Page last updated: 2024-08-22

zalcitabine and stavudine

zalcitabine has been researched along with stavudine in 140 studies

Research

Studies (140)

TimeframeStudies, this research(%)All Research%
pre-19906 (4.29)18.7374
1990's79 (56.43)18.2507
2000's36 (25.71)29.6817
2010's17 (12.14)24.3611
2020's2 (1.43)2.80

Authors

AuthorsStudies
Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E1
Augustyns, K; Balzarini, J; Blaton, N; De Clercq, E; De Ranter, C; Everaert, D; Janssen, G; Jie, L; Peeters, O; Van Aerschot, A1
Broder, S; Driscoll, JS; Kim, CH; Marquez, VE; Mitsuya, H1
Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H1
Chen, MS; Gao, YS; Ghazzouli, I; Lin, TS; McLaren, C; Prusoff, WH1
Antonenko, SV; Chentsova, NP; Kukhar, VP; Luik, AI; Poda, GI; Tetko, IV1
Cha, SH; Endou, H; Kanai, Y; Kimura, M; Sekine, T; Tsuda, M; Wada, S1
Cheng, YC; Dutschman, GE; Gullen, EA; Lin, TS; Liu, MC; Luo, MZ; Mozdziesz, DE; Sartorelli, AC1
Bader, JP; Cragg, GM; Newman, DJ; Yang, SS1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E1
Amblard, F; Bassit, L; Bondada, L; Coats, SJ; Detorio, M; Grier, J; Hernandez-Santiago, BI; Koontz, D; Mellors, JW; Rapp, KL; Schinazi, RF; Sluis-Cremer, N1
Behrens, GM; Das, AM; Lücke, T; Schmidt, RE; Stankov, MV2
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Li, Y; Liotta, DC; Liu, L; Lutz, S; Soni, PB; Zhang, X1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Gangadhara, KL; Herdewijn, P; Lescrinier, E; Pannecouque, C1
Anderson, KS; Chordia, MD; Frey, KM; Iyidogan, P; Sullivan, TJ1
Arumugam, SR; Badri, KR; He, JJ; Visalli, RJ; Zhang, X; Zhao, H; Ziobrowski, H1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Peck, A; Schinazi, RF; Sommadossi, JP1
Cooper, DA; Danner, SA; Lange, JM1
Keilbaugh, SA; Prusoff, WH; Simpson, MV1
Gerber, MA; Lampertico, P; Malter, JS1
Broder, S; Kageyama, S; Mitsuya, H; Yarchoan, R1
Chen, CH; Cheng, YC; Vazquez-Padua, M1
Fukushima, S; Kawaguchi, T; Mishima, M; Nakano, M; Ohmura, M1
Hiraoka, W; Kuwabara, M; Matsuda, A; Sato, F; Tanabe, K; Ueda, T1
Hamamoto, Y; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N1
Portegies, P1
Nelson, H1
Mitsuya, H1
Lacey, SF; Larder, BA1
López-Galíndez, C; Nájera, I; Nájera, R; Olivares, I; Peinado, MA; Perucho, M; Richman, DD; Rojas, JM1
Cheng, YC; Liu, SH; Skalski, V1
Stretcher, BN1
Gunnarsson, G; Hammer, SM1
Hoernle, EH; Reid, TE1
Simpson, DM; Tagliati, M1
Dudley, MN1
Cheng, YC; Hsiung, GD; Medina, DJ; Tsai, CH1
Lüthy, R1
Gao, Q; Gu, Z; Nagai, K; Parniak, MA; Salomon, H; Wainberg, MA1
Balzarini, J1
Volberding, PD1
Magnuson, T; Mourton, T; Toltzis, P1
Cooper, DA; Emery, S1
Chou, TC; Hirsch, MS; Merrill, DP; Moonis, M1
Besley, D; Graham, NM; Jacobson, LP; Muñoz, A; Murphy, R; Park, LP; Zucconi, S1
Ho, DD1
Chikami, GK; Piazza-Hepp, TD; Styrt, BA1
Lane, HC; Masur, H; Spooner, KM1
Baba, M; Hashimoto, KI; Okamoto, M; Shigeta, S; Tsunoda, R1
De Simone, C; Famularo, G; Longo, A; Marcellini, S; Moretti, S; Santini, G; Trinchieri, V; Tzantzoglou, S1
Aguirrebengoa, K; Mallolas, J; Torres Tortosa, M; Uriz, J1
Cui, L; Locatelli, L; Sommadossi, JP; Xie, MY1
Hirschel, B; Rutschmann, O1
Heins, JR1
Brizzi, M; Ceccherini-Nelli, L; Forastieri, G; Iuliano, R; Mazzotta, F; Mecocci, L1
Collins, DO; Sakamoto, A1
Roca, B; Simón, E1
Chiang, Y; Drake, RR; Govindarajan, R; Hume, SD; Krisa, S; McMasters, R; Munshi, NC; Rechtin, TM; Saylors, RL1
Back, DJ; Barry, MG; Hoggard, PG; Kewn, S; Veal, GJ1
Back, DJ; Barry, MG; Hoggard, PG; Manion, V1
Barton, S; Blaxhult, A; Clotet, B; Goebel, FD; Hirschel, B; Katlama, C; Lundgren, JD; Pedersen, C; Phillips, AN; Vella, S1
Conway, B; Hogg, RS; Montaner, JS; O'Shaughnessy, MV; Rhone, SA; Schechter, MT; Sherlock, C; Yip, B1
Blanchard, G; Blum, L; Calvo, F; Danne, O; Lebbé, C; Morel, P; Pellet, C; Vérola, O1
Bloor, S; de Béthune, MP; Gröschel, B; Harrigan, PR; Hertogs, K; Kemp, SD; Larder, BA; Miller, V; Pauwels, R; Staszewski, S; Stürmer, M1
Bridges, EG; Cheng, YC; Dutschman, GE; Gullen, E; Guo, X; Kukhanova, M; Liu, SH1
Baldeweg, T; Catalan, J; Gazzard, BG1
Bachmeyer, C; Blum, L1
Kempf-Durepaire, G; Krantz, V; Lang, JM; Nicolle, M; Partisani, M; Rey, D; Schmitt, AC; Schmitt, MP1
Saag, MS; Schooley, RT1
Gitterman, SR; Pratt, RD; Struble, KA1
Moyle, GJ; Sadler, M1
AbdelHameed, MH; Dorr, A; Griffy, K; Jung, D; Teitelbaum, P1
Temesgen, Z; Wright, AJ1
Arlotto, C; Bernard, A; Bernard-Pomier, G; Breittmayer, JP; Dellamonica, P; Pradier, C; Pugliese, P; Roger, PM1
Arrizabalaga, J; Clotet, BG; Cruceta, A; Dalmau, D; Gallart, T; García, F; Gatell, JM; Gomez-Sirvent, JL; Grau, I; Knobel, H; Miró, JM; O'Brien, WA; Podzamczer, D; Pumarola, T; Romeu, J; Sambeat, MA1
Flepp, M; Jost, J; Ledergerber, B; Opravil, M; Paris, D; Ruef, C; Weber, R; Zimmerli, S1
Aoki, M; Genka, I; Kikuchi, Y; Oka, S; Tachikawa, N; Teruya, K; Yamaguchi, M; Yamamoto, Y; Yasuoka, A; Yasuoka, C1
Degenhardt, E; Glück, T; Grossmann, J; Lang, B; Schölmerich, J; Straub, RH1
Allende, MC; Belloso, WH; Benetucci, JA; Cahn, PE; Davey, RT; Emery, S; Lane, HC; Lasala, MC; Law, MG; Lopardo, G; Losso, MH; Nelson, E; Salomon, H; Saracco, M1
Beylot, J; Dabis, F; Dequae-Merchadou, L; Marimoutou, C; Mercié, P; Morlat, P; Neau, D; Pellegrin, I1
Boschini, A; Calista, D1
Bossi, P; Calvez, V; Delaugerre, C; Delfraissy, JF; Diquet, B; Do, B; Dohin, E; Katlama, C; Legrand, M; Mouroux, M; Peytavin, G; Trylesinski, A; Yvon-Groussin, A1
Albright, AV; Erickson-Viitanen, S; Frank, I; González-Scarano, F; O'Connor, M; Rayner, MM1
Back, DJ; Hart, CA; Hoggard, PG; Kewn, S; Khoo, SH; Sales, SD; Sunderland, D1
Arendt, G; Hefter, H; Theisen, A; von Giesen, HJ1
Copeland, WC; Lim, SE1
Gilden, D1
Poscher, M1
Conant, M1
Japour, AJ1
Smart, T3
Cheng, B1
Cain, D; Clarke, JR; Erlwein, O; Frater, AJ; Grigg, AR; Hill, CL; McClure, MO; Patton, G; Rosenblum, LL1
Blumoff, K; Garcia-Lerma, JG; Heneine, W; Nidtha, S; Weinstock, H1
Aquilina, C; Calvez, V; Delfraissy, JF; Dohin, E; Goehrs, JM; Katlama, C; Lacoste, D; Lantz, O; Montestruc, F; Mouroux, M; Pellegrin, JL; Pialoux, G; Raffi, F; Raguin, G; Trylesinski, A; Vittecoq, D1
Blanquet, D; Hage, F; Hallard, M; Mathe, G; Morette, C; Pontiggia, P1
Birkus, G; Cihlar, T; Greenwalt, DE; Hitchcock, MJ1
Domínguez Castellanos, A; Justo Alpañés, E; Orbea Ríos, L1
Copeland, WC; Lim, SE; Longley, MJ; Ponamarev, MV1
Derse, D; Hill, SA; Lloyd, PA; McDonald, S; Wykoff, J1
Macher, A; Paul, SM; Thomas, D1
Bäuerle, J; Gatell, JM; Laguno, M; Mallolas, J; Mauss, S; Miquel, R; Murillas, J; Schmutz, G; Setzer, B; Walker, UA1
Bates, M; Chappey, C; Clair, MS; Fisher, R; Lanier, ER; Parkin, N; Ross, L; Tisdale, M1
Schlesier, M; Setzer, B; Thomas, AK; Walker, UA1
Arastèh, K; Beard, A; Cartee, L; Drauz, D; Herzmann, C; Kreckel, P; Murphy, RL; Otto, MJ; Schinazi, RF; Schulbin, H1
Bouillaud, F; Leibowitch, J; Lesne, A; Leste-Lasserre, T; Mathez, D; Naviaux, RK; Petit, C; Piétri-Rouxel, F; Sonigo, P1
de Baar, MP; de Ronde, A; Ruiter, JP; Tebas, P; Timmermans, EC; Wanders, RJ1
Karandreas, N; Kokotis, PI; Konstantinou, K; Kontos, AN; Kordossis, T; Panayiotakopoulos, GD; Skopelitis, EE1
Chiche, L; Cretel, E; Durand, JM; Figuarella-Branger, D; Jean, R1
Carvalho, AT; Fernandes, PA; Ramos, MJ1
Laclair, DD; McKee, EE; Morris, GW1
Baruffini, E; Dallabona, C; Donnini, C; Ferrari, J; Lodi, T1
Garcia-Perez, E; Serra, J; Solà, R; Sumalla, M1
Brul, S; de Boer, R; De Vos, WH; Manders, EM; Smith, RL; van der Spek, H1
Galeotti, N; Ghelardini, C; Sanna, MD1
Abad-Carrillo, MA; Álvarez-Ríos, AI; Bernal-Morell, E; Genebat, M; González-García, J; Herrero-Fernández, I; Leal, M; Montero, M; Pacheco, YM; Pulido, F; Rosado-Sánchez, I; Ruiz-Mateos, E; Vidal, F1
Fernández, S; Ferrero, M; Martín-Nieves, V; Sanghvi, YS1

