zacopride has been researched along with tropisetron in 32 studies
| Studies (zacopride) | Trials (zacopride) | Recent Studies (post-2010) (zacopride) | Studies (tropisetron) | Trials (tropisetron) | Recent Studies (post-2010) (tropisetron) |
|---|---|---|---|---|---|
| 180 | 4 | 16 | 944 | 218 | 150 |
| Protein | Taxonomy | zacopride (IC50) | tropisetron (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 3.1623 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 3.1623 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 3.45 | |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | 1.8 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.488 | |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | 1.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.25) | 18.7374 |
| 1990's | 26 (81.25) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McLean, S; Nagel, AA; Rizzi, JP; Rosen, T; Seeger, T | 1 |
| Bryce, D; Chalabi, PM; Furman, J; Guarino, KJ; Ives, JL; McLean, S; Nagel, AA; Rosen, T; Roth, RW; Seeger, TF | 1 |
| Bloomquist, W; Cohen, ML; Reid, LR; Robertson, DW; Schenck, K; Wong, DT | 1 |
| Adham, N; Branchek, T; Gerald, C; Schechter, L; Vaysse, P; Weinshank, R | 1 |
| Bockaert, J; Claeysen, S; Dumuis, A; Journot, L; Sebben, M | 1 |
| Borrelli, G; Budriesi, R; Butini, S; Caccia, S; Cagnotto, A; Campiani, G; Catalanotti, B; Chiarini, A; Coccone, SS; Colovic, M; Fattorusso, C; Fiorini, I; Fracasso, C; Gemma, S; Hamon, M; Ioan, P; Mennini, T; Morelli, E; Nacci, V; Novellino, E; Persico, M; Ros, S | 1 |
| Bourdin, CM; Lebreton, J; Mathé-Allainmat, M; Thany, SH | 1 |
| Contesse, V; Delarue, C; Feuilloley, M; Grise, P; Hery, F; Lefebvre, H; Raynaud, G; Vaudry, H; Verhofstad, AA; Wolf, LM | 1 |
| Adrien, J; Franc, B; Haj-Dahmane, S; Hamon, M; Jolas, T; Lanfumey, L; Tissier, MH | 1 |
| Hitzemann, R; Svingos, AL | 1 |
| Gozlan, H; Martin, P; Puech, AJ | 1 |
| Ashby, CR; Edwards, E; Wang, RY | 1 |
| Boddeke, HW; Kalkman, HO | 2 |
| Andrews, PL; Bhandari, P | 1 |
| Barrett, JE; Grant, KA | 1 |
| Gandara, DR; Hesketh, PJ | 1 |
| Costall, B; Domeney, AM; Naylor, RJ | 1 |
| Coffman, WJ; Cohen, ML; Wilson, H | 1 |
| Bueno, L; Fargeas, MJ; Fioramonti, J; Theodorou, V | 1 |
| Reith, ME | 1 |
| Bockaert, J; Dumuis, A; Sebben, M | 1 |
| Jackson, CB; Munson, HR; Pinkus, LM; Sancilio, LF | 1 |
| Bloomquist, W; Cohen, ML; Gidda, JS; Lacefield, W | 1 |
| Lucot, JB | 1 |
| Contesse, V; Delarue, C; Hamel, C; Lefebvre, H; Vaudry, H | 1 |
| Barrett, JE; Critchett, D; Hu, W; Sokol, PT; Solomon, AJ; Toral, J; Ziai, MR | 1 |
| Nishida, A; Shimizu, M; Yamawaki, S; Zensho, H | 1 |
| Dahl, SG; Junien, JL; Langlois, A; Pascaud, X; Rivière, PJ | 1 |
| Chen, Y; Matsuki, N; Saito, H | 1 |
| Berry, N; McBride, WJ; McKinzie, DL; Melendez, RI; Murphy, JM; Rodd-Henricks, ZA | 1 |
| Dukat, M; Wesołowska, A | 1 |
32 other study(ies) available for zacopride and tropisetron
| Article | Year |
|---|---|
An initial three-component pharmacophore for specific serotonin-3 receptor ligands.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Computer Graphics; Computer Simulation; Imidazoles; In Vitro Techniques; Indoles; Ligands; Mice; Models, Molecular; Ondansetron; Rats; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Thiazoles; Tropisetron | 1990 |
Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.
Topics: Animals; Blood-Brain Barrier; Brain; Chemical Phenomena; Chemistry; Glioma; Imidazoles; Mice; Molecular Structure; Neuroblastoma; Serotonin Antagonists; Thiazoles; Tumor Cells, Cultured | 1990 |
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.
