zanamivir has been researched along with 2-deoxy-2,3-dehydro-n-acetylneuraminic acid in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 16 (51.61) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bethell, R; Cherry, PC; Cleasby, A; Colman, P; Howes, PD; Singh, O; Skarzynski, T; Smith, PW; Sollis, SL; Taylor, NR; Varghese, J; Wonacott, AJ | 1 |
| Blick, TJ; Colman, PM; McKimm-Breschkin, JL; Sahasrabudhe, A; Smith, PW; Sollis, SL; Varghese, JN | 1 |
| Ananth, SL; Babu, YS; Bantia, S; Chand, P; Dehghani, A; El-Kattan, Y; Elliott, AJ; Horn, LL; Hutchison, TL; Kotian, P; Laver, GW; Lin, TH; Montgomery, JA; Parker, CD | 1 |
| Kollman, PA; Kuntz, ID; Masukawa, KM | 1 |
| Dyason, JC; Kuwahara, Y; Maki, N; Suzuki, T; Suzuki, Y; Thomson, RJ; Tindal, DJ; Ueyama, H; von Itzstein, M | 1 |
| Chen, XG; Chen, YL; Hu, ZD; Liu, MC; Lü, WJ; Luan, F; Ma, WP; Zhang, XY | 1 |
| Hata, K; Hirai, G; Koseki, K; Miyagi, T; Moriya, S; Sodeoka, M; Suzuki, Y; von Itzstein, M; Yamaguchi, K; Yingsakmongkon, S | 1 |
| Chavas, LM; Dyason, JC; Fusi, P; Kato, R; Mann, MC; McKimm-Breschkin, J; Monti, E; Suzuki, N; Tettamanti, G; Thomson, RJ; Tringali, C; Venerando, B; von Itzstein, M; Wakatsuki, S | 1 |
| Cheng, YS; Fang, JM; Tsai, KC; Wang, SY; Wen, WH; Wong, CH; Yang, AS | 1 |
| Haselhorst, T; McAtamney, S; Mohan, S; Pinto, BM; von Itzstein, M | 1 |
| Albohy, A; Cairo, CW; Sandbhor, M; Zou, Y | 1 |
| Albohy, A; Cairo, CW; Mohan, S; Pinto, BM; Zheng, RB | 1 |
| Bhatt, B; Böhm, R; Dyason, JC; Kerry, PS; Russell, RJ; Thomson, RJ; von Itzstein, M | 1 |
| Andrew, PW; Borgianni, L; Docquier, JD; Hayre, JK; Oggioni, MR; Taylor, GL; Xu, G | 1 |
| Feng, E; Jiang, H; Li, J; Liu, H; Liu, X; No, KT; Seong, BL; Shin, WJ; Tang, W; Wang, J; Ye, D; Zheng, M; Zhu, W; Zhu, X; Zuo, JP | 1 |
| Dyason, JC; Maggioni, A; Rudrawar, S; Thomson, RJ; von Itzstein, M | 1 |
| Albohy, A; Cairo, CW; Pshezhetsky, AV; Smutova, V; Zhang, Y | 1 |
| Ando, H; Hiramatsu, H; Hori, T; Imamura, A; Ishida, H; Ishikawa, T; Ishitsubo, E; Kiso, M; Kuwata, K; Magesh, S; Miyagi, T; Moriya, S; Odagiri, T; Sakai, M; Sriwilaijaroen, N; Suzuki, Y; Tashiro, M; Tokiwa, H; Tsukamoto, K | 1 |
| Cairo, CW; Dätwyler, P; Demina, E; Ernst, B; Fougerat, A; Ge, P; Guo, T; Pshezhetsky, AV; Richards, MR; Zheng, R; Zou, C | 1 |
| Cairo, CW; Guo, T; Hunter, CD; Richards, MR | 1 |
| Bourguet, E; Figurska, S; Fra Czek, MM | 1 |
| Aljohani, MA; Keil, JM; Rafn, GR; Sahebjam-Atabaki, R; Sun, XL; Turan, IM | 1 |
| Bethell, RC; Blick, TJ; Colman, PM; Hart, GJ; McDonald, M; McKimm-Breschkin, JL; Sahasrabudhe, A; Varghese, JN | 1 |
| Barnett, JM; Hiscox, SA; Morris, SJ; Price, GE; Smith, H; Sweet, C | 1 |
| Arai, M; Honda, T; Masuda, T; Yamashita, M; Yoshida, S | 1 |
| Chou, KC; Du, QS; Sun, H; Wei, DQ | 1 |
| Andrew, PW; Carter, M; Hayre, J; Iannelli, F; Kadioglu, A; Oggioni, MR; Pozzi, G; Trappetti, C | 1 |
| Gervay-Hague, J; Horn, EJ | 1 |
| Barrett, S; McKimm-Breschkin, JL; Mohr, PG; Schmidt, PM | 1 |
| Bhatt, B; Smee, DF; Tarbet, EB; von Itzstein, M | 1 |
| Liu, GJ; Wang, B; Wang, S; Xing, GW; Yang, X; Zhang, Y | 1 |
2 review(s) available for zanamivir and 2-deoxy-2,3-dehydro-n-acetylneuraminic acid
| Article | Year |
|---|---|
Human Neuraminidases: Structures and Stereoselective Inhibitors.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Models, Molecular; Neuraminidase; Stereoisomerism; Structure-Activity Relationship | 2022 |
Sialidase Inhibitors with Different Mechanisms.