Reviews

22 review(s) available for zalcitabine and stavudine

ArticleYear
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
    Journal of natural products, 2001, Volume: 64, Issue:2

    Topics: Amino Acid Sequence; Anti-HIV Agents; HIV-1; Models, Biological; Models, Chemical; Molecular Sequence Data; National Institutes of Health (U.S.); Retrospective Studies; United States; Virus Replication

2001
[Anti-HIV treatment, today and in the near future].
    Nederlands tijdschrift voor geneeskunde, 1992, Aug-01, Volume: 136, Issue:31

    Topics: Antiviral Agents; Didanosine; Dideoxynucleosides; DNA, Viral; Drug Therapy, Combination; HIV Infections; Humans; Reverse Transcriptase Inhibitors; Stavudine; Transcription, Genetic; Zalcitabine; Zidovudine

1992
Targeted therapy of human immunodeficiency virus-related disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1991, Volume: 5, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; CD4 Antigens; Didanosine; Dideoxynucleosides; Dipyridamole; Drug Synergism; Gene Expression Regulation, Viral; Genes, nef; Genes, rev; Genes, tat; HIV; HIV Protease; Interferon Type I; Organophosphonates; RNA-Directed DNA Polymerase; Stavudine; Transcription, Genetic; Zalcitabine; Zidovudine

1991
Pharmacokinetic optimisation of antiretroviral therapy in patients with HIV infection.
    Clinical pharmacokinetics, 1995, Volume: 29, Issue:1

    Topics: Aging; Antineoplastic Agents; Antiviral Agents; Didanosine; Drug Interactions; Guidelines as Topic; HIV Infections; Humans; Phosphorylation; Racial Groups; Sex Characteristics; Stavudine; Zalcitabine; Zidovudine

1995
An approach to antiretroviral treatment of HIV disease. Nucleoside monotherapy.
    Hospital practice (1995), 1995, Volume: 30 Suppl 1

    Topics: Antiviral Agents; Didanosine; HIV Infections; HIV-1; Humans; Lamivudine; Nucleosides; Stavudine; Zalcitabine; Zidovudine

1995
Human immunodeficiency virus infection in children.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1995, May-01, Volume: 52, Issue:9

    Topics: Adolescent; AIDS-Related Opportunistic Infections; Child; Child, Preschool; Dapsone; Didanosine; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Pentamidine; Pneumonia, Pneumocystis; Pregnancy; Pregnancy Complications, Infectious; Recurrence; Stavudine; Trimethoprim, Sulfamethoxazole Drug Combination; Zalcitabine; Zidovudine

1995
Nucleoside analogue-associated peripheral neuropathy in human immunodeficiency virus infection.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Jun-01, Volume: 9, Issue:2

    Topics: Animals; Didanosine; Dideoxynucleosides; Disease Models, Animal; HIV Infections; Humans; Peripheral Nervous System Diseases; Stavudine; Zalcitabine

