Compounds > zacopride
Page last updated: 2024-09-02

zacopride and clonidine

zacopride has been researched along with clonidine in 4 studies

Compound Research Comparison

Studies
(zacopride)		Trials
(zacopride)		Recent Studies (post-2010)
(zacopride)		Studies
(clonidine)		Trials
(clonidine)		Recent Studies (post-2010) (clonidine)
18041613,6922,0441,394

Protein Interaction Comparison

ProteinTaxonomyzacopride (IC50)clonidine (IC50)
Alpha-2A adrenergic receptorHomo sapiens (human)0.101
Alpha-2B adrenergic receptorHomo sapiens (human)0.0353
Alpha-2C adrenergic receptorHomo sapiens (human)0.0115
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)5.365
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-1D adrenergic receptorHomo sapiens (human)1.21
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)5.365
Alpha-2A adrenergic receptorBos taurus (cattle)0.002
NischarinRattus norvegicus (Norway rat)0.3662

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cheng, CH; Costall, B; Ge, J; Naylor, RJ1
Kamato, T; Miyata, K; Nagakura, Y; Naitoh, Y; Yamano, M1
Dukat, M; Wesolowska, A; Young, S1
Dukat, M; WesoĊ‚owska, A1

Other Studies

4 other study(ies) available for zacopride and clonidine

ArticleYear
The profiles of interaction of yohimbine with anxiolytic and putative anxiolytic agents to modify 5-HT release in the frontal cortex of freely-moving rats.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Clonidine; Dialysis; Diazepam; Drug Interactions; Extracellular Space; Frontal Lobe; Hydroxyindoleacetic Acid; Male; Ondansetron; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Yohimbine

1993
Compounds possessing 5-HT3 receptor antagonistic activity inhibit intestinal propulsion in mice.
    European journal of pharmacology, 1996, Sep-05, Volume: 311, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Benzamides; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Cisapride; Clonidine; Gastrointestinal Transit; Intestines; Male; Mice; Mice, Inbred C57BL; Neostigmine; Ondansetron; Piperidines; Receptors, Serotonin; Serotonin Antagonists

1996
MD-354 potentiates the antinociceptive effect of clonidine in the mouse tail-flick but not hot-plate assay.
    European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3

    Topics: Analgesics; Animals; Benzamides; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Mice; Mice, Inbred ICR; Morphine; Pain; Pain Measurement; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Serotonin

2004
Antinociception: mechanistic studies on the action of MD-354 and clonidine. Part 1. The 5-HT3 component.
    European journal of pharmacology, 2005, Dec-28, Volume: 528, Issue:1-3

    Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Indoles; Male; Mice; Mice, Inbred ICR; Models, Animal; Motor Activity; Ondansetron; Pain; Pain Measurement; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Time Factors; Tropisetron

2005