Page last updated: 2024-09-03

ym 529 and cimadronate

ym 529 has been researched along with cimadronate in 7 studies

Compound Research Comparison

Studies
(ym 529)
Trials
(ym 529)
Recent Studies (post-2010)
(ym 529)
Studies
(cimadronate)
Trials
(cimadronate)
Recent Studies (post-2010) (cimadronate)
140237110534

Protein Interaction Comparison

ProteinTaxonomyym 529 (IC50)cimadronate (IC50)
Farnesyl pyrophosphate synthaseHomo sapiens (human)0.1863
Farnesyl pyrophosphate synthase Leishmania donovani0.16

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (85.71)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burzynska, A; Chan, JM; Colantino, A; Ghosh, S; Kafarski, P; Meints, G; Morita, CT; Oldfield, E; Raker, AM; Sanders, JM; Song, Y; Wang, H1
Hall, P; Hudock, MP; Leon, A; Liu, L; Morita, CT; Oldfield, E; Puan, KJ; Studer, D; Yang, Y; Yin, F1
Ashihara, E; Hatsuse, M; Hirai, H; Inaba, T; Nakagawa, M; Okamoto, A; Okano, A; Shimazaki, C; Takahashi, R1
Iguchi, T; Ikeda, Y; Kizaki, M; Miyakawa, Y; Yamamoto, K1
Fushiki, S; Horie, N; Kimura, S; Kubo, T; Maekawa, T; Matsui, T; Murata, H; Nishigaki, Y; Nogawa, M; Segawa, H; Yuasa, T1
Kubo, T; Matsuo, T; Ochi, M; Sakai, A; Shimose, S; Tanaka, K; Yasunaga, Y1
Imano, M; Itoh, T; Komai, M; Mukai, J; Nishida, S; Ogawa, N; Satou, T; Tsubaki, M1

Other Studies

7 other study(ies) available for ym 529 and cimadronate

ArticleYear
Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.
    Journal of medicinal chemistry, 2004, Jan-15, Volume: 47, Issue:2

    Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Diphosphonates; Geranyltranstransferase; Humans; Leishmania major; Lymphocyte Activation; Models, Molecular; Quantitative Structure-Activity Relationship; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Tumor Necrosis Factor-alpha

2004
Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.
    Journal of medicinal chemistry, 2006, Dec-14, Volume: 49, Issue:25

    Topics: Anti-Bacterial Agents; Cluster Analysis; Diphosphonates; Drug Synergism; Escherichia coli K12; Fosfomycin; Gene Expression; Geranyltranstransferase; Models, Molecular; Oligonucleotide Array Sequence Analysis; Quantitative Structure-Activity Relationship; Terpenes

2006
A newly developed bisphosphonate, YM529, is a potent apoptosis inducer of human myeloma cells.
    Leukemia research, 2001, Volume: 25, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Division; Diphosphonates; Flow Cytometry; Humans; Imidazoles; Multiple Myeloma; Pamidronate; Tumor Cells, Cultured

2001
Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway.
    Cellular signalling, 2003, Volume: 15, Issue:7

    Topics: Apoptosis; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Imidazoles; Interleukin-6; MAP Kinase Signaling System; Mevalonic Acid; Multiple Myeloma; Phosphorylation; Protein Kinases; S Phase; Signal Transduction; Stromal Cells

2003
The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis.
    Cancer letters, 2006, Jul-08, Volume: 238, Issue:1

    Topics: Animals; Apoptosis; Bone Density Conservation Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Diphosphonates; Disease Models, Animal; Drug Screening Assays, Antitumor; GTP-Binding Proteins; Imidazoles; Mice; Osteosarcoma

2006
Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2006, Volume: 24, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Density Conservation Agents; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Diphosphonates; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Inhibitory Concentration 50; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Sarcoma; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2006
Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.
    Biochemical pharmacology, 2013, Jan-15, Volume: 85, Issue:2

    Topics: Alendronate; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Bone Density Conservation Agents; Cell Line, Tumor; Cell Nucleus; Cell Survival; Diphosphonates; Gene Expression Regulation, Neoplastic; Gene Silencing; Hematologic Neoplasms; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Prenylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; TOR Serine-Threonine Kinases

2013