; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epoprostenol; Hypertension, Pulmonary; Naphthyridines; Phosphodiesterase Inhibitors; Pulmonary Circulation; Purinones; Pyridazines; Rabbits; Rolipram; Vasoconstrictor Agents; Vasodilation | 1999 |
Phosphodiesterase activity in neutrophils from horses with chronic obstructive pulmonary disease.
Topics: Animals; Dose-Response Relationship, Immunologic; Guanidines; Horse Diseases; Horses; Isoenzymes; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Disease, Chronic Obstructive; Pyridazines; Pyridines; Rolipram | 2000 |
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzamides; Bronchi; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glycoproteins; Histamine; Humans; In Vitro Techniques; Leukotriene C4; Lung Neoplasms; Muscle Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridines; Rolipram; Theophylline | 2000 |