1995
Clinical pharmacokinetics of nucleoside antiretroviral agents.
    The Journal of infectious diseases, 1995, Volume: 171 Suppl 2

    Topics: Animals; Didanosine; Dideoxynucleosides; HIV Infections; Humans; Lamivudine; Stavudine; Zalcitabine; Zidovudine

1995
[Antiretroviral therapy. Current status and perspectives].
    Der Internist, 1994, Volume: 35, Issue:10

    Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV; HIV Infections; Humans; Stavudine; Zalcitabine; Zidovudine

1994
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.
    Pharmacy world & science : PWS, 1994, Apr-15, Volume: 16, Issue:2

    Topics: Animals; Antiviral Agents; Dideoxyadenosine; Dideoxynucleosides; Humans; Lamivudine; Purines; Pyrimidines; Retroviridae; Spiro Compounds; Stavudine; Thymidine; Uridine; Zalcitabine; Zidovudine

1994
Perspectives on the use of antiretroviral drugs in the treatment of HIV infection.
    Infectious disease clinics of North America, 1994, Volume: 8, Issue:2

    Topics: Didanosine; Dideoxynucleosides; Drug Administration Schedule; HIV Infections; Humans; Stavudine; Zalcitabine; Zidovudine

1994
Antiretroviral therapy of human immunodeficiency virus type-1 (HIV-1) infection.
    Australian and New Zealand journal of medicine, 1995, Volume: 25, Issue:4

    Topics: Antiviral Agents; Didanosine; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

1995
Clinical toxicity of antiretroviral nucleoside analogs.
    Antiviral research, 1996, Volume: 31, Issue:3

    Topics: Animals; Antiviral Agents; Didanosine; Humans; Lamivudine; Mitochondria; Nucleosides; Stavudine; Zalcitabine; Zidovudine

1996
Guide to major clinical trials of antiretroviral therapy administered to patients infected with human immunodeficiency virus.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23, Issue:1

    Topics: Anti-HIV Agents; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Meta-Analysis as Topic; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

1996
[Nucleoside analogs inhibiting reverse transcriptase: use in adult patient with HIV infection].
    Enfermedades infecciosas y microbiologia clinica, 1996, Volume: 14 Suppl 1

    Topics: Adult; Anti-HIV Agents; Clinical Trials as Topic; Didanosine; Dideoxynucleosides; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

1996
Antiretroviral therapy: a guide to the most important trials.
    Schweizerische medizinische Wochenschrift, 1997, Mar-15, Volume: 127, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Indinavir; Lamivudine; Nevirapine; Pyridines; Ritonavir; Saquinavir; Stavudine; Viral Load; Zalcitabine; Zidovudine

1997
[Antiretroviral treatment in human immunodeficiency virus infection].
    Annales de dermatologie et de venereologie, 1997, Volume: 124, Issue:9

    Topics: Antiviral Agents; Didanosine; Drug Interactions; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Ritonavir; Saquinavir; Stavudine; Treatment Outcome; Viral Load; Zalcitabine; Zidovudine

1997
Antiretroviral chemotherapy.
    Current clinical topics in infectious diseases, 1998, Volume: 18

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Delavirdine; Didanosine; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Indinavir; Lamivudine; Nelfinavir; Nevirapine; Oxazines; Ritonavir; Saquinavir; Stavudine; Zalcitabine; Zidovudine

1998
Toxicity of antiretroviral agents.
    The American journal of medicine, 1997, May-19, Volume: 102, Issue:5B

    Topics: Anti-HIV Agents; Didanosine; Health Personnel; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Occupational Exposure; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Stavudine; Zalcitabine; Zidovudine

1997
Peripheral neuropathy with nucleoside antiretrovirals: risk factors, incidence and management.
    Drug safety, 1998, Volume: 19, Issue:6

    Topics: Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Peripheral Nervous System Diseases; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

1998
Antiretrovirals.
    Mayo Clinic proceedings, 1999, Volume: 74, Issue:12

    Topics: Adolescent; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; Cyclopropanes; Delavirdine; Didanosine; Dideoxynucleosides; Female; Furans; HIV Infections; Humans; Indinavir; Lamivudine; Nelfinavir; Nevirapine; Oxazines; Pregnancy; Pregnancy Complications, Infectious; Protease Inhibitors; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Stavudine; Sulfonamides; Zalcitabine; Zidovudine

1999
Contraindicated antiretroviral drug combinations.
    New Jersey medicine : the journal of the Medical Society of New Jersey, 2003, Volume: 100, Issue:9 Suppl

    Topics: Anti-Retroviral Agents; Contraindications; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Saquinavir; Stavudine; Zalcitabine

2003

Trials

10 trial(s) available for zalcitabine and stavudine

ArticleYear
Acetyl-carnitine deficiency in AIDS patients with neurotoxicity on treatment with antiretroviral nucleoside analogues.
    AIDS (London, England), 1997, Volume: 11, Issue:2

    Topics: Acetylcarnitine; Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Axons; Cross-Sectional Studies; Didanosine; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine

1997
Antiviral effect of double and triple drug combinations amongst HIV-infected adults: lessons from the implementation of viral load-driven antiretroviral therapy.
    AIDS (London, England), 1998, Feb-12, Volume: 12, Issue:3

    Topics: Adult; Anti-HIV Agents; Cohort Studies; Didanosine; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Male; Multivariate Analysis; Stavudine; Viral Load; Zalcitabine; Zidovudine

1998
The pharmacokinetics and safety profile of oral ganciclovir combined with zalcitabine or stavudine in asymptomatic HIV- and CMV-seropositive patients.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:5

    Topics: Administration, Oral; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Cross-Over Studies; Cytomegalovirus Retinitis; Drug Interactions; Female; Ganciclovir; HIV Seropositivity; Humans; Male; Stavudine; Zalcitabine

1999
A randomized study comparing triple versus double antiretroviral therapy or no treatment in HIV-1-infected patients in very early stage disease: the Spanish Earth-1 study.
    AIDS (London, England), 1999, Dec-03, Volume: 13, Issue:17

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-CD8 Ratio; Didanosine; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Palatine Tonsil; Ritonavir; RNA, Viral; Spain; Stavudine; Viremia; Zalcitabine; Zidovudine

1999
A randomized, controlled, phase II trial comparing escalating doses of subcutaneous interleukin-2 plus antiretrovirals versus antiretrovirals alone in human immunodeficiency virus-infected patients with CD4+ cell counts >/=350/mm3.
    The Journal of infectious diseases, 2000, Volume: 181, Issue:5

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Didanosine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; Humans; Indinavir; Injections, Subcutaneous; Interleukin-2; Lamivudine; Lymphocyte Count; Male; Nelfinavir; Nevirapine; Ritonavir; RNA, Viral; Saquinavir; Stavudine; Zalcitabine; Zidovudine

2000
Dual nucleoside regimens in nonadvanced HIV infection: prospective follow-up of 130 patients, Aquitaine Cohort, 1996 to 1998. Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA).
    Journal of acquired immune deficiency syndromes (1999), 2000, Mar-01, Volume: 23, Issue:3

    Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Didanosine; Drug Therapy, Combination; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lamivudine; Multivariate Analysis; Prospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Treatment Outcome; Zalcitabine; Zidovudine

