yh 1885 has been researched along with pyrimidinones in 26 studies
| Studies (yh 1885) | Trials (yh 1885) | Recent Studies (post-2010) (yh 1885) | Studies (pyrimidinones) | Trials (pyrimidinones) | Recent Studies (post-2010) (pyrimidinones) |
|---|---|---|---|---|---|
| 30 | 4 | 22 | 6,059 | 604 | 2,692 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 15 (57.69) | 24.3611 |
| 2020's | 6 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, HC; Han, KS; Lee, JW; Lee, MG; Yoo, JK | 1 |
| Han, KS; Kim, YG; Lee, JW; Lee, MG | 1 |
| Han, KS; Kim, YG; Lee, JW; Lee, MG; Yoo, JK | 1 |
| Chung, SJ; Kim, DC; Kim, HS; Lee, JW; Li, H; Shim, CK | 1 |
| Bae, KS; Cho, JY; Chung, JY; Jang, IJ; Lim, HS; Moon, BS; Shin, SG; Shon, JH; Song, KS; Yi, SY; Yu, KS | 1 |
| Park, SY | 1 |
| Choi, KH; Chung, WC; Jung, SH; Kang, BK; Kang, BR; Kim, EJ; Kong, SE; Lee, KM; Oak, JH; Paik, CN | 1 |
| Chen, Y; Fang, L; Li, W; Mu, L; Tian, Y; Xu, X; Yang, Y; Zhang, Y | 1 |
| Chung, JW; Hahm, KB; Kim, JH; Kim, YJ; Kwon, KA; Lim, YJ; Ock, CY | 1 |
| Hahm, KB; Hong, H; Kim, EH; Kim, JH; Kim, YJ; Kwon, KA; Ock, C; Park, DK | 1 |
| Cho, SH; Hong, KS; Jung, JW; Kang, HR; Kim, TE; Kwon, JW; Lee, SH; Yu, KS | 1 |
| Bae, KS; Choi, HY; Jang, SB; Jin, SJ; Kim, MJ; Kim, YH; Lee, SJ; Lim, HS; Noh, YH; Sung, H | 1 |
| Dial, EJ; Graham, DY; Lichtenberger, LM; Lim, YJ; Phan, TM | 1 |
| Cheng, J; Cun, D; Fang, L; Li, W; Liu, J; Quan, P; Xiang, R; Zhang, Y | 1 |
| Li, S; Song, W; Xu, W; Zhang, X | 1 |
| Ahn, SB; Jo, Y; Jo, YK; Kim, HJ; Kim, SH; Park, E; Park, YS; Son, B | 1 |
| Choi, HG; Kim, DS; Kim, DW; Kim, JO; Kim, JS; Lim, SJ; Mustapha, O; Oh, KT; Park, JH; Yong, CS; Youn, YS; Yousaf, AM | 1 |
| Choi, HG; Din, FU; Jeong, SC; Jin, SG; Kim, DS; Kim, JO; Kim, JS; Oh, KT; Park, JH; Yong, CS; Youn, YS; Yousaf, AM | 1 |
| Cho, JH; Choi, HG; Din, FU; Kim, DS; Kim, DW; Kim, JO; Kim, JS; Oh, KT; Park, JH; Yong, CS; Youn, YS | 1 |
| Tytgat, GNJ | 1 |
| Hahm, KB; Han, YM; Her, S; Kim, MS; Park, JM; Park, YJ | 1 |
| Ban, MS; Jang, IJ; Ji, SC; Kim, B; Lee, S; Nam, JY; Oh, J; Song, GS; Sunwoo, J; Yu, KS | 1 |
| Kim, B; Lee, S; Nam, JY; Song, GS; Sunwoo, J | 1 |
| Howden, CW | 1 |
| Choi, JY; Choi, YW; Goo, YT; Kim, CH; Kim, HK; Kim, MS; Sa, CK | 1 |
| Choi, YW; Goo, YT; Kang, MJ; Kim, CH; Kim, HK; Kim, MS; Lee, S; Sa, CK; Sin, GH | 1 |
4 trial(s) available for yh 1885 and pyrimidinones
| Article | Year |
|---|---|
Pharmacokinetic and pharmacodynamic evaluation of a novel proton pump inhibitor, YH1885, in healthy volunteers.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Drug Evaluation; Half-Life; Humans; Hydrogen-Ion Concentration; Male; Metabolic Clearance Rate; Proton Pump Inhibitors; Pyrimidinones; Tetrahydroisoquinolines | 2004 |
Bioavailability and tolerability of combination treatment with revaprazan 200 mg + itopride 150 mg: a randomized crossover study in healthy male Korean volunteers.
Topics: Adult; Area Under Curve; Benzamides; Benzyl Compounds; Biological Availability; Cholinesterase Inhibitors; Chromatography, Liquid; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Humans; Male; Proton Pump Inhibitors; Pyrimidinones; Republic of Korea; Tandem Mass Spectrometry; Tetrahydroisoquinolines; Young Adult | 2012 |
A Proton Pump Inhibitor's Effect on Bone Metabolism Mediated by Osteoclast Action in Old Age: A Prospective Randomized Study.
Topics: Aged; Amino Acids; Bone and Bones; Bone Remodeling; Calcium; Female; Humans; Intention to Treat Analysis; Linear Models; Male; Middle Aged; Multivariate Analysis; Osteoclasts; Prospective Studies; Proton Pump Inhibitors; Pyrimidinones; Tetrahydroisoquinolines | 2015 |
Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects.
Topics: Administration, Oral; Adult; Benzene Derivatives; Dose-Response Relationship, Drug; Gastroesophageal Reflux; Humans; Imidazoles; Male; MicroRNAs; Pyrimidinones; Republic of Korea; Stomach; Tetrahydroisoquinolines; Young Adult | 2020 |
22 other study(ies) available for yh 1885 and pyrimidinones
| Article | Year |
|---|---|
Determination of a new proton pump inhibitor, YH1885, in human plasma and urine by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Isoquinolines; Male; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tetrahydroisoquinolines | 1997 |
Blood partition and protein binding of a new reversible proton pump inhibitor, YH1885.
Topics: Animals; Blood Preservation; Dialysis; Humans; Imidazoles; In Vitro Techniques; Isoquinolines; Protein Binding; Proton Pump Inhibitors; Pyrimidinones; Rabbits; Serum Albumin; Tetrahydroisoquinolines | 1998 |
Pharmacokinetics of a new reversible proton pump inhibitor, YH1885, after intravenous and oral administrations to rats and dogs: hepatic first-pass effect in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Dogs; Injections, Intravenous; Isoquinolines; Jugular Veins; Liver; Male; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Tissue Distribution | 1998 |
The transport of a reversible proton pump antagonist, 5, 6-dimethyl-2-(4-Fluorophenylamino)-4-(1-methyl-1,2,3, 4-tetrahydroisoquinoline-2-yl) pyrimidine hydrochloride (YH1885), across caco-2 cell monolayers.
Topics: Biological Transport; Caco-2 Cells; Epithelial Cells; Humans; Isoquinolines; Proton Pump Inhibitors; Pyrimidinones; Sodium; Tetrahydroisoquinolines | 2001 |
[Effect of acid pump antagonist (Revaprazan, Revanex(R)) on the result of 13C urea breath test in the patients with Helicobacter pylori associated peptic ulcer disease].
Topics: Breath Tests; Carbon Isotopes; False Negative Reactions; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer; Proton Pump Inhibitors; Pyrimidinones; Tetrahydroisoquinolines; Urea | 2011 |
[Effect of acid pump antagonist (Revaprazan, Revanex(R)) on result of 13C urea breath test in patients with Helicobacter pylori associated peptic ulcer disease].
Topics: Breath Tests; Carbon Isotopes; False Negative Reactions; Female; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Peptic Ulcer; Proton Pump Inhibitors; Pyrimidinones; Tetrahydroisoquinolines; Urea | 2011 |
Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension.
Topics: Administration, Oral; Animals; Biological Availability; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Dose-Response Relationship, Drug; Drug Carriers; Freeze Drying; Male; Microscopy, Electron, Scanning; Molecular Structure; Nanoparticles; Particle Size; Phase Transition; Powders; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Wistar; Solubility; Surface Properties; Tetrahydroisoquinolines; X-Ray Diffraction | 2011 |
Acid pump antagonist-provoked HSP27 dephosphorylation and accentuation rescues stomach from indomethacin-induced damages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Culture Techniques; Electrophoresis, Gel, Two-Dimensional; Gastric Mucosa; HSP27 Heat-Shock Proteins; Indomethacin; Pyrimidinones; Rats; Stomach; Tetrahydroisoquinolines | 2011 |
Mitigating endoplasmic reticulum stress with revaprazan ameliorates stress-related mucosal disease.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cytoprotection; Disease Models, Animal; DNA-Binding Proteins; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Gastric Mucosa; Heat-Shock Proteins; Immersion; Inflammation Mediators; Metabolic Detoxication, Phase II; Mice; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Wistar; Regulatory Factor X Transcription Factors; Severity of Illness Index; Stomach Diseases; Stress, Physiological; Stress, Psychological; Tetrahydroisoquinolines; Time Factors; Transcription Factor CHOP; Transcription Factors; X-Box Binding Protein 1 | 2012 |
The potential inhibitory effect of revaprazan, an acid pump antagonist, on anticoagulation with warfarin.
Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Anticoagulants; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Prothrombin Time; Proton Pump Inhibitors; Pyrimidinones; Tetrahydroisoquinolines; Thrombosis; Warfarin | 2011 |
In vitro and in vivo protection against indomethacin-induced small intestinal injury by proton pump inhibitors, acid pump antagonists, or indomethacin-phosphatidylcholine.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Survival; Cells, Cultured; Epithelial Cells; Gastrointestinal Hemorrhage; Indomethacin; Intestinal Mucosa; Intestine, Small; Lansoprazole; Male; Omeprazole; Phosphatidylcholines; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines | 2012 |
Influence of drug physicochemical properties on absorption of water insoluble drug nanosuspensions.
Topics: 1-Octanol; Absorption; Albendazole; Animals; Biological Availability; Calorimetry, Differential Scanning; Fenofibrate; Itraconazole; Male; Microscopy, Electron, Scanning; Nanoparticles; Pharmaceutical Preparations; Powder Diffraction; Probucol; Pyrimidinones; Rats; Rats, Wistar; Solubility; Surface Properties; Suspensions; Tetrahydroisoquinolines; Transition Temperature; Water; X-Ray Diffraction | 2014 |
Design, synthesis, and preliminary activity evaluation of novel pyrimidine derivatives as acid pump antagonists.
Topics: Animals; Benzimidazoles; Drug Design; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; Isoquinolines; Male; Proton Pump Inhibitors; Pyrimidines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tetrahydroisoquinolines | 2015 |
Comparison of a revaprazan-loaded solid dispersion, solid SNEDDS and inclusion compound: Physicochemical characterisation and pharmacokinetics.
Topics: Administration, Oral; Animals; beta-Cyclodextrins; Biological Availability; Drug Carriers; Drug Compounding; Emulsions; Glycerides; Hydrophobic and Hydrophilic Interactions; Hypromellose Derivatives; Male; Oleic Acids; Polyethylene Glycols; Polysorbates; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Solubility; Tetrahydroisoquinolines | 2018 |
Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability.
Topics: Administration, Oral; Animals; Biological Availability; Drug Carriers; Drug Compounding; Gelatin; Male; Particle Size; Pyrimidinones; Rats, Sprague-Dawley; Solubility; Tetrahydroisoquinolines | 2018 |
Revaprazan-loaded surface-modified solid dispersion: physicochemical characterization and in vivo evaluation.
Topics: Administration, Oral; Crystallization; Drug Carriers; Hypromellose Derivatives; Polyethylene Glycols; Proton Pump Inhibitors; Proton-Translocating ATPases; Pyrimidinones; Solubility; Surface-Active Agents; Tetrahydroisoquinolines | 2019 |
Highlights from Gastro Update Europe - Budapest June 26-27, 2019.
Topics: Celiac Disease; Clostridioides difficile; Colorectal Neoplasms; Endoscopy, Digestive System; Enterocolitis, Pseudomembranous; Foodborne Diseases; Gastroesophageal Reflux; Gastrointestinal Diseases; Humans; Pancreatic Intraductal Neoplasms; Pancreatitis; Proton Pump Inhibitors; Pyrimidinones; Pyrroles; Sulfonamides; Tetrahydroisoquinolines | 2019 |
Revaprazan prevented indomethacin-induced intestinal damages by enhancing tight junction related mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Humans; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Tight Junctions | 2020 |
Editorial: pharmacodynamics of potassium-competitive acid blockers: comparing apples with apples - and with oranges. Authors' reply.
Topics: Benzene Derivatives; Citrus sinensis; Healthy Volunteers; Humans; Imidazoles; Malus; Potassium; Pyrimidinones; Tetrahydroisoquinolines | 2021 |
Editorial: pharmacodynamics of potassium-competitive acid blockers: comparing apples with apples-and with oranges.
Topics: Benzene Derivatives; Citrus sinensis; Healthy Volunteers; Humans; Imidazoles; Malus; Potassium; Pyrimidinones; Tetrahydroisoquinolines | 2021 |
Development of a Solid Supersaturable Micelle of Revaprazan for Improved Dissolution and Oral Bioavailability Using Box-Behnken Design.
Topics: Administration, Oral; Animals; Biological Availability; Drug Compounding; Male; Micelles; Models, Theoretical; Particle Size; Polyethylene Glycols; Pyrimidinones; Rats, Sprague-Dawley; Solubility; Solutions; Surface-Active Agents; Tetrahydroisoquinolines | 2021 |
Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system.
Topics: Administration, Oral; Animals; Biological Availability; Drug Delivery Systems; Drug Liberation; Emulsions; Nanoparticles; Particle Size; Pyrimidinones; Rats; Solubility; Tetrahydroisoquinolines | 2022 |