ym-201636 has been researched along with apilimod* in 2 studies
1 review(s) available for ym-201636 and apilimod
| Article | Year |
|---|---|
Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2.
Ion channels are necessary for correct lysosomal function including degradation of cargoes originating from endocytosis. Almost all enveloped viruses, including coronaviruses (CoVs), enter host cells via endocytosis, and do not escape endosomal compartments into the cytoplasm (via fusion with the endolysosomal membrane) unless the virus-encoded envelope proteins are cleaved by lysosomal proteases. With the ongoing outbreak of severe acute respiratory syndrome (SARS)-CoV-2, endolysosomal two-pore channels represent an exciting and emerging target for antiviral therapies. This review focuses on the latest knowledge of the effects of lysosomal ion channels on the cellular entry and uncoating of enveloped viruses, which may aid in development of novel therapies against emerging infectious diseases such as SARS-CoV-2. Topics: Aminopyridines; Antiviral Agents; COVID-19; Drug Design; Endocytosis; Endosomes; Heterocyclic Compounds, 3-Ring; Humans; Hydrazones; Ion Channels; Lysosomes; Models, Biological; Morpholines; Pyrimidines; SARS-CoV-2; Vacuolar Proton-Translocating ATPases; Viral Envelope; Virus Internalization; Virus Uncoating | 2021 |
1 other study(ies) available for ym-201636 and apilimod
| Article | Year |
|---|---|
The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.
Neutrophils rapidly arrive at an infection site because of their unparalleled chemotactic ability, after which they unleash numerous attacks on pathogens through degranulation and reactive oxygen species (ROS) production, as well as by phagocytosis, which sequesters pathogens within phagosomes. Phagosomes then fuse with lysosomes and granules to kill the enclosed pathogens. A complex signaling network composed of kinases, GTPases, and lipids, such as phosphoinositides, helps to coordinate all of these processes. There are seven species of phosphoinositides that are interconverted by lipid kinases and phosphatases. PIKfyve is a lipid kinase that generates phosphatidylinositol-3,5-bisphosphate and, directly or indirectly, phosphatidylinositol-5-phosphate [PtdIns(5)P]. PIKfyve inactivation causes massive lysosome swelling, disrupts membrane recycling, and, in macrophages, blocks phagosome maturation. In this study, we explored for the first time, to our knowledge, the role of PIKfyve in human and mouse neutrophils. We show that PIKfyve inhibition in neutrophils does not affect granule morphology or degranulation, but it causes LAMP1 Topics: Aminopyridines; Animals; Cell Degranulation; Cells, Cultured; Chemotaxis; GTP Phosphohydrolases; Heterocyclic Compounds, 3-Ring; Humans; Hydrazones; Lysosomal-Associated Membrane Protein 1; Lysosomes; Membrane Fusion; Mice; Mice, Inbred Strains; Morpholines; Neutrophils; Phagocytosis; Phagosomes; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Reactive Oxygen Species; Transient Receptor Potential Channels; Triazines | 2017 |