2000
Early virological failure in naive human immunodeficiency virus patients receiving saquinavir (soft gel capsule)-stavudine-zalcitabine (MIKADO trial) is not associated with mutations conferring viral resistance.
    Journal of clinical microbiology, 2000, Volume: 38, Issue:7

    Topics: Anti-HIV Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Genotype; HIV Infections; HIV-1; Humans; Mutation; Phenotype; Reverse Transcriptase Inhibitors; RNA, Viral; Saquinavir; Stavudine; Treatment Failure; Zalcitabine

2000
Therapeutic effects of nucleoside analogues on psychomotor slowing in HIV infection.
    AIDS (London, England), 2001, Mar-09, Volume: 15, Issue:4

    Topics: Adult; Anti-HIV Agents; Central Nervous System Diseases; Didanosine; Drug Therapy, Combination; Female; HIV Infections; HIV Seropositivity; HIV-1; Humans; Lamivudine; Male; Middle Aged; Motor Skills; Stavudine; Zalcitabine; Zidovudine

2001
MIKADO: a multicentre, open-label pilot study to evaluate the antiretroviral activity and safety of saquinavir with stavudine and zalcitabine.
    HIV medicine, 2001, Volume: 2, Issue:1

    Topics: Adult; Anti-HIV Agents; Capsules; Drug Administration Schedule; Drug Therapy, Combination; France; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lymphocyte Count; Male; Middle Aged; Pilot Projects; RNA, Viral; Saquinavir; Stavudine; Treatment Outcome; Viral Load; Zalcitabine

2001
Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:7

    Topics: Administration, Oral; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Middle Aged; Oxazines; Plasma; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Urine; Zalcitabine

2005

Other Studies

108 other study(ies) available for zalcitabine and stavudine

ArticleYear
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Kinetics; Molecular Structure; Phosphorylation; Pyrimidine Nucleosides; Rabbits; Stavudine; T-Lymphocytes; Thymidine Kinase; Thymus Gland; Zidovudine

1990
Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:6

    Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; HIV; Humans; Molecular Conformation; X-Ray Diffraction

1990
Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogues.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Cell Line; Chemical Phenomena; Chemistry; Deoxycytidine; HIV; Structure-Activity Relationship; T-Lymphocytes, Helper-Inducer; Zalcitabine

1987
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication

1987
Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogues of pyrimidine deoxyribonucleosides against retroviruses.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:2

    Topics: Antiviral Agents; Cell Line; HIV; Indicators and Reagents; Magnetic Resonance Spectroscopy; Moloney murine leukemia virus; Pyrimidine Nucleosides; Spectrophotometry; Structure-Activity Relationship

1987
HIV-1 reverse transcriptase inhibitor design using artificial neural networks.
    Journal of medicinal chemistry, 1994, Aug-05, Volume: 37, Issue:16

    Topics: Algorithms; Cell Line; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Structure; Neural Networks, Computer; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; T-Lymphocytes; Zidovudine

1994
Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Acyclovir; Animals; Anion Transport Proteins; Antiviral Agents; Carrier Proteins; Didanosine; In Vitro Techniques; Lamivudine; Oocytes; Rats; Stavudine; Transfection; Trifluridine; Xenopus laevis; Zalcitabine; Zidovudine

2000
Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides.
    Bioorganic & medicinal chemistry letters, 2000, Sep-18, Volume: 10, Issue:18

    Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Antiviral Agents; Cell Division; Cytosine; Dioxolanes; Hepatitis B virus; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Nucleosides; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
    Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2

    Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship

2009
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Anti-HIV Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Molecular Structure; Reverse Transcriptase Inhibitors

2009
Mitochondrial DNA depletion and respiratory chain activity in primary human subcutaneous adipocytes treated with nucleoside analogue reverse transcriptase inhibitors.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Adipocytes; Azo Compounds; Cell Survival; Cells, Cultured; Coloring Agents; DNA, Mitochondrial; Electron Transport; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glycerides; Humans; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA; Skin

2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
    Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3

    Topics: Animals; Drosophila melanogaster; Fluorescent Dyes; Nucleosides; Phosphotransferases (Alcohol Group Acceptor)

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents.
    Bioorganic & medicinal chemistry letters, 2014, Feb-01, Volume: 24, Issue:3

    Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Dideoxynucleosides; Drug Delivery Systems; Fatty Acids; HIV-1; Humans; Hydroxy Acids; Molecular Structure; Prodrugs

2014
Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase.
    ACS medicinal chemistry letters, 2013, Dec-12, Volume: 4, Issue:12

    Topics:

2013
Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase.
    Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16

    Topics: Acyclovir; Animals; Antiviral Agents; Betulinic Acid; Chlorocebus aethiops; Herpesvirus 2, Human; HIV Reverse Transcriptase; HIV-1; Humans; Pentacyclic Triterpenes; Triterpenes; Vero Cells; Virus Replication

2015
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity.
    Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2

    Topics: Antiviral Agents; Biological Availability; Deoxyuridine; Dideoxynucleosides; Emtricitabine; Escherichia coli; HIV; Pyrimidine Nucleosides; Stavudine; Substrate Specificity; Thymidine Phosphorylase; Zalcitabine

1992
The PC12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs.
    Biochemical pharmacology, 1991, Jun-21, Volume: 42, Issue:1

    Topics: Animals; Axons; Bone Marrow; Cell Division; Cell Line, Transformed; Didanosine; Dideoxynucleosides; Dose-Response Relationship, Drug; Peripheral Nervous System Diseases; Stavudine; Tumor Cells, Cultured; Zalcitabine; Zidovudine

1991
Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics.
    Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:3

    Topics: Antiviral Agents; Dideoxynucleosides; DNA Replication; DNA, Viral; Hepatitis B; Hepatitis B virus; Humans; In Vitro Techniques; Interferon Type I; Stavudine; Vidarabine; Vidarabine Phosphate; Virus Replication; Zalcitabine; Zidovudine

1991
Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity.
    Molecular pharmacology, 1991, Volume: 39, Issue:5

    Topics: Antiviral Agents; Cell Line; Cytarabine; Didanosine; Dideoxynucleosides; DNA, Mitochondrial; HIV; Humans; Lymphocyte Activation; Nucleosides; Stavudine; T-Lymphocytes; Zalcitabine; Zidovudine

1991
Enzymatic and chemical stability of 2',3'-dideoxy-2',3'-didehydropyrimidine nucleosides: potential anti-acquired immunodeficiency syndrome agents.
    Chemical & pharmaceutical bulletin, 1989, Volume: 37, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Chemical Phenomena; Chemistry; Cytarabine; Dideoxynucleosides; Drug Stability; Humans; Mice; Stavudine; Zalcitabine

1989
Sensitization of X-irradiated Chinese hamster V79 cells by derivatives of pyrimidine nucleosides.
    Journal of radiation research, 1988, Volume: 29, Issue:4

    Topics: Animals; Antiviral Agents; Cell Count; Cell Line; Cell Survival; Dideoxynucleosides; Pyrimidine Nucleosides; Radiation-Sensitizing Agents; Stavudine; Zalcitabine; Zidovudine

1988
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:6

    Topics: Antigens, Viral; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Thymidine; Viral Plaque Assay; Virus Replication; Zalcitabine; Zidovudine

1987
HIV-1, the brain, and combination therapy.
    Lancet (London, England), 1995, Nov-11, Volume: 346, Issue:8985

    Topics: Adult; AIDS Dementia Complex; Antiviral Agents; Child; Didanosine; Drug Combinations; HIV-1; Humans; Lamivudine; Neuroprotective Agents; Stavudine; Zalcitabine; Zidovudine

