zanamivir has been researched along with n-acetylneuraminic acid in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Cairo, CW; Guo, T; Hunter, CD; Richards, MR | 1 |
| Bethell, RC; Blick, TJ; Colman, PM; Hart, GJ; McDonald, M; McKimm-Breschkin, JL; Sahasrabudhe, A; Varghese, JN | 1 |
| Barnett, JM; Hiscox, SA; Morris, SJ; Price, GE; Smith, H; Sweet, C | 1 |
| Luo, C; Nakajima, K; Nobusawa, E | 1 |
| Arai, M; Honda, T; Kaneko, S; Masuda, T; Yamashita, M; Yoshida, S | 1 |
| Arai, M; Honda, T; Masuda, T; Yamashita, M; Yoshida, S | 1 |
| Brokstad, KA; Brytting, M; Jonsson, R; Linde, A; Mittelholzer, CM; Pauksens, K | 1 |
| Chou, KC; Du, QS; Sun, H; Wei, DQ | 1 |
| Aruksakunwong, O; Decha, P; Hannongbua, S; Intharathep, P; Malaisree, M; Rungrotmongkol, T | 1 |
| Andrew, PW; Carter, M; Hayre, J; Iannelli, F; Kadioglu, A; Oggioni, MR; Pozzi, G; Trappetti, C | 1 |
| Gervay-Hague, J; Horn, EJ | 1 |
| Belshe, RB; Fang, F; Gubareva, LV; Hedlund, M; Klimov, AI; Larson, JL; Moss, RB; Triana-Baltzer, GB; Wurtman, DF | 1 |
| Barrett, S; McKimm-Breschkin, JL; Mohr, PG; Schmidt, PM | 1 |
| Chuman, H; Harada, M; Hirokawa, T; Hitaoka, S; Itoh, K; Matoba, H; Tsuji, D; Yoshida, T | 1 |
| Ikeda, K; Itoh, Y; Sando, A; Suzuki, T; Tokiwa, H | 1 |
| Bhatt, B; Smee, DF; Tarbet, EB; von Itzstein, M | 1 |
| Gao, GF; Kiyota, H; Li, Q; Li, Y; Liu, Y; Qi, J; Sriwilaijaroen, N; Suzuki, Y; Tanaka, K; Vavricka, CJ; Wu, Y; Yan, J | 1 |
| Chi, HC; Hsiao, NW; Lin, CY; Shih, KC; Tang, CY; Zhou, J | 1 |
| Liu, GJ; Wang, B; Wang, S; Xing, GW; Yang, X; Zhang, Y | 1 |
| Herrera-Camacho, I; Márquez-Domínguez, L; Reyes-Leyva, J; Santos-López, G; Scior, T | 1 |
| Anu Radha, C; Jeyaram, RA | 1 |
| Aljohani, MA; Keil, JM; Rafn, GR; Sahebjam-Atabaki, R; Sun, XL; Turan, IM | 1 |
| Bethell, R; Cherry, PC; Cleasby, A; Colman, P; Howes, PD; Singh, O; Skarzynski, T; Smith, PW; Sollis, SL; Taylor, NR; Varghese, J; Wonacott, AJ | 1 |
| Bourguet, E; Figurska, S; Fra Czek, MM | 1 |
2 review(s) available for zanamivir and n-acetylneuraminic acid
| Article | Year |
|---|---|
Sialidase Inhibitors with Different Mechanisms.
Topics: Antiviral Agents; Biological Products; Enzyme Inhibitors; Humans; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Sialic Acids; Zanamivir | 2022 |
Human Neuraminidases: Structures and Stereoselective Inhibitors.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Models, Molecular; Neuraminidase; Stereoisomerism; Structure-Activity Relationship | 2022 |
22 other study(ies) available for zanamivir and n-acetylneuraminic acid
| Article | Year |
|---|---|
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity.
Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Molecular Dynamics Simulation; Neuraminidase; Sequence Alignment; Viral Proteins; Zanamivir | 2018 |
Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors.
Topics: Acetamides; Adsorption; Animals; Binding Sites; Birds; Cell Line; Conserved Sequence; Dogs; Drug Resistance, Microbial; Enzyme Inhibitors; Guanidines; Heating; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A virus; Kinetics; Molecular Structure; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Phenotype; Pyrans; Sialic Acids; Substrate Specificity; Viral Plaque Assay; Virus Replication; Zanamivir | 1998 |
Role of neuraminidase in influenza virus-induced apoptosis.
Topics: alpha-Fetoproteins; Amantadine; Amino Acid Sequence; Ammonium Chloride; Animals; Antiviral Agents; Apoptosis; Base Sequence; Cell Line; DNA, Viral; Dogs; Enzyme Inhibitors; Guanidines; Humans; Influenza A virus; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Pyrans; Sialic Acids; Substrate Specificity; Time Factors; Ultraviolet Rays; Zanamivir | 1999 |
Analysis of the desialidation process of the haemagglutinin protein of influenza B virus: the host-dependent desialidation step.
Topics: Animals; Cell Line; Chlorocebus aethiops; COS Cells; Dogs; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Golgi Apparatus; Guanidines; Hemadsorption; Hemagglutinin Glycoproteins, Influenza Virus; Immunohistochemistry; Influenza B virus; N-Acetylneuraminic Acid; Neuraminidase; Pyrans; Sialic Acids; Species Specificity; Virus Replication; Zanamivir | 2002 |
Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir.
Topics: Antiviral Agents; Enzyme Inhibitors; Glyceryl Ethers; Guanidines; Influenza A virus; Inhibitory Concentration 50; N-Acetylneuraminic Acid; Neuraminidase; Pyrans; Sialic Acids; Structure-Activity Relationship; Viral Plaque Assay; Zanamivir | 2002 |
Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives.
Topics: Animals; Antiviral Agents; Enzyme Inhibitors; Glutamic Acid; Glyceryl Ethers; Guanidine; Guanidines; Influenza A virus; Inhibitory Concentration 50; Mice; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae Infections; Pyrans; Sialic Acids; Structure-Activity Relationship; Viral Plaque Assay; Zanamivir | 2002 |
Human cell lines used in a micro neutralization test for measuring influenza-neutralizing antibodies.
Topics: Adolescent; Adult; Animals; Antibodies, Viral; Cell Line; Cell Membrane; Dogs; Dose-Response Relationship, Immunologic; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Guanidines; Humans; Influenza A virus; Microscopy, Electron; Middle Aged; N-Acetylneuraminic Acid; Neutralization Tests; Pyrans; Sialic Acids; Zanamivir | 2006 |
Insights from modeling the 3D structure of H5N1 influenza virus neuraminidase and its binding interactions with ligands.
Topics: Acetamides; Binding Sites; Computer Simulation; Enzyme Activation; Guanidines; Influenza A Virus, H5N1 Subtype; Models, Chemical; Models, Molecular; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Protein Binding; Protein Conformation; Pyrans; Sequence Analysis, Protein; Sialic Acids; Structure-Activity Relationship; Zanamivir | 2006 |
Understanding of known drug-target interactions in the catalytic pocket of neuraminidase subtype N1.
Topics: Acids, Carbocyclic; Algorithms; Antiviral Agents; Binding Sites; Catalysis; Computer Simulation; Cyclopentanes; Databases, Protein; Guanidines; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Influenza A Virus, H5N1 Subtype; Inhibitory Concentration 50; Ligands; Models, Molecular; Molecular Conformation; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Pressure; Protein Binding; Protein Structure, Secondary; Static Electricity; Temperature; Thermodynamics; Time Factors; Water; Zanamivir | 2008 |
Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.
Topics: Animals; Biofilms; DNA Primers; Gene Expression Regulation, Bacterial; Humans; Mice; N-Acetylneuraminic Acid; Neuraminidase; Pneumococcal Infections; Saliva; Streptococcus pneumoniae; Zanamivir | 2009 |
Efficient method for the preparation of peracetylated Neu5Ac2en by flash vacuum pyrolysis.
Topics: Acetylation; Antiviral Agents; Enzyme Inhibitors; Heating; Methods; N-Acetylneuraminic Acid; Neuraminidase; Organic Chemistry Phenomena; Vacuum; Zanamivir | 2009 |
Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein.
Topics: Animals; Antiviral Agents; Binding Sites; Caco-2 Cells; Cell Proliferation; Dogs; Humans; Influenza, Human; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Oseltamivir; Recombinant Fusion Proteins; Zanamivir | 2009 |
Real time enzyme inhibition assays provide insights into differences in binding of neuraminidase inhibitors to wild type and mutant influenza viruses.
Topics: Acids, Carbocyclic; Binding, Competitive; Cyclopentanes; Enzyme Assays; Enzyme Inhibitors; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H5N1 Subtype; Inhibitory Concentration 50; Kinetics; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Oseltamivir; Protein Binding; Substrate Specificity; Time Factors; Viral Proteins; Zanamivir | 2011 |
Correlation analyses on binding affinity of sialic acid analogues and anti-influenza drugs with human neuraminidase using ab initio MO calculations on their complex structures--LERE-QSAR analysis (IV).
Topics: Antiviral Agents; Electrons; Humans; Influenza A virus; Molecular Dynamics Simulation; N-Acetylneuraminic Acid; Neuraminidase; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Quantum Theory; Static Electricity; Thermodynamics; Zanamivir | 2011 |
Origin of the inhibitory activity of 4-O-substituted sialic derivatives of human parainfluenza virus.
Topics: Antiviral Agents; Binding Sites; HN Protein; Humans; Models, Molecular; N-Acetylneuraminic Acid; Parainfluenza Virus 1, Human; Zanamivir | 2012 |
Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs.
Topics: Administration, Intranasal; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Female; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Virus Replication; Zanamivir | 2012 |
Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors.
Topics: Animals; Antiviral Agents; Biocatalysis; Conserved Sequence; Crystallography, X-Ray; Drug Resistance, Viral; Enzyme Inhibitors; Fluorescence; Humans; Kinetics; Madin Darby Canine Kidney Cells; Magnetic Resonance Spectroscopy; Models, Molecular; Mutant Proteins; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Oseltamivir; Tyrosine; Virus Replication; Zanamivir | 2013 |
Development of 3D-QSAR combination approach for discovering and analysing neuraminidase inhibitors in silico.
Topics: Algorithms; Binding Sites; Computational Biology; Drug Design; Humans; Influenza, Human; Inhibitory Concentration 50; Least-Squares Analysis; Models, Molecular; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Quantitative Structure-Activity Relationship; Software; Technology, Pharmaceutical; Zanamivir | 2014 |
A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial va
Topics: Adult; Clostridium perfringens; Enzyme Inhibitors; Female; Fluorescence; Fluorescent Dyes; Fluorometry; High-Throughput Screening Assays; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Limit of Detection; Middle Aged; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Sialic Acids; Stilbenes; Vaginosis, Bacterial; Vibrio cholerae; Young Adult; Zanamivir | 2018 |
Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus.
Topics: Antiviral Agents; Benzoic Acid; Binding Sites; Binding, Competitive; Enzyme Inhibitors; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N2 Subtype; Kinetics; Ligands; Molecular Docking Simulation; N-Acetylneuraminic Acid; Neuraminidase; Structure-Activity Relationship; Zanamivir | 2020 |
N1 neuraminidase of H5N1 avian influenza A virus complexed with sialic acid and zanamivir - A study by molecular docking and molecular dynamics simulation.
Topics: Antiviral Agents; Influenza A Virus, H5N1 Subtype; Molecular Docking Simulation; Molecular Dynamics Simulation; N-Acetylneuraminic Acid; Neuraminidase; Zanamivir | 2022 |
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
Topics: Acetamides; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Guanidines; Influenza A virus; Influenza B virus; Models, Molecular; Neuraminidase; Protein Conformation; Pyrans; Sialic Acids; Zanamivir | 1998 |