Page last updated: 2024-08-22

zalcitabine and dideoxyadenosine

zalcitabine has been researched along with dideoxyadenosine in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199018 (51.43)18.7374
1990's11 (31.43)18.2507
2000's3 (8.57)29.6817
2010's1 (2.86)24.3611
2020's2 (5.71)2.80

Authors

AuthorsStudies
Balzarini, J; Bentrude, WG; De Clercq, E; Mullah, KB; Rao, TS1
Baba, M; Hayakawa, H; Miyasaka, T; Nitta, I; Sakamaki, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M1
Corbett, TH; Court, BA; Kessel, D; Phadtare, S; Renis, HE; Zimlicka, J1
Aoki, S; Barchi, JJ; Driscoll, JS; Ford, H; Kelley, JA; Marquez, VE; Mitsuya, H; Shirasaka, T1
Baba, M; Balzarini, J; De Clercq, E; Hayakawa, H; Miyasaka, T; Tanaka, H; Walker, RT1
Broder, S; Driscoll, JS; Kim, CH; Marquez, VE; Mitsuya, H1
Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H1
Antonenko, SV; Chentsova, NP; Kukhar, VP; Luik, AI; Poda, GI; Tetko, IV1
Agrawal, B; Johar, M; Kumar, R; Kunimoto, DY; Manning, T; Rai, D; Srivastav, NC1
Aubertin, AM; Périgaud, C; Peyrottes, S; Villard, AL1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Chattopadhyaya, J; Koole, LH; Plavec, J1
Cao, W; Fuchs, BA; Germolec, DR; Luster, MI; Munson, AE; Prejean, JD; Rosenthal, GJ; Shopp, G; Thompson, MB; Tomaszewski, JE1
Broder, S; DeVico, AL; Di Marzo Veronese, F; Jarrett, RF; Johns, DG; Matsukura, M; Mitsuya, H; Reitz, MS; Sarngadharan, MG1
Benveniste, RE; Follis, KE; Tsai, CC1
Chisaka, O; Matsubara, K; Nagahata, T; Tsurimoto, T; Ueda, K1
Ganser, A; Greher, J; Hoelzer, D; Staszewski, S; Völkers, B1
de Noronha, F; Postie, L; Roneker, C; Tavares, L1
Blair, PC; Fort, MM; Fuchs, BA; Germolec, DR; Luster, MI; McCay, JA; Munson, AE; Thompson, M; Tomaszewski, JE; White, KL1
Plagemann, PG; Woffendin, C1
Carson, DA; Kornbluth, RS; Richman, DD1
Fridland, A; Johns, DG; Johnson, MA1
Broder, S; Mitsuya, H2
Pardridge, WM; Terasaki, T1
Cooney, DA; Gartner, S; Gerrard, TL; Hao, Z; Hartman, NR; Johns, DG; Perno, CF; Popovic, M; Wilson, YA; Yarchoan, R1
Hill, DL; Kalin, JR1
Haugwitz, RD; Quinn, FR; Silverton, JV; Torado, LJ1
Kitos, TE; Tyrrell, DL1
Balzarini, J1
Howe, AY; Robins, MJ; Tyrrell, DL; Wilson, JS1
Davies, RJ; Starrs, S1
Knecht, W; Munch-Petersen, B; Piskur, J1
Dickman, K; Lake-Bakaar, G; Lyubsky, S; Mazzoccoli, V1
Asif, G; Coats, SJ; Detorio, M; Koontz, D; Mellors, JW; Meteer, JD; Schinazi, RF; Sluis-Cremer, N; Solomon, S; Zhang, HW1

Reviews

1 review(s) available for zalcitabine and dideoxyadenosine

ArticleYear
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.
    Pharmacy world & science : PWS, 1994, Apr-15, Volume: 16, Issue:2

    Topics: Animals; Antiviral Agents; Dideoxyadenosine; Dideoxynucleosides; Humans; Lamivudine; Purines; Pyrimidines; Retroviridae; Spiro Compounds; Stavudine; Thymidine; Uridine; Zalcitabine; Zidovudine

1994

Other Studies

34 other study(ies) available for zalcitabine and dideoxyadenosine

ArticleYear
Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities.
    Journal of medicinal chemistry, 1992, Jul-24, Volume: 35, Issue:15