1995
FDA advised to license three anti-HIV agents.
    Lancet (London, England), 1995, Nov-18, Volume: 346, Issue:8986

    Topics: Adult; Antiviral Agents; Child; Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Lamivudine; Quinolines; Saquinavir; Stavudine; United States; United States Food and Drug Administration; Zalcitabine

1995
[AIDS therapy with reverse transcriptase inhibitors].
    Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51 Suppl

    Topics: Acquired Immunodeficiency Syndrome; Didanosine; Drug Therapy, Combination; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

1993
Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2',3'-didehydro-2',3'-dideoxythymidine in cell culture.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:6

    Topics: Base Sequence; Cells, Cultured; Drug Resistance, Microbial; Emtricitabine; HeLa Cells; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Stavudine; Zalcitabine; Zidovudine

1994
Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates.
    AIDS research and human retroviruses, 1994, Volume: 10, Issue:11

    Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Cloning, Molecular; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Nevirapine; Point Mutation; Polymerase Chain Reaction; Pyridines; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Stavudine; Virus Cultivation; Zalcitabine; Zidovudine

1994
Drugs for AIDS and associated infections.
    The Medical letter on drugs and therapeutics, 1995, Oct-13, Volume: 37, Issue:959

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Antiprotozoal Agents; Antiviral Agents; Atovaquone; Candidiasis, Oral; Clindamycin; Clotrimazole; Cryptosporidiosis; Cytomegalovirus Infections; Dapsone; Didanosine; Drug Combinations; Drug Therapy, Combination; Fluconazole; Flucytosine; Folic Acid Antagonists; Foscarnet; Glucuronates; Herpes Simplex; Herpes Zoster; Humans; Isoniazid; Itraconazole; Ketoconazole; Lamivudine; Mycobacterium avium-intracellulare Infection; Naphthoquinones; Nystatin; Pentamidine; Pneumocystis Infections; Pneumonia, Pneumocystis; Prednisone; Primaquine; Reverse Transcriptase Inhibitors; Stavudine; Syphilis; Toxoplasmosis; Trimetrexate; Tuberculosis; Zalcitabine; Zidovudine

1995
Removal of anti-human immunodeficiency virus 2',3'-dideoxynucleoside monophosphates from DNA by a novel human cytosolic 3'-->5' exonuclease.
    Biochemical pharmacology, 1995, Sep-07, Volume: 50, Issue:6

    Topics: Antiviral Agents; Base Sequence; Cell Line; Cytosol; Dideoxynucleosides; DNA, Single-Stranded; Exonucleases; HIV-1; Humans; Molecular Sequence Data; Phosphates; Stavudine; Stereoisomerism; Substrate Specificity; Virus Replication; Zalcitabine; Zidovudine

1995
Approval of drugs for HIV infection.
    American family physician, 1994, Volume: 50, Issue:5

    Topics: HIV Infections; Humans; Stavudine; Zalcitabine

1994
Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:8

    Topics: Cell Survival; Cells, Cultured; Didanosine; DNA, Mitochondrial; Humans; Mitochondria; Stavudine; Zalcitabine

1994
Generation of multiple drug resistance by sequential in vitro passage of the human immunodeficiency virus type 1.
    Archives of virology, 1994, Volume: 136, Issue:1-2

    Topics: Antiviral Agents; Cell Line; Cloning, Molecular; Didanosine; Drug Interactions; Drug Resistance, Microbial; HIV-1; Humans; Interferon-alpha; Neutralization Tests; Phenotype; Serial Passage; Stavudine; Zalcitabine; Zidovudine

1994
Comparative embryonic cytotoxicity of antiretroviral nucleosides.
    The Journal of infectious diseases, 1994, Volume: 169, Issue:5

    Topics: Animals; Antiviral Agents; Culture Techniques; Didanosine; Embryo, Mammalian; HIV; Mice; Nucleosides; Stavudine; Zalcitabine; Zidovudine

1994
Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro.
    The Journal of infectious diseases, 1996, Volume: 173, Issue:2

    Topics: Antiviral Agents; Drug Combinations; Drug Synergism; HIV Reverse Transcriptase; HIV Seropositivity; HIV-1; Humans; Lamivudine; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Stavudine; Virus Replication; Zalcitabine

1996
New drugs for HIV infection.
    The Medical letter on drugs and therapeutics, 1996, Apr-12, Volume: 38, Issue:972

    Topics: Antiviral Agents; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Lamivudine; Pyridines; Quinolines; Ritonavir; Saquinavir; Stavudine; Thiazoles; Valine; Zalcitabine

1996
Factors associated with changes in the use of antiretroviral therapy by a cohort of homosexual men infected with human immunodeficiency virus type 1.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21, Issue:4

    Topics: Antiviral Agents; CD4 Lymphocyte Count; Cohort Studies; Didanosine; Drug Therapy, Combination; Drug Utilization; Follow-Up Studies; Hemoglobins; HIV Infections; HIV-1; Homosexuality, Male; Humans; Male; Multicenter Studies as Topic; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

1995
Therapy of HIV infections: problems and prospects.
    Bulletin of the New York Academy of Medicine, 1996,Summer, Volume: 73, Issue:1

    Topics: Anti-HIV Agents; Didanosine; Drug Resistance, Microbial; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Stavudine; Urban Health; Zalcitabine; Zidovudine

1996
Stavudine selectively induces apoptosis in HIV type 1-infected cells.
    AIDS research and human retroviruses, 1997, Jan-20, Volume: 13, Issue:2

    Topics: Anti-HIV Agents; Apoptosis; Cell Line; Didanosine; DNA Fragmentation; Down-Regulation; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reverse Transcriptase Inhibitors; Stavudine; T-Lymphocytes; Thymidine; Zalcitabine; Zidovudine

1997
Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:3

    Topics: Animals; Didanosine; Dideoxynucleosides; DNA Replication; DNA, Mitochondrial; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Rats; Stavudine; Zalcitabine; Zidovudine

1997
Treatment options for human immunodeficiency virus.
    South Dakota journal of medicine, 1996, Volume: 49, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Child; Didanosine; Drug Approval; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant, Newborn; Lamivudine; Male; Saquinavir; Stavudine; United States; United States Food and Drug Administration; Zalcitabine; Zidovudine

1996
Correlation between plasma HIV-1 RNA levels and the rate of immunologic decline.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1997, Apr-15, Volume: 14, Issue:5

    Topics: Anti-HIV Agents; beta 2-Microglobulin; CD4 Lymphocyte Count; Didanosine; Disease Progression; DNA, Viral; Drug Therapy, Combination; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Longitudinal Studies; RNA, Viral; Stavudine; Viral Load; Viremia; Virus Replication; Zalcitabine; Zidovudine

1997
Cure or control of HIV/AIDS?
    Medical hypotheses, 1997, Volume: 48, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Didanosine; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; Humans; Indinavir; Lamivudine; Models, Biological; Nevirapine; Pyridines; Ritonavir; Saquinavir; Stavudine; Zalcitabine; Zidovudine

1997
[Anti-retrovirals].
    Medicina clinica, 1997, Jun-07, Volume: 109, Issue:2

    Topics: Anti-HIV Agents; Didanosine; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