Topics: Antiviral Agents; Biological Products; Enzyme Inhibitors; Humans; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Sialic Acids; Zanamivir | 2022 |
29 other study(ies) available for zanamivir and 2-deoxy-2,3-dehydro-n-acetylneuraminic acid
| Article | Year |
|---|---|
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
Topics: Acetamides; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Guanidines; Influenza A virus; Influenza B virus; Models, Molecular; Neuraminidase; Protein Conformation; Pyrans; Sialic Acids; Zanamivir | 1998 |
Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Topics: Antiviral Agents; Arginine; Drug Design; Drug Resistance, Microbial; Influenza A virus; Mutation; Neuraminidase | 1998 |
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.
Topics: Acids, Carbocyclic; Administration, Oral; Animals; Antiviral Agents; Catalytic Domain; Crystallography, X-Ray; Cyclopentanes; Drug Design; Enzyme Inhibitors; Guanidines; Influenza A virus; Influenza B virus; Mice; Models, Molecular; Neuraminidase; Orthomyxoviridae Infections; Protein Binding; Stereoisomerism; Structure-Activity Relationship | 2000 |
Investigation of neuraminidase-substrate recognition using molecular dynamics and free energy calculations.
Topics: Alanine; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Ligands; Models, Molecular; Molecular Conformation; Neuraminidase; Substrate Specificity; Thermodynamics; Viral Core Proteins; Water | 2003 |
Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity.
Topics: Cell Line; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Indicators and Reagents; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 3, Human; Spectrometry, Fluorescence | 2007 |
QSAR study of neuraminidase inhibitors based on heuristic method and radial basis function network.
Topics: Enzyme Inhibitors; Linear Models; Models, Biological; Neuraminidase; Quantitative Structure-Activity Relationship | 2008 |
Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.
Topics: Antiviral Agents; Cell Line; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Neuraminidase; Orthomyxoviridae; Oseltamivir; Recombinant Proteins; RNA, Messenger; Zanamivir | 2008 |
Complexity in influenza virus targeted drug design: interaction with human sialidases.
Topics: Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; Models, Molecular; Molecular Conformation; Neuraminidase; Orthomyxoviridae | 2010 |
Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses.
Topics: Antiviral Agents; Enzyme Inhibitors; Influenza A Virus, H1N1 Subtype; Inhibitory Concentration 50; Neuraminidase; Orthomyxoviridae; Protein Binding; Protein Conformation; Structure-Activity Relationship; Zanamivir | 2010 |
Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors. Binding to N1 enzymes in the context of virus-like particles.
Topics: Antiviral Agents; Catalytic Domain; Influenza A virus; Magnetic Resonance Spectroscopy; Models, Molecular; Neuraminidase; Oseltamivir; Protein Binding; Stereoisomerism; Triazoles; Virion | 2010 |
Inhibition of human neuraminidase 3 (NEU3) by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic acid.
Topics: Alkynes; Azides; Binding Sites; Catalysis; Computer Simulation; Copper; Humans; N-Acetylneuraminic Acid; Neuraminidase; Structure-Activity Relationship; Triazoles | 2010 |
Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes.
Topics: Antiviral Agents; Catalytic Domain; Enzyme Inhibitors; Humans; Influenza A virus; Neuraminidase; Oseltamivir; Protein Isoforms; Structure-Activity Relationship; Viral Proteins | 2011 |
Exploring the interactions of unsaturated glucuronides with influenza virus sialidase.
Topics: Acetamides; Antiviral Agents; Catalytic Domain; Enzyme Assays; Fluorometry; Glucuronides; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Neuraminidase; Orthomyxoviridae; Static Electricity; Structure-Activity Relationship | 2012 |
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases.
Topics: Biocatalysis; Buffers; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; N-Acetylneuraminic Acid; Neuraminidase; Recombinant Proteins; Spectrophotometry, Ultraviolet; Streptococcus pneumoniae; Substrate Specificity | 2012 |
Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
Topics: Antiviral Agents; Drug Design; Enzyme Inhibitors; Models, Molecular; Neuraminidase; Zanamivir | 2013 |
Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop.
Topics: Molecular Probes; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Protein Binding; Protein Structure, Secondary; Sialic Acids | 2013 |
Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4.
Topics: | 2013 |
A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions.
Topics: Animals; Antiviral Agents; Chickens; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Madin Darby Canine Kidney Cells; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Neuraminidase; Orthomyxoviridae; Structure-Activity Relationship; Virus Replication | 2016 |
Selective Inhibitors of Human Neuraminidase 3.
Topics: Animals; Enzyme Inhibitors; Humans; Isoenzymes; Mice; N-Acetylneuraminic Acid; Neuraminidase; Small Molecule Libraries | 2018 |
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity.
Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Molecular Dynamics Simulation; Neuraminidase; Sequence Alignment; Viral Proteins; Zanamivir | 2018 |
Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors.
Topics: Acetamides; Adsorption; Animals; Binding Sites; Birds; Cell Line; Conserved Sequence; Dogs; Drug Resistance, Microbial; Enzyme Inhibitors; Guanidines; Heating; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A virus; Kinetics; Molecular Structure; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Phenotype; Pyrans; Sialic Acids; Substrate Specificity; Viral Plaque Assay; Virus Replication; Zanamivir | 1998 |
Role of neuraminidase in influenza virus-induced apoptosis.
Topics: alpha-Fetoproteins; Amantadine; Amino Acid Sequence; Ammonium Chloride; Animals; Antiviral Agents; Apoptosis; Base Sequence; Cell Line; DNA, Viral; Dogs; Enzyme Inhibitors; Guanidines; Humans; Influenza A virus; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Pyrans; Sialic Acids; Substrate Specificity; Time Factors; Ultraviolet Rays; Zanamivir | 1999 |
Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives.
Topics: Animals; Antiviral Agents; Enzyme Inhibitors; Glutamic Acid; Glyceryl Ethers; Guanidine; Guanidines; Influenza A virus; Inhibitory Concentration 50; Mice; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae Infections; Pyrans; Sialic Acids; Structure-Activity Relationship; Viral Plaque Assay; Zanamivir | 2002 |
Insights from modeling the 3D structure of H5N1 influenza virus neuraminidase and its binding interactions with ligands.
Topics: Acetamides; Binding Sites; Computer Simulation; Enzyme Activation; Guanidines; Influenza A Virus, H5N1 Subtype; Models, Chemical; Models, Molecular; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Protein Binding; Protein Conformation; Pyrans; Sequence Analysis, Protein; Sialic Acids; Structure-Activity Relationship; Zanamivir | 2006 |
Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.
Topics: Animals; Biofilms; DNA Primers; Gene Expression Regulation, Bacterial; Humans; Mice; N-Acetylneuraminic Acid; Neuraminidase; Pneumococcal Infections; Saliva; Streptococcus pneumoniae; Zanamivir | 2009 |
Efficient method for the preparation of peracetylated Neu5Ac2en by flash vacuum pyrolysis.
Topics: Acetylation; Antiviral Agents; Enzyme Inhibitors; Heating; Methods; N-Acetylneuraminic Acid; Neuraminidase; Organic Chemistry Phenomena; Vacuum; Zanamivir | 2009 |
Real time enzyme inhibition assays provide insights into differences in binding of neuraminidase inhibitors to wild type and mutant influenza viruses.
Topics: Acids, Carbocyclic; Binding, Competitive; Cyclopentanes; Enzyme Assays; Enzyme Inhibitors; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H5N1 Subtype; Inhibitory Concentration 50; Kinetics; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Oseltamivir; Protein Binding; Substrate Specificity; Time Factors; Viral Proteins; Zanamivir | 2011 |
Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs.
Topics: Administration, Intranasal; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Female; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Virus Replication; Zanamivir | 2012 |
A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial va
Topics: Adult; Clostridium perfringens; Enzyme Inhibitors; Female; Fluorescence; Fluorescent Dyes; Fluorometry; High-Throughput Screening Assays; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Limit of Detection; Middle Aged; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Sialic Acids; Stilbenes; Vaginosis, Bacterial; Vibrio cholerae; Young Adult; Zanamivir | 2018 |