    Topics: Antiviral Agents; Cytopathogenic Effect, Viral; Dideoxyadenosine; Dideoxynucleosides; HIV-1; Humans; Microbial Sensitivity Tests; Prodrugs; Tumor Cells, Cultured; Virus Replication; Viruses

1992
A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Antiviral Agents; Cell Line; Cell Survival; HIV-1; Humans; Indicators and Reagents; Molecular Structure; Structure-Activity Relationship; Thymine

1991
Unsaturated and carbocyclic nucleoside analogues: synthesis, antitumor, and antiviral activity.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Adenosine Deaminase; Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Friend murine leukemia virus; HIV-1; HIV-2; Humans; Indicators and Reagents; Leukemia L1210; Mice; Molecular Structure; Nucleosides; Rauscher Virus; Structure-Activity Relationship

1991
Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:5

    Topics: Adenosine Deaminase; Antiviral Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dideoxynucleosides; HIV; Kinetics; Prodrugs; Structure-Activity Relationship

1991
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:12

    Topics: Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; HIV-1; HIV-2; Mice; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymine; Virus Replication

1989
Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogues.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Cell Line; Chemical Phenomena; Chemistry; Deoxycytidine; HIV; Structure-Activity Relationship; T-Lymphocytes, Helper-Inducer; Zalcitabine

1987
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication

1987
HIV-1 reverse transcriptase inhibitor design using artificial neural networks.
    Journal of medicinal chemistry, 1994, Aug-05, Volume: 37, Issue:16

    Topics: Algorithms; Cell Line; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Structure; Neural Networks, Computer; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; T-Lymphocytes; Zidovudine

1994
Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by novel dideoxy nucleosides.
    Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19

    Topics: Adenosine; Alkynes; Animals; Anti-Bacterial Agents; Cell Line; Cell Survival; Dideoxynucleosides; Drug Resistance, Bacterial; Guanosine; Microbial Sensitivity Tests; Mycobacterium avium; Mycobacterium bovis; Mycobacterium tuberculosis; Purine Nucleosides; Structure-Activity Relationship; Uridine

2007
An original pronucleotide strategy for the simultaneous delivery of two bioactive drugs.
    European journal of medicinal chemistry, 2021, Apr-15, Volume: 216

    Topics: Anti-HIV Agents; Antiviral Agents; Cell Line, Tumor; Cell Survival; Drug Carriers; HIV-1; Humans; Nucleotides; Prodrugs

2021
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Structural analysis of 2',3'-dideoxyinosine, 2',3'-dideoxyadenosine, 2',3'-dideoxyguanosine and 2',3'-dideoxycytidine by 500-MHz 1H-NMR spectroscopy and ab-initio molecular orbital calculations.
    Journal of biochemical and biophysical methods, 1992, Volume: 25, Issue:4

    Topics: Didanosine; Dideoxyadenosine; Dideoxynucleosides; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Structure; Spectrum Analysis; Structure-Activity Relationship; Temperature; Thermodynamics; Zalcitabine

1992
Experimental studies of the hematologic and immune system toxicity of nucleoside derivatives used against HIV infection.
    International journal of immunopharmacology, 1991, Volume: 13 Suppl 1

    Topics: Animals; Bone Marrow; Didanosine; Dideoxyadenosine; Female; HIV Infections; Immune System; Immunoglobulin M; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Zalcitabine; Zidovudine

1991
Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:7

    Topics: Antiviral Agents; Base Sequence; Cell Line; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; DNA Replication; HIV; Humans; RNA-Directed DNA Polymerase; RNA, Messenger; T-Lymphocytes; Transcription, Genetic; Zalcitabine

1987
Antiviral effects of 3'-azido-3'-deoxythymidine, 2',3'-dideoxycytidine, and 2',3'-dideoxyadenosine against simian acquired immunodeficiency syndrome-associated type D retrovirus in vitro.
    AIDS research and human retroviruses, 1988, Volume: 4, Issue:5

    Topics: Animals; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Dideoxyadenosine; Dideoxynucleosides; Humans; Macaca mulatta; Microbial Sensitivity Tests; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Zalcitabine; Zidovudine