1997
Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.
    Antiviral research, 1997, Volume: 35, Issue:3

    Topics: Acyclovir; Cell Line; Dose-Response Relationship, Drug; Ganciclovir; Genetic Therapy; Growth Inhibitors; Herpesvirus 1, Human; HIV-1; Humans; Hydroxyurea; Nucleosides; Stavudine; Substrate Specificity; T-Lymphocytes; Thymidine Kinase; Zalcitabine; Zidovudine

1997
Lamivudine (3TC) phosphorylation and drug interactions in vitro.
    Biochemical pharmacology, 1997, Sep-01, Volume: 54, Issue:5

    Topics: Anti-HIV Agents; Cells, Cultured; Deoxycytidine; Didanosine; Dideoxynucleosides; Drug Interactions; Humans; Kinetics; Lamivudine; Lymphocyte Activation; Lymphocytes; Mitogens; Models, Chemical; Monocytes; Phosphorylation; Stavudine; Tumor Cells, Cultured; Zalcitabine; Zidovudine

1997
Effect of protease inhibitors on nucleoside analogue phosphorylation in vitro.
    British journal of clinical pharmacology, 1998, Volume: 45, Issue:2

    Topics: Anti-HIV Agents; Cell Count; Cell Survival; Didanosine; Drug Interactions; Humans; Indinavir; Lamivudine; Leukocytes, Mononuclear; Nucleosides; Phosphorylation; Protease Inhibitors; Ritonavir; Saquinavir; Stavudine; Trypan Blue; Tumor Cells, Cultured; Zalcitabine; Zidovudine

1998
Survival in 2367 zidovudine-treated patients according to use of other nucleoside analogue drugs. The EuroSIDA Study Group.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1998, Mar-01, Volume: 17, Issue:3

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Didanosine; Dideoxynucleosides; Disease Progression; Drug Therapy, Combination; Europe; Female; Follow-Up Studies; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Stavudine; Survival Analysis; Zalcitabine; Zidovudine

1998
Clinical and biological impact of antiretroviral therapy with protease inhibitors on HIV-related Kaposi's sarcoma.
    AIDS (London, England), 1998, May-07, Volume: 12, Issue:7

    Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Therapy, Combination; Female; Herpesvirus 8, Human; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Male; Middle Aged; Prospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sarcoma, Kaposi; Stavudine; Treatment Outcome; Viral Load; Viremia; Zalcitabine; Zidovudine

1998
The M184V mutation in HIV-1 reverse transcriptase (RT) conferring lamivudine resistance does not result in broad cross-resistance to nucleoside analogue RT inhibitors.
    AIDS (London, England), 1998, May-07, Volume: 12, Issue:7

    Topics: Anti-HIV Agents; Cohort Studies; Didanosine; Dideoxynucleosides; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Methionine; Point Mutation; Reverse Transcriptase Inhibitors; Stavudine; Valine; Zalcitabine; Zidovudine

1998
Metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7

    Topics: Anti-HIV Agents; Cell Line; Deamination; Deoxycytidine Kinase; Didanosine; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; DNA, Viral; Drug Interactions; HIV Reverse Transcriptase; HIV-1; Phosphorylation; Stavudine; Virus Replication; Zalcitabine; Zidovudine

1998
Risk of HIV dementia and opportunistic brain disease in AIDS and zidovudine therapy.
    Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 65, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Brain Diseases; Didanosine; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Retrospective Studies; Risk; Stavudine; Treatment Outcome; Zalcitabine; Zidovudine

1998
[Weak antiviral effect of changing two nucleoside analogues combined with antiretroviral agents. 3TC and d4T after ZDU and ddi or ddc].
    Presse medicale (Paris, France : 1983), 1998, Feb-28, Volume: 27, Issue:8

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Didanosine; Drug Therapy, Combination; Female; HIV Seropositivity; HIV-1; Humans; Lamivudine; Male; Retrospective Studies; Stavudine; Viral Load; Zalcitabine; Zidovudine

1998
Highly active anti-retroviral therapy (HAART) is associated with a lower level of CD4+ T cell apoptosis in HIV-infected patients.
    Clinical and experimental immunology, 1999, Volume: 118, Issue:3

    Topics: Adult; Aged; Anti-HIV Agents; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Didanosine; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Stavudine; Viral Load; Zalcitabine; Zidovudine

1999
Incidence and predictors of virologic failure of antiretroviral triple-drug therapy in a community-based cohort.
    AIDS research and human retroviruses, 1999, Dec-10, Volume: 15, Issue:18

    Topics: Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Didanosine; Disease Progression; Drug Administration Schedule; Drug Resistance, Microbial; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Incidence; Indinavir; Lamivudine; Male; Middle Aged; Reverse Transcriptase Inhibitors; Risk Factors; Ritonavir; RNA, Viral; Salvage Therapy; Saquinavir; Stavudine; Switzerland; Treatment Failure; Viral Load; Zalcitabine; Zidovudine

1999
Drugs for HIV infection.
    The Medical letter on drugs and therapeutics, 2000, Jan-10, Volume: 42, Issue:1069

    Topics: Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Costs; Drug Therapy, Combination; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

2000
Mitigation of hepato-cellular injury caused by HAART with glycyrrhizin compound in patients co-infected with HIV and HCV.
    Japanese journal of infectious diseases, 1999, Volume: 52, Issue:6

    Topics: Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug Combinations; Drug Therapy, Combination; Glycine; Glycyrrhetinic Acid; Hemophilia A; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Stavudine; Viral Load; Zalcitabine; Zidovudine

1999
Autonomic neuropathy in patients with HIV: course, impact of disease stage, and medication.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2000, Volume: 10, Issue:1

    Topics: Adult; Aged; Anti-HIV Agents; Autonomic Nervous System Diseases; Brain Diseases; Cardiovascular System; Didanosine; Female; Follow-Up Studies; HIV Infections; Humans; Iris Diseases; Male; Middle Aged; Movement; Prevalence; Sensation; Stavudine; Zalcitabine

2000
Cutaneous side effects induced by indinavir.
    European journal of dermatology : EJD, 2000, Volume: 10, Issue:4

    Topics: Adult; Alopecia; Didanosine; Drug Eruptions; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Lipodystrophy; Male; Middle Aged; Pruritus; Pyoderma Gangrenosum; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Scalp Dermatoses; Skin; Stavudine; Zalcitabine; Zidovudine

2000
Efavirenz is a potent nonnucleoside reverse transcriptase inhibitor of HIV type 1 replication in microglia in vitro.
    AIDS research and human retroviruses, 2000, Oct-10, Volume: 16, Issue:15

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cells, Cultured; Coculture Techniques; Cyclopropanes; HIV-1; Humans; Microglia; Neuroglia; Nucleosides; Oxazines; Reverse Transcriptase Inhibitors; Stavudine; Virus Replication; Zalcitabine; Zidovudine

2000
Correlation between intracellular pharmacological activation of nucleoside analogues and HIV suppression in vitro.
    Antiviral chemistry & chemotherapy, 2000, Volume: 11, Issue:6

    Topics: Anti-HIV Agents; HIV Infections; HIV-1; Humans; Reverse Transcriptase Inhibitors; Stavudine; Virus Replication; Zalcitabine; Zidovudine

2000
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.
    The Journal of biological chemistry, 2001, Jun-29, Volume: 276, Issue:26

