Page last updated: 2024-09-03

ym 022 and l 365260

ym 022 has been researched along with l 365260 in 12 studies

Compound Research Comparison

Studies
(ym 022)
Trials
(ym 022)
Recent Studies (post-2010)
(ym 022)
Studies
(l 365260)
Trials
(l 365260)
Recent Studies (post-2010) (l 365260)
6518422108

Protein Interaction Comparison

ProteinTaxonomyym 022 (IC50)l 365260 (IC50)
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0081
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0081
Cholecystokinin receptor type ARattus norvegicus (Norway rat)0.4981
Gastrin/cholecystokinin type B receptorRattus norvegicus (Norway rat)0.039
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.0081
Histamine H1 receptorCavia porcellus (domestic guinea pig)5
Cholecystokinin receptor type AHomo sapiens (human)0.1585
Gastrin/cholecystokinin type B receptorHomo sapiens (human)0.0079
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)5
Cholecystokinin receptor type ACavia porcellus (domestic guinea pig)0.044
Cysteinyl leukotriene receptor 2Homo sapiens (human)5
Cysteinyl leukotriene receptor 1Homo sapiens (human)5

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (91.67)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Akuzawa, S; Ito, H; Kamato, T; Katuyama, Y; Kobayashi, A; Miyata, K; Nishida, A; Tsutsumi, R; Yamano, M; Yuki, H1
Ding, XQ; Håkanson, R1
Akuzawa, S; Batt, AR; Kendrick, DA; Miyata, K; Nishida, A; Ohta, M; Rooker, DP; Ryder, H; Satoh, M; Semple, G; Szelke, M1
Akuzawa, S; Ito, H; Miyake, A; Miyata, K; Nishida, A; Takemoto, Y; Takinami, Y; Yuki, H1
Brammer, N; Dunlop, J; Ennis, C; Evans, N1
Beinborn, M; Kopin, AS; Quinn, SM1
Alchepo, B; Attoub, S; Bado, A; Laigneau, JP; Lewin, MJ; Moizo, L1
Dunlop, J1
Beinborn, M; Bläker, M; Gordon, MC; Hsu, JE; Kopin, AS; Ren, Y1
Black, JW; Griffin, EP; Harper, EA; Shankley, NP1
Black, JW; Harper, EA; Shankley, NP1
Capellà, G; Clavé, P; Farré, R; González, AA; Monés, J1

Reviews

1 review(s) available for ym 022 and l 365260

ArticleYear
CCK receptor antagonists.
    General pharmacology, 1998, Volume: 31, Issue:4

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Humans; Phenylurea Compounds; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin

1998

Other Studies

11 other study(ies) available for ym 022 and l 365260

ArticleYear
Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:2

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Indoles; Male; Meglumine; Pentagastrin; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide

1994
Evaluation of the specificity and potency of a series of cholecystokinin-B/gastrin receptor antagonists in vivo.
    Pharmacology & toxicology, 1996, Volume: 79, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Ulcer Agents; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; Female; Gastric Emptying; Gastric Mucosa; Histidine Decarboxylase; Hormone Antagonists; Infusions, Intravenous; Lethal Dose 50; Male; Mice; Phenylurea Compounds; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Structure-Activity Relationship

1996
(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.
    Journal of medicinal chemistry, 1997, Jan-31, Volume: 40, Issue:3

    Topics: Administration, Oral; Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Devazepide; Dogs; Gastric Acid; Hormone Antagonists; Molecular Structure; Pancreas; Pentagastrin; Phenylurea Compounds; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Structure-Activity Relationship

1997
YM022, a potent and selective gastrin/CCK-B receptor antagonist, inhibits peptone meal-induced gastric acid secretion in Heidenhain pouch dogs.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:4

    Topics: Animals; Atropine; Benzodiazepines; Benzodiazepinones; Devazepide; Dogs; Dose-Response Relationship, Drug; Eating; Famotidine; Gastric Acid; Histamine; Histamine H2 Antagonists; Hormone Antagonists; Male; Methacholine Chloride; Muscarinic Antagonists; Pentagastrin; Peptones; Phenylurea Compounds; Receptors, Cholecystokinin; Sincalide; Stomach

1997
YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]-3-(3-methylphenyl)urea]: an irreversible cholecystokinin type-B receptor antagonist.
    Biochemical pharmacology, 1997, Jul-01, Volume: 54, Issue:1

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Humans; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Signal Transduction; Tetragastrin; Transfection

1997
Minor modifications of a cholecystokinin-B/gastrin receptor non-peptide antagonist confer a broad spectrum of functional properties.
    The Journal of biological chemistry, 1998, Jun-05, Volume: 273, Issue:23

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; COS Cells; Hormone Antagonists; Inositol Phosphates; Molecular Structure; Mutation; Peptides; Phenylurea Compounds; Receptors, Cholecystokinin; Signal Transduction; Transfection

1998
YM022, a highly potent and selective CCKB antagonist inhibiting gastric acid secretion in the rat, the cat and isolated rabbit glands.
    Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:3

    Topics: Aminopyrine; Animals; Benzodiazepines; Benzodiazepinones; Cats; Cholecystokinin; Dose-Response Relationship, Drug; Gastric Acid; Gastric Fistula; Gastric Mucosa; Gastrins; Hormone Antagonists; Indoles; Male; Meglumine; Phenylurea Compounds; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin

1998
Mutations within the cholecystokinin-B/gastrin receptor ligand 'pocket' interconvert the functions of nonpeptide agonists and antagonists.
    Molecular pharmacology, 1998, Volume: 54, Issue:5

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Cell Membrane; COS Cells; DNA, Complementary; Hormone Antagonists; Humans; Inositol Phosphates; Iodine Radioisotopes; Ligands; Mutagenesis, Site-Directed; Mutation; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide

1998
Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Bridged-Ring Compounds; Cerebral Cortex; Dipeptides; Guinea Pigs; Hormone Antagonists; Indoleacetic Acids; Indoles; Iodine Radioisotopes; Male; Meglumine; Mice; Pancreas; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Succinimides; Thiazoles; Tritium

1999
Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Bridged-Ring Compounds; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Hormone Antagonists; Indoles; Kinetics; Male; Meglumine; Membranes; Nootropic Agents; Pentagastrin; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Tritium

1999
Pharmacological and molecular characterization of muscular cholecystokinin receptors in the human lower oesophageal sphincter.
    Neurogastroenterology and motility, 2000, Volume: 12, Issue:6

    Topics: Adult; Aged; Benzodiazepines; Benzodiazepinones; Esophagogastric Junction; Female; Gastric Emptying; Gastrins; Gastrointestinal Agents; Gene Expression; Hormone Antagonists; Humans; In Vitro Techniques; Indoleacetic Acids; Male; Middle Aged; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sincalide; Thiazoles

2000