1988
An in vitro system for screening anti-hepatitis B virus drugs.
    Virology, 1989, Volume: 169, Issue:1

    Topics: Acyclovir; Adenine; Antiviral Agents; Blotting, Southern; Carcinoma, Hepatocellular; Cytarabine; Dideoxyadenosine; Dideoxynucleosides; DNA Replication; DNA, Viral; Hepatitis B virus; Humans; Interferons; Liver Neoplasms; Tumor Cells, Cultured; Vidarabine; Virus Replication; Zalcitabine; Zidovudine

1989
Inhibitory effect of azidothymidine, 2'-3'-dideoxyadenosine, and 2'-3'-dideoxycytidine on in vitro growth of hematopoietic progenitor cells from normal persons and from patients with AIDS.
    Experimental hematology, 1989, Volume: 17, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Bone Marrow; Colony-Forming Units Assay; Deoxyribonucleosides; Dideoxyadenosine; Dideoxynucleosides; Dose-Response Relationship, Drug; Growth Inhibitors; Hematopoiesis; Hematopoietic Stem Cells; Humans; Zalcitabine; Zidovudine

1989
Testing of nucleoside analogues in cats infected with feline leukemia virus: a model.
    Intervirology, 1989, Volume: 30 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Viral; Antiviral Agents; Cats; Cell Line; Didanosine; Dideoxyadenosine; Dideoxynucleosides; Disease Models, Animal; Drug Evaluation, Preclinical; Immunologic Deficiency Syndromes; Leukemia Virus, Feline; Leukemia, Experimental; Nucleosides; Specific Pathogen-Free Organisms; Virus Replication; Zalcitabine; Zidovudine

1989
A comparison of three nucleoside analogs with anti-retroviral activity on immune and hematopoietic functions in mice: in vitro toxicity to precursor cells and microstromal environment.
    Toxicology and applied pharmacology, 1989, Volume: 101, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antigen-Antibody Reactions; Antiviral Agents; Bone Marrow; Dideoxyadenosine; Female; Hematopoiesis; HIV; Immunity, Cellular; Macrophages; Mice; Mice, Inbred C57BL; Spleen; Stem Cells; T-Lymphocytes; Virus Replication; Zalcitabine; Zidovudine

1989
Permeation and salvage of dideoxyadenosine in mammalian cells.
    Molecular pharmacology, 1989, Volume: 36, Issue:1

    Topics: Animals; Carrier Proteins; Coformycin; Deamination; Dideoxyadenosine; Dideoxynucleosides; Erythrocytes; Humans; Leukemia, Experimental; Membrane Proteins; Mice; Nucleoside Transport Proteins; Pentostatin; Permeability; Zalcitabine

1989
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.
    The Journal of experimental medicine, 1987, Oct-01, Volume: 166, Issue:4

    Topics: Adenosine Kinase; Cell Line; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dideoxyadenosine; HIV; Humans; Macrophages; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Uridine Kinase; Virus Replication; Zalcitabine; Zidovudine

1987
2',3'-Dideoxynucleoside phosphorylation by deoxycytidine kinase from normal human thymus extracts: activation of potential drugs for AIDS therapy.
    Biochemical and biophysical research communications, 1987, Nov-13, Volume: 148, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Coformycin; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dideoxyadenosine; Humans; Kinetics; Pentostatin; Phosphorylation; Phosphotransferases; Structure-Activity Relationship; Thymus Extracts; Thymus Gland; Zalcitabine

1987
Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro.
    AIDS research and human retroviruses, 1988, Volume: 4, Issue:2

    Topics: Cytopathogenic Effect, Viral; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; HIV; In Vitro Techniques; Nucleosides; Retroviridae; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Proteins; Virus Replication; Zalcitabine; Zidovudine

1988
Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:3

    Topics: Animals; Antiviral Agents; Blood-Brain Barrier; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; Liver; Male; Rats; Rats, Inbred Strains; Thymidine; Zalcitabine; Zidovudine

1988
Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.
    The Journal of experimental medicine, 1988, Sep-01, Volume: 168, Issue:3