Topics: Animals; Cell Membrane; Cerebral Cortex; Guinea Pigs; Heart Rate; Ileum; Indazoles; Male; Methylation; Myocardium; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Tritium; Tropanes | 1990 |
[3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor.
Topics: Affinity Labels; Animals; Binding, Competitive; Cloning, Molecular; COS Cells; Indoles; Radioligand Assay; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Transfection | 1996 |
Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.
Topics: Age Factors; Amino Acid Sequence; Animals; Animals, Newborn; Base Sequence; Binding Sites; Brain; Brain Chemistry; Cloning, Molecular; Inferior Colliculi; Mice; Molecular Sequence Data; Rats; Rats, Inbred Strains; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity; Transfection | 1996 |
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Topics: Animals; Baroreflex; Chemical Phenomena; Female; Guinea Pigs; Heart; Heart Atria; Male; Mice; Models, Molecular; Myocardium; Pyrroles; Quinoxalines; Quipazine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists; Structure-Activity Relationship | 2009 |
Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammalian α7 nicotinic acetylcholine receptor.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Humans; Nicotine; Nicotinic Antagonists; Oocytes; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2015 |
Serotonin-induced stimulation of cortisol secretion from human adrenocortical tissue is mediated through activation of a serotonin4 receptor subtype.
Topics: Adrenal Cortex; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Hydrocortisone; Hydroxyindoleacetic Acid; In Vitro Techniques; Indoles; Ketanserin; Methysergide; Radioimmunoassay; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropisetron | 1992 |
Central action of 5-HT3 receptor ligands in the regulation of sleep-wakefulness and raphe neuronal activity in the rat.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Electrophysiology; Indoles; Male; Neurons; Ondansetron; Propranolol; Pyrimidines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Reference Values; Serotonin; Serotonin Antagonists; Sleep; Time Factors; Tropanes; Tropisetron; Wakefulness | 1992 |
5-HT3 receptor antagonists block cocaine-induced locomotion via a PCPA-sensitive mechanism.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dose-Response Relationship, Drug; Fenclonine; Indoles; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Tropanes; Tropisetron | 1992 |
5-HT3 receptor antagonists reverse helpless behaviour in rats.
Topics: Analysis of Variance; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Depression; Disease Models, Animal; Helplessness, Learned; Imidazoles; Indoles; Male; Ondansetron; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tropisetron | 1992 |
Action of serotonin in the medial prefrontal cortex: mediation by serotonin3-like receptors.
Topics: Analysis of Variance; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Frontal Lobe; Indoles; Injections, Intravenous; Iontophoresis; Male; Metergoline; Pindolol; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Spiperone; Tropisetron | 1992 |
Agonist effects at putative central 5-HT4 receptors in rat hippocampus by R(+)- and S(-)-zacopride; no evidence for stereo-selectivity.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Ventricles; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Indoles; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Stereoisomerism; Tropisetron | 1992 |
Preliminary evidence for the involvement of the putative 5-HT4 receptor in zacopride- and copper sulphate-induced vomiting in the ferret.
Topics: Analysis of Variance; Animals; Antiemetics; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Copper; Copper Sulfate; Female; Ferrets; Granisetron; Imidazoles; Indazoles; Indoles; Loperamide; Male; Ondansetron; Receptors, Serotonin; Serotonin Antagonists; Tropisetron; Vomiting | 1991 |
Blockade of the discriminative stimulus effects of ethanol with 5-HT3 receptor antagonists.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Columbidae; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Haloperidol; Indoles; Ketanserin; Male; Serotonin Antagonists; Tropanes; Tropisetron | 1991 |
Serotonin antagonists: a new class of antiemetic agents.
Topics: Antiemetics; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Granisetron; Humans; Imidazoles; Indazoles; Indoles; Metoclopramide; Ondansetron; Quinolizines; Receptors, Serotonin; Serotonin Antagonists; Tropanes; Tropisetron; Vomiting | 1991 |
5-HT3 receptor antagonists attenuate dopamine-induced hyperactivity in the rat.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopamine Antagonists; Female; Granisetron; Indazoles; Indoles; Injections; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tropisetron | 1990 |
5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs.