    Topics: Anti-HIV Agents; Cytidine Triphosphate; Deoxyguanine Nucleotides; Deoxyribonucleotides; Dideoxynucleotides; DNA; DNA Polymerase gamma; DNA Replication; DNA-Directed DNA Polymerase; Exodeoxyribonucleases; Humans; Kinetics; Lamivudine; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; Stavudine; Substrate Specificity; Thymine Nucleotides; Zalcitabine; Zidovudine

2001
Treatment briefs.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1995, Volume: 9, Issue:4

    Topics: CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Drug Industry; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Nerve Growth Factors; Nervous System Diseases; Pyridines; Recombinant Proteins; Stavudine; Zalcitabine; Zidovudine

1995
What we know about anti-HIV drugs.
    Treatment review, 1995, Issue:no 18

    Topics: Antiviral Agents; Didanosine; DNA, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lamivudine; RNA, Viral; Stavudine; Zalcitabine; Zidovudine

1995
Combination treatment and single drugs: interview with Margaret Poscher, M.D. Interview by John S. James.
    AIDS treatment news, 1995, Jul-07, Issue:no 226

    Topics: Acyclovir; Administration, Oral; Antiviral Agents; CD4 Lymphocyte Count; Didanosine; Drug Administration Schedule; Drug Resistance, Microbial; Drug Therapy, Combination; Ganciclovir; HIV Infections; Humans; Lamivudine; Stavudine; Zalcitabine; Zidovudine

1995
New antiretroviral strategies: interview with Marcus Conant, M.D. Interview by John S. James.
    AIDS treatment news, 1995, Aug-04, Issue:no 228

    Topics: Antiviral Agents; CD4 Lymphocyte Count; DNA, Viral; Drug Therapy, Combination; HIV; HIV Infections; Humans; Isoquinolines; Lamivudine; Peripheral Nervous System Diseases; Protease Inhibitors; Quinolines; Saquinavir; Stavudine; Zalcitabine; Zidovudine

1995
Antiretroviral drug resistance.
    AIDS clinical care, 1995, Volume: 7, Issue:8

    Topics: Antiviral Agents; CD4 Lymphocyte Count; Didanosine; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lamivudine; RNA, Viral; Stavudine; Viremia; Zalcitabine; Zidovudine

1995
Update on clinical trials of combination therapies for HIV infection.
    NIAID AIDS agenda, 1995

    Topics: Adult; Antiviral Agents; CD4 Lymphocyte Count; Child; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Hydroxyurea; Lamivudine; RNA-Directed DNA Polymerase; Stavudine; Zalcitabine; Zidovudine

1995
FDA triple header. Food and Drug Administration.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1995, Volume: 9, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; CD4 Lymphocyte Count; Child; Didanosine; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Protease Inhibitors; Humans; Isoquinolines; Lamivudine; Mutation; Quinolines; Salvage Therapy; Saquinavir; Stavudine; United States; United States Food and Drug Administration; Zalcitabine; Zidovudine

1995
Combination therapy increases survival.
    Treatment review, 1995, Issue:no 20

    Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Stavudine; Zalcitabine; Zidovudine

1995
FDA antiviral advisory hearings on lamivudine (Epivir, 3TC), saquinavir (Invirase), stavudine (Zerit, d4T), November 6-8. Food and Drug Administration.
    AIDS treatment news, 1995, Oct-20, Issue:no 233

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; CD4 Lymphocyte Count; Drug Resistance, Microbial; HIV Protease Inhibitors; Humans; Isoquinolines; Lamivudine; Quinolines; Saquinavir; Stavudine; United States; United States Food and Drug Administration; Zalcitabine

1995
Back to the nukes.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1996, Volume: 10, Issue:2

    Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Drug Therapy, Combination; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Stavudine; Zalcitabine; Zidovudine

1996
Update on other antivirals.
    PI perspective, 1996, Issue:no 18

    Topics: Adenine; Antiviral Agents; Didanosine; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Stavudine; Zalcitabine; Zidovudine

1996
Nipping HIV in the bud.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1996, Volume: 10, Issue:8

    Topics: Antiviral Agents; CD4 Lymphocyte Count; Didanosine; DNA, Viral; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Lamivudine; Pyridines; Quinolines; Ritonavir; Saquinavir; Stavudine; Thiazoles; Valine; Virus Replication; Zalcitabine; Zidovudine

1996
Top AIDS researchers' strategy for antiretroviral treatment.
    AIDS alert, 1996, Volume: 11, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; CD4 Lymphocyte Count; Didanosine; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Patient Compliance; Practice Guidelines as Topic; RNA, Viral; Stavudine; Zalcitabine; Zidovudine

1996
ddI and d4T plus protease inhibitors.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1996, Volume: 10, Issue:11

    Topics: Anti-HIV Agents; Didanosine; HIV Infections; Humans; Lamivudine; Stavudine; Zalcitabine; Zidovudine

1996
Antiretroviral therapy for adults and children.
    AIDS Institute newsletter. New York (State). AIDS Institute, 1995

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Child; Didanosine; Female; HIV Infections; Humans; Pregnancy; Pregnancy Complications, Infectious; Primary Health Care; Stavudine; Viral Load; Zalcitabine; Zidovudine

1995
Differential susceptibility of retroviruses to nucleoside analogues.
    Antiviral chemistry & chemotherapy, 2001, Volume: 12, Issue:2

    Topics: Animals; Antiviral Agents; Cell Line; Cricetinae; Didanosine; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Lamivudine; Mink; Nucleosides; Retroviridae; Reverse Transcriptase Inhibitors; Stavudine; Substrate Specificity; Zalcitabine; Zidovudine

2001
Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Nov-20, Volume: 98, Issue:24

    Topics: Anti-HIV Agents; Base Sequence; Didanosine; Dideoxynucleosides; DNA, Viral; Drug Resistance, Viral; Evolution, Molecular; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutagenesis; Recombination, Genetic; Reverse Transcriptase Inhibitors; Stavudine; Virus Replication; Zalcitabine; Zidovudine

2001
Viral and immunologic follow up of 4 to 9 years of AIDS treatments by quadruple combinations of virostatics including integrase inhibitors applied in short sequences differing by drug rotation.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Acriflavine; Adult; Anti-HIV Agents; Antiviral Agents; CD4-CD8 Ratio; Didanosine; Drug Therapy, Combination; Ellipticines; Female; Follow-Up Studies; HIV-1; Humans; Integrase Inhibitors; Male; Middle Aged; Protease Inhibitors; Stavudine; Vitamin B 12; Zalcitabine; Zidovudine

2002
Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.
    Antiviral research, 2002, Volume: 54, Issue:1

    Topics: Adenine; Anti-HIV Agents; Antigens, CD34; Cell Line; Didanosine; Dideoxynucleosides; Epithelial Cells; Hematopoietic Stem Cells; Humans; Kidney Tubules, Proximal; Liver; Muscle, Skeletal; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Tumor Cells, Cultured; Zalcitabine; Zidovudine

2002
[Mononucleosis syndrome with viro-immunologic parameters similar to those of a primary HIV-1 infection after interruption of highly effective anti-retroviral treatment].
    Anales de medicina interna (Madrid, Spain : 1984), 2002, Volume: 19, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4-CD8 Ratio; Depression; Didanosine; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infectious Mononucleosis; Male; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Treatment Refusal; Trimethoprim, Sulfamethoxazole Drug Combination; Viral Load; Viremia; Zalcitabine; Zidovudine

2002
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.
    Journal of molecular biology, 2003, May-23, Volume: 329, Issue:1

    Topics: Amino Acid Sequence; Anti-HIV Agents; Baculoviridae; Binding Sites; DNA Polymerase gamma; DNA Primers; DNA-Directed DNA Polymerase; DNA, Viral; Electrophoretic Mobility Shift Assay; Humans; Lamivudine; Mitochondria; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Conformation; Protein Folding; Recombinant Fusion Proteins; Reverse Transcriptase Inhibitors; Sequence Homology, Amino Acid; Stavudine; Zalcitabine; Zidovudine

2003
Susceptibility of human T cell leukemia virus type I to nucleoside reverse transcriptase inhibitors.
    The Journal of infectious diseases, 2003, Aug-01, Volume: 188, Issue:3

    Topics: Adenine; Cell Line; Dideoxynucleosides; Human T-lymphotropic virus 1; Humans; Lamivudine; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Virus Replication; Zalcitabine; Zidovudine

2003
Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine.
    Hepatology (Baltimore, Md.), 2004, Volume: 39, Issue:2

    Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Didanosine; DNA, Mitochondrial; Female; Hepatitis C, Chronic; HIV Infections; Humans; Lactic Acid; Liver; Male; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine

2004
Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.
    AIDS (London, England), 2004, Aug-20, Volume: 18, Issue:12

    Topics: Adenine; Algorithms; Anti-HIV Agents; Databases, Genetic; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV; HIV Infections; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zalcitabine; Zidovudine

2004
Mitochondrial toxicity of nucleoside analogues in primary human lymphocytes.
    Antiviral therapy, 2005, Volume: 10, Issue:2

    Topics: CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Didanosine; DNA, Mitochondrial; Female; Humans; Lactic Acid; Lymphocyte Activation; Male; Mitochondrial Diseases; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine

2005
Oxygen consumption by cultured human cells is impaired by a nucleoside analogue cocktail that inhibits mitochondrial DNA synthesis.
    Mitochondrion, 2005, Volume: 5, Issue:3

    Topics: Adipocytes; Cell Culture Techniques; Cell Line; Cell Respiration; DNA, Mitochondrial; Humans; Lipids; Models, Biological; Oxygen Consumption; Reverse Transcriptase Inhibitors; Stavudine; Zalcitabine; Zidovudine

2005
Real-time nucleic acid sequence-based amplification assay to quantify changes in mitochondrial DNA concentrations in cell cultures and blood cells from HIV-infected patients receiving antiviral therapy.
    Clinical chemistry, 2006, Volume: 52, Issue:6

    Topics: Anti-HIV Agents; Base Sequence; Blood Platelets; Cell Nucleus; Cells, Cultured; Didanosine; DNA, Mitochondrial; Drug Therapy, Combination; Feasibility Studies; Fibroblasts; HIV Infections; Humans; Indinavir; Lactic Acid; Lamivudine; Leukocytes, Mononuclear; Nucleic Acid Amplification Techniques; Pyruvic Acid; Stavudine; Zalcitabine

2006
Distal sensory polyneuropathy in HIV-positive patients in the HAART era: an entity underestimated by clinical examination.
    International journal of STD & AIDS, 2006, Volume: 17, Issue:7

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; Electrophysiology; Female; HIV Infections; Humans; Male; Middle Aged; Polyneuropathies; Prevalence; Reverse Transcriptase Inhibitors; Risk Factors; Stavudine; Zalcitabine

2006
[Central nervous system HIV-associated polyarteritis nodosa: long-term outcome].
    La Revue de medecine interne, 2006, Volume: 27, Issue:8

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Central Nervous System Infections; Female; Follow-Up Studies; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Polyarteritis Nodosa; Stavudine; Time Factors; Treatment Outcome; Virus Replication; Zalcitabine

2006
Insights on resistance to reverse transcriptase: the different patterns of interaction of the nucleoside reverse transcriptase inhibitors in the deoxyribonucleotide triphosphate binding site relative to the normal substrate.
    Journal of medicinal chemistry, 2006, Dec-28, Volume: 49, Issue:26

    Topics: Binding Sites; Computer Simulation; Deoxyribonucleotides; Drug Resistance, Multiple, Viral; HIV; HIV Reverse Transcriptase; Humans; Molecular Conformation; Nucleosides; Point Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymine Nucleotides; Zalcitabine

2006
Relationship of mitochondrial DNA depletion and respiratory chain activity in preadipocytes treated with nucleoside reverse transcriptase inhibitors.
    Antiviral therapy, 2007, Volume: 12, Issue:2

    Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Cell Differentiation; Cell Proliferation; Cell Shape; Dideoxynucleosides; DNA, Mitochondrial; Dose-Response Relationship, Drug; Electron Transport; HIV-Associated Lipodystrophy Syndrome; Mice; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Triglycerides; Zalcitabine; Zidovudine

2007
Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria.
    Antiviral therapy, 2010, Volume: 15, Issue:4

    Topics: Animals; Anti-HIV Agents; Deoxycytidine; Male; Mitochondria, Heart; Myocardium; Nucleosides; Perfusion; Phosphorylation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zalcitabine; Zidovudine

2010
Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.
    Mitochondrion, 2015, Volume: 20

    Topics: DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Genomic Instability; Humans; Mitochondria; Point Mutation; Polymorphism, Single Nucleotide; Reverse Transcriptase Inhibitors; Saccharomyces cerevisiae; Stavudine; Zalcitabine

2015
Behavioral and electrophysiological abnormalities in two rat models of antiretroviral drug-induced neuropathy.
    Pain, 2015, Volume: 156, Issue:9

    Topics: Action Potentials; Animals; Anti-HIV Agents; Disease Models, Animal; Male; Nerve Fibers, Unmyelinated; Neural Conduction; Neurophysiology; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stavudine; Zalcitabine

2015
Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Animals; Anti-HIV Agents; Caenorhabditis elegans; Didanosine; Dideoxynucleosides; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Drug Evaluation; Humans; Mitochondria; Mitochondrial Proteins; Models, Biological; Oxygen Consumption; Reverse Transcriptase Inhibitors; Stavudine; Ubiquinone; Zalcitabine; Zidovudine

2015
Blockade of the spinal BDNF-activated JNK pathway prevents the development of antiretroviral-induced neuropathic pain.
    Neuropharmacology, 2016, Volume: 105

    Topics: Animals; Anthracenes; Anti-Retroviral Agents; Brain-Derived Neurotrophic Factor; Caspase 3; Cold Temperature; Hyperalgesia; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Models, Animal; Neuralgia; Protein Kinase Inhibitors; Random Allocation; Spinal Cord; Stavudine; Touch; Zalcitabine

2016
A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:8

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cell Survival; Didanosine; Female; HIV Infections; Humans; Male; Middle Aged; Receptors, CXCR4; Stavudine; T-Lymphocytes, Regulatory; Viral Load; Zalcitabine; Zidovudine

2017
Sustainable Protocol for the Synthesis of 2',3'-Dideoxynucleoside and 2',3'-Didehydro-2',3'-dideoxynucleoside Derivatives.
    Molecules (Basel, Switzerland), 2022, Jun-21, Volume: 27, Issue:13

    Topics: Anti-HIV Agents; Didanosine; Dideoxynucleosides; Stavudine; Zalcitabine; Zidovudine

2022