zalcitabine has been researched along with deoxycytidine in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (51.85) | 18.7374 |
| 1990's | 12 (22.22) | 18.2507 |
| 2000's | 8 (14.81) | 29.6817 |
| 2010's | 6 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E | 1 |
| Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H | 1 |
| Li, Y; Liotta, DC; Liu, L; Lutz, S; Soni, PB; Zhang, X | 1 |
| Matthes, E; Merz, H; Müller, WE; Schröder, HC; Steffen, R; von Janta-Lipinski, M; Will, H | 1 |
| Mancini, WR | 1 |
| Patel, SS; Szebeni, J; Wahl, LM; Weinstein, JN | 1 |
| De Clercq, E | 1 |
| Cheng, YC; Starnes, MC | 1 |
| Broder, S; DeVico, AL; Di Marzo Veronese, F; Jarrett, RF; Johns, DG; Matsukura, M; Mitsuya, H; Reitz, MS; Sarngadharan, MG | 1 |
| Balzarini, J; De Clercq, E; Desmyter, J; Goubau, P; Herdewijn, P; Pauwels, R; Vandeputte, M; Vanderhaeghe, H | 1 |
| Carson, DA; Kornbluth, RS; Richman, DD | 1 |
| Fridland, A; Johns, DG; Johnson, MA | 1 |
| Miller, JL | 1 |
| Balzarini, J; Broder, S; Cooney, DA; Cupp, JE; Dalal, M; DeClercq, E; Johns, DG; Kang, GJ | 1 |
| Baba, M; Balzarini, J; Broder, S; de Clercq, E; Herdewijn, P; Johns, DG; Pauwels, R | 1 |
| Brady, RO; O'Neill, RR | 1 |
| Birnbaum, GI; Lin, TS; Prusoff, WH | 1 |
| Broder, S; Mitsuya, H | 2 |
| Baba, M; Balzarini, J; De Clerq, E; Herdewijn, P; Pauwels, R | 1 |
| Chou, TC; Coleman, LA; Durno, AG; Hirsch, MS; Kaplan, JC; Paradis, TJ; Schooley, RT; Vogt, MW | 1 |
| Balfour, HH; Henry, K; Thurn, JR | 1 |
| Coons, T; McCartan, K; Rockwell, S; Ullman, B | 1 |
| Pardridge, WM; Terasaki, T | 1 |
| Allain, JP; Dubinsky, R; Fischl, MA; Klecker, RW; McAtee, N; McNeely, MC; Perno, CF; Thomas, RV; Wills, RJ; Yarchoan, R | 1 |
| Broder, S; Dalakas, M; Dubinsky, RM; Yarchoan, R | 1 |
| Balzarini, J; Broder, S; Cooney, DA; Dalal, M; Johns, DG; McMahon, JB; Mitsuya, H; Nadkarni, M | 1 |
| Balzarini, J; Broder, S; Cooney, DA; Dalal, M; De Clercq, E; Herdewijn, P; Johns, DG; Kang, GJ; Pauwels, R | 1 |
| Chen, MS; Kinney-Thomas, E; Lin, TS; Prusoff, WH; Schinazi, RF | 1 |
| Broder, S; Driscoll, JS; Kim, CH; Marquez, VE; Mitsuya, H | 1 |
| Offerhaus, L | 1 |
| Broder, S; Matsushita, S; Mitsuya, H; Reitz, MS | 1 |
| Lin, TS; Mancini, WR | 1 |
| Kemp, SD; Larder, BA; Parry, NR; Tisdale, M | 1 |
| Kitos, TE; Tyrrell, DL | 1 |
| Ashman, C; Belmonte, AR; Cammack, N; Hooker, EU; Jin, H; Mansour, TS; Salomon, H; Wainberg, MA; Wang, W | 1 |
| Arnér, ES; Eriksson, S | 1 |
| Barbosa, P; Buchbinder, S; Feinberg, M; Harrer, E; Harrer, T; Johnson, RP; Walker, BD | 1 |
| Back, DJ; Barry, MG; Hoggard, PG; Kewn, S; Veal, GJ | 1 |
| Kawaguchi, T; Saneyoshi, M; Shudo, K; Tomikawa, A; Yamaguchi, T | 1 |
| Bridges, EG; Cheng, YC; Dutschman, DE; Liu, SH; Zhu, YL | 1 |
| Cheng, YC; Chou, KM; Kukhanova, M | 1 |
| Emm, T; Gallagher, K; Geleziunas, R; Li, Y; Olah, T; Shi, G; Unger, S; Wu, JT | 1 |
| Colacino, E; Gosselin, G; Mathé, C; Sindona, G | 1 |
| Avci, A; Erhardt, A; Häussinger, D; Heintges, T; Lörke, J; Sagir, A | 1 |
| Almond, MR; Liotta, DC; Mao, S; Painter, GR | 1 |
| Otto, MJ | 1 |
| Nelson, MR; Waters, L | 1 |
| Armand, R; Kintner, J; Lewis, LD; Perez, R; Yeo, TK | 1 |
| Bünger, H; Matthes, E | 1 |
| Laclair, DD; McKee, EE; Morris, GW | 1 |
| Couvreur, P; Desmaële, D; Gref, R | 1 |
| Berrino, L; Scaglione, F | 1 |
| Ambike, A; Bekkara-Aounallah, F; Couvreur, P; Gref, R; Rosilio, V | 1 |
6 review(s) available for zalcitabine and deoxycytidine
| Article | Year |
|---|---|
Chemotherapeutic approaches to the treatment of the acquired immune deficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adsorption; Antibodies, Viral; Antigens, Viral; Aurintricarboxylic Acid; Deltaretrovirus; Deoxycytidine; Foscarnet; Genes, Viral; Glycoproteins; Humans; Interferons; Male; Phosphonoacetic Acid; Retroviridae Infections; Reverse Transcriptase Inhibitors; Ribavirin; RNA, Viral; Suramin; Thymidine; Transcription, Genetic; Viral Proteins; Virus Replication; Zalcitabine; Zidovudine | 1986 |
[New approaches in the treatment of hepatitis B].
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Contraindications; Deoxycytidine; Emtricitabine; Famciclovir; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Organophosphorus Compounds; Polyethylene Glycols; Prodrugs; Prognosis; Recombinant Proteins; Tenofovir; Zalcitabine | 2004 |
Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.
Topics: Adenine; Cytidine Triphosphate; Deoxycytidine; Deoxycytidine Monophosphate; Deoxyribonucleotides; Dioxolanes; DNA, Viral; Emtricitabine; HIV Infections; HIV Reverse Transcriptase; Humans; Kinetics; Molecular Structure; Nucleosides; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Protein Binding; Protein Conformation; Purine Nucleosides; Reverse Transcriptase Inhibitors; Substrate Specificity; Tenofovir; Zalcitabine | 2004 |
New nucleoside reverse transcriptase inhibitors for the treatment of HIV infections.
Topics: Animals; Anti-HIV Agents; Clinical Trials as Topic; Cytidine Triphosphate; Deoxycytidine; Dideoxynucleosides; Dioxolanes; Emtricitabine; HIV Infections; Humans; Purine Nucleosides; Reverse Transcriptase Inhibitors; Thionucleosides; Zalcitabine | 2004 |
New drugs.
Topics: Anti-HIV Agents; Benzophenones; Cytidine Triphosphate; Darunavir; Deoxycytidine; Emtricitabine; HIV; HIV Fusion Inhibitors; HIV Reverse Transcriptase; Humans; Imidazoles; Nitriles; Protease Inhibitors; Pyridazines; Pyridines; Pyrimidines; Pyrones; Reverse Transcriptase Inhibitors; Sulfonamides; Sulfur Compounds; Zalcitabine | 2005 |
Squalenoylation: a generic platform for nanoparticular drug delivery.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Deoxycytidine; Didanosine; Drug Delivery Systems; Gemcitabine; Humans; Nanoparticles; Squalene; Zalcitabine | 2012 |
3 trial(s) available for zalcitabine and deoxycytidine
| Article | Year |
|---|---|
Progress in antiviral drug and vaccine development assessed at international AIDS conference.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Evaluation; Drug Therapy, Combination; Humans; Ribavirin; Thymidine; Viral Vaccines; Zalcitabine; Zidovudine | 1987 |
AIDS. Treatment strategies and the Minnesota AIDS Clinical Trials Unit.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Humans; Opportunistic Infections; Thymidine; Zalcitabine; Zidovudine | 1988 |
[Azidothymidine and HIV infection].
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Interactions; Humans; Thymidine; Zalcitabine; Zidovudine | 1987 |
45 other study(ies) available for zalcitabine and deoxycytidine
| Article | Year |
|---|---|
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Kinetics; Molecular Structure; Phosphorylation; Pyrimidine Nucleosides; Rabbits; Stavudine; T-Lymphocytes; Thymidine Kinase; Thymus Gland; Zidovudine | 1990 |
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication | 1987 |
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
Topics: Animals; Drosophila melanogaster; Fluorescent Dyes; Nucleosides; Phosphotransferases (Alcohol Group Acceptor) | 2010 |
Inhibition of hepatitis B virus production by modified 2',3'-dideoxy-thymidine and 2',3'-dideoxy-5-methylcytidine derivatives. In vitro and in vivo studies.
Topics: Animals; Antigens, Viral; Deoxycytidine; Dideoxynucleosides; DNA, Viral; Dose-Response Relationship, Drug; Ducks; Hepatitis B virus; Humans; Transfection; Tumor Cells, Cultured; Virus Replication; Zalcitabine | 1992 |
The role of deoxycytidine-metabolizing enzymes in the cytotoxicity induced by 3'-amino-2',3'-dideoxycytidine and cytosine arabinoside.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; HeLa Cells; Humans; Leukemia L1210; Mice; Nucleoside Deaminases; Sensitivity and Specificity; Tumor Cells, Cultured; Zalcitabine | 1992 |
Differential inhibition of 2'-deoxycytidine salvage as a possible mechanism for potentiation of the anti-human immunodeficiency virus activity of 2',3'-dideoxycytidine by dipyridamole.
Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Deoxycytidine; Dipyridamole; Drug Synergism; HIV-1; Humans; Monocytes; Phosphorylation; Zalcitabine | 1991 |
Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro.
Topics: Cell Line; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Dideoxynucleotides; DNA; HIV; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Phosphorylation; RNA; T-Lymphocytes; Zalcitabine | 1987 |
Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro.
Topics: Antiviral Agents; Base Sequence; Cell Line; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; DNA Replication; HIV; Humans; RNA-Directed DNA Polymerase; RNA, Messenger; T-Lymphocytes; Transcription, Genetic; Zalcitabine | 1987 |
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.
Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Deoxycytidine; Flow Cytometry; Fluorescent Antibody Technique; HIV; Humans; Thymidine; Zalcitabine; Zidovudine | 1987 |
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.
Topics: Adenosine Kinase; Cell Line; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dideoxyadenosine; HIV; Humans; Macrophages; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Uridine Kinase; Virus Replication; Zalcitabine; Zidovudine | 1987 |
2',3'-Dideoxynucleoside phosphorylation by deoxycytidine kinase from normal human thymus extracts: activation of potential drugs for AIDS therapy.
Topics: Acquired Immunodeficiency Syndrome; Coformycin; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dideoxyadenosine; Humans; Kinetics; Pentostatin; Phosphorylation; Phosphotransferases; Structure-Activity Relationship; Thymus Extracts; Thymus Gland; Zalcitabine | 1987 |
2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis.
Topics: Animals; Antiviral Agents; Deoxycytidine; Deoxycytosine Nucleotides; HIV; Humans; Leukemia L1210; Mice; Phosphorylation; Pyrimidine Nucleosides; Pyrimidine Nucleotides; Pyrimidines; Thymidine; Tritium; Tumor Cells, Cultured; Zalcitabine | 1987 |
The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.
Topics: Animals; Antiviral Agents; Cell Line; Deoxycytidine; HIV; Humans; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Retroviridae; Thymidine; Zalcitabine; Zidovudine | 1988 |
Therapy for neurological involvement in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Blood-Brain Barrier; Central Nervous System Diseases; Deoxycytidine; Humans; Immunotherapy; Molecular Biology; Retroviridae; Thymidine; Zalcitabine; Zidovudine | 1988 |
Unusual structural features of 2',3'-dideoxycytidine, an inhibitor of the HIV (AIDS) virus.
Topics: Acquired Immunodeficiency Syndrome; Chemical Phenomena; Chemistry; Crystallography; Deoxycytidine; HIV; Models, Molecular; Molecular Conformation; Zalcitabine | 1988 |
Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro.
Topics: Cytopathogenic Effect, Viral; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; HIV; In Vitro Techniques; Nucleosides; Retroviridae; T-Lymphocytes, Helper-Inducer; Thymidine; Viral Proteins; Virus Replication; Zalcitabine; Zidovudine | 1988 |
Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues.
Topics: Animals; Antimetabolites; Antiviral Agents; Cell Division; Deoxycytidine; Deoxycytidine Kinase; Dideoxynucleosides; DNA; HIV; Kinetics; Mice; Phosphorylation; Pyrimidine Nucleosides; Retroviridae; Thymidine; Thymidine Kinase; Zalcitabine | 1988 |
Synergistic interaction of 2',3'-dideoxycytidine and recombinant interferon-alpha-A on replication of human immunodeficiency virus type 1.
Topics: Antiviral Agents; Cell Line; Deoxycytidine; Drug Synergism; HIV; Humans; Interferon Type I; Leukocytes; Recombinant Proteins; Thymidine; Virus Replication; Zalcitabine; Zidovudine | 1988 |
Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured human T lymphoblasts.
Topics: Acquired Immunodeficiency Syndrome; Biological Transport; Cell Division; Cell Survival; Deoxycytidine; Deoxycytidine Kinase; Dipyridamole; Humans; Kinetics; Leukemia, Lymphoid; Mutation; Nucleosides; Phosphorylation; Phosphotransferases; T-Lymphocytes; Thioinosine; Tumor Cells, Cultured; Zalcitabine | 1988 |
Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier.
Topics: Animals; Antiviral Agents; Blood-Brain Barrier; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; Liver; Male; Rats; Rats, Inbred Strains; Thymidine; Zalcitabine; Zidovudine | 1988 |
Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Deoxycytidine; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; HIV; Humans; Male; Middle Aged; Thymidine; Zalcitabine; Zidovudine | 1988 |
Follow-up of neuropathy from 2',3'-dideoxycytidine.
Topics: Deoxycytidine; Drug Administration Schedule; Follow-Up Studies; Humans; Peripheral Nervous System Diseases; Zalcitabine | 1988 |
Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.
Topics: Antiviral Agents; Carbohydrate Conformation; Cell Division; Cytopathogenic Effect, Viral; Deltaretrovirus; Deoxyadenosines; Deoxycytidine; Deoxyribonucleosides; Dideoxyadenosine; Dideoxynucleosides; Gene Products, gag; Humans; Lymphocyte Activation; Mitogens; Retroviridae Proteins; Structure-Activity Relationship; T-Lymphocytes; Thymidine; Vidarabine; Zalcitabine | 1986 |
Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cytopathogenic Effect, Viral; Deltaretrovirus; Deoxycytidine; Deoxycytidine Kinase; Female; Goats; Humans; Leukemia P388; Mice; Structure-Activity Relationship; Thioinosine; Zalcitabine | 1986 |
Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.
Topics: Animals; Antigens, Viral; Antineoplastic Agents; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Deoxycytidine; Deoxycytidine Kinase; HIV; Humans; Mice; Zalcitabine | 1986 |
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
Topics: Antiviral Agents; Deoxycytidine; Fluorescence; HIV; Humans; In Vitro Techniques; Monocytes; Thymidine; Zalcitabine; Zidovudine | 1987 |
Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogues.
Topics: Acquired Immunodeficiency Syndrome; Cell Line; Chemical Phenomena; Chemistry; Deoxycytidine; HIV; Structure-Activity Relationship; T-Lymphocytes, Helper-Inducer; Zalcitabine | 1987 |
Pharmacological inhibition of in vitro infectivity of human T lymphotropic virus type I.
Topics: Deltaretrovirus; Deoxycytidine; DNA, Viral; Humans; Lymphocyte Activation; T-Lymphocytes, Helper-Inducer; Tetanus Toxoid; Thymidine; Virus Replication; Zalcitabine; Zidovudine | 1987 |
Ribo- and deoxyribonucleoside effect on 3'-amino-2',3'-dideoxycytidine-induced cytotoxicity in cultured L1210 cells.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cytarabine; Deamination; Deoxycytidine; Deoxyribonucleosides; DNA, Neoplasm; Leukemia L1210; Ribonucleosides; Zalcitabine | 1983 |
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.
Topics: Amino Acid Sequence; Antiviral Agents; Cell Line; Conserved Sequence; Deoxycytidine; Drug Resistance, Microbial; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Structure-Activity Relationship; T-Lymphocytes; Thionucleosides; Zalcitabine; Zidovudine | 1993 |
Intracellular metabolism of 2',3'-dideoxynucleosides in duck hepatocyte primary cultures.
Topics: Animals; Animals, Newborn; Antiviral Agents; Cells, Cultured; Deoxycytidine; Dideoxyadenosine; Dideoxynucleosides; Ducks; Hepatitis B Virus, Duck; Liver; Phosphorylation; Zalcitabine | 1995 |
Anti-human immunodeficiency virus and anti-hepatitis-B virus activities and toxicities of the enantiomers of 2'-deoxy-3'-oxa-4'-thiocytidine and their 5-fluoro analogues in vitro.
Topics: Animals; Antiviral Agents; Deoxycytidine; Hepatitis B virus; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Liver Neoplasms, Experimental; Stereoisomerism; Thionucleosides; Zalcitabine | 1995 |
Deoxycytidine and 2',3'-dideoxycytidine metabolism in human monocyte-derived macrophages. A study of both anabolic and catabolic pathways.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chromatography, Thin Layer; Deoxycytidine; Humans; Macrophages; Monocytes; Tritium; Zalcitabine | 1993 |
Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor.
Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Conserved Sequence; Deoxycytidine; Didanosine; DNA Primers; Drug Resistance, Microbial; Epitopes; HIV Infections; HIV Reverse Transcriptase; HIV-1; HLA-A2 Antigen; Humans; Lamivudine; Molecular Sequence Data; Oligopeptides; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; T-Lymphocytes, Cytotoxic; Zalcitabine | 1996 |
Lamivudine (3TC) phosphorylation and drug interactions in vitro.
Topics: Anti-HIV Agents; Cells, Cultured; Deoxycytidine; Didanosine; Dideoxynucleosides; Drug Interactions; Humans; Kinetics; Lamivudine; Lymphocyte Activation; Lymphocytes; Mitogens; Models, Chemical; Monocytes; Phosphorylation; Stavudine; Tumor Cells, Cultured; Zalcitabine; Zidovudine | 1997 |
Chiral influences of feedback inhibition with dCTP on murine deoxycytidine kinase.
Topics: Adenosine Triphosphate; Animals; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Feedback; Humans; Kinetics; Leukemia P388; Mice; Stereoisomerism; Substrate Specificity; Zalcitabine | 1997 |
Anti-hepatitis B virus activity and metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine.
Topics: Antiviral Agents; Biological Products; Deoxycytidine; Deoxycytidine Kinase; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Hepatitis B virus; Humans; Lamivudine; Phosphorylation; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured; Zalcitabine | 1998 |
A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.
Topics: Anions; Antineoplastic Agents; Antiviral Agents; Blotting, Western; Carbon-Oxygen Lyases; Cations; Chromatography, Agarose; Chromatography, Ion Exchange; Cytarabine; Cytosine; Deoxycytidine; Deoxycytidine Monophosphate; Deoxyribonuclease IV (Phage T4-Induced); Dioxolanes; DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; Electrophoresis, Polyacrylamide Gel; Endonucleases; Humans; Oligonucleotides; Recombinant Proteins; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Thionucleosides; Tumor Cells, Cultured; Zalcitabine | 2000 |
Novel direct detection method for quantitative determination of intracellular nucleoside triphosphates using weak anion exchange liquid chromatography/tandem mass spectrometry.
Topics: Chromatography, Liquid; Cytidine Triphosphate; Deoxycytidine; Mass Spectrometry; Monocytes; Reverse Transcriptase Inhibitors; Zalcitabine | 2002 |
Synthesis and biological evaluation of some 5-nitro- and 5-amino derivatives of 2'-deoxycytidine, 2',3'-dideoxyuridine, and 2',3'-dideoxycytidine.
Topics: Animals; Anti-HIV Agents; Antiviral Agents; Deoxycytidine; Dideoxynucleosides; Humans; Nitro Compounds; Zalcitabine | 2003 |
Sublethal concentrations of gemcitabine (2',2'-difluorodeoxycytidine) alter mitochondrial ultrastructure and function without reducing mitochondrial DNA content in BxPC-3 human pancreatic carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Deoxycytidine; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Inhibitory Concentration 50; Lactic Acid; Mitochondria; Pancreatic Neoplasms; Reverse Transcriptase Inhibitors; Zalcitabine | 2007 |
Cellular pharmacology of the anti-hepatitis B virus agent beta-L-2',3'-didehydro-2',3'-dideoxy-N4-hydroxycytidine: relevance for activation in HepG2 cells.
Topics: Antiviral Agents; Biotransformation; Cell Line; Chromatography, High Pressure Liquid; Cytidine Deaminase; Deoxycytidine; Half-Life; Hepatitis B virus; Humans; Liver; Phosphorylation; Zalcitabine | 2010 |
Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria.
Topics: Animals; Anti-HIV Agents; Deoxycytidine; Male; Mitochondria, Heart; Myocardium; Nucleosides; Perfusion; Phosphorylation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zalcitabine; Zidovudine | 2010 |
Cytosine deoxyribonucleoside anti-HIV analogues: a small chemical substitution allows relevant activities.
Topics: Anti-HIV Agents; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; HIV Infections; HIV-1; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Treatment Outcome; Zalcitabine | 2012 |
Interfacial behavior of PEGylated lipids and their effect on the stability of squalenoyl-drug nanoassemblies.
Topics: Adsorption; Cholesterol; Deoxycytidine; Drug Carriers; Drug Compounding; Drug Stability; Gemcitabine; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Polyethylene Glycols; Prodrugs; Squalene; Surface Tension; Zalcitabine | 2014 |