ym 022 and l 365260
ym 022 has been researched along with l 365260 in 12 studies
Compound Research Comparison
| Studies (ym 022) | Trials (ym 022) | Recent Studies (post-2010) (ym 022) | Studies (l 365260) | Trials (l 365260) | Recent Studies (post-2010) (l 365260) |
|---|---|---|---|---|---|
| 65 | 1 | 8 | 422 | 10 | 8 |
Protein Interaction Comparison
| Protein | Taxonomy | ym 022 (IC50) | l 365260 (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0081 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0081 | |
| Cholecystokinin receptor type A | Rattus norvegicus (Norway rat) | 0.4981 | |
| Gastrin/cholecystokinin type B receptor | Rattus norvegicus (Norway rat) | 0.039 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0081 | |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | 5 | |
| Cholecystokinin receptor type A | Homo sapiens (human) | 0.1585 | |
| Gastrin/cholecystokinin type B receptor | Homo sapiens (human) | 0.0079 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5 | |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | 0.044 | |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | 5 | |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | 5 |
Research
Studies (12)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (91.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Akuzawa, S; Ito, H; Kamato, T; Katuyama, Y; Kobayashi, A; Miyata, K; Nishida, A; Tsutsumi, R; Yamano, M; Yuki, H | 1 |
| Ding, XQ; Håkanson, R | 1 |
| Akuzawa, S; Batt, AR; Kendrick, DA; Miyata, K; Nishida, A; Ohta, M; Rooker, DP; Ryder, H; Satoh, M; Semple, G; Szelke, M | 1 |
| Akuzawa, S; Ito, H; Miyake, A; Miyata, K; Nishida, A; Takemoto, Y; Takinami, Y; Yuki, H | 1 |
| Brammer, N; Dunlop, J; Ennis, C; Evans, N | 1 |
| Beinborn, M; Kopin, AS; Quinn, SM | 1 |
| Alchepo, B; Attoub, S; Bado, A; Laigneau, JP; Lewin, MJ; Moizo, L | 1 |
| Dunlop, J | 1 |
| Beinborn, M; Bläker, M; Gordon, MC; Hsu, JE; Kopin, AS; Ren, Y | 1 |
| Black, JW; Griffin, EP; Harper, EA; Shankley, NP | 1 |
| Black, JW; Harper, EA; Shankley, NP | 1 |
| Capellà, G; Clavé, P; Farré, R; González, AA; Monés, J | 1 |
Reviews
1 review(s) available for ym 022 and l 365260
| Article | Year |
|---|---|
CCK receptor antagonists.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Humans; Phenylurea Compounds; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1998 |
Other Studies
11 other study(ies) available for ym 022 and l 365260
| Article | Year |
|---|---|
Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Indoles; Male; Meglumine; Pentagastrin; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1994 |
Evaluation of the specificity and potency of a series of cholecystokinin-B/gastrin receptor antagonists in vivo.
Topics: Analysis of Variance; Animals; Anti-Ulcer Agents; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; Female; Gastric Emptying; Gastric Mucosa; Histidine Decarboxylase; Hormone Antagonists; Infusions, Intravenous; Lethal Dose 50; Male; Mice; Phenylurea Compounds; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Structure-Activity Relationship | 1996 |
(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.
Topics: Administration, Oral; Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Devazepide; Dogs; Gastric Acid; Hormone Antagonists; Molecular Structure; Pancreas; Pentagastrin; Phenylurea Compounds; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Structure-Activity Relationship | 1997 |
YM022, a potent and selective gastrin/CCK-B receptor antagonist, inhibits peptone meal-induced gastric acid secretion in Heidenhain pouch dogs.
Topics: Animals; Atropine; Benzodiazepines; Benzodiazepinones; Devazepide; Dogs; Dose-Response Relationship, Drug; Eating; Famotidine; Gastric Acid; Histamine; Histamine H2 Antagonists; Hormone Antagonists; Male; Methacholine Chloride; Muscarinic Antagonists; Pentagastrin; Peptones; Phenylurea Compounds; Receptors, Cholecystokinin; Sincalide; Stomach | 1997 |
YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]-3-(3-methylphenyl)urea]: an irreversible cholecystokinin type-B receptor antagonist.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Humans; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Signal Transduction; Tetragastrin; Transfection | 1997 |
Minor modifications of a cholecystokinin-B/gastrin receptor non-peptide antagonist confer a broad spectrum of functional properties.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; COS Cells; Hormone Antagonists; Inositol Phosphates; Molecular Structure; Mutation; Peptides; Phenylurea Compounds; Receptors, Cholecystokinin; Signal Transduction; Transfection | 1998 |
YM022, a highly potent and selective CCKB antagonist inhibiting gastric acid secretion in the rat, the cat and isolated rabbit glands.
Topics: Aminopyrine; Animals; Benzodiazepines; Benzodiazepinones; Cats; Cholecystokinin; Dose-Response Relationship, Drug; Gastric Acid; Gastric Fistula; Gastric Mucosa; Gastrins; Hormone Antagonists; Indoles; Male; Meglumine; Phenylurea Compounds; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1998 |
Mutations within the cholecystokinin-B/gastrin receptor ligand 'pocket' interconvert the functions of nonpeptide agonists and antagonists.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Cell Membrane; COS Cells; DNA, Complementary; Hormone Antagonists; Humans; Inositol Phosphates; Iodine Radioisotopes; Ligands; Mutagenesis, Site-Directed; Mutation; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1998 |
Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Bridged-Ring Compounds; Cerebral Cortex; Dipeptides; Guinea Pigs; Hormone Antagonists; Indoleacetic Acids; Indoles; Iodine Radioisotopes; Male; Meglumine; Mice; Pancreas; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Succinimides; Thiazoles; Tritium | 1999 |
Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Bridged-Ring Compounds; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Hormone Antagonists; Indoles; Kinetics; Male; Meglumine; Membranes; Nootropic Agents; Pentagastrin; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Tritium | 1999 |
Pharmacological and molecular characterization of muscular cholecystokinin receptors in the human lower oesophageal sphincter.
Topics: Adult; Aged; Benzodiazepines; Benzodiazepinones; Esophagogastric Junction; Female; Gastric Emptying; Gastrins; Gastrointestinal Agents; Gene Expression; Hormone Antagonists; Humans; In Vitro Techniques; Indoleacetic Acids; Male; Middle Aged; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sincalide; Thiazoles | 2000 |