ym-254890 and inositol-1-phosphate

ym-254890 has been researched along with inositol-1-phosphate* in 1 studies

Other Studies

1 other study(ies) available for ym-254890 and inositol-1-phosphate

Article	Year
G protein subtype-specific signaling bias in a series of CCR5 chemokine analogs. Science signaling, 2018, 10-16, Volume: 11, Issue:552 Chemokines and some chemical analogs of chemokines prevent cellular HIV-1 entry when bound to the HIV-1 coreceptors C-C chemokine receptor 5 (CCR5) or C-X-C chemokine receptor 4 (CXCR4), which are G protein-coupled receptors (GPCRs). The ideal HIV-1 entry blocker targeting the coreceptors would display ligand bias and avoid activating G protein-mediated pathways that lead to inflammation. We compared CCR5-dependent activation of second messenger pathways in a single cell line. We studied two endogenous chemokines [RANTES (also known as CCL5) and MIP-1α (also known as CCL3)] and four chemokine analogs of RANTES (5P12-, 5P14-, 6P4-, and PSC-RANTES). We found that CCR5 signaled through both G Topics: Calcium; Chemokine CCL3; Chemokine CCL5; Chemokines; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; HIV-1; Humans; Inflammation; Inositol Phosphates; Ligands; Peptides, Cyclic; Receptors, CCR5; Signal Transduction; Transfection	2018

Article

Year

G protein subtype-specific signaling bias in a series of CCR5 chemokine analogs.

Science signaling, 2018, 10-16, Volume: 11, Issue:552

Chemokines and some chemical analogs of chemokines prevent cellular HIV-1 entry when bound to the HIV-1 coreceptors C-C chemokine receptor 5 (CCR5) or C-X-C chemokine receptor 4 (CXCR4), which are G protein-coupled receptors (GPCRs). The ideal HIV-1 entry blocker targeting the coreceptors would display ligand bias and avoid activating G protein-mediated pathways that lead to inflammation. We compared CCR5-dependent activation of second messenger pathways in a single cell line. We studied two endogenous chemokines [RANTES (also known as CCL5) and MIP-1α (also known as CCL3)] and four chemokine analogs of RANTES (5P12-, 5P14-, 6P4-, and PSC-RANTES). We found that CCR5 signaled through both G

Topics: Calcium; Chemokine CCL3; Chemokine CCL5; Chemokines; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; HIV-1; Humans; Inflammation; Inositol Phosphates; Ligands; Peptides, Cyclic; Receptors, CCR5; Signal Transduction; Transfection

2018