    Topics: Antiviral Agents; Deoxycytidine Kinase; Dideoxyadenosine; Dideoxynucleosides; HIV; Humans; In Vitro Techniques; Macrophages; Monocytes; Phosphorylation; Thymidine Kinase; Time Factors; Virus Replication; Zalcitabine; Zidovudine

1988
Determination of 2',3'-dideoxyadenosine, 2',3'-dideoxyinosine and 2',3'-dideoxycytidine in biological samples.
    Journal of chromatography, 1988, Sep-23, Volume: 431, Issue:1

    Topics: Animals; Antiviral Agents; Cats; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Didanosine; Dideoxyadenosine; Dideoxynucleosides; Female; Half-Life; Injections, Intravenous; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344; Spectrophotometry, Ultraviolet; Zalcitabine

1988
Structures of two dideoxynucleosides: 2',3'-dideoxyadenosine and 2',3'-dideoxycytidine.
    Acta crystallographica. Section C, Crystal structure communications, 1988, Feb-15, Volume: 44 ( Pt 2)

    Topics: Crystallography; Dideoxyadenosine; Hydrogen Bonding; Molecular Conformation; Molecular Structure; X-Ray Diffraction; Zalcitabine

1988
Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:6

    Topics: Antiviral Agents; Carbohydrate Conformation; Cell Division; Cytopathogenic Effect, Viral; Deltaretrovirus; Deoxyadenosines; Deoxycytidine; Deoxyribonucleosides; Dideoxyadenosine; Dideoxynucleosides; Gene Products, gag; Humans; Lymphocyte Activation; Mitogens; Retroviridae Proteins; Structure-Activity Relationship; T-Lymphocytes; Thymidine; Vidarabine; Zalcitabine

1986
Intracellular metabolism of 2',3'-dideoxynucleosides in duck hepatocyte primary cultures.
    Biochemical pharmacology, 1995, May-11, Volume: 49, Issue:9

    Topics: Animals; Animals, Newborn; Antiviral Agents; Cells, Cultured; Deoxycytidine; Dideoxyadenosine; Dideoxynucleosides; Ducks; Hepatitis B Virus, Duck; Liver; Phosphorylation; Zalcitabine

1995
Selective inhibition of the reverse transcription of duck hepatitis B virus by binding of 2',3'-dideoxyguanosine 5'-triphosphate to the viral polymerase.
    Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:1

    Topics: Animals; Antiviral Agents; Blotting, Northern; Blotting, Southern; Deoxyguanine Nucleotides; Depression, Chemical; Dideoxyadenosine; Dideoxynucleotides; DNA-Directed DNA Polymerase; Ducks; Hepatitis B Virus, Duck; RNA-Directed DNA Polymerase; Transcription, Genetic; Virus Replication; Zalcitabine

1996
Prevention of anomalous band mobility in A + G sequencing ladders of 3'-end-labeled DNA.
    BioTechniques, 1999, Volume: 27, Issue:1

    Topics: Dideoxyadenosine; DNA; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Phosphorus Radioisotopes; Sequence Analysis, DNA; Zalcitabine

1999
Identification of residues involved in the specificity and regulation of the highly efficient multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster.
    Journal of molecular biology, 2000, Aug-25, Volume: 301, Issue:4

    Topics: Animals; Cytarabine; Dideoxyadenosine; Directed Molecular Evolution; Drosophila melanogaster; Enzyme Activation; Feedback; Inhibitory Concentration 50; Kinetics; Mutation; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Substrate Specificity; Thymidine; Thymine Nucleotides; Zalcitabine; Zidovudine

2000
Differential effects of nucleoside analogs on oxidative phosphorylation in human pancreatic cells.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:9

    Topics: Antimetabolites; Cells, Cultured; Didanosine; Dideoxyadenosine; DNA, Mitochondrial; Humans; Oxidative Phosphorylation; Pancreas; Zalcitabine

2001
The base component of 3'-azido-2',3'-dideoxynucleosides influences resistance mutations selected in HIV-1 reverse transcriptase.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:8

    Topics: Anti-HIV Agents; Azides; Base Sequence; Dideoxyadenosine; Dideoxynucleosides; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Mutagenesis, Site-Directed; Reverse Transcriptase Inhibitors; Sequence Analysis, RNA; Zalcitabine; Zidovudine

2011