zaprinast and 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine

zaprinast has been researched along with 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine* in 2 studies

Other Studies

2 other study(ies) available for zaprinast and 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine

Article	Year
In vitro and in vivo inhibition of SK-N-MC neuroblastoma growth using cyclic nucleotide phosphodiesterase inhibitors. Journal of neuro-oncology, 2001, Volume: 51, Issue:1 The effect of cyclic nucleotide phosphodiesterase (PDE) inhibitors Zaprinast and DC-TA-46 has been tested on SK-N-MC neuroblastoma growth. Antiproliferative activity of the tested drugs was assayed both in vitro and in the xenograft model of nude mice. In clonal density experiments, the IC50 value was 3.3 microM for Zaprinast and 1.9 microM for DC-TA-46, while 7.5 microM BCNU alkylating agent was required to obtain the same effect. SK-N-MC cells xenografted in the nude mouse showed that the administration of Zaprinast and DC-TA-46 caused a significant 50% decrease of the tumour weight. These data demonstrate that PDE inhibitors may be useful for at least reducing tumour growth; they may be of interest for further evaluation as alternative molecules in the design of multiple agent protocols for neuroblastoma treatment. Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antineoplastic Agents; Cell Division; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neuroblastoma; Phosphodiesterase Inhibitors; Piperazines; Pteridines; Purinones; Tumor Cells, Cultured	2001
Phosphodiesterase specific inhibitors control cell growth of a human neuroepithelioma cell line. Journal of neuro-oncology, 1997, Volume: 31, Issue:1-2 The effects of cyclic nucleotide phosphodiesterase (PDE) inhibitors on cell proliferation of SK-N-MC human neuroepithelioma cell line was studied. Clonal density experiments in the presence of 100 microM rolipram and zaprinast showed respectively 27% and 91% inhibition. The effects of PDE inhibitors were then investigated on crude cell extracts; the calculated IC50 were 32 microM for zaprinast and 16 nM for DC-TA-46; the latter inhibitor was used instead of rolipram for its higher efficacy. Dose-response experiments in clonal density conditions showed IC50 of 5 microM and 1.8 microM in the presence respectively of zaprinast and rolipram. These data show that both inhibitors are effective in reducing cell growth, although the response was quantitatively different. Topics: Cell Division; Humans; Neuroectodermal Tumors, Primitive, Peripheral; Phosphodiesterase Inhibitors; Piperazines; Pteridines; Purinones; Pyrrolidinones; Rolipram; Tumor Cells, Cultured	1997

Article

Year

In vitro and in vivo inhibition of SK-N-MC neuroblastoma growth using cyclic nucleotide phosphodiesterase inhibitors.

Journal of neuro-oncology, 2001, Volume: 51, Issue:1

The effect of cyclic nucleotide phosphodiesterase (PDE) inhibitors Zaprinast and DC-TA-46 has been tested on SK-N-MC neuroblastoma growth. Antiproliferative activity of the tested drugs was assayed both in vitro and in the xenograft model of nude mice. In clonal density experiments, the IC50 value was 3.3 microM for Zaprinast and 1.9 microM for DC-TA-46, while 7.5 microM BCNU alkylating agent was required to obtain the same effect. SK-N-MC cells xenografted in the nude mouse showed that the administration of Zaprinast and DC-TA-46 caused a significant 50% decrease of the tumour weight. These data demonstrate that PDE inhibitors may be useful for at least reducing tumour growth; they may be of interest for further evaluation as alternative molecules in the design of multiple agent protocols for neuroblastoma treatment.

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antineoplastic Agents; Cell Division; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neuroblastoma; Phosphodiesterase Inhibitors; Piperazines; Pteridines; Purinones; Tumor Cells, Cultured

2001

Phosphodiesterase specific inhibitors control cell growth of a human neuroepithelioma cell line.

Journal of neuro-oncology, 1997, Volume: 31, Issue:1-2

The effects of cyclic nucleotide phosphodiesterase (PDE) inhibitors on cell proliferation of SK-N-MC human neuroepithelioma cell line was studied. Clonal density experiments in the presence of 100 microM rolipram and zaprinast showed respectively 27% and 91% inhibition. The effects of PDE inhibitors were then investigated on crude cell extracts; the calculated IC50 were 32 microM for zaprinast and 16 nM for DC-TA-46; the latter inhibitor was used instead of rolipram for its higher efficacy. Dose-response experiments in clonal density conditions showed IC50 of 5 microM and 1.8 microM in the presence respectively of zaprinast and rolipram. These data show that both inhibitors are effective in reducing cell growth, although the response was quantitatively different.

Topics: Cell Division; Humans; Neuroectodermal Tumors, Primitive, Peripheral; Phosphodiesterase Inhibitors; Piperazines; Pteridines; Purinones; Pyrrolidinones; Rolipram; Tumor Cells, Cultured

1997