Topics: Animals; Benzamides; Blood Pressure; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Ergolines; Heart Rate; Hexamethonium; Hexamethonium Compounds; Imidazoles; Indoles; Male; Ondansetron; Receptors, Serotonin; Serotonin; Tropisetron | 1990 |
Involvement of 5-hydroxytryptamine in the intestinal motor disturbances induced by mast cell degranulation in rats.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Duodenum; Gastrointestinal Motility; Indoles; Jejunum; Ketanserin; Lasalocid; Male; Mast Cells; Methysergide; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropisetron | 1991 |
Zacopride and BRL 24924 induce an increase in EEG-energy in rats.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Electroencephalography; Indoles; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Scopolamine; Serotonin Antagonists; Tropisetron | 1990 |
5-HT3 receptor antagonists attenuate cocaine-induced locomotion in mice.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Caffeine; Cocaine; Drug Interactions; Indoles; Male; Methysergide; Mice; Mice, Inbred C57BL; Motor Activity; Receptors, Serotonin; Serotonin Antagonists; Tropisetron | 1990 |
Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives.
Topics: Adenylyl Cyclases; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Activation; Guinea Pigs; Hippocampus; In Vitro Techniques; Indoles; Male; Receptors, Serotonin; Serotonin; Signal Transduction; Spiperone; Structure-Activity Relationship; Tropisetron | 1990 |
Emetic activity of zacopride in ferrets and its antagonism by pharmacological agents.
Topics: Animals; Antiemetics; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Dopamine Antagonists; Emetics; Fasting; Ferrets; Haloperidol; Indoles; Male; Prochlorperazine; Serotonin Antagonists; Tropisetron | 1990 |
Comparison of the 5-HT3 receptor antagonist properties of ICS 205-930, GR38032F and zacopride.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbachol; Cisplatin; Guinea Pigs; Heart Rate; Imidazoles; In Vitro Techniques; Indoles; Male; Ondansetron; Receptors, Serotonin; Serotonin Antagonists; Tropisetron; Vomiting | 1989 |
Blockade of 5-hydroxytryptamine3 receptors prevents cisplatin-induced but not motion- or xylazine-induced emesis in the cat.
Topics: Animals; Antiemetics; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cats; Cisplatin; Indoles; Motion Sickness; Receptors, Serotonin; Serotonin Antagonists; Thiazines; Tropanes; Tropisetron; Vomiting; Xylazine | 1989 |
Effect of a series of 5-HT4 receptor agonists and antagonists on steroid secretion by the adrenal gland in vitro.
Topics: Adrenal Glands; Aldosterone; Animals; Benzamides; Benzimidazoles; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Corticosterone; Dose-Response Relationship, Drug; Indoles; Male; Radioligand Assay; Ranidae; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tropisetron | 1994 |
5-HT3 receptor-independent inhibition of the depolarization-induced 86Rb efflux from human neuroblastoma cells, TE671, by ondansetron.
Topics: Anti-Anxiety Agents; Benzamides; Benzofurans; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; Humans; Hypoglycemic Agents; Indazoles; Indoles; Neuroblastoma; Neurotoxins; Ondansetron; Potassium Channels; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Rubidium Radioisotopes; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Tropanes; Tropisetron; Tumor Cells, Cultured | 1995 |
Chronic amitriptyline exposure reduces 5-HT3 receptor-mediated cyclic GMP formation in NG 108-15 cells.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Benzamides; Bradykinin; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cyclic GMP; Fluorescent Dyes; Fura-2; Glioma; Hybrid Cells; Indoles; Kinetics; Neuroblastoma; Receptors, Serotonin; Serotonin Antagonists; Tropisetron; Tumor Cells, Cultured | 1996 |
Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Colon; Granisetron; Indoles; Male; Muscle Contraction; Muscle, Smooth; Ondansetron; Pain; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Tropisetron | 1996 |
Ethanol-induced emesis in the house musk shrew, Suncus murinus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetaldehyde; Alcohol Deterrents; Animals; Antiemetics; Baclofen; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System Depressants; Disulfiram; Dose-Response Relationship, Drug; Ethanol; Female; GABA Antagonists; Indoles; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Piperidines; Serotonin Antagonists; Serotonin Receptor Agonists; Shrews; Tiopronin; Tropisetron; Vagotomy; Vomiting | 1997 |
Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System Depressants; Drug Interactions; Ethanol; Female; Indazoles; Indoles; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Self Administration; Serotonin Antagonists; Stereoisomerism; Tropanes; Tropisetron; Ventral Tegmental Area | 2003 |
Antinociception: mechanistic studies on the action of MD-354 and clonidine. Part 1. The 5-HT3 component.
Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Indoles; Male; Mice; Mice, Inbred ICR; Models, Animal; Motor Activity; Ondansetron; Pain; Pain Measurement; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Time Factors; Tropisetron